The Berlin Treatment Algorithm: recommendations for tailored innovative therapeutic strategies for multiple sclerosis-related fatigue

Veauthier, Christian; Hasselmann, Helge; Gold, Stefan M.; Paul, Friedemann

doi:10.1186/s13167-016-0073-3

Cited by 71Multiple Sclerosis Research StudiesCancer survivorship and careFibromyalgia and Chronic Fatigue Syndrome Research

The Berlin Treatment Algorithm: recommendations for tailored innovative therapeutic strategies for multiple sclerosis-related fatigue

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Veauthier, Christian, Hasselmann, Helge, Gold, Stefan M., Paul, Friedemann·2016·EPMA Journal

DOI 10.1186/s13167-016-0073-3PMC PMC5121967

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Abstract

More than 80% of multiple sclerosis (MS) patients suffer from fatigue. Despite this, there are few therapeutic options and evidence-based pharmacological treatments are lacking. The associated societal burden is substantial (MS fatigue is a major reason for part-time employment or early retirement), and at least one out of four MS patients view fatigue as the most burdensome symptom of their disease. The mechanisms underlying MS-related fatigue are poorly understood, and objective criteria for distinguishing and evaluating levels of fatigue and tiredness have not yet been developed. A further complication is that both symptoms may also be unspecific indicators of many other diseases (including depression, sleep disorders, anemia, renal failure, liver diseases, chronic obstructive pulmonary disease, drug side effects, recent MS relapses, infections, nocturia, cancer, thyroid hypofunction, lack of physical exercise). This paper reviews current treatment options of MS-related fatigue in order to establish an individualized therapeutic strategy that factors in existing comorbid disorders. To ensure that such a strategy can also be easily and widely implemented, a comprehensive approach is needed, which ideally takes into account all other possible causes and which is moreover cost efficient. Using a diagnostic interview, depressive disorders, sleep disorders and side effects of the medication should be identified and addressed. All MS patients suffering from fatigue should fill out the Modified Fatigue Impact Scale, Epworth Sleepiness Scale, the Beck Depression Inventory (or a similar depression scale), and the Pittsburgh Sleep Quality Index (or the Insomnia Severity Index). In some patients, polygraphic or polysomnographic investigations should be performed. The treatment of underlying sleep disorders, drug therapy with alfacalcidol or fampridine, exercise therapy, and cognitive behavioral therapy-based interventions may be effective against MS-related fatigue. The objectives of this article are to identify the reasons for fatigue in patients suffering from multiple sclerosis and to introduce individually tailored treatment approaches. Moreover, this paper focuses on current knowledge about MS-related fatigue in relation to brain atrophy and lesions, cognition, disease course, and other findings in an attempt to identify future research directions.

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Fatigue is an unpleasant subjective feeling that impairs physical and mental function and prevents patients from daily activities.
“خستگی نوعی احساس ذهنی ناخوشایند است که عملکرد جسمی و روحی فرد را مختل میکند و بیمار را از انجام کارهای روزمره بازمیدارد ] 5 [ .”
