Cited by 329DNA Repair MechanismsGenetic factors in colorectal cancerCarcinogens and Genotoxicity Assessment

The DOI matches its Crossref record; 351 of the 357 references it cites were found in a registry or an index.

Base excision repair and cancer

Open access

Wallace, Susan S., Murphy, Drew L., Sweasy, Joann B.·2012·Cancer Letters

DOI 10.1016/j.canlet.2011.12.038PMC PMC3361536

Open this paper in CoChat — free account

Abstract

Base excision repair is the system used from bacteria to man to remove the tens of thousands of endogenous DNA damages produced daily in each human cell. Base excision repair is required for normal mammalian development and defects have been associated with neurological disorders and cancer. In this paper we provide an overview of short patch base excision repair in humans and summarize current knowledge of defects in base excision repair in mouse models and functional studies on short patch base excision repair germ line polymorphisms and their relationship to cancer. The biallelic germ line mutations that result in MUTYH-associated colon cancer are also discussed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.canlet.2011.12.038

Cites

351 of 351 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

DNA Repair and Mutagenesis
Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
Ito, S., Shen, L., Dai, Q., Wu, S. C., Collins, L. B., Swenberg, J. A., He, C., & Zhang, Y. (2011) · Science · doi:10.1126/science.1210597 · Cited by 3,451
Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA
He, Y., Li, B.-Z., Li, Z., Liu, P., Wang, Y., Tang, Q., Ding, J., Jia, Y., Chen, Z., Li, L., et al. (2011) · Science · doi:10.1126/science.1210944 · Cited by 2,776
Genome-wide association study identifies novel breast cancer susceptibility loci
Easton, D. F., Pooley, K. A., Dunning, A. M., Pharoah, P. D. P., Thompson, D., Ballinger, D. G., Struewing, J. P., Morrison, J., Field, H., Luben, R., et al. (2007) · Nature · doi:10.1038/nature05887 · Cited by 2,319
Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors
Tassan, N. A. A., Chmiel, N. H., Maynard, J. H., Fleming, N. I., Livingston, A. L., Williams, G. T., Hodges, A., Davies, D. R., David, S. S., Sampson, J. R., et al. (2002) · Nature Genetics · doi:10.1038/ng828 · Cited by 1,412
Deletion of a DNA Polymerase β Gene Segment in T Cells Using Cell Type-Specific Gene Targeting
Gu, H., Marth, J. D., Orban, P. C., Mossmann, H., & Rajewsky, K. (1994) · Science · doi:10.1126/science.8016642 · Cited by 1,397
Hereditary and Familial Colon Cancer
Jasperson, K. W., Tuohy, T. M. F., Neklason, D. W., & Burt, R. W. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.01.054 · Cited by 1,370
Base-excision repair of oxidative DNA damage
David, S. S., O'Shea, V. L., & Kundu, S. (2007) · Nature · doi:10.1038/nature05978 · Cited by 1,238
Single-strand break repair and genetic disease
Caldecott, K. W. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2380 · Cited by 1,097
Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA
Bruner, S. D., Norman, D. P. G., & Verdine, G. L. (2000) · Nature · doi:10.1038/35002510 · Cited by 972

