HDAC family: What are the cancer relevant targets?

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1. Cladribine in combination with entinostat synergistically elicits anti-proliferative/anti-survival effects on multiple myeloma cells
   Bolun Wang, Hui Lyu, Shanshan Pei, Deye Song, Jiangdong Ni, Bolin Liu · 2018 · Cell Cycle
2. Highly expressed histone deacetylase 5 promotes the growth of hepatocellular carcinoma cells by inhibiting the TAp63-maspin pathway.
   Hongqian Gu, Zejun Fang, Xiang Cai, Rui Yin Song, Min Lin, Jiangwei Ye, Xiaokun Ding, Qinjian Ke, Haihong Chen, Chaoju Gong et al. · 2018 · PubMed Central
3. Efficiently functionalized oxacalix[4]arenes: Synthesis, characterization and exploration of their biological profile as novel HDAC inhibitors
   Viren Mehta, Mohd Athar, Prakash Chandra Jha, Manthan K. Panchal, Krunal Modi, Vinod Kumar Jain · 2015 · Bioorganic & Medicinal Chemistry Letters
4. The role of class IIa histone deacetylases in regulating endothelial function
   Zexu Shen, Yun Bei, Haoran Lin, Tao-Feng Wei, Yunjian Dai, Yangmin Hu, Chao Zhang, Haibin Dai · 2023 · Frontiers in Physiology
5. Electrophilic MiniFrags Revealed Unprecedented Binding Sites for Covalent HDAC8 Inhibitors
   Aaron B. Keeley, Aleksandra Kopranovic, Vincenzo Di Lorenzo, Péter Ábrányi‐Balogh, Niklas Jänsch, Linh N. Lai, László Petri, Zoltán Orgován, Daniel Pölöske, Anna Orlova et al. · 2023 · Journal of Medicinal Chemistry
6. Heterocycles–Containing HDAC Inhibitors Active in Cancer: An Overview of the Last Fifteen Years
   Alessia Raucci, Carola Castiello, Antonello Mai, Clemens Zwergel, Sérgio Valente · 2024 · ChemMedChem
7. Combination of metformin and valproic acid synergistically induces cell cycle arrest and apoptosis in clear cell renal cell carcinoma.
   Xiao Zhang, Xiaopeng Zhang, Tianbao Huang, Jiang Geng, Min Liu, Junhua Zheng · 2015 · PubMed Central
8. Design and Synthesis of Terephthalic Acid‐Based Histone Deacetylase Inhibitors with Dual‐Stage Anti‐Plasmodium Activity
   Katharina Stenzel, Ming Jang Chua, Sandra Duffy, Yevgeniya Antonova‐Koch, Stephan Meister, Alexandra Hamacher, Matthias Ulrich Kassack, Elizabeth A. Winzeler, Vicky M. Avery, Thomas Kurz et al. · 2017 · ChemMedChem
9. Fluorescent analogs of peptoid-based HDAC inhibitors: Synthesis, biological activity and cellular uptake kinetics
   Rick Raudszus, Robert Nowotny, Christoph G. W. Gertzen, Andrea Schöler, Andor Krizsan, I Gockel, Hermann Kalwa, Holger Gohlke, René Thieme, Finn Kristian Hansen · 2019 · Bioorganic & Medicinal Chemistry
