HDAC family: What are the cancer relevant targets?

The Consensus Coding Sequences of Human Breast and Colorectal Cancers

Sjöblom, T., Jones, S., Wood, L. D., Parsons, D. W., Lin, J., Barber, T. D., Mandelker, D. L., Leary, R. J., Ptak, J., Silliman, N., et al. (2006) · Science · doi:10.1126/science.1133427 · Cited by 3,161

Histone deacetylases (HDACs): characterization of the classical HDAC family

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Anticancer activities of histone deacetylase inhibitors

Bolden, J. E., Peart, M. J., & Johnstone, R. W. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2133 · Cited by 2,919

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

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HDAC6 is a microtubule-associated deacetylase

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Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

Minucci, S., & Pelicci, P. G. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1779 · Cited by 2,234

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

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Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

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The Deacetylase HDAC6 Regulates Aggresome Formation and Cell Viability in Response to Misfolded Protein Stress

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Histone deacetylase 5 promotes Wilms' tumor cell proliferation through the upregulation of c-Met

Cao, X., LIU, D.-H., Zhou, Y. F., Yan, X., Yuan, L., Pan, J. G., Fu, M., Zhang, T., & WANG, J. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4828 · Cited by 12

Synthesis and Biological Evaluation of 1-(2-Aminophenyl)-3-arylurea Derivatives as Potential EphA2 and HDAC Dual Inhibitors

Zhu, Y., Ran, T., Chen, X., Niu, J., Zhao, S., Lu, T., & Tang, W. (2016) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c16-00154 · Cited by 12

Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Amine‐based Histone Deacetylase Inhibitors

Abdelkarim, H., Neelarapu, R., Madriaga, A., Vaidya, A. S., Kastrati, I., Karumudi, B., Wang, Y., Taha, T. Y., Thatcher, G. R. J., Frasor, J. M., et al. (2017) · ChemMedChem · doi:10.1002/cmdc.201700449 · Cited by 13

Identification of Tumor and Invasion Suppressor Gene Modulators in Bladder Cancer by Different Classes of Histone Deacetylase Inhibitors Using Reverse Phase Protein Arrays

Gould, J. J., Kenney, P. A., Rieger‐Christ, K., Neto, B. S., Wszolek, M. F., LaVoie, A., Holway, A. H., Spurrier, B., Austin, J., Cammarata, B. K., et al. (2010) · The Journal of Urology · doi:10.1016/j.juro.2010.02.004 · Cited by 12

2-Benzazolyl-4-Piperazin-1-Ylsulfonylbenzenecarbohydroxamic Acids as Novel Selective Histone Deacetylase-6 Inhibitors with Antiproliferative Activity

Wang, L., Kofler, M., Brosch, G., Melesina, J., Sippl, W., Martínez, E. D., & Easmon, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134556 · Cited by 12

Novel histone deacetylase 6 inhibitors using benzimidazole as caps for cancer treatment

Nguyen, P. H., Huê, B. T. B., Quân, P. M., Hoa, T. P., Tran, Q. D., Jung, H., Hieu, L. T., Nguyễn, C. Q., Hong, V. Q., Quy, N. P., et al. (2023) · New Journal of Chemistry · doi:10.1039/d2nj05731j · Cited by 11

Discovery of novel inhibitors of histone deacetylase 6: Structure-based virtual screening, molecular dynamics simulation, enzyme inhibition and cell viability assays

Uba, A. İ., Hryb, M., Singh, M., Bui-Linh, C., Tran, A., Atienza, J., Misbah, S., Mou, X., & Wu, C. F. (2024) · Life Sciences · doi:10.1016/j.lfs.2023.122395 · Cited by 11

The impact of selective HDAC inhibitors on the transcriptome of early mouse embryos

Shao, R., Suzuki, T., Suyama, M., & Tsukada, Y.-I. (2024) · BMC Genomics · doi:10.1186/s12864-024-10029-3 · Cited by 11

Preferential HDAC6 inhibitors derived from HPOB exhibit synergistic antileukemia activity in combination with decitabine

Tretbar, M., Schliehe‐Diecks, J., von Bredow, L., Tan, K., Roatsch, M., Tu, J., Kemkes, M., Sönnichsen, M., Schöler, A., Borkhardt, A., et al. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116447 · Cited by 11

Development of Novel ROCK Inhibitors via 3D-QSAR and Molecular Docking Studies: A Framework for Multi-Target Drug Design

Beljkaš, M., Petković, M., Vuletić, A. M., Djurić, A., Santibanez, J. F., Srdić‐Rajić, T., Nikolic, K. M., & Oljačić, S. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16101250 · Cited by 11

Synthesis of new pyridine based ONNO type schiff bases and Cd(II) complexes, investigation of structural, electronic and anti-cancer properties as computationally and experimentally

Nasif, V., & Sayın, K. (2024) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2024.140359 · Cited by 11

Discovery of epigenetic modulators targeting HDACs and EZH2 simultaneously for the treatment of hematological malignancies

Zhang, J., Yang, M., Liu, Q., Xue, X., Tian, S., Hu, X., Li, M., 李, 进., Chai, Q., Liu, F., et al. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107964 · Cited by 12

Cutaneous Lymphomas: Molecular Pathways Leading to New Drugs

Dummer, R., Goldinger, S. M., Cozzio, A., French, L. E., & Karpova, M. B. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.370 · Cited by 11

Targeting histone deacetylase in lung cancer for early diagnosis: (18)F-FAHA PET/CT imaging of NNK-treated A/J mice model.

Tang, W., Kuruvilla, S. A., Galitovskiy, V., Pan, M., Grando, S. A., & Mukherjee, J. (2014) · PubMed Central · Cited by 11

Design, synthesis and in vitro evaluation of amidoximes as histone deacetylase inhibitors for cancer therapy

Jiao, P., Jin, P., Li, C., Cui, L., Dong, L., Pan, B., Song, W., Ma, L., Dong, J., Song, L., et al. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.08.073 · Cited by 11

Zap‐Pano: a Photocaged Prodrug of the KDAC Inhibitor Panobinostat

Troelsen, K. R., Calder, E. D. D., Skwarska, A., Sneddon, D., Hammond, E. M., & Conway, S. J. (2021) · ChemMedChem · doi:10.1002/cmdc.202100403 · Cited by 11

Class I HDAC inhibitor entinostat synergizes with PLK1 inhibitors in MYC-amplified medulloblastoma cells

Valinciute, G., Ecker, J., Selt, F., Hielscher, T., Sigaud, R., Ridinger, J., Thatikonda, V., Gatzweiler, C., Robinson, S., Talbot, J., et al. (2023) · Journal of Neuro-Oncology · doi:10.1007/s11060-023-04319-1 · Cited by 11

Inactivating mutation in histone deacetylase 3 stabilizes its active conformation

Arrar, M., de Oliveira, C. A. F., & McCammon, J. A. (2013) · Protein Science · doi:10.1002/pro.2317 · Cited by 11

The Histone Deacetylase Inhibitor BML-210 Influences Gene and Protein Expression in Human Promyelocytic Leukemia NB4 Cells via Epigenetic Reprogramming

Borutinskaite, V. V., & Navakauskienė, R. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160818252 · Cited by 11

Strong Correlation between the Expression Levels of HDAC4 and SIRT6 in Hematological Malignancies of the Adults

Gaál, Z., Oláh, É., Rejtő, L., Erdődi, F., & Csernoch, L. J. (2016) · Pathology & Oncology Research · doi:10.1007/s12253-016-0139-5 · Cited by 11

Design, synthesis and biological evaluation of 4-piperazinyl-containing Chidamide derivatives as HDACs inhibitors

Zhang, Q., Lu, B., & Li, J. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.05.026 · Cited by 11

A novel benzamine lead compound of histone deacetylase inhibitor ZINC24469384 can suppresses HepG2 cells proliferation by upregulating NR1H4

Song, Q., Li, M., Fan, C., Liu, Y., Zheng, L., Bao, Y., Sun, L., Yu, C., Song, Z., Sun, Y., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-39487-6 · Cited by 11

Autophagy and mTOR pathways in mouse embryonic stem cell, lung cancer and somatic fibroblast cell lines