From The Effect of Acceptance and Commitment Therapy on the Psychological Consequences of Anxiety, Pain Intensity, and Fatigue in Women with Fibromyalgia: Study with the Effect of Waiting (2022) · cites this paper as [5]
The Background defines MS-related fatigue as a subjective lack of physical or mental energy that interferes with usual activities, and describes it as burdensome. That supports the general description, but the claim’s statement that fatigue prevents daily activities is stronger than the source’s wording; the Clinical correlates section also says severe fatigue does not necessarily reduce cognitive performance. (LLM, conf=0.83)
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Improvement in Fatigue during Natalizumab Treatment is Linked to Improvement in Depression and Day-Time Sleepiness
Penner, I., Sivertsdotter, E. C., Celius, E. G., Fuchs, S., Schreiber, K. I., Berkö, S., Svenningsson, A., & for the TYNERGY trial investigators (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00018 · Cited by 45 · see citing works
Fatigue in multiple sclerosis presenting as acute relapse: subjective and objective assessment
Flachenecker, P., & Meißner, H. (2007) · Multiple Sclerosis Journal · doi:10.1177/1352458507082480 · Cited by 45 · see citing works
Validity of visual perceptive computing for static posturography in patients with multiple sclerosis
Behrens, J. R., Mertens, S., Krüger, T., Grobelny, A., Otte, K., Mansow‐Model, S., Gusho, E., Paul, F., Brandt, A. U., & Schmitz‐Hübsch, T. (2016) · Multiple Sclerosis Journal · doi:10.1177/1352458515625807 · Cited by 44 · see citing works
Self-citation
Carnitine for fatigue in multiple sclerosis
Tejani, A. M., Wasdell, M. B., Spiwak, R. P., Rowell, G., & Nathwani, S. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007280.pub3 · Cited by 43 · see citing works
Characterizing the phenotype of multiple sclerosis–associated depression in comparison with idiopathic major depression
Hasselmann, H., Bellmann–Strobl, J., Ricken, R., Oberwahrenbrock, T., Rose, M., Otte, C., Adli, M., Paul, F., Brandt, A. U., Finke, C., et al. (2016) · Multiple Sclerosis Journal · doi:10.1177/1352458515622826 · Cited by 41 · see citing works
Self-citation
Fatigue in multiple sclerosis: which patient should be referred to a sleep specialist?
Veauthier, C., & Paul, F. (2011) · Multiple Sclerosis Journal · doi:10.1177/1352458511411229 · Cited by 40 · see citing works
Self-citation
Serum lipid antibodies are associated with cerebral tissue damage in multiple sclerosis
Bakshi, R., Yeste, A., Patel, B., Tauhid, S., Tummala, S., Rahbari, R., Chu, R., Regev, K., Kivisäkk, P., Weiner, H. L., et al. (2016) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000200 · Cited by 40 · see citing works
Atrophy of reward-related striatal structures in fatigued MS patients is independent of physical disability
Damasceno, A., Damasceno, B. P., & Cendes, F. (2015) · Multiple Sclerosis Journal · doi:10.1177/1352458515599451 · Cited by 39 · see citing works
Impact of a switch to fingolimod versus staying on glatiramer acetate or beta interferons on patient- and physician-reported outcomes in relapsing multiple sclerosis: post hocanalyses of the EPOC trial
Calkwood, J., Cree, B., Crayton, H. J., Kantor, D., Steingo, B., Barbato, L., Hashmonay, R., Agashivala, N., McCague, K., Tenenbaum, N., et al. (2014) · BMC Neurology · doi:10.1186/s12883-014-0220-1 · Cited by 38 · see citing works
Impact of Natalizumab Treatment on Fatigue, Mood, and Aspects of Cognition in Relapsing–Remitting Multiple Sclerosis
Kunkel, A., Fischer, M., Faiss, J., Dähne, D., KÃ¶hler, W., & Faiss, J. ⁄. R. H. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00097 · Cited by 37 · see citing works
Comparison of the efficacies of oral iron and pramipexole for the treatment of restless legs syndrome patients with low serum ferritin
Lee, C. S., Lee, S. D., Kang, S., Park, H., & Yoon, I. (2013) · European Journal of Neurology · doi:10.1111/ene.12286 · Cited by 36 · see citing works
Multiple sclerosis and primary vascular dysregulation (Flammer syndrome)