Show all 357 references

Sorted by citations

Base Excision Repair
Krokan, H. E., & Bjoras, M. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012583 · Cited by 1,322
The impact of oxidative DNA damage and stress on telomere homeostasis
Barnes, R. P., Fouquerel, E., & Opresko, P. L. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.03.013 · Cited by 585
Base excision repair: A critical player in many games
Wallace, S. S. (2014) · DNA Repair · doi:10.1016/j.dnarep.2014.03.030 · Cited by 401
Self-citation
DNA Damage Response Genes and the Development of Cancer Metastasis
Broustas, C. G., & Lieberman, H. B. (2014) · Radiation Research · doi:10.1667/rr13515.1 · Cited by 284
DNA Damage and Associated DNA Repair Defects in Disease and Premature Aging
Tiwari, V., & Wilson, D. M. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.06.005 · Cited by 244
Human Apurinic/Apyrimidinic Endonuclease 1
Li, M., & Wilson, D. M. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5492 · Cited by 261
Oxidatively induced DNA damage and its repair in cancer
Dizdaroğlu, M. (2014) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2014.11.002 · Cited by 264
Helicobacter pylori and Gastric Cancer: Pathogenetic Mechanisms
Salvatori, S., Marafini, I., Laudisi, F., Monteleone, G., & Stolfi, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032895 · Cited by 275
Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress
Yan, S., Sorrell, M., & Berman, Z. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1666-4 · Cited by 247
Targeting the ATR-CHK1 Axis in Cancer Therapy
Rundle, S., Bradbury, A., Drew, Y., & Curtin, N. J. (2017) · Cancers · doi:10.3390/cancers9050041 · Cited by 242
Mitochondria, Oxidative Stress and the Kynurenine System, with a Focus on Ageing and Neuroprotection
Sas, K., Szabó, E., & Vécsei, L. (2018) · Molecules · doi:10.3390/molecules23010191 · Cited by 206
Interplay between DNA repair and inflammation, and the link to cancer
Kidane, D., Chae, W. J., Czochor, J. R., Eckert, K. A., Glazer, P. M., Bothwell, A. L. M., & Sweasy, J. B. (2014) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.875514 · Cited by 191
Self-citation
Structure and Mechanism of DNA Polymerase β
Beard, W. A., & Wilson, S. H. (2014) · Biochemistry · doi:10.1021/bi500139h · Cited by 164
miRNA dysregulation is an emerging modulator of genomic instability
Cardoso, A. P. F., Banerjee, M., Nail, A. N., Lykoudi, A., & States, J. C. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.05.004 · Cited by 173
Repair of 8-oxo-7,8-dihydroguanine in prokaryotic and eukaryotic cells: Properties and biological roles of the Fpg and OGG1 DNA N-glycosylases
Boiteux, S., Coste, F., & Castaing, B. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.042 · Cited by 172
Regulation of DNA Alkylation Damage Repair: Lessons and Therapeutic Opportunities
Soll, J. M., Sobol, R. W., & Mosammaparast, N. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.10.001 · Cited by 128
Rules of engagement for base excision repair in chromatin
Odell, I. D., Wallace, S. S., & Pederson, D. S. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24134 · Cited by 113
Self-citation
DNA glycosylases search for and remove oxidized DNA bases
Wallace, S. S. (2013) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21820 · Cited by 109
Self-citation
Placental promoter methylation of DNA repair genes and prenatal exposure to particulate air pollution: an ENVIR ON AGE cohort study
Neven, K. Y., Saenen, N. D., Tarantini, L., Janssen, B. G., Lefebvre, W., Vanpoucke, C., Bollati, V., & Nawrot, T. S. (2018) · The Lancet Planetary Health · doi:10.1016/s2542-5196(18)30049-4 · Cited by 103
Repair of 8-oxoG:A mismatches by the MUTYH glycosylase: Mechanism, metals and medicine
Banda, D. M., Nuñez, N. N., Burnside, M. A., Bradshaw, K. M., & David, S. S. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.008 · Cited by 105
Base excision repair regulates PD-L1 expression in cancer cells
Permata, T. B. M., Hagiwara, Y., Sato, H., Yasuhara, T., Oike, T., Gondhowiardjo, S. A., Held, K. D., Nakano, T., & Shibata, A. (2019) · Oncogene · doi:10.1038/s41388-019-0733-6 · Cited by 103
Dual mode of cell death upon the photo-irradiation of a Ru II polypyridyl complex in interphase or mitosis
Pierroz, V., Rubbiani, R., Gentili, C., Patra, M., Mari, C., Gasser, G., & Ferrari, S. M. (2016) · Chemical Science · doi:10.1039/c6sc00387g · Cited by 100
Repair of oxidatively induced DNA damage by DNA glycosylases: Mechanisms of action, substrate specificities and excision kinetics