10. SET7 interacts with HDAC6 and suppresses the development of colon cancer through inactivation of HDAC6.
    Shi-Lan Zhang, Xiao Du, Linna Tan, Feihong Deng, Bingyi Zhou, Hejun Zhou, Hongyi Zhu, Yi Chu, Deliang Liu, Yuyong Tan · 2020 · PubMed Central
11. Exosome-derived miR-2682-5p suppresses cell viability and migration by HDAC1-silence-mediated upregulation of ADH1A in non-small cell lung cancer
    Guangxian Mao, Zhimin Mu, Da Wu · 2021 · Human & Experimental Toxicology
12. A Novel Hydroxamic Acid-Based Curcumin Derivative as Potent Histone Deacetylase Inhibitor for the Treatment of Glioblastoma
    Hao Wang, Lei Shi, Zhimin Wang · 2021 · Frontiers in Oncology
13. Selective Inhibition of HDAC Class I Sensitizes Leukemia and Neuroblastoma Cells to Anticancer Drugs
    E. Vagapova, M. Kozlov, T. Lebedev, K. Ivanenko, O. Leonova, V. Popenko, P. Spirin, S. Kochetkov, V. Prassolov · 2021 · Biomedicines
14. Epigenetic Metalloenzymes
    Christophe Blanquart, Camille Linot, Pierre‐François Cartron, Daniela Tomaselli, Antonello Mai, Philippe Bertrand · 2018 · Current Medicinal Chemistry
15. Tumor Suppressor Maspin as a Rheostat in HDAC Regulation to Achieve the Fine-Tuning of Epithelial Homeostasis
    Alexander Kaplun, Sijana H. Dzinic, M. Margarida Bernardo, Shijie Sheng · 2012 · Critical Reviews in Eukaryotic Gene Expression
16. 14-3-3ε Mediates the Cell Fate Decision-Making Pathways in Response of Hepatocellular Carcinoma to Bleomycin-Induced DNA Damage
    Siwei Tang, Huimin Bao, Yang Zhang, Jun Yao, Pengyuan Yang, Xian Chen · 2013 · PLoS ONE
17. Global histone deacetylase enzymatic activity is an independent prognostic marker associated with a shorter overall survival in chronic lymphocytic leukemia patients
    Michaël Van Damme, Emerence Crompot, Nathalie Meuleman, Philippe Mineur, Barbara Dessars, Hakim El Housni, D Bron, Laurence Lagneaux, Basile Stamatopoulos · 2014 · Epigenetics
18. Histone H3 Lysine 4 Trimethylation, Lysine 27 Trimethylation, and Lysine 27 Acetylation Contribute to the Transcriptional Repression of Solute Carrier Family 47 Member 2 in Renal Cell Carcinoma
    Qinqin Yu, Yanqing Liu, Xiaoli Zheng, Qianying Zhu, Zhuowei Shen, Hua Wang, Huadong He, Nengming Lin, Huidi Jiang, Lushan Yu et al. · 2016 · Drug Metabolism and Disposition
19. Design, synthesis and biological evaluation of β-peptoid-capped HDAC inhibitors with anti-neuroblastoma and anti-glioblastoma activity
    Nina Reßing, Viktoria Marquardt, Christoph G. W. Gertzen, Andrea Schöler, Alexander R. Schramm, Thomas Kurz, Holger Gohlke, Achim Michael Aigner, Marc Remke, Finn K. Hansen · 2018 · MedChemComm
20. Chromatin Dynamics in Intestinal Epithelial Homeostasis: A Paradigm of Cell Fate Determination versus Cell Plasticity
    Jérémie Rispal, Fabrice Escaffit, Didier Trouche · 2020 · Stem Cell Reviews and Reports
21. The epigenetic modifier HDAC2 and the checkpoint kinase ATM determine the responses of microsatellite instable colorectal cancer cells to 5-fluorouracil
    Nicole Kiweler, Helena Schwarz, Alexandra Nguyen, Stephanie Matschos, Christina Susanne Mullins, Andrea Piée‐Staffa, Christina Brachetti, Wynand Paul Roos, Günter Schneider, Michael Linnebacher et al. · 2022 · Cell Biology and Toxicology
22. Recent Developments and Future Perspectives of Purine Derivatives as a Promising Scaffold in Drug Discovery
