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Cited by 163

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Vagus Nerve Stimulation Therapy Randomized to Different Amounts of Electrical Charge for Treatment-Resistant Depression: Acute and Chronic Effects

Open access
Aaronson, Scott T., Carpenter, Linda L., Conway, Charles R., Reimherr, Frederick W., Lisanby, Sarah H., Schwartz, Thomas L., Moreno, Francisco A., Dunner, David L., Lesem, Michael D., Thompson, Peter M., Husain, Mustafa, Vine, Craig J., Banov, Michael D., Bernstein, Lawrence P., Lehman, Robert B., Brannon, Guy E., Keepers, George A., O'Reardon, John P., Rudolph, Richard L., Bunker, Mark·2013·Brain Stimulation
DOI 10.1016/j.brs.2012.09.013
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Abstract

BACKGROUND Major depressive disorder is a prevalent, disabling, and often chronic or recurrent psychiatric condition. About 35% of patients fail to respond to conventional treatment approaches and are considered to have treatment-resistant depression (TRD). OBJECTIVE We compared the safety and effectiveness of different stimulation levels of adjunctive vagus nerve stimulation (VNS) therapy for the treatment of TRD. METHODS In a multicenter, double blind study, 331 patients with TRD were randomized to one of three dose groups: LOW (0.25 mA current, 130 μs pulse width), MEDIUM (0.5-1.0 mA, 250 μs), or HIGH (1.25-1.5 mA, 250 μs). A highly treatment-resistant population (>97% had failed to respond to ≥6 previous treatments) was enrolled. Response and adverse effects were assessed for 22 weeks (end of acute phase), after which output current could be increased, if clinically warranted. Assessments then continued until Week 50 (end of long-term phase). RESULTS VNS therapy was well tolerated. During the acute phase, all groups showed statistically significant improvement on the primary efficacy endpoint (change in Inventory of Depressive Symptomatology-Clinician Administered Version [IDS-C]), but not for any between-treatment group comparisons. In the long-term phase, mean change in IDS-C scores showed continued improvement. Post-hoc analyses demonstrated a statistically significant correlation between total charge delivered per day and decreasing depressive symptoms; and analysis of acute phase responders demonstrated significantly greater durability of response at MEDIUM and HIGH doses than at the LOW dose. CONCLUSIONS TRD patients who received adjunctive VNS showed significant improvement at study endpoint compared with baseline, and the effect was durable over 1 year. Higher electrical dose parameters were associated with response durability.

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Cites

Show all 10 references

Research works printed but not linked: 16

  1. Marangell, 2002, Vagus nerve stimulation (VNS) for major depressive episodes: one year outcomes, Biol Psychiatry, 51, 280, 10.1016/S0006-3223(01)01343-9 · DOI · Paper page
  2. Rush, 2005, Effects of 12 months of vagus nerve stimulation in treatment-resistant depression: a naturalistic study, Biol Psychiatry, 58, 355, 10.1016/j.biopsych.2005.05.024 · DOI · Paper page
  3. Rush, 2005, Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial, Biol Psychiatry, 58, 347, 10.1016/j.biopsych.2005.05.025 · DOI · Paper page
  4. Rush, 2000, Vagus nerve stimulation (VNS) for treatment-resistant depressions: a multicenter study, Biol Psychiatry, 47, 276, 10.1016/S0006-3223(99)00304-2 · DOI · Paper page
  5. Grimm, 2010, Efficacy of vagus nerve stimulation in the treatment of depression, Expert Rev Neurother, 10, 87, 10.1586/ern.09.138 · DOI
  6. Daban, 2008, Safety and efficacy of vagus nerve stimulation in treatment-resistant depression. A systematic review, J Affect Disord, 110, 1, 10.1016/j.jad.2008.02.012 · DOI · Paper page
  7. Peterchev, 2011, Fundamentals of transcranial electric and magnetic stimulation dose: definition, selection, and reporting practices, Brain Stimul, 5, 435, 10.1016/j.brs.2011.10.001 · DOI · Paper page
  8. Handforth, 1998, Vagus nerve stimulation therapy for partial-onset seizures: a randomized active-control trial, Neurology, 51, 48, 10.1212/WNL.51.1.48 · DOI · Paper page
  9. 1995, A randomized controlled trial of chronic vagus nerve stimulation for treatment of medically intractable seizures, Neurology, 45, 224, 10.1212/WNL.45.2.224 · DOI · Paper page
  10. Sheehan, 1998, The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10, J Clin Psychiatry, 59, 22
  11. Montgomery, 1979, A new depression scale designed to be sensitive to change, Br J Psychiatry, 134, 382, 10.1192/bjp.134.4.382 · DOI · Paper page
  12. Hochberg, 1988, A sharper Bonferroni procedure for multiple tests of significance, Biometrika, 75, 800, 10.1093/biomet/75.4.800 · DOI · Paper page
  13. Sackeim, 2007, Durability of antidepressant response to vagus nerve stimulation (VNS), Int J Neuropsychopharmacol, 10, 817, 10.1017/S1461145706007425 · DOI
  14. Sackeim, 1990, The impact of medication resistance and continuation pharmacotherapy on relapse following response to electroconvulsive therapy in major depression, J Clin Psychopharmacol, 10, 96, 10.1097/00004714-199004000-00004 · DOI · Paper page
  15. Conway, 2012, Pretreatment cerebral metabolic activity correlates with antidepressant efficacy of vagus nerve stimulation in treatment-resistant major depression: A potential marker for response?, J Affect Disord, 139, 283, 10.1016/j.jad.2012.02.007 · DOI
  16. Lozano, 2012, A multicenter pilot study of subcallosal cingulate area deep brain stimulation for treatment-resistant depression, J Neurosurg, 116, 315

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Metadata

Authors
Aaronson, S. T., Carpenter, L. L., Conway, C. R., Reimherr, F. W., Lisanby, S. H., Schwartz, T. L., Moreno, F. A., Dunner, D. L., Lesem, M. D., Thompson, P. M., Husain, M., Vine, C. J., Banov, M. D., Bernstein, L. P., Lehman, R. B., Brannon, G. E., Keepers, G. A., O'Reardon, J. P., Rudolph, R. L., & Bunker, M.
Venue
Brain Stimulation
Publisher
Elsevier BV
Published
2013-07
Volume
6
Issue
4
Pages
631-640
ISSN
  • 1876-4754 (ISSN-L)
  • 1935-861X
DOI
10.1016/j.brs.2012.09.013
OpenAlex
W1970665765
Cited by
163
References
10
FWCI
4.36
Type
journal article
Language
en
Open access
green
Licence

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CoChat. (2026). Citation check: Vagus Nerve Stimulation Therapy Randomized to Different Amounts of Electrical Charge for Treatment-Resistant Depression: Acute and Chronic Effects. https://app.cochat.ai/papers/10.1016/j.brs.2012.09.013
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Aaronson, S. T., Carpenter, L. L., Conway, C. R., Reimherr, F. W., Lisanby, S. H., Schwartz, T. L., Moreno, F. A., Dunner, D. L., Lesem, M. D., Thompson, P. M., Husain, M., Vine, C. J., Banov, M. D., Bernstein, L. P., Lehman, R. B., Brannon, G. E., Keepers, G. A., O'Reardon, J. P., Rudolph, R. L., & Bunker, M. (2013). Vagus Nerve Stimulation Therapy Randomized to Different Amounts of Electrical Charge for Treatment-Resistant Depression: Acute and Chronic Effects. Brain Stimulation. https://doi.org/10.1016/j.brs.2012.09.013

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.