Konieczka, K., Koch, S., Binggeli, T., Schoetzau, A., & Kesselring, J. (2016) · The EPMA Journal · doi:10.1186/s13167-016-0062-6 · Cited by 36 · see citing works
Predictive value of early brain atrophy on response in patients treated with interferon β
Miralles, F. C. P., Sastre‐Garriga, J., Vidal‐Jordana, Á., Río, J., Auger, C., Pareto, D., Tintoré, M., Rovira, À., & Montalbán, X. (2015) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000132 · Cited by 34 · see citing works
Integrity of hypothalamic fibers and cognitive fatigue in multiple sclerosis
Hanken, K., Eling, P., Kastrup, A., Klein, J., & Hildebrandt, H. (2014) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2014.11.006 · Cited by 31 · see citing works
Fatigue and Cognition in Patients with Relapsing Multiple Sclerosis Treated with Interferon Beta
Melanson, M., Grossberndt, A., Klowak, M., Leong, C., Frost, E. E., Prout, M., Dorze, J.-A. L., Gramlich, C., Doupe, M., Wong, L., et al. (2010) · International Journal of Neuroscience · doi:10.3109/00207454.2010.511732 · Cited by 31 · see citing works
Hypnotic use and fatigue in multiple sclerosis
Braley, T. J., Segal, B. M., & Chervin, R. D. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2014.09.006 · Cited by 30 · see citing works
Serum Interleukin 2 and Soluble Interleukin 2 Receptor in Patients With Multiple Sclerosis Who Are Experiencing Severe Fatigue
Rudick, R. A., & Barna, B. P. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530030018008 · Cited by 28 · see citing works
Drugs for the treatment of fatigue in palliative care
Radbruch, L., Elsner, F., Krumm, N., Peuckmann‐Post, V., & Trottenberg, P. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006788 · Cited by 27 · see citing works
Treatment of Mood Disorders in Multiple Sclerosis
Pintor, L., Sánchez, R., & Lázaro, E. B. (2014) · Current Treatment Options in Neurology · doi:10.1007/s11940-014-0323-4 · Cited by 27 · see citing works
Improved patient-reported health impact of multiple sclerosis: The ENABLE study of PR-fampridine
Macdonell, R. A. L., Nagels, G., Laplaud, D. A., Pozzilli, C., de Jong, B., SILVA, A. C. F. D., Nicholas, R. S., Lechner‐Scott, J., Gaebler, J. A., Agarwal, S., et al. (2015) · Multiple Sclerosis Journal · doi:10.1177/1352458515606809 · Cited by 27 · see citing works
Fatigue and health-related quality of life in relapsing-remitting multiple sclerosis after 2 years glatiramer acetate treatment are predicted by changes at 6 months: an observational multi-center study
The FOCUS Extension Study Group, Jongen, P. J., Lehnick, D., Koeman, J., Frequin, S. T. F. M., Heersema, D. J., Kornips, B., Schyns-Soeterboek, A., Visser, L. H., Schiphof, P., et al. (2014) · Journal of Neurology · doi:10.1007/s00415-014-7363-2 · Cited by 24 · see citing works
Does amantadine have favourable effects on fatigue in Persian patients suffering from multiple sclerosis?
Ashtari, F., Fatehi, F., Shaygannejad, V., & Chitsaz, A. (2009) · PubMed · Cited by 24 · see citing works
Investigation of Fatigability during Repetitive Robot-Mediated Arm Training in People with Multiple Sclerosis
Severijns, D., Octavia, J. R., Kerkhofs, L., Coninx, K., Lamers, I., & Feys, P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133729 · Cited by 23 · see citing works
Recent developments in the assessment of quality of life in Multiple Sclerosis (MS)
Fischer, J. S., LaRocca, N. G., Miller, D. M., et al. (1999) · Multiple Sclerosis Journal · doi:10.1191/135245899678846177 · Cited by 23 · see citing works
Effects of Dalfampridine Extended-release Tablets on 6-minute Walk Distance in Patients With Multiple Sclerosis: A Post Hoc Analysis of a Double-blind, Placebo-controlled Trial
Applebee, A., Goodman, A. D., Mayadev, A. S., Béthoux, F., Goldman, M. D., Klingler, M. J., Blight, A. R., & Carrazana, E. J. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.10.014 · Cited by 21 · see citing works
Efficacy of physical activity counseling plus sleep restriction therapy on the patients with chronic insomnia
Wang, J., Yin, G., Li, G., Liang, W., & Wei, Q. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s94724 · Cited by 21 · see citing works
