HDAC family: What are the cancer relevant targets?

The Consensus Coding Sequences of Human Breast and Colorectal Cancers

Sjöblom, T., Jones, S., Wood, L. D., Parsons, D. W., Lin, J., Barber, T. D., Mandelker, D. L., Leary, R. J., Ptak, J., Silliman, N., et al. (2006) · Science · doi:10.1126/science.1133427 · Cited by 3,161

Histone deacetylases (HDACs): characterization of the classical HDAC family

RUIJTER, A. J. M. D., GENNIP, A. H. V., CARON, H. N., KEMP, S., & KUILENBURG, A. B. P. V. (2003) · Biochemical Journal · doi:10.1042/bj20021321 · Cited by 3,114

Anticancer activities of histone deacetylase inhibitors

Bolden, J. E., Peart, M. J., & Johnstone, R. W. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2133 · Cited by 2,919

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

Gu, W., & Roeder, R. G. (1997) · Cell · doi:10.1016/s0092-8674(00)80521-8 · Cited by 2,559

HDAC6 is a microtubule-associated deacetylase

Hubbert, C., Guardiola, A., Shao, R., Kawaguchi, Y., Ito, A., Nixon, A., Yoshida, M., Wang, X.-F., & Yao, T.-P. (2002) · Nature · doi:10.1038/417455a · Cited by 2,403

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

Minucci, S., & Pelicci, P. G. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1779 · Cited by 2,234

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

Taunton, J., Hassig, C. A., & Schreiber, S. L. (1996) · Science · doi:10.1126/science.272.5260.408 · Cited by 1,829

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

Finnin, M. S., Donigian, J. R., Cohen, A., Richon, V. M., Rifkind, R. A., Marks, P. A., Breslow, R., & Pavletich, N. P. (1999) · Nature · doi:10.1038/43710 · Cited by 1,714

The Deacetylase HDAC6 Regulates Aggresome Formation and Cell Viability in Response to Misfolded Protein Stress

Kawaguchi, Y., Kovacs, J. J., McLaurin, A. C., Vance, J. M., Ito, A., & Yao, T. (2003) · Cell · doi:10.1016/s0092-8674(03)00939-5 · Cited by 1,529

Combined approach of homology modeling, molecular dynamics, and docking: computer-aided drug discovery

Chahal, V., Nirwan, S., & Kakkar, R. (2019) · Physical Sciences Reviews · doi:10.1515/psr-2019-0066 · Cited by 7

Effect of two series of isoindolines over HDAC8 activity and expression

Trejo‐Muñoz, C. R., Jiménez, E. M., Pinto‐Almazán, R., Díaz‐Gandarilla, J. A., Correa‐Basurto, J., Trujillo-Ferrara, J. G., Guerra‐Araiza, C., Talamás‐Rohana, P., & Mancilla, T. (2014) · Medicinal Chemistry Research · doi:10.1007/s00044-013-0903-y · Cited by 7

Triclabendazole inhibits PKM2 nuclear localization and glycolysis by enhancing HDAC6-mediated deacetylation in lung cancer

Yan, L., Sun, Y., Shi, S., Li, Y., Zhang, Y., Qu, L.-Z., Liu, J., Dai, Y., Zha, Q., & Fan, J. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06905-5 · Cited by 6

Impact of HDAC6-mediated progesterone receptor expression on the response of breast cancer cells to hormonal therapy

Ramadan, W. S. H., Alseksek, R. K., Mouffak, S., Talaat, I. M., Saber-Ayad, M. M., Menon, V., İlçe, B. Y., & El‐Awady, R. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.177001 · Cited by 6

Design, synthesis and biological evaluation of novel hydroxamic acid-derived histone deacetylase inhibitors bearing a 2-oxoindoline scaffold as potential antitumor agents

Hương, T. T. L., Kim, H. K., Thien, N. D., Dung, D. T. M., Kim, J. S., Kim, J., Kang, J. S., Oanh, D. T. K., Tùng, T. T., Thang, N. Q., et al. (2025) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2025.118143 · Cited by 6

Plant polysaccharides influence tumor development based on epigenetics: a review

Li, C., Hu, Y., & Yang, H. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1588857 · Cited by 6

Histone Deacetylase Inhibition in Alzheimer’s Disease: Molecular Mechanisms, Therapeutic Potential, and Future Perspectives

Joshi, N., Khadse, P., Jadhav, S., & Alavala, R. R. (2025) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266360664250606110220 · Cited by 6

Novel quinazoline-triazole-based N -hydroxybenzamides/ N -hydroxypropenamides as HDAC inhibitors: design, synthesis, biological evaluation, and docking studies

Dung, N. P., Kim, H. K., Nga, N. T., Cuong, B. Q., Kang, D. H., Kim, H. Y., Kang, J. S., Anh, D. T., Tùng, T. T., Han, S., et al. (2025) · RSC Advances · doi:10.1039/d5ra04193g · Cited by 6

The Effect of MGCD0103 on CYP450 Isoforms Activity of Rats by Cocktail Method

Cai, J., Zhang, Q., Lin, K., Hu, L., & Zheng, Y. (2015) · BioMed Research International · doi:10.1155/2015/517295 · Cited by 6

Novel Therapeutic Strategies for Cutaneous T-Cell Lymphoma in Advanced Stages

Kun, L., Hernandez‐Ilizaliturri, F. J., & Reddy, N. M. (2013) · Seminars in Hematology · doi:10.1053/j.seminhematol.2013.11.004 · Cited by 6

Isoform-Selective HDAC Inhibition in Autoimmune DiseaseNicole L Regna1* and Christopher M Reilly2

Reilly, C. M. (2014) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000207 · Cited by 6

Cancer Chemoprevention by Black Tea Polyphenols

Nagini, S., & Murugan, R. S. (2012) · Tea in Health and Disease Prevention · doi:10.1016/b978-0-12-384937-3.00062-8 · Cited by 6

An Overview of the Epigenetic Modifications of Gene Expression in Tumorigenesis

Amiri, L. S., Barzegar, A., Rafiei, A., & Amjadi, O. (2019) · Research in Molecular Medicine · doi:10.18502/rmm.v6i3.4606 · Cited by 6

What we have learnt from Drosophila model organism: the coordination between insulin signaling pathway and tumor cells

Tang, W., Li, Y., Yiwen, W., & Qiao, H. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09957 · Cited by 6

Azumamides A-E: Isolation, Synthesis, Biological Activity, and Structure–Activity Relationship

Jo, S., Kim, J., Lee, J., Park, Y. J., & Jang, J. (2022) · Molecules · doi:10.3390/molecules27238438 · Cited by 6

Discovery of Potent Selective HDAC6 Inhibitors with 5-Phenyl-1H-indole Fragment: Virtual Screening, Rational Design, and Biological Evaluation

Li, X., Wang, C., Chai, X., Liu, X., Qiao, K., Fu, Y., Jin, Y., Jia, Q., Zhu, F., & Zhang, Y. (2024) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.4c01052 · Cited by 6

5-Aryl-1,3,4-Thiadiazole-Based Hydroxamic Acids as Histone Deacetylase Inhibitors and Antitumor Agents: Synthesis, Bioevaluation and Docking Study

Hương, T. T., Dung, D. T. M., Oanh, D., Lan, T. T. N., Dung, P. T. P., Loi, V. D., Kim, K. B., Han, B. W., Yun, J., Kang, J. S., et al. (2014) · Medicinal Chemistry · doi:10.2174/1573406410666140925153128 · Cited by 6

A novel hydroxysuberamide derivative potentiates MG132‐mediated anticancer activity against human hormone refractory prostate cancers—the role of histone deacetylase and endoplasmic reticulum stress