    Neha Rana, Parul Grover, Hridayanand Singh · 2024 · Current Topics in Medicinal Chemistry
23. HDAC7: a promising target in cancer
    Cui Liu, Dan Zheng, Xuan Pu, Sijun Li · 2024 · Frontiers in Oncology
24. Targeted intervention of tumor microenvironment with HDAC inhibitors and their combination therapy strategies
    Wanli Zhang, Luqi Ge, Yiwen Zhang, Zhentao Zhang, Wendong Zhang, Feifeng Song, Ping Huang, Tong Xu · 2025 · European journal of medical research
25. Synergistic activity of imatinib and AR-42 against chronic myeloid leukemia cells mainly through HDAC1 inhibition
    Danna Wei, Tingting Lu, Dan Ma, Kunlin Yu, Tianzhuo Zhang, Jie Xiong, Weili Wang, Zhaoyuan Zhang, Qin Fang, Jishi Wang · 2018 · Life Sciences
26. LINC00162 participates in the pathogenesis of diabetic nephropathy via modulating the miR-383/HDAC9 signalling pathway
    Wenxing Fan, Xiaoling Wen, Zheng JinFeng, KunHua Wang, Hongyu Qiu, Jing Zhang, Feng Su · 2020 · Artificial Cells Nanomedicine and Biotechnology
27. 8a, a New Acridine Antiproliferative and Pro-Apoptotic Agent Targeting HDAC1/DNMT1
    Qiting Zhang, Ziyan Wang, Xinyuan Chen, Haoxiang Qiu, Yifan Gu, Ning Wang, Tao Wang, Ze Wang, Huabin Ma, Yufen Zhao et al. · 2021 · International Journal of Molecular Sciences
28. Genome-wide CRISPR/Cas9 screening identifies determinant of panobinostat sensitivity in acute lymphoblastic leukemia
    Chuang Jiang, Maoxiang Qian, Yoshihiro Gocho, Wentao Yang, Guoqing Du, Shuhong Shen, Jun Yang, Hui Zhang · 2022 · Blood Advances
29. New Insights into the Connection Between Histone Deacetylases, Cell Metabolism, and Cancer
    Ferdinando Chiaradonna, Claudia Cirulli, Roberta Palorini, Giuseppina Votta, Lilia Alberghina · 2014 · Antioxidants and Redox Signaling
30. HDAC inhibitors: applications in oncology and beyond
    Omika Katoch, Bilikeri S Dwarakanath, Paban K. Agrawala · 2013 · HOAJ Biology
31. Chlorophyllin abrogates canonical Wnt/β-catenin signaling and angiogenesis to inhibit the development of DMBA-induced hamster cheek pouch carcinomas
    Siddavaram Nagini, Vidya Priyadarsini Ramamurthi, Veeran Veeravarmal, Rajakishore Mishra · 2012 · Cellular Oncology
32. Synthesis, biological evaluation and molecular modeling studies of psammaplin A and its analogs as potent histone deacetylases inhibitors and cytotoxic agents
    Jiachen Wen, Yu J. Bao, Qun Niu, Jiang Liu, Jinyu Yang, Wanqiao Wang, Tao Jiang, Yinbo Fan, Kun Li, Jian Wang et al. · 2015 · Bioorganic & Medicinal Chemistry Letters
33. Clinical and molecular insights into adenoid cystic carcinoma: Neural crest‐like stemness as a target
    Wendell Gray Yarbrough, Alexander Panaccione, Michael T. Chang, Sergey V. Ivanov · 2016 · Laryngoscope Investigative Otolaryngology
34. The effect of histone deacetylase inhibition on the expression of P-glycoprotein in human placental trophoblast cell lines
    Hongyu Duan, Chuan Wang, Kaiyu Zhou, Tao Wang, Yifei Li, Dajian Qiu, Qiang Li, Yi Zhang, Yimin Hua · 2016 · Placenta
35. Identification of lysine acetylome in cervical cancer by label-free quantitative proteomics
    Zhang, Lu, Wang, Wanyue, Zhang, Shanqiang, Wang, Yuxin, Guo, Weikang, Liu, Yunduo, Wang, Yaoxian, Zhang, Yunyan · 2020 · Cancer Cell International
36. HDAC inhibitors as anticancer drugs: chemical diversity, clinical trials, challenges and perspectives