Obstructive sleep apnea: its prevention and screening may contribute to the prevention of hypertension, diabetes and cardiovascular diseases
Tanigawa, T. (2011) · The EPMA Journal · doi:10.1007/s13167-011-0073-2 · Cited by 19 · see citing works
Obstructive sleep apnoea as a risk factor for atherosclerosis – implication for preventive and personalised treatment
Tuleta, I., Pabst, S., Juergens, U. R., Nickenig, G., & Skowasch, D. (2011) · The EPMA Journal · doi:10.1007/s13167-011-0070-5 · Cited by 18 · see citing works
Fatigue in progressive multiple sclerosis: results of a randomized, double-blind, placebo-controlled, crossover trial of oral 4-aminopyridine
Rossini, P. M., Pasqualetti, P., Pozzilli, C., et al. (2001) · Multiple Sclerosis Journal · doi:10.1191/135245801701567050 · Cited by 18 · see citing works
Periodic limb movements during REM sleep in multiple sclerosis: a previously undescribed entity
Veauthier, C., Gaede, G., Radbruch, H., Sieb, J. P., Wernecke, K., & Paul, F. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s83350 · Cited by 15 · see citing works
Self-citation
Carnitine for fatigue in multiple sclerosis
Tejani, A. M., Wasdell, M. B., Spiwak, R. P., Rowell, G., & Nathwani, S. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007280.pub2 · Cited by 15 · see citing works
Therapie der Fatigue bei Multipler Sklerose
Veauthier, C., & Paul, F. (2016) · Der Nervenarzt · doi:10.1007/s00115-016-0128-7 · Cited by 14 · see citing works
Self-citation
Younger age, female sex, and high number of awakenings and arousals predict fatigue in patients with sleep disorders: a retrospective polysomnographic observational study
Veauthier, C. (2013) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s50763 · Cited by 13 · see citing works
Self-citation
Fatigue in multiple sclerosis: a diagnostic and therapeutic challenge
Paul, F., & Veauthier, C. (2012) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2012.667075 · Cited by 11 · see citing works
Self-citation
Patient-reported outcomes in multiple sclerosis: Relationships among existing scales and the development of a brief measure
Chua, A. S., Glanz, B. I., GUARINO, A. J., Cook, S. L., Greeke, E. E., Little, G. E., Chitnis, T., & Healy, B. C. (2015) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2015.09.004 · Cited by 10 · see citing works
Hypnotic use and multiple sclerosis related fatigue: a forgotten confounder
Veauthier, C. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2014.11.012 · Cited by 5 · see citing works
Self-citation
Factorial structure of the aftermath of suicide instrument
Spence, N. D., Goldney, R. D., & Moffitt, P. F. (1984) · Journal of Clinical Psychology · doi:10.1002/1097-4679(198411)40:6 · Cited by 2 · see citing works

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Multiple sclerosis
Filippi, M., Bar-Or, A., Piehl, F., Preziosa, P., Solari, A., Vukusic, S., & Rocca, M. A. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0041-4 · Cited by 1,562 · see citing works
Fatigue as a symptom or comorbidity of neurological diseases
Penner, I., & Paul, F. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.117 · Cited by 407 · see citing works
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Distinguishing between Fatigue and Fatigability in Multiple Sclerosis
Enoka, R. M., Almuklass, A. M., Alenazy, M. S., Álvarez, E., & Duchateau, J. (2021) · Neurorehabilitation and neural repair · doi:10.1177/15459683211046257 · Cited by 136 · see citing works
Vitamin D in the prevention, prediction and treatment of neurodegenerative and neuroinflammatory diseases
Bäcker‐Koduah, P., Paul, F., & Dörr, J.-M. (2017) · The EPMA Journal · doi:10.1007/s13167-017-0120-8 · Cited by 129 · see citing works
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Perceived social support as a moderator between negative life events and depression in adolescence: implications for prediction and targeted prevention
Miloseva, L., Vukosavljević‐Gvozden, T., Richter, K., Milosev, V., & Niklewski, G. (2017) · The EPMA Journal · doi:10.1007/s13167-017-0095-5 · Cited by 71 · see citing works
Fatigue in multiple sclerosis: Does the functional or structural damage prevail?