Chen, Y., Huang, W., Hsu, J., Yu, C., Wang, W., & Guh, J. (2013) · The Prostate · doi:10.1002/pros.22641 · Cited by 6

The combination of histone deacetylase and p53 expressions and histological subtype has prognostic implication in uterine leiomyosarcoma

Baek, M., Park, J., Park, Y., Kim, K.-R., Kim, D., Suh, D., Kim, J.-H., Kim, Y., Kim, Y., & Nam, J. (2019) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyz059 · Cited by 6

Enantioselective synthesis and biological investigation of tetrahydro‐β‐carboline‐based HDAC6 inhibitors with improved solubility

Grünstein, E., Sellmer, A., & Mahboobi, S. (2019) · Archiv der Pharmazie · doi:10.1002/ardp.201900026 · Cited by 6

Interactive Effects of a Combination of the HDAC3 and HDAC9 Genes with Diabetes Mellitus on the Risk of Ischemic Stroke

Chiou, H., Bai, C., Lien, L.-M., Hu, C., Jeng, J., Tang, S., Lin, H.-J., & Hsieh, Y. (2020) · Thrombosis and Haemostasis · doi:10.1055/s-0040-1717116 · Cited by 6

Design and Synthesis of a Tetrahydroisoquinoline‐Based Hydroxamate Derivative ( ZYJ ‐34v), An Oral Active Histone Deacetylase Inhibitor with Potent Antitumor Activity

Zhang, Y., Liu, C., Chou, C. J., Wang, X., Jia, Y., & Xu, W. (2013) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12144 · Cited by 6

Trichostatin A suppresses hearing loss by reducing oxidative stress and inflammation in an Alport syndrome model

Nam, Y. S., Gi, E.-J., Ko, Y.-S., Lee, S., & Cho, H. (2025) · PLoS ONE · doi:10.1371/journal.pone.0316033 · Cited by 5

Histone deacetylase HDAC2 regulates microRNA‐125a expression in neuroblastoma

Liu, D., Tang, X., Huang, Z., Wen, J., & Zhou, Y. (2022) · Brain and Behavior · doi:10.1002/brb3.2401 · Cited by 5

The catalytic domain of free or ligand bound histone deacetylase 4 occurs in solution predominantly in closed conformation

Schweipert, M., Nehls, T., Frühauf, A., Debarnot, C., Kumar, A. M., Knapp, S., Lermyte, F., & Meyer‐Almes, F. (2024) · Protein Science · doi:10.1002/pro.4917 · Cited by 5

HDAC6 mediates tumorigenesis during mitosis and the development of targeted deactivating agents

Peng, J., Liu, H., Liu, Y., Liu, J., Zhao, Q., Liu, W., Niu, H., Xue, H., Sun, J., & Wu, J. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107818 · Cited by 5

Development of new pyrazoles as class I HDAC inhibitors: Synthesis, molecular modeling, and biological characterization in leukemia cells

Berluti, F., Baselious, F., Hagemann, S., Hilscher, S., Schmidt, M., Hüttelmaier, S., Schutkowski, M., Sippl, W., & Ibrahim, H. S. (2024) · Archiv der Pharmazie · doi:10.1002/ardp.202400437 · Cited by 5

Epigenetic Modification of MicroRNAs

Pal, D., Ghatak, S., & Sen, C. K. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405544-5.00003-4 · Cited by 6

The in vitro apoptotic effects of A248 and A1659, newly synthetic histone deacetylase inhibitors in oral cancer cells

Shin, J., Han, G., Park, S., Lee, K., Kim, H., Cho, S., & Kim, H. (2013) · Oral Diseases · doi:10.1111/odi.12161 · Cited by 5

Small Molecule Modulators of Sirtuin Activity

Alcain, F. J., Minor, R. K., Villalba, J. M., & de Cabo, R. (2010) · Springer eBooks · doi:10.1007/978-90-481-3999-6_10 · Cited by 5