    A. AbdAllah · 2026 · RSC Advances
37. miR-874: An Important Regulator in Human Diseases
    Qiudan Zhang, Chenming Zhong, Qianqian Yan, Linghui Zeng, Wei Gao, Shiwei Duan · 2022 · Frontiers in Cell and Developmental Biology
38. Design, synthesis, biological evaluation and molecular docking study of novel chalcone-based hydroxamic acids possessing a central 2, 4-dimethy pyrrole linker as potential HDAC (Histone Deacetylase) inhibitors and anticancer agents
    Mozhdeh Yousefian, Maryam Hashemi, Vahid Eskandarpour, Farzin Hadizadeh, Afshin Zarghi, Razieh Ghodsi · 2024 · Journal of Molecular Structure
39. Histone deacetylases: potential therapeutic targets for idiopathic pulmonary fibrosis
    Haipeng Cheng, Shi-he Jiang, Jin Cai, Ziqiang Luo, Xiaohong Li, Dandan Feng · 2024 · Frontiers in Cell and Developmental Biology
40. A clinical investigation of inhibitory effect of panobinostat on CYP2D6 substrate in patients with advanced cancer
    Ronald D. Feld, Margaret M. Woo, Natasha B. Leighl, Frances A. Shepherd, Joseph Thaddeus Beck, Lihui Zhao, Lucien Gazi, Thomas Hengelage, Maria Grazia Porro, Asha Nayak · 2013 · Cancer Chemotherapy and Pharmacology
41. Influence of Natural and Synthetic Histone Deacetylase Inhibitors on Chromatin
    Paul Vincent Licciardi, Faith A. A. Kwa, Katherine Ververis, Natasha Di Costanzo, Aneta Balcerczyk, Mimi L.K. Tang, Assam El‐Osta, Tom C. Karagiannis · 2012 · Antioxidants and Redox Signaling
42. HR23b expression is a potential predictive biomarker for HDAC inhibitor treatment in mesenchymal tumours and is associated with response to vorinostat
    Michaela A. Ihle, Sabine Merkelbach‐Bruse, Wolfgang Hartmann, Sebastian Bauer, Nancy Ratner, Hiroshi Sonobe, Jun Nishio, Olle Larsson, Pierre Åman, Florence Pédeutour et al. · 2015 · The Journal of Pathology Clinical Research
43. Histone deacetylase 10 suppresses proliferation and invasion by inhibiting the phosphorylation of β-catenin and serves as an independent prognostic factor for human clear cell renal cell carcinoma.
    Wenxing Fan, Jie Huang, Hua Xiao · 2015 · Europe PMC (PubMed Central)
44. Synthesis, characterization, and evaluation of Cd[L-proline]2, a novel histone deacetylase inhibitor that induces epigenetic modification of histone deacetylase isoforms in A549 cells
    Chidambaram Anusha, Arunachalam Sekar, Kavya S.H., Ramesh Kumar Chidambaram, Arunachalam Kalaiarasi, G. P. Senthilkumar, Vilwanathan Ravikumar · 2017 · Investigational New Drugs
45. Investigation of the in vitro and in vivo efficacy of peptoid-based HDAC inhibitors with dual-stage antiplasmodial activity
    Marcel K. W. Mackwitz, Eva Hesping, Korina Eribez, Andrea Schöler, Yevgeniya Antonova‐Koch, Jana Held, Elizabeth A. Winzeler, Katherine T. Andrews, Finn Kristian Hansen · 2020 · European Journal of Medicinal Chemistry
46. Comprehensive analysis of a new prognosis signature based on histone deacetylases in clear cell renal cell carcinoma
    Fajuan Cheng, Bin Zheng, Jianwei Wang, Guiting Zhao, Zhongshun Yao, Zhihong Niu, Wei He · 2021 · Cancer Medicine
47. Borinostats: solid-phase synthesis of carborane-capped histone deacetylase inhibitors with a tailor-made selectivity profile
    Christoph Selg, Andrea Schöler, Julian Schliehe‐Diecks, Maria Hanl, Laura Sinatra, Arndt Borkhardt, Menyhárt B. Sárosi, Sanil Bhatia, Evamarie Hey‐Hawkins, Finn K. Hansen · 2021 · Chemical Science