Bertoli, M., & Tecchio, F. (2020) · Multiple Sclerosis Journal · doi:10.1177/1352458520912175 · Cited by 59 · see citing works
Fatigue in patients with neuromyelitis optica spectrum disorder and its impact on quality of life
Seok, J. M., Choi, M., Cho, E. B., Lee, H. L., Kim, B. J., Lee, K. H., Song, P., Joo, E. Y., & Min, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177230 · Cited by 57 · see citing works
Novel uses of retinal imaging with optical coherence tomography in multiple sclerosis
Oertel, F. C., Zimmermann, H. G., Brandt, A. U., & Paul, F. (2018) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1559051 · Cited by 57 · see citing works
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10th Anniversary of the European Association for Predictive, Preventive and Personalised (3P) Medicine - EPMA World Congress Supplement 2020
Golubnitschaja, O., Topolčan, O., Kučera, R., Costigliola, V., EPMA, Akopyan, M., Akulov, S. N., Alexandrova, O., Alonso, A., Andrews, R. J., et al. (2020) · The EPMA Journal · doi:10.1007/s13167-020-00206-1 · Cited by 56 · see citing works
Ozanimod for the treatment of relapsing remitting multiple sclerosis
Rasche, L., & Paul, F. (2018) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2018.1540592 · Cited by 43 · see citing works
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Suggestions for improving the design of clinical trials in multiple sclerosis—results of a systematic analysis of completed phase III trials
Gehr, S., Kaiser, T., Kreutz, R. H., Ludwig, W.-D., & Paul, F. (2019) · The EPMA Journal · doi:10.1007/s13167-019-00192-z · Cited by 43 · see citing works
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Visualizing the Central Nervous System: Imaging Tools for Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders
Kuchling, J., & Paul, F. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00450 · Cited by 39 · see citing works
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Diffusion tensor imaging for multilevel assessment of the visual pathway: possibilities for personalized outcome prediction in autoimmune disorders of the central nervous system
Kuchling, J., Brandt, A. U., Paul, F., & Scheel, M. (2017) · The EPMA Journal · doi:10.1007/s13167-017-0102-x · Cited by 37 · see citing works
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Vitamin D deficiency and its association with fatigue and quality of life in multiple sclerosis patients
Beckmann, Y. Y., Türe, S., & Duman, S. U. (2019) · The EPMA Journal · doi:10.1007/s13167-019-00191-0 · Cited by 33 · see citing works
Psychological well-being in people with multiple sclerosis and its association with illness perception and self-esteem
Timková, V., Mikula, P., Fedičová, M., Szilasiová, J., & Nagyová, I. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.103114 · Cited by 33 · see citing works
Efficacy of an Internet-Based Program to Promote Physical Activity and Exercise after Inpatient Rehabilitation in Persons with Multiple Sclerosis: A Randomized, Single-Blind, Controlled Study
Flachenecker, P., Bures, A. K., Gawlik, A., Weiland, A.-C., Kuld, S., Gusowski, K., Streber, R., Pfeifer, K., & Tallner, A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17124544 · Cited by 32 · see citing works
Efficacy of nanoceria for periodontal tissues alteration in glutamate-induced obese rats—multidisciplinary considerations for personalized dentistry and prevention
Beregova, T. V., Непорада, К. С., Скрипник, М. І., Falalyeyeva, T. M., Nm, Z., Shcherbakov, A. B., Spivak, M. Y., & Bubnov, R. V. (2017) · The EPMA Journal · doi:10.1007/s13167-017-0085-7 · Cited by 30 · see citing works
Association Between Fatigue and Motor Exertion in Patients With Multiple Sclerosis—a Prospective Study
Drebinger, D. A., Rasche, L., Kroneberg, D., Althoff, P., Bellmann–Strobl, J., Weygandt, M., Paul, F., Brandt, A. U., & Schmitz‐Hübsch, T. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00208 · Cited by 30 · see citing works
Self-citation
Autologous hematopoietic stem cell transplantation improves fatigue in multiple sclerosis
Bose, G., Atkins, H. L., Bowman, M. A., & Freedman, M. S. (2018) · Multiple Sclerosis Journal · doi:10.1177/1352458518802544 · Cited by 30 · see citing works
High-intensity interval training and energy management education, compared with moderate continuous training and progressive muscle relaxation, for improving health-related quality of life in persons with multiple sclerosis: study protocol of a randomized controlled superiority trial with six months’ follow-up
Patt, N., Kool, J., Hersche, R., Oberste, M., Walzik, D., Joisten, N., Caminada, D., Ferrara, F., Gonzenbach, R. R., Nigg, C. R., et al. (2021) · BMC Neurology · doi:10.1186/s12883-021-02084-0 · Cited by 23 · see citing works
Measuring objective fatigability and autonomic dysfunction in clinical populations: How and why?
Millet, G. Y., Bertrand, M. F., Lapole, T., Féasson, L., Rozand, V., & Hupin, D. (2023) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2023.1140833 · Cited by 22 · see citing works
Validation of Nursing Outcomes and Interventions to Older Adults Care with Risk or Frail Elderly Syndrome: Proposal of Linkages Among NOC, NIC, and NANDA-I to clinical practice
Lucena, A. D. F., Argenta, C., Almeida, M. D. A., Moorhead, S. A., & Swanson, E. A. (2018) · International Journal of Nursing Knowledge · doi:10.1111/2047-3095.12225 · Cited by 18 · see citing works
Elevated serum [Met5]-enkephalin levels correlate with improved clinical and behavioral outcomes in experimental autoimmune encephalomyelitis
Ludwig, M. D., Zagon, I. S., & McLaughlin, P. J. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.06.015 · Cited by 18 · see citing works
Nocturia in Patients With Multiple Sclerosis.
Peyronnet, B., Krupp, L., Reynolds, W. M., Gamé, X., Amarenco, G., Cornu, J., Ryerson, L. Z., Sammarco, C. L., Howard, J., Charlson, R. W., et al. (2019) · PubMed Central · Cited by 18 · see citing works
Wrist actigraphic approach in primary, secondary and tertiary care based on the principles of predictive, preventive and personalised (3P) medicine
Acker, J. G., Golubnitschaja, O., Büttner‐Teleagă, A., & Richter, K. (2021) · The EPMA Journal · doi:10.1007/s13167-021-00250-5 · Cited by 15 · see citing works
Role of selective attention in fatigue in neurological disorders
Kuppuswamy, A. (2023) · European Journal of Neurology · doi:10.1111/ene.15739 · Cited by 15 · see citing works
Pilot randomized active-placebo-controlled trial of low-dose ketamine for the treatment of multiple sclerosis–related fatigue
Fitzgerald, K. C., Morris, B., Soroosh, A. J., Balshi, A., Maher, D. P., Kaplin, A. I., & Nourbakhsh, B. (2020) · Multiple Sclerosis Journal · doi:10.1177/1352458520936226 · Cited by 15 · see citing works
Neuropsychological Training of Attention Improves MS-Related Fatigue: Results of a Randomized, Placebo-Controlled, Double-Blind Pilot Study
Flachenecker, P., Meißner, H., Frey, R., & Guldin, W. O. (2017) · European Neurology · doi:10.1159/000481941 · Cited by 13 · see citing works
Two healthy lifestyle scores are associated with lower subsequent fatigue risk using inverse probability weighting in an international longitudinal cohort of people with multiple sclerosis
Weiland, T. J., Nag, N., Livera, A. M. D., Jelinek, G. A., Neate, S. L., Bevens, W., & Simpson, S. (2021) · European Journal of Neurology · doi:10.1111/ene.14956 · Cited by 12 · see citing works
What’s in a name? That which we call Multiple Sclerosis Fatigue
Hubbard, A. L., Golla, H., & Lausberg, H. (2020) · Multiple Sclerosis Journal · doi:10.1177/1352458520941481 · Cited by 11 · see citing works
Evidence-based Management of Multiple Sclerosis Spasticity With Nabiximols Oromucosal Spray in Clinical Practice: A 10-year Recap
Chan, A., & Silván, C. V. (2022) · Neurodegenerative Disease Management · doi:10.2217/nmt-2022-0002 · Cited by 12 · see citing works
Sleep Disorders and Fatigue among Patients with MS: The Role of Depression, Stress, and Anxiety