Synthesis of Pyridyl-4-Oxy-Substituted N-Hydroxy Amides of Cinnamic Acid as New Inhibitors of Histone Deacetylase Activity and Hepatitis C Virus Replication

Kozlov, M. V., Malikova, A. Z., Kamarova, K. A., Konduktorov, K. A., & Kochetkov, S. N. (2018) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162018040118 · Cited by 5

HDAC inhibitor SB939 potentiates TRAIL-induced apoptosis in colorectal cancer cells

Shin, M. W., Seo, S. Y., Kim, S., & Kim, S.-W. (2023) · Cellular and Molecular Biology · doi:10.14715/cmb/2023.69.5.3 · Cited by 5

Epigenetic Modifications as Antidedifferentiation Strategy for Primary Hepatocytes in Culture

Bolleyn, J., Fraczek, J., Rogiers, V., & Vanhaecke, T. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-2074-7_14 · Cited by 5

Synthesis of thiazolyl-based hydroxamic acids as histone deacetylase inhibitors

Asfaha, Y., Skerhut, A. J., Avelar, L. A. A., Horstick‐Muche, N., Lungerich, B., Klinken, S., Kassack, M. U., & Kurz, T. (2020) · ARKIVOC · doi:10.24820/ark.5550190.p011.279 · Cited by 5

Competitive Intelligence–based Lead Generation and Fast Follower Approaches

Jiang, Y. Y., Liu, Z., Holenz, J., & Yang, H. D. (2016) · Methods and principles in medicinal chemistry · doi:10.1002/9783527677047.ch08 · Cited by 5

Novel nuclear role of HDAC6 in prognosis and therapeutic target for colorectal cancerPreprint

García-Domínguez, D. J., Hontecillas‐Prieto, L., Kaliszczak, M. A., He, M., Burguillos, M. Á., Bekay, R. E., Abdul‐Salam, V. B., Khozoie, C., Shah, K., O’Neill, K., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.02.356121 · Cited by 5

Genome-wide identification of the histone modification gene family in Aquilaria sinensis and functional analysis of several HMs in response to MeJA and NaCl stress

Rong, M., Gao, S., Huang, P.-C., Guo, Y., Wen, D., Jiang, J., Xu, Y., & Wei, J.-H. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.135871 · Cited by 4

HDAC6 is involved in diabetic nephropathy by regulating TGFβ/Smads and NF-κB signaling pathways

Li, J., Zhang, J., Huang, X., Jin, S., Yu, Z., Liu, Z., & Wu, S. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116996 · Cited by 4

Deciphering the dynamics of histone acetylation and chromatin remodeling in multiple myeloma: a tale beyond the tails

Xiong, S., Zhou, J., & Chng, W. J. (2025) · Blood · doi:10.1182/blood.2025028403 · Cited by 4

HDAC and PI3K dual inhibitors in the treatment of cancers: Current status, trends, and solutions

Zeng, W., Zhang, Z., Kaiyin, L., Yin, Y., Dong, S., & Ma, M. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.118511 · Cited by 4

Phosphatidylinositol-3-Kinase (PI3K) and Histone Deacetylase (HDAC) Multitarget Inhibitors: An Update on Clinical and Preclinical Candidates

Lima, A. D. S., & Lima, L. M. (2026) · Pharmaceuticals · doi:10.3390/ph19010130 · Cited by 4

InhibitWin duo: Rational design and structural insights into dual PARP/HDAC inhibitors for synergistic DNA repair disruption and epigenetic modulation

Elkafoury, E. M., El-Moselhy, T. F., El‐Hamamsy, M. H., El-Bastawissy, E. A., Afarinkia, K., Salih, M. A. M., El‐Damasy, A. K., Ibrahim, M. A. A., ElShewy, A. M., Shawky, A. M., et al. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.118743 · Cited by 4

Selective Antiproliferative and Apoptotic Effects of 2,6‐Diketopiperazines on MDA ‐ MB ‐231 Triple‐Negative Breast Cancer