48. Synthesis and biological evaluation of aminobenzamides containing purine moiety as class I histone deacetylases inhibitors
    Ping Mao, Wei He, Xi Mai, Li-Huang Feng, Na Li, Yi-Jing Liao, Caicai Zhu, Jian Li, Ting Chen, Shu-Hao Liu et al. · 2021 · Bioorganic & Medicinal Chemistry
49. HDAC7 inhibits cell proliferation via NudCD1/GGH axis in triple‑negative breast cancer
    Mengdi Zhu, Nianqiu Liu, Jinna Lin, Jingru Wang, Hongna Lai, Yujie Liu · 2022 · Oncology Letters
50. Groebke Blackburn Bienaymé-mediated multi-component synthesis of selective HDAC6 inhibitors with anti-inflammatory properties
    Fabian B. Kraft, Jana Enns, Irina Honin, Jonas Engelhardt, Andrea Schöler, Shannon T. Smith, Jens Meiler, Linda Schäker‐Hübner, Günther Weindl, Finn Kristian Hansen · 2024 · Bioorganic Chemistry
51. Targeting the epigenome: effects of epigenetic treatment strategies on genomic stability in healthy human cells
    Jan Christoph Purrucker, Ulrich Mahlknecht · 2010 · Clinical Epigenetics
52. Histone deacetylases expression in atypical teratoid rhabdoid tumors
    Simone Treiger Sredni, Abby L. Halpern, Christopher Allan Hamm, Maria F. Bonaldo, Tadanori Tomita · 2012 · Child s Nervous System
53. Histone Deacetylase 1 and 3 Regulate the Mesodermal Lineage Commitment of Mouse Embryonic Stem Cells
    Weiying Lv, Xudong Guo, Guiying Wang, Yanxin Xu, Jiuhong Kang · 2014 · PLoS ONE
54. Exploring the binding mechanism of HDAC8 selective inhibitors: Lessons from the modification of Cap group
    Min Zhang, Jun Biao Ying, Song Wang, Dian He, Hongtian Zhu, Chenghong Zhang, Lei Tang, Ruili Lin, Yang Zhang · 2020 · Journal of Cellular Biochemistry
55. Epidermal Growth Factor Receptor and its Trafficking Regulation by Acetylation: Implication in Resistance and Exploring the Newer Therapeutic Avenues in Cancer
    Manvendra Kumar, Gaurav Joshi, Joydeep Chatterjee, Raj Kumar · 2020 · Current Topics in Medicinal Chemistry
56. HDAC8 Enhances the Function of HIF‐2α by Deacetylating ETS1 to Decrease the Sensitivity of TKIs in ccRCC
    Kang Qian, Wei Li, Shangqing Ren, Weilin Peng, Bei Qing, Xinlin Liu, Xiong Wei, Liang Zhu, Yapeng Wang, Xin Jin · 2024 · Advanced Science
57. The Epigenetically Regulated Effects of Wnt Antagonists on the Expression of Genes in the Apoptosis Pathway in Human Bladder Cancer Cell Line (T24)
    Nuray Varol, Ece Konaç, Ilke Hacer Onen, Serhat Gürocak, Ebru Alp, Akın Yılmaz, Sevda Menevşe, Sinan Sözen · 2014 · DNA and Cell Biology
58. Chemopreventive Effects of an HDAC2-Selective Inhibitor on Rat Colon Carcinogenesis and APCmin/+ Mouse Intestinal Tumorigenesis
    Durgadevi Ravillah, Altaf Mohammed, Qian Li, Misty F. Brewer, Yuting Zhang, Laura Biddick, Vernon E. Steele, Chinthalapally V. Rao · 2013 · Journal of Pharmacology and Experimental Therapeutics
59. An Integrated Approach to Uncover Driver Genes in Breast Cancer Methylation Genomes
    Xiaopei Shen, Shan Li, Lin Zhang, Hongdong Li, Guini Hong, Xianxiao Zhou, Tingting Zheng, Wenjing Zhang, Chunxiang Hao, Tongwei Shi et al. · 2013 · PLoS ONE
60. Identification of chromatin organization-related gene signature for hepatocellular carcinoma prognosis and predicting immunotherapy response
    Jingbo Chen, Xingte Chen, Ting Li, Lei Wang, Guishan Lin · 2022 · International Immunopharmacology