Mohammadi, N. Z., Kianimoghadam, A. S., Mikaeili, N., Asgharian, S. S., Jafari, M., & Masjedi‐Arani, A. (2024) · Neurology Research International · doi:10.1155/2024/6776758 · Cited by 11 · see citing works
Enhancing Mood, Cognition, and Quality of Life in Pediatric Multiple Sclerosis
Fernandez-Carbonell, C., Charvet, L. E., & Krupp, L. (2021) · Pediatric Drugs · doi:10.1007/s40272-021-00451-5 · Cited by 10 · see citing works
Testing Feasibility of a Mobile Application to Monitor Fatigue in People With Multiple Sclerosis
Newland, P., Oliver, B. J., Newland, J. M., & Thomas, F. P. (2019) · Journal of Neuroscience Nursing · doi:10.1097/jnn.0000000000000479 · Cited by 10 · see citing works
Integrated Imaginative Distention Therapy to Cope with Fatigue. DIMMI SI Study: The First Randomized Controlled Trial in Multiple Sclerosis
Sgoifo, A., Bignamini, A., Mantia, L. L., Celani, M. G., Parietti, P., Ceriani, M. A., Marazzi, M. R., Proserpio, P., Nobili, L., Protti, A., et al. (2017) · Neurology and Therapy · doi:10.1007/s40120-017-0081-9 · Cited by 9 · see citing works
Changes of central noradrenaline transporter availability in immunotherapy-naïve multiple sclerosis patients
Schmidt, E., Schinke, C., Rullmann, M., Luthardt, J., Becker, G., Haars, S., Stoppe, M., Lobsien, D., Hoffmann, K., Sabri, O., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-70732-5 · Cited by 9 · see citing works
Consensus recommendations for the diagnosis and treatment of primary progressive multiple sclerosis in Latin America
Cristiano, E., Rojas, J. I., Abad, P., Adoni, T., Barahona, J., Becker, J., Carrá, A., Flores, J., Manuel Fruns, Q., Liguori, N. F., et al. (2018) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2018.07.024 · Cited by 9 · see citing works
Subjective and physiological stress measurement in a multiple sclerosis sample and the relation with executive functions performance
Scheffer, M., Becker, J., de Azeredo, L. A., Grassi‐Oliveira, R., & de Almeida, R. M. M. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-01981-6 · Cited by 9 · see citing works
Open study with (−)-OSU6162 in multiple sclerosis-related fatigue
Haghighi, S., Forsmark, S., Carlsson, A., Nilsson, M. K. L., Carlsson, M. L., Schuit, R. C., & Gottfries, C. (2018) · Acta Neurologica Scandinavica · doi:10.1111/ane.13007 · Cited by 8 · see citing works
Biochemical Correlations with Fatigue in Multiple Sclerosis Detected by MR 2D Localized Correlated Spectroscopy
Arm, J., Al‐iedani, O., Ribbons, K., Lea, R. A., Lechner‐Scott, J., & Ramadan, S. A. (2021) · Journal of Neuroimaging · doi:10.1111/jon.12836 · Cited by 8 · see citing works
Behavioral disorders in multiple sclerosis: a comprehensive review
Jellinger, K. (2024) · Journal of neural transmission · doi:10.1007/s00702-024-02816-9
Neurorehabilitation in Multiple Sclerosis – Resilience in Practice
Kesselring, J. (2017) · European Neurological Review · doi:10.17925/enr.2017.12.01.31 · Cited by 6 · see citing works
Flammer syndrome in multiple sclerosis: diagnostics, prediction, and personalization of treatments