Oltulu, F., Calik-Kocaturk, D., Adalı, Y., Özdil, B., Açıkgöz, E., Gürel, Ç., Yavaşoğlu, N. Ü. K., & Aktuğ, H. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29110 · Cited by 11

Potential of histone deacetylase inhibitors for bladder cancer treatment

Tanji, N., Ozawa, A., Kikugawa, T., Miura, N., Sasaki, T., Azuma, K., & Yokoyama, M. (2011) · Expert Review of Anticancer Therapy · doi:10.1586/era.10.230 · Cited by 11

Valproate inhibits MAP kinase signalling and cell cycle progression in S. cerevisiae

Desfossés-Baron, K., Hammond-Martel, I., Simoneau, A., Sellam, A., Roberts, S., & Würtele, H. (2016) · Scientific Reports · doi:10.1038/srep36013 · Cited by 11

Histone deacetylase inhibitors inhibit lung adenocarcinoma metastasis via HDAC2/YY1 mediated downregulation of Cdh1

Wang, D., Yang, Y., Cao, Y., Meng, M., Wang, X., Zhang, Z., Fu, W., Duan, S., & Tang, L. (2023) · Scientific Reports · doi:10.1038/s41598-023-38848-6 · Cited by 10

Deacetylation of Histones and Non-histone Proteins in Inflammatory Diseases and Cancer Therapeutic Potential of Histone Deacetylase Inhibitors

Man, E., & Evran, S. (2023) · Current Genomics · doi:10.2174/0113892029265046231011100327 · Cited by 10

Preclinical and first-in-human of purinostat mesylate, a novel selective HDAC I/IIb inhibitor, in relapsed/refractory multiple myeloma and lymphoma

Yang, L., Qiu, Q., Wang, J., Wen, Y., Li, H., Liang, R., Feng, Y., Wang, F., Lin, X., Tang, M., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02285-w · Cited by 10

The power and the promise of epigenetic drugs in oncology

Scandolara, T. B., Siqueira, I. V. M., Pinto, L. F. R., & Soares‐Lima, S. C. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2025.1622115 · Cited by 10

Discovery of Potent and Isoform‐selective Histone Deacetylase Inhibitors Using Structure‐based Virtual Screening and Biological Evaluation

Peng, Z., Zhao, Q., Tian, X., Lei, T., Xiang, R., Chen, L., & Yang, Y. (2022) · Molecular Informatics · doi:10.1002/minf.202100295 · Cited by 10

Advances in the Histone Acetylation Modification in the Oral Squamous Cell Carcinoma

Lu, Y. C., Yang, J., Zhu, J., Shu, Y., Zou, X., Ruan, Q., Luo, S., Wang, Y., & Wen, J. (2023) · Journal of Oncology · doi:10.1155/2023/4616682 · Cited by 10

Rapid screening of aminopeptidase N inhibitors by capillary electrophoresis with electrophoretically mediated microanalysis

Wang, H., Xu, W., Cao, J., & Wang, W. (2014) · Electrophoresis · doi:10.1002/elps.201400283 · Cited by 10

High throughput screening identifies modulators of histone deacetylase inhibitors

Gaupel, A., Begley, T. J., & Tenniswood, M. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-528 · Cited by 10

Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137)

Simões‐Pires, C. A., Bertrand, P., & Cuendet, M. (2017) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2017.1282945 · Cited by 10

Anticancer effect of histone deacetylase inhibitor scriptaid as a single agent for hepatocellular carcinoma

Liu, L., Sun, X., Xie, Y., Zhuang, Y., Yao, R., & Xu, K. (2018) · Bioscience Reports · doi:10.1042/bsr20180360 · Cited by 10

Modeling zinc‐oxygen coordination in histone deacetylase: A comparison of semiempirical methods performance

Pinheiro, P. D. S. M., Rodrigues, D. A., Sant’Anna, C. M. R., & Fraga, C. A. M. (2018) · International Journal of Quantum Chemistry · doi:10.1002/qua.25720 · Cited by 10

Extending Cross Metathesis To Identify Selective HDAC Inhibitors: Synthesis, Biological Activities, and Modeling

Bouchet, S., Linot, C., Ružić, D., Agbaba, D. D., Fouchaq, B., Roche, J., Nikolic, K. M., Blanquart, C., & Bertrand, P. (2019) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.8b00440 · Cited by 10