61. HDAC11 Regulates the Proliferation of Bovine Muscle Stem Cells through the Notch Signaling Pathway and Inhibits Muscle Regeneration
    Ruimen Zhang, Yu Pan, Wanyou Feng, Yimin Zhao, Yan-Yan Yang, Leyi Wang, Yongwang Zhang, Juanru Cheng, Qinyang Jiang, Zihua Zheng et al. · 2022 · Journal of Agricultural and Food Chemistry
62. Antiproliferative effects of TSA, PXD‑101 and MS‑275 in A2780 and MCF7 cells: Acetylated histone H4 and acetylated tubulin as markers for HDACi potency and selectivity
    Vasilis P. Androutsopoulos, Demetrios A. Spandidos · 2017 · Oncology Reports
63. Image-based drug screen identifies HDAC inhibitors as novel Golgi disruptors synergizing with JQ1
    Mathieu Gendarme, Jan Baumann, Tatiana I. Ignashkova, Ralph K. Lindemann, Jan H. Reiling · 2017 · Molecular Biology of the Cell
64. Novel hydroxamic acids incorporating 1-((1H-1,2,3-Triazol-4-yl)methyl)-3-hydroxyimino-indolin-2-ones: synthesis, biological evaluation, and SAR analysis
    Do Thi Mai Dung, Hai Pham‐The, Duong Tien Anh, Huong Le‐Thi‐Thu, Nguyen Thi Kim Yen, Byung Woo Han, Eun Jae Park, Yeo Jin Choi, Jong Soon Kang, Văn Thị Mỹ Huệ et al. · 2018 · Journal of Chemical Sciences
65. Promoter conservation in HDACs points to functional implications
    Toni A. Boltz, Sawsan Khuri, Stefan Wuchty · 2019 · BMC Genomics
66. Histone deacetylases inhibitors as new potential drugs against Leishmania braziliensis, the main causative agent of new world tegumentary leishmaniasis
    Luciana Ângelo de Souza, Matheus Silva e Bastos, Joice de Melo Agripino, Thiago Souza Onofre, Lourdes Fanny Apaza Calla, Tino Heimburg, Ehab Ghazy, Theresa Bayer, Victor Hugo Ferraz da Silva, Paula Dutra Ribeiro et al. · 2020 · Biochemical Pharmacology
67. Design, Synthesis and Biological Evaluation of Nitro Oxide Donating N-Hydroxycinnamamide Derivatives as Histone Deacetylase Inhibitors
    Shiliang Tu, Hang Yuan, Jie Hu, Chengguang Zhao, Rui Chai, Hongfeng Cao · 2014 · Chemical and Pharmaceutical Bulletin
68. Overexpression of SIRT2 contributes tumor cell growth in hepatocellular carcinomas
    Hong Jian Xie, Kwang Hwa Jung, Suk Woo Nam · 2011 · Molecular & Cellular Toxicology
69. Histone Deacetylases in Neurodegenerative Diseases and Their Potential Role as Therapeutic Targets: Shedding Light on Astrocytes
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70. A Nuclear‐Targeted AIE Photosensitizer for Enzyme Inhibition and Photosensitization in Cancer Cell Ablation
    Kang‐Nan Wang, Liu‐Yi Liu, Duo Mao, Ming‐Xuan Hou, Cai‐Ping Tan, Zong‐Wan Mao, Bin Liu · 2022 · Angewandte Chemie
71. HDAC8 As an Emerging Target in Drug Discovery With Special Emphasis on Medicinal Chemistry
    Srinidhi Rajaraman, Ranjani Balakrishnan, Dhruv Deshmukh, Abhiram Ganorkar, Swati Biswas, Sravani Pulya, Balaram Ghosh · 2023 · Future Medicinal Chemistry
72. Dual-targeting compounds possessing enhanced anticancer activity via microtubule disruption and histone deacetylase inhibition
    Yu‐Wei Tseng, Tsung-Jung Yang, Yuan‐Ling Hsu, Jyung‐Hurng Liu, Yin‐Chen Tseng, Tse-Wei Hsu, Yueh Lu, Szu‐Hua Pan, Ting-Jen Rachel Cheng, Jim‐Min Fang · 2023 · European Journal of Medicinal Chemistry
73. Dual-target EZH2 inhibitor: latest advances in medicinal chemistry
    Lai Wei, Dan Mei, Sijia Hu, Shufang Du · 2024 · Future Medicinal Chemistry