González, F. P. G., Pérez, M. E. M., Cortés, O. R., Jiménez, E. M., & Mancilla, T. (2025) · Chemical Biology & Drug Design · doi:10.1111/cbdd.70098 · Cited by 4

Life Extension in Drosophila by Histone Deacetylase Inhibitors

Vaiserman, A. M., & PASYUKOVA, E. G. (2015) · Healthy ageing and longevity · doi:10.1007/978-3-319-18326-8_11 · Cited by 4

Panobinostat to revert bortezomib resistance

Moreau, P. (2013) · Blood · doi:10.1182/blood-2013-08-522417 · Cited by 4

Epigenetic programming contributes to development of drug resistance in hematological malignancies

Zhong, H. (2015) · Frontiers in bioscience · doi:10.2741/4333 · Cited by 4

Design, synthesis, and biological evaluation of N-hydroxycinnamamide/salicylic acid hybrids as histone deacetylase inhibitors

You, T., Chen, K., Wang, F.-H., Li, P., Li, L., Wu, Z.-H., Ni, K.-H., & Zheng, Z. (2013) · Chinese Chemical Letters · doi:10.1016/j.cclet.2013.11.039 · Cited by 4

Total Synthesis of the Depsipeptide FR901375 and Preliminary Evaluation of Its Biological Activity

Narita, K., Katoh, Y., Ojima, K.-I., Dan, S., Yamori, T., Ito, A., Yoshida, M., & Katoh, T. (2016) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201601023 · Cited by 4

Design, Synthesis and Evaluation of Novel 3/4-((Substituted benzamidophenoxy) methyl)-N-hydroxybenzamides/propenamides as Histone Deacetylase Inhibitors and Antitumor Agents

Anh, D. T., Thuần, N. T. D., Pham‐The, H., Le‐Thi‐Thu, H., Yen, N. T. K., Han, B. W., Park, E. J., Choi, Y. J., Kang, J. S., Huệ, V. T. M., et al. (2018) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520618666181114113347 · Cited by 4

Exploration of Structure-Activity Relationship Using Integrated Structure and Ligand Based Approach: Hydroxamic Acid-Based HDAC Inhibitors and Cytotoxic Agents

Shirbhate, E., Pandey, J., Patel, V. K., Veerasamy, R., & Rajak, H. (2022) · Turkish Journal of Pharmaceutical Sciences · doi:10.4274/tjps.galenos.2022.12269 · Cited by 4

Nuclear receptor coactivator 6 ( NCoA6 ) promotes cell proliferation, migration, and invasion in pancreatic cancer

Wang, X., Jia, Y., Xu, X., Hu, Y., Fan, G., Jing, D., Zhang, Z., Wang, C., Song, C., Qin, Y., et al. (2023) · Cancer Medicine · doi:10.1002/cam4.6427 · Cited by 4

Candidate Oligo Therapeutic Target, miR-330-3p, Induces Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Cells via HDAC4

Zhang, M., Wang, M., Jiang, Z., Fu, Z., Ma, J., & Gao, S. (2023) · The Breast Journal · doi:10.1155/2023/2875972 · Cited by 4

Design, Synthesis, and Antiproliferative Activity of Selective Histone Deacetylases 6 Inhibitors Containing a Tetrahydropyridopyrimidine Scaffold

Wang, B., Liu, Y., Zhang, L., Wang, Y., Li, Z., & Chen, X. (2023) · Molecules · doi:10.3390/molecules28217323 · Cited by 4

Decreased HDAC1 Gene Expression in Patients with Alzheimer’s Disease

Bayram, A. (2014) · International Journal of Human Genetics · doi:10.31901/24566330.2014/14.03-04.09 · Cited by 4

Design, synthesis and biological evaluation of urea-based benzamides derivatives as HDAC inhibitors

Zhu, Y., Chen, X., Ran, T., Niu, J., Zhao, S., Lu, T., & Tang, W. (2017) · Medicinal Chemistry Research · doi:10.1007/s00044-017-1987-6 · Cited by 4

A fluorogenic probe targeting two spatially separated enzymes for selective imaging of cancer cells

Park, S.-H., Jung, H., Kim, Y., & Shin, I. (2022) · Chemical Communications · doi:10.1039/d2cc01082h · Cited by 4

Synthesis and structure‐activity relationship of thiol‐based histone deacetylase 6 inhibitors

Guo, Z., Zhang, Y., Bao, Y., Huang, Z., Gu, X. Q., Wang, G., & Li, J. (2022) · Chemical Biology & Drug Design · doi:10.1111/cbdd.14055 · Cited by 4

Natural Products for Cancer Prevention and Therapy

Bishayee, A., & Yerer-Aycan, M. B. (2018) · MDPI eBooks · doi:10.3390/books978-3-03897-311-9 · Cited by 4

Correction: Inhibition of the NAD-Dependent Protein Deacetylase SIRT2 Induces Granulocytic Differentiation in Human Leukemia Cells

Sunami, Y., Araki, M., Hironaka, Y., Morishita, S., Kobayashi, M., Liew, E. L., Edahiro, Y., Tsutsui, M., Ohsaka, A., & Komatsu, N. (2013) · PLoS ONE · doi:10.1371/annotation/36fa9e18-5e99-466d-b10d-dc67cfd14682 · Cited by 4

Design, synthesis, and biological evaluation of substituted benzyl-triazolopyridine derivatives as non-hydroxamate based HDAC8 inhibitors

Bandaru, N. V. M. R., Fathima, A., Joshi, V., Schweipert, M., Pathur, O., Chaitanya, K. S., Trinath, J., Sharma, V., Abbineni, C., Meyer‐Almes, F., et al. (2025) · European Journal of Medicinal Chemistry Reports · doi:10.1016/j.ejmcr.2025.100255 · Cited by 3

Epigenetic potentiation of 5-fluorouracil by HDAC inhibitor quisinostat enhances antitumor effects in colorectal cancer

Calibasi‐Kocal, G., Kurter, H., Nartas, E. D., Ellidokuz, E., & Başbınar, Y. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03992-8 · Cited by 3

The Potential of Epigenetic Compounds in Treating Diabetes

Gray, S. G. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812215-0.00017-0 · Cited by 3

In Silico Prediction of Binding Affinities of Hybrid Molecules of Benzothiazole cross-linked with Hydroxamic acid by certain linkers

Alqaysi, Y., Alwan, S. M., & Dawood, A. H. (2024) · Al Mustansiriyah Journal of Pharmaceutical Sciences · doi:10.32947/ajps.v24i1.1006 · Cited by 3

Design, synthesis and bioevaluation of novel N-heterocyclic hydroxamic acids as histone deacetylase inhibitors and their antitumor activity study

Quoc, T. N., Nga, N. T., Kim, J. S., Kim, H. K., Kim, J., Kang, J. S., Tùng, T. T., Dung, D. T. M., Anh, D. T., Han, S., et al. (2024) · New Journal of Chemistry · doi:10.1039/d4nj03452j · Cited by 3

A monoclonal antibody specific for prophase phosphorylation of histone deacetylase 1: a readout for early mitotic cells

Segré, C. V., Senese, S., Loponte, S., Santaguida, S., Soffientini, P., Grigorean, G., Cinquanta, M., Ossolengo, G., Seiser, C., & Chiocca, S. (2015) · mAbs · doi:10.1080/19420862.2015.1098795 · Cited by 3

Low-dose spiruchostatin-B, a potent histone deacetylase inhibitor enhances radiation-induced apoptosis in human lymphoma U937 cells via modulation of redox signaling

Rehman, M. U., Jawaid, P., Zhao, Q., Li, P., Narita, K., Katoh, T., Shimizu, T., & Kondo, T. (2016) · Free Radical Research · doi:10.3109/10715762.2015.1115029 · Cited by 3