Novel Conjugated Quinazolinone-Based Hydroxamic Acids: Design, Synthesis and Biological Evaluation

Vu, T. K., Thanh, N. T., Minh, N. V., Linh, N. H., Thảo, N. T. P., Nguyen, T. T. B., Hien, D. T., Chinh, L. V., Duc, T. H., Anh, L. D., et al. (2020) · Medicinal Chemistry · doi:10.2174/1573406416666200420081540 · Cited by 10

Mechanism of androgen receptor corepression by CKβBP2/CRIF1, a multifunctional transcription factor coregulator expressed in prostate cancer

Tan, J.-A., Bai, S., Grossman, G., Titus, M. A., Ford, O. H., POP, E. A., Smith, G. J., Mohler, J. L., Wilson, E. M., & French, F. S. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.09.036 · Cited by 10

CoREST1 Promotes Tumor Formation and Tumor Stroma Interactions in a Mouse Model of Breast Cancer

Mazumdar, S., Arendt, L. M., Phillips, S. M., Sedic, M., Kuperwasser, C., & Gill, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121281 · Cited by 10

mTOR inhibition sensitizes human hepatocellular carcinoma cells to resminostat

Peng, X., Zhang, D., Li, Z., Fu, M., & Liu, H. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.06.060 · Cited by 10

Histone Deacetylase Inhibitors Enhance Cytotoxicity Towards Breast Tumors While Preserving the Wound-Healing Function of Adipose-Derived Stem Cells

Koko, K. R., Chang, S., Hagaman, A. L. R., Fromer, M. W., Nolan, R. S., Gaughan, J., Zhang, P., Carpenter, J. P., Brown, S. A., Matthews, M. S., et al. (2017) · Annals of Plastic Surgery · doi:10.1097/sap.0000000000001066 · Cited by 10

Mechanistic Insights into Binding of Ligands with Thiazolidinedione Warhead to Human Histone Deacetylase 4

Schweipert, M., Jänsch, N., Upadhyay, N., Tilekar, K. N., Wozny, E., Basheer, S., Wurster, E., Müller, M., Ramaa, C. S., & Meyer‐Almes, F. (2021) · Pharmaceuticals · doi:10.3390/ph14101032 · Cited by 10

Histone Deacetylase Inhibitors Promote the Anticancer Activity of Cisplatin: Mechanisms and Potential

Zhou, Y., Luo, Q., Gu, L., Tian, X., Zhao, Y., Zhang, Y., & Wang, F. (2025) · Pharmaceuticals · doi:10.3390/ph18040563 · Cited by 9

Integrated analysis of the molecular action of Vorinostat identifies epi-sensitised targets for combination therapy

Hay, J., Lappin, K. M., Liberante, F. G., Kettyle, L. M., Matchett, K. B., Thompson, A., & Mills, K. (2017) · Oncotarget · doi:10.18632/oncotarget.18910 · Cited by 9

Design and synthesis of 1H-benzo[d]imidazole selective HDAC6 inhibitors with potential therapy for multiple myeloma

Liu, L., Zhang, L., Chen, X., Yang, K., Hao, C., Qian, R., Zhao, S., Wang, L., Su, X., Zhao, M., et al. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115833 · Cited by 9

Design of novel small molecules derived from styrylpyridine as potent HDAC1 inhibitors for the treatment of gastric cancer using 3D-QSAR, drug similarity, ADMET prediction, molecular docking, and molecular dynamics studies

Haloui, R., Elkhattabi, K., Mkhayar, K., Daouı, O., Chtita, S., Haoudi-Mazzah, A., & Elkhattabi, S. (2023) · Scientific African · doi:10.1016/j.sciaf.2023.e01990 · Cited by 9

An interplay between multiple sirtuins promotes completion of DNA replication in cells with short telomeres

Simoneau, A., Ricard, É., & Würtele, H. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007356 · Cited by 9

Targeting Epigenetic Dependencies in Solid Tumors: Evolutionary Landscape Beyond Germ Layers Origin

Citron, F., & Fabris, L. (2020) · Cancers · doi:10.3390/cancers12030682 · Cited by 9