74. Role of the histone deacetylase family in lipid metabolism: Structural specificity and functional diversity
    Yunxia Li, Qi Han, Yuxin Liu, Jie Lin Yin, Jie Ma · 2024 · Pharmacological Research
75. Optimizing preclinical study design in oncology research
    Luke A. Wittenburg, Daniel L. Gustafson · 2011 · Chemico-Biological Interactions
76. Yakushinamides, Polyoxygenated Fatty Acid Amides That Inhibit HDACs and SIRTs, from the Marine Sponge Theonella swinhoei
    Kentaro Takada, Yasufumi Imae, Yuji Ise, Susumu Ohtsuka, Akihiro Ito, Shigeru Okada, Minoru Yoshida, Shigeki Matsunaga · 2016 · Journal of Natural Products
77. A small molecular compound CC1007 induces cross-lineage differentiation by inhibiting HDAC7 expression and HDAC7/MEF2C interaction in BCR-ABL1− pre-B-ALL
    Zhi-Hua Wang, Yang Zhang, Shi-Cong Zhu, Hong-Ling Peng, Yongheng Chen, Zhao Cheng, Su-Fang Liu, Yun-ya Luo, Rui-Juan Li, M. Deng et al. · 2020 · Cell Death and Disease
78. Metastasising Fibroblasts Show an HDAC6-Dependent Increase in Migration Speed and Loss of Directionality Linked to Major Changes in the Vimentin Interactome
    Caroline A. Evans, Hyejeong Rosemary Kim, Sarah C. Macfarlane, Poppy I. A. Nowicki, Carsten Baltes, Lei Xu, Jerker Widengren, Franziska Lautenschläger, Bernard Michael Corfe, Annica K. B. Gad · 2022 · International Journal of Molecular Sciences
79. Novel β-dicarbonyl derivatives as inhibitors of aminopeptidase N (APN)
    Chunhua Ma, Xiaoguang Li, Xuewu Liang, Kang Jin, Jiangying Cao, Wenfang Xu · 2013 · Bioorganic & Medicinal Chemistry Letters
80. Isotype-Specific Inhibition of Histone Deacetylases: Identification of Optimal Targets for Radiosensitization
    Jin Ho Kim, Sung Ho Moon, Mina No, Jae Jin Kim, Eun Jung Choi, Bong Jun Cho, Kim Js, Il Han Kim, In Ah Kim · 2015 · Cancer Research and Treatment
81. Synthesis of HDAC Substrate Peptidomimetic Inhibitors Using Fmoc Amino Acids Incorporating Zinc-Binding Groups
    Amit Mahindra, Christopher J. Millard, I. Black, Lewis J. Archibald, John W. R. Schwabe, Andrew G. Jamieson · 2019 · Organic Letters
82. GasPhos: Protein Phosphorylation Site Prediction Using a New Feature Selection Approach with a GA-Aided Ant Colony System
    Chi-Wei Chen, Lan-Ying Huang, Chia-Feng Liao, Kai-Po Chang, Yen-Wei Chu · 2020 · International Journal of Molecular Sciences
83. HDAC INHIBITORS SODIUM BUTYRATE AND SODIUM VALPROATE DO NOT AFFECT HUMAN NCOR1 AND NCOR2 GENE EXPRESSION IN HL-60 CELLS
    Jiřı́ Vrba, Kateřina Smešný Trtková, Jitka Ulrichová A · 2011 · Biomedical Papers
84. High levels of HDAC expression correlate with microglial aging
    Jaione Auzmendi-Iriarte, Leire Moreno‐Cugnon, Ander Saenz‐Antoñanzas, Daniela Grassi, Marian M. de Pancorbo, María‐Ángeles Arévalo, Ian C Wood, Ander Matheu · 2022 · Expert Opinion on Therapeutic Targets
85. Design, Synthesis and Mechanistic Study of New Dual Targeting HDAC/Tubulin Inhibitors
    Mona S. El‐Zoghbi, Amr K. A. Bass, Gamal El‐Din A. Abuo‐Rahma, Mamdouh F. A. Mohamed, Mohamed Badr, Hanan Al-Ghulikah, Elshimaa M. N. Abdelhafez · 2024 · Future Medicinal Chemistry
86. ADORA3 activation promotes goblet cell differentiation via enhancing HMGCS2-mediated ketogenesis in ulcerative colitis
    Xi Zeng, Yuxiao Hu, Simiao Qiao, Xiaoying Cao, Yue Dai, Feihua Wu, Zhifeng Wei · 2024 · International Immunopharmacology