Histone acetylation-related IncRNA: Potential biomarkers for predicting prognosis and immune response in lung adenocarcinoma, and distinguishing hot and cold tumours

Li, R., Qiu, T., Zhou, Q., He, F., Chen, J., Zheng, X., Lu, Z., Wu, Q., & Xie, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1139599 · Cited by 3

Strategies for Stage-Specific Extension of Longevity

Arking, R. (2015) · Healthy ageing and longevity · doi:10.1007/978-3-319-18326-8_15 · Cited by 3

Design, synthesis, inhibiting HDACs ability and antitumor activity of pyrimidin-4(3H)-one hydroxamate derivatives

Lu, H., Jin, X., Jin, Y., Huang, B., Wang, C., Wang, C., Ma, F., Chen, Y., Li, J., Cong, Y., et al. (2016) · Chemical Research in Chinese Universities · doi:10.1007/s40242-016-6105-7 · Cited by 3

Synthesis and Biochemical Evaluation of Biotinylated Conjugates of Largazole Analogues: Selective Class I Histone Deacetylase Inhibitors

Zhao, L., Dunne, C. E., Clausen, D. J., Roberts, J. M., Paulk, J., Liu, H., Wiest, O., Bradner, J. E., & Williams, R. M. (2017) · Israel Journal of Chemistry · doi:10.1002/ijch.201600130 · Cited by 3

The Nonepigenetic Role for Small Molecule Histone Deacetylase Inhibitors in the Regulation of Cardiac Function

Romanick, S., & Ferguson, B. S. (2019) · Future Medicinal Chemistry · doi:10.4155/fmc-2018-0311 · Cited by 3

An Improved Protocol for the Virtual Screening Discovery of Novel Histone Deacetylase Inhibitors

Song, Q., Liu, T., Liu, Y., Wang, S., Fan, C., Zheng, L., Bao, Y., Sun, L., Yu, C., Sun, Y., et al. (2019) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c19-00321 · Cited by 3

Hydroxamic Acids Immobilized on Resins (HAIRs): Synthese von Dual‐Target‐HDAC‐Inhibitoren und HDAC‐PROTACs

Sinatra, L., Bandolik, J. J., Roatsch, M., Sönnichsen, M., Schoeder, C. T., Hamacher, A., Schöler, A., Borkhardt, A., Meiler, J., Bhatia, S., et al. (2020) · Angewandte Chemie · doi:10.1002/ange.202006725 · Cited by 3

Development of a Cellular Model Mimicking Specific HDAC Inhibitors

Hess, L., Moos, V., & Seiser, C. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2788-4_4 · Cited by 3

Cancer: An Epigenetic Landscape

Dhanasekaran, K., Arif, M., & Kundu, T. K. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-4525-4_17 · Cited by 3

Panspecies Small-Molecule Disruptors of Heterochromatin-Mediated Transcriptional Gene Silencing

Castonguay, E., White, S. A., Kagansky, A., St‐Cyr, D. J., Castillo, A. G., Brugger, C., White, R., Bonilla, C., Spitzer, M., Earnshaw, W. C., et al. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01102-14 · Cited by 3

DFT Study, Linear and Nonlinear Multiple Regression in the Prediction of HDAC7 Inhibitory Activities on a Series of Hydroxamic Acids

Doh, S., Ekou, L., Ouattara, B., Koné, M. G.-R., Ekou, T., & Ziao, N. (2019) · Computational Molecular Bioscience · doi:10.4236/cmb.2019.93006 · Cited by 3

[A Review of Epigenetic Modifications Regulate MicroRNA Expression in Lung Cancer].

Hu, X., & Tian, K. (2020) · PubMed Central · doi:10.3779/j.issn.1009-3419.2020.102.29 · Cited by 3

Chidamide works synergistically with Dasatinib by inducing cell-cycle arrest and apoptosis in acute myeloid leukemia cells

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