Hsp90 regulates HDAC3-dependent gene transcription while HDAC3 regulates the functions of Hsp90

Kotwal, A., & Subbarao, S. A. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109801 · Cited by 9

CUDC-101 enhances the chemosensitivity of gemcitabine-treated lymphoma cells

Li, H., Cui, R., Ji, M., & Jin, S. (2021) · Leukemia Research · doi:10.1016/j.leukres.2021.106575 · Cited by 9

Potential new targets and drugs related to histone modifications in glioma treatment

Wei, X., Xiao, B., Wang, L., Zang, L., & Che, F. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.104942 · Cited by 9

Direct Amidation to Access 3-Amido-1,8-Naphthalimides Including Fluorescent Scriptaid Analogues as HDAC Inhibitors

Hearn, K. N., Ashton, T. D., Acharya, R., Feng, Z., Gueven, N., & Pfeffer, F. M. (2021) · Cells · doi:10.3390/cells10061505 · Cited by 9

Upregulation of miR-489-3p Attenuates Cerebral Ischemia/Reperfusion Injury by Targeting Histone Deacetylase 2 (HDAC2)

Jia, T., Wang, M., Yan, W., Wu, W., & Shen, R. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.12.009 · Cited by 9

CG0006, a novel histone deacetylase inhibitor, induces breast cancer cell death via histone-acetylation and chaperone-disrupting pathways independent of ER status

Kim, T. H., Kim, C., Lee, J., Jang, S. J., Hwang, J. J., Ro, S., Hyun, Y., & Choi, J. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1310-4 · Cited by 9

A new synthesis of 6-N-hydroxy-4-(2-methyl-l,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-ylmethyl)benzamide, tubastatin a, a highly selective inhibitor of histone deacetylase

Kozlov, M. V., Kleymenova, A. A., Konduktorov, K. A., & Kochetkov, S. N. (2013) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162012060076 · Cited by 9

Design, Synthesis, and Biological Activity of Hydroxamic Tertiary Amines as Histone Deacetylase Inhibitors

Terracciano, S., Chini, M. G., Riccio, R., Bruno, I., & Bifulco, G. (2012) · ChemMedChem · doi:10.1002/cmdc.201100531 · Cited by 9

Design, Synthesis and Biological Evaluation of Novel N-hydroxyheptanamides Incorporating 6-hydroxy-2-methylquinazolin-4(3H)-ones as Histone Deacetylase Inhibitors and Cytotoxic Agents

Minh, N. V., Thanh, N. T., Lien, H. T., Anh, D. T. P., Cuong, H. D., Nam, N., Pham‐The, H., Minh-Ngoc, L., Le‐Thi‐Thu, H., Chinh, L. V., et al. (2019) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520619666190702142654 · Cited by 10

The pivotal role of histidine 976 in human histone deacetylase 4 for enzyme function and ligand recognition

Schweipert, M., Nehls, T., Wurster, E., Böltner, J., Anton, K., Lammer, P., Lermyte, F., & Meyer‐Almes, F. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107883 · Cited by 8

Hit Identification and Functional Validation of Novel Dual Inhibitors of HDAC8 and Tubulin Identified by Combining Docking and Molecular Dynamics Simulations

Curcio, A., Rocca, R., Chiera, F., Cantafio, M. E. G., Valentino, I., Ganino, L., Murfone, P., Simone, A. D., Napoli, G. D., Alcaro, S., et al. (2024) · Antioxidants · doi:10.3390/antiox13111427 · Cited by 8

HDAC inhibitors and IBD: Charting new approaches in disease management

Du, X., Yu, W., Chen, F., Jin, X., Xue, L., Zhang, Y., Wu, Q., & Tong, H. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114193 · Cited by 8

Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice

Duan, H., Zhou, K., Wang, T., Zhang, Y., Li, Y., Hua, Y., & Wang, C. (2018) · Chinese Medical Journal · doi:10.4103/0366-6999.239311 · Cited by 9

Discovery of N-(2-Amino-4-Fluorophenyl)-4-[bis-(2-Chloroethyl)-Amino]-Benzamide as a Potent HDAC3 Inhibitor