Dizdaroğlu, M., Coşkun, E., & Jaruga, P. (2017) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2017.02.001 · Cited by 99
Role of MUTYH in human cancer
Mazzei, F., Viel, A., & Bignami, M. (2013) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2013.03.003 · Cited by 95
Genome-wide maps of alkylation damage, repair, and mutagenesis in yeast reveal mechanisms of mutational heterogeneityPreprint
Mao, P., Brown, A. J., Malc, E. P., Mieczkowski, P. A., Smerdon, M. J., Roberts, S. A., & Wyrick, J. J. (2017) · Genome Research · doi:10.1101/gr.225771.117 · Cited by 97
DNA Damage and Repair in Schizophrenia and Autism: Implications for Cancer Comorbidity and Beyond
Markkanen, E., Meyer, U., & Dianov, G. L. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060856 · Cited by 84
NTHL1 and MUTYH polyposis syndromes: two sides of the same coin?
Weren, R. D. A., Ligtenberg, M. J. L., van Kessel, A. G., de Voer, R. M., Hoogerbrugge, N., & Kuiper, R. P. (2017) · The Journal of Pathology · doi:10.1002/path.5002 · Cited by 86
Simultaneous sensitive detection of multiple DNA glycosylases from lung cancer cells at the single-molecule level
Hu, J., Liu, M.-H., Li, Y., Tang, B., & Zhang, C. (2017) · Chemical Science · doi:10.1039/c7sc04296e · Cited by 73
Revisiting Two Decades of Research Focused on Targeting APE1 for Cancer Therapy: The Pros and Cons
Malfatti, M. C., Bellina, A., Antoniali, G., & Tell, G. (2023) · Cells · doi:10.3390/cells12141895 · Cited by 70
Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition
Middleton, F. K., Patterson, M. J., Elstob, C. J., Fordham, S. E., Herriott, A., Wade, M., McCormick, A., Edmondson, R. J., May, F. E. B., Allan, J. M., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6136 · Cited by 70
DNA damage response and repair in perspective: Aedes aegypti, Drosophila melanogaster and Homo sapiens
Mota, M. B. S., Carvalho, M. A., Monteiro, Á. N. A., & Mesquita, R. D. (2019) · Parasites & Vectors · doi:10.1186/s13071-019-3792-1 · Cited by 67
Base and Nucleotide Excision Repair of Oxidatively Generated Guanine Lesions in DNA
Shafirovich, V., Kropachev, K. Y., Anderson, T., Liu, Z., Kolbanovskiy, M., Martin, B. D., Sugden, K. D., Shim, Y., Chen, X., Min, J., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.693218 · Cited by 64
Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases
Woods, R. D., O’Shea, V. L., Chu, A. M., Cao, S., Richards, J. L., Horvath, M. P., & David, S. S. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1469 · Cited by 57
5′,8-Cyclopurine Lesions in DNA Damage: Chemical, Analytical, Biological, and Diagnostic Significance
Chatgilialoglu, C., Ferreri, C., Geacintov, N. E., Krokidis, M. G., Liu, Y., Masi, A., Shafirovich, V., Terzidis, M. A., & Tsegay, P. S. (2019) · Cells · doi:10.3390/cells8060513 · Cited by 59
Oxidative Stress Fundamentals: Unraveling the Pathophysiological Role of Redox Imbalance in Non-Communicable Diseases
García-Llorens, G., Ouardi, M. E., & Valls‐Bellés, V. (2025) · Applied Sciences · doi:10.3390/app151810191 · Cited by 66
Variation within 3′-UTRs of Base Excision Repair Genes and Response to Therapy in Colorectal Cancer Patients: A Potential Modulation of microRNAs Binding
Pardini, B., Rosa, F., Barone, E., Gaetano, C. D., Slyšková, J., Novotný, J. P., Levý, M., Garritano, S., Vodičková, Ľ., Büchler, T., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0314 · Cited by 58
DNA damage response and repair in ovarian cancer: Potential targets for therapeutic strategies
Mirza‐Aghazadeh‐Attari, M., Ostadian, C., Saei, A. A., Mihanfar, A., Darband, S. G., Sadighparvar, S., Kaviani, M., Kafil, H. S., Yousefi, B., & Majidinia, M. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.06.005 · Cited by 56
Both genetic and dietary factors underlie individual differences in DNA damage levels and DNA repair capacity
Slyšková, J., Lorenzo, Y., Karlsen, A. S., Carlsen, M. H., Novosadová, V., Blomhoff, R., Vodička, P., & Collins, A. R. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.01.016 · Cited by 56
Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models
Martínez-Vélez, N., Marigil, M., García-Moure, M., González-Huarriz, M., Aristu, J., Ramos-García, L.-I., Tejada, S., Díez-Valle, R., Patiño‐García, A., Becher, O. J., et al. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0714-6 · Cited by 56
Removal of oxidatively generated DNA damage by overlapping repair pathways
Shafirovich, V., & Geