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Mindfulness-based cognitive therapy as a treatment for chronic depression: A preliminary study
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This pilot study investigated the effectiveness of Mindfulness-Based Cognitive Therapy (MBCT), a treatment combining mindfulness meditation and interventions taken from cognitive therapy, in patients suffering from chronic-recurrent depression. Currently symptomatic patients with at least three previous episodes of depression and a history of suicidal ideation were randomly allocated to receive either MBCT delivered in addition to treatment-as-usual (TAU; N=14 completers) or TAU alone (N=14 completers). Depressive symptoms and diagnostic status were assessed before and after treatment phase. Self-reported symptoms of depression decreased from severe to mild levels in the MBCT group while there was no significant change in the TAU group. Similarly, numbers of patients meeting full criteria for depression decreased significantly more in the MBCT group than in the TAU group. Results are consistent with previous uncontrolled studies. Although based on a small sample and, therefore, limited in their generalizability, they provide further preliminary evidence that MBCT can be used to successfully reduce current symptoms in patients suffering from a protracted course of the disorder.
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“Mindfulness has been shown to be inversely related to depressive symptoms in both cross‐sectional (Gilbert & Christopher, 2010; Gilbert & Gruber, 2014) and intervention (Barnhofer et al., 2009) studies.”
From A mindful yoga intervention for young women with major depressive disorder: Design and baseline sample characteristics of a randomized controlled trial (2020) · cites this paper as Barnhofer et al., 2009
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“Self-reported symptoms of depression were also found to be significantly reduced after receiving MBCT, whereas a similar reduction was not identified in patients who only received their usual pharmacological treatment [51].”
From Potential therapeutic effects of meditation for treating affective dysregulation (2014) · cites this paper as [51]
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“There is also preliminary evidence that MBCT is more effective than treatment as usual (TAU) in reducing depressive symptoms among currently depressed patients (Barnhofer et al., 2009; Hepburn et al., 2009)”
From Effects of mindfulness on psychological health: A review of empirical studies (2011) · cites this paper as Barnhofer et al., 2009
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“Training produces a decoupling of the medial prefrontal cortex (associated with narrative focus) from the insula (viscero-somatic signals), and an increased connection between the insula and the lateral prefrontal cortex (associated with experiential focus).”
From Mindfulness in psychiatry - Where are we now? (2016) · cites this paper as [10]
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“Where substantially larger effects have been observed, these have been based on small samples (Barnhofer et al. 2009; Chiesa et al. 2015; Eisendrath et al. 2015; Kingston et al. 2007).”
From The Effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) in Real-World Healthcare Services (2020) · cites this paper as Barnhofer et al. 2009
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Metadata
- Authors
- Barnhofer, T., Crane, C., Hargus, E., Amarasinghe, M., Winder, R., & Williams, J. M. G.
- Affiliations
- Warneford Hospital (GB)
- Corresponding author
- Barnhofer, Thorsten
- Venue
- Behaviour Research and Therapy
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 47
- Issue
- 5
- Pages
- 366-373
- ISSN
- 0005-7967 (ISSN-L)
- PMC
- PMC2866254
- OpenAlex
- W2027963802
- Cited by
- 396
- References
- 44
- Citations by year
- 2026: 5 · 2025: 16 · 2024: 12 · 2023: 11 · 2022: 27 · 2021: 22 · 2020: 27 · 2019: 19 · 2018: 25 · 2017: 16 · 2016: 32 · 2015: 29 · 2014: 27 · 2013: 25 · 2012: 39
- FWCI
- 36.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Behaviour Research and Therapy (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, other-oa)
- Funders
- Wellcome Trust
- Mind and Life Institute
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- mindfulness-based cognitive therapy, chronic depression, recurrent depression, mindfulness meditation, cognitive therapy, suicidal ideation, depressive symptoms, treatment efficacy
- MeSH terms
- Adult, Depressive Disorder, Female, Humans, Male, Middle Aged, Patient Compliance, Pilot Projects, Psychiatric Status Rating Scales, Recurrence, Cognitive Behavioral Therapy, Treatment Outcome, Meditation, Suicidal Ideation
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