87. Replacing a Cereblon Ligand by a DDB1 and CUL4 Associated Factor 11 (DCAF11) Recruiter Converts a Selective Histone Deacetylase 6 PROTAC into a Pan‐Degrader
    Felix Feller, Heiko Weber, Martina Miranda, Irina Honin, Maria Hanl, Finn K. Hansen · 2025 · ChemMedChem
88. HDACs and Their Inhibitors on Post-Translational Modifications: The Regulation of Cardiovascular Disease
    Siyi Yang, Yidong Sun, Wei Yu · 2025 · Cells
89. A preliminary study on epigenetic regulation of Acanthopanax senticosus in leukemia cell lines
    Qingyuan Wang, Hua Zhong, Fangyuan Chen, Minyue Zhang, Jiayi Cai, Jihua Zhong · 2016 · Experimental Hematology
90. Synthesis, docking study and inhibitory activity of 2,6-diketopiperazines derived from α-amino acids on HDAC8
    Flor Paulina Garrido González, Teresa Mancilla · 2020 · Bioorganic Chemistry
91. Identification of Some Glutamic Acid Derivatives with Biological Potential by Computational Methods
    Octavia-Laura Moldovan, Alexandra Sandulea, Ioana-Andreea Lungu, Andrei Şerban Gâz, Aura Rusu · 2023 · Molecules
92. Mechanistic insights into genomic structure and functions of a novel oncogene YEATS4
    Qingqing Xian, Yiying Song, Chengzhi Gui, Yunying Zhou · 2023 · Frontiers in Cell and Developmental Biology
93. ZFP64 Promotes Gallbladder Cancer Progression through Recruiting HDAC1 to Activate NOTCH1 Signaling Pathway
    Zhiqiang He, Yuhan Zhong, Hai‐Jie Hu, Fu‐Yu Li · 2023 · Cancers
94. Histone deacetylase inhibitors merged with protein tyrosine kinase inhibitors
    Nan Zhou, Wenfang Xu, Yingjie Zhang · 2015 · Drug Discoveries & Therapeutics
95. Histone deacetylase inhibitors in multiple myeloma
    Sarah Deleu, Eline Menu, Els Van Valckenborgh, Ben Van Camp, Joanna Fraczek, Isabelle Vande Broek, Vera Rogiers, Karin Vanderkerken · 2009 · Hematology Reports
96. Shifts in Developmental Timing, and Not Increased Levels of Experience-Dependent Neuronal Activity, Promote Barrel Expansion in the Primary Somatosensory Cortex of Rats Enucleated at Birth
    Ingrid Fetter-Pruneda, Helga Geovannini Acuña, Cecilia Santiago, Ana Sofia Ibarraran-Viniegra, Eduardo Martínez‐Martínez, Marcela Sandoval‐Velasco, Laura Uribe-Figueroa, Patricia Padilla-Cortés, Gabriela Mercado, Gabriel Gutiérrez‐Ospina · 2013 · PLoS ONE
97. Dinuclear Gold(III) Complexes as Potential Anticancer Agents: Structure, Reactivity and Biological Profile of a Series of Gold(III) Oxo-BridgedDerivatives
    Chiara Gabbiani, Annalisa Guerri, Maria Agostina Cinellu, Luigi Messori A · 2010 · UnissResearch (Università degli Studi di Sassari)
98. Histone deacetylase inhibitors: can we consider potent anti-neoplastic agents for the treatment of asthma?
    Simon G. Royce, Katherine Ververis, Tom C. Karagiannis · 2012 · PubMed
99. Phenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladder
    Susana Junqueira-Neto, Filipa Quintela Vieira, Diana Montezuma, Natália Rios Costa, Luís Antunes, Tiago Baptista, Ana Isabel Oliveira, Inês C. R. Graça, Ângelo Rodrigues, José Sanches Magalhães et al. · 2013 · Molecular Carcinogenesis
100. Synthesis and biochemical analysis of 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-octanediamides as inhibitors of human histone deacetylases
     Leonhard M. Henkes, Patricia Haus, Felix Jäger, Joachim Ludwig, Franz‐Josef Meyer‐Almes · 2011 · Bioorganic & Medicinal Chemistry