Cited by 248Mental Health and PsychiatryMental Health Research TopicsPsychology and Mental Health

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The Research Domain Criteria (RDoC): An analysis of methodological and conceptual challenges

Lilienfeld, Scott O.·2014·Behaviour Research and Therapy

DOI 10.1016/j.brat.2014.07.019

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Abstract

In a bold effort to address the longstanding shortcomings of the Diagnostic and Statistical Manual (DSM) framework for the classification and diagnosis of psychopathology, the National Institute of Mental Health recently launched a research program - the Research Domain Criteria (RDoC) - in the hopes of developing an alternative taxonomic system rooted in dysfunctional brain circuitry. Although the RDoC endeavor has considerable promise, it faces several methodological and conceptual challenges, four of which I address here: (a) an overemphasis on biological units and measures, (b) neglect of measurement error, (c) biological and psychometric limitations of endophenotypes, and (d) the distinction between biological predispositions and their behavioral manifestations. Because none of these challenges is in principle insurmountable, I encourage investigators to consider potential remedies for them. RDoC is a calculated gamble that appears to be worth the risk, but its chances of success will be maximized by a thoughtful consideration of hard-won lessons learned--but frequently forgotten--over the past several decades of psychological and psychiatric research.

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Authors: Lilienfeld, S. O.
Affiliations: Emory University (US)
Corresponding author: Lilienfeld, Scott O.
ORCID: Lilienfeld, Scott O.
Venue: Behaviour Research and Therapy
Publisher: Elsevier BV
Published: 2014-11
Volume: 62
Pages: 129-139
ISSN: 0005-7967 (ISSN-L)
DOI: 10.1016/j.brat.2014.07.019
OpenAlex: W2080055550
Cited by: 248
References: 150
Citations by year: 2026: 8 · 2025: 27 · 2024: 8 · 2023: 17 · 2022: 12 · 2021: 21 · 2020: 31 · 2019: 22 · 2018: 24 · 2017: 26 · 2016: 29 · 2015: 18 · 2014: 3
FWCI: 154.12
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behaviour Research and Therapy (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
Social Sciences › Psychology › Clinical Psychology › Psychology and Mental Health
Keywords: Research Domain Criteria, psychopathology classification, DSM, endophenotypes, measurement error, biological predispositions, behavioral manifestations, psychiatric diagnosis
MeSH terms: Mental Disorders, Humans, National Institute of Mental Health (U.S.), Psychiatric Status Rating Scales, Research, United States

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The Research Domain Criteria (RDoC): An analysis of methodological and conceptual challenges

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