Uzunköprü, C., & Beckmann, Y. Y. (2019) · The EPMA Journal · doi:10.1007/s13167-019-00179-w · Cited by 6 · see citing works
Leczenie i postępowanie objawowe w stwardnieniu rozsianym Rekomendacje Sekcji SM i Neuroimmunologii Polskiego Towarzystwa Neurologicznego
Zakrzewska‐Pniewska, B., Adamczyk-Sowa, M. H., Brola, W., Kalinowska, A., Kułakowska, A., Losy, J., Mirowska-Guzel, D. M., Potemkowski, A., Rejdak, K., Sarzyńska-Długosz, I. M., et al. (2020) · Polski Przegląd Neurologiczny · doi:10.5603/ppn.2019.0033 · Cited by 6 · see citing works
Effect of Nabiximols On Goal Attainment Scale Scores in Patients With treatment-resistant Multiple Sclerosis Spasticity
Paul, F., & Silván, C. V. (2021) · Neurodegenerative Disease Management · doi:10.2217/nmt-2020-0060 · Cited by 5 · see citing works
Self-citation
Increases in Fatigue do Not Change Spasticity Scores in Persons With Multiple Sclerosis
Karpatkin, H., Babyar, S. R., DiCarrado, S., McDarby, M., Narovlianski, M., Perez, B., & Rimawi, I. (2018) · Neurodegenerative Disease Management · doi:10.2217/nmt-2017-0049 · Cited by 5 · see citing works
NUTRISEP: Assessment of the nutritional status of patients with multiple sclerosis and link to fatigue
Donzé, C., Massot, C., Defer, G. L., Vermersch, P., Lecoz, P., Dereeper, O., Khedr, A. A., Neuville, V., Devos, P., Lenne, B., et al. (2023) · Revue Neurologique · doi:10.1016/j.neurol.2022.10.004 · Cited by 4 · see citing works
Longitudinal analysis of primary and secondary factors related to fatigue in multiple sclerosis
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Relationship of Fatigue to Heat Sensitivity in Patients With Multiple Sclerosis: A Review for Management
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Authors: Veauthier, C., Hasselmann, H., Gold, S. M., & Paul, F.
Affiliations: Charité – Universitätsmedizin Berlin (DE)
University Medical Center Hamburg-Eppendorf (DE)
Max Delbrück Center (DE)
Corresponding author: Veauthier, Christian
ORCID: Veauthier, Christian
Gold, Stefan M.
Paul, Friedemann
Venue: EPMA Journal
Publisher: Springer Science and Business Media LLC
Published: 2016-11-24
Volume: 7
Issue: 1
Pages: 25-25
ISSN: 1878-5077 (ISSN-L)
1878-5085
DOI: 10.1186/s13167-016-0073-3
PMC: PMC5121967
OpenAlex: W2553775483
Cited by: 71
References: 192
Citations by year: 2024: 2 · 2023: 7 · 2022: 4 · 2021: 11 · 2020: 13 · 2019: 11 · 2018: 12 · 2017: 11
FWCI: 1.78
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
Locations: The EPMA Journal (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (acceptedVersion)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
Health Sciences › Medicine › Oncology › Cancer survivorship and care
Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Keywords: multiple sclerosis, fatigue, treatment algorithm, personalized treatment, comorbidities, sleep disorders, depression, Modified Fatigue Impact Scale, Epworth Sleepiness Scale, Beck Depression Inventory, Pittsburgh Sleep Quality Index, insomnia, alfacalcidol, fampridine, exercise therapy, cognitive behavioral therapy, brain atrophy, cognitive impairment

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