Chen, Y., Feng, J., Hu, Y., Wang, X., Song, W., & Zhang, L. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.592385 · Cited by 8

Protective effect of trichostatin A on CD19 + CD5 + CD1d high regulatory B cells in heart transplantation

Zhou, B., Mei, F., Wu, C., Xu, H., Liu, Z., & Cui, Y. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.11978 · Cited by 8

Dysregulated histone acetylation causes congenital diseases

Matsushita, N. (2023) · Gene Reports · doi:10.1016/j.genrep.2023.101778 · Cited by 8

Evaluation and molecular docking study of two flavonoids from Oroxylum indicum (L.) Kurz and their semi-synthetic derivatives as histone deacetylase inhibitors

Somsakeesit, L., Senawong, T., Senawong, G., Kumboonma, P., Samankul, A., Namwan, N., Yenjai, C., & Phaosiri, C. (2023) · Journal of Natural Medicines · doi:10.1007/s11418-023-01758-y · Cited by 8

Suberoylanilide Hydroxamic Acid Analogs with Heteroaryl Amide Group and Different Chain Length: Synthesis and Effect on Histone Deacetylase

Micheletti, G., Boga, C., Drius, G., Bordoni, S., & Calonghi, N. (2024) · Molecules · doi:10.3390/molecules29010238 · Cited by 8

Association of changes in expression of HDAC and SIRT genes after drug treatment with cancer cell line sensitivity to kinase inhibitors

Krushkal, J., Zhao, Y., Roney, K., Zhu, W., Brooks, A., Wilsker, D. F., Parchment, R. E., McShane, L. M., & Doroshow, J. H. (2024) · Epigenetics · doi:10.1080/15592294.2024.2309824 · Cited by 8

Effect of C7-substitution of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines on the selectivity towards a subclass of histone deacetylases

Lee, H., Wang, L., Li, Y.-H., Pan, S., Chen, Y.-L., Teng, C., & Liou, J. (2014) · Organic & Biomolecular Chemistry · doi:10.1039/c4ob00542b · Cited by 8

Discovery of a tetrahydroisoquinoline-based HDAC inhibitor with improved plasma stability

Zhou, N., Yan, Y., Liu, C., Hou, J., Xu, W., & Zhang, Y. (2017) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2017.06.039 · Cited by 8

A Phase II Trial of the Double Epigenetic Priming Regimen Including Chidamide and Decitabine for Relapsed/Refractory Acute Myeloid Leukemia

Yin, J., Wan, C., Zhang, L., Zhang, H., Bai, L., Zhou, H., Xu, M., Chen, L., Qian, C., Qiu, H.-Y., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.726926 · Cited by 8

Clinicopathological characteristics and prognostic significance of HDAC11 protein expression in non-small cell lung cancer: a retrospective study

Lu, D., Ma, Z., Huang, D., Zhang, J., Li, J., Zhi, P., Zhang, L., Feng, Y., Ge, X., Zhai, J., et al. (2022) · Translational Lung Cancer Research · doi:10.21037/tlcr-22-403 · Cited by 8

The effect of valproic acid on intrinsic, extrinsic, and JAK/STAT pathways in neuroblastoma and glioblastoma cell lines

Sanaei, M., & Kavoosi, F. (2022) · Research in Pharmaceutical Sciences · doi:10.4103/1735-5362.350240 · Cited by 8

Direct trifluoroacetylation of mono- and disubstituted thiophene derivatives

Andicsová, A. E., Kozma, E., Tokárová, Z., & Végh, D. (2015) · Journal of Fluorine Chemistry · doi:10.1016/j.jfluchem.2015.10.011 · Cited by 8

Expression characterization and the promoter activity analysis of zebrafish hdac4

Zhu, K., Wang, H., Gul, Y., Zhao, Y., Wang, W., Liu, S., & Wang, M. (2011) · Fish Physiology and Biochemistry · doi:10.1007/s10695-011-9540-x · Cited by 8

Optimization and application of a fluorimetric assay for the identification of histone deacetylase inhibitors from plant origin

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Mass spectrometry and DigiWest technology emphasize protein acetylation profile from Quisinostat-treated HuT78 CTCL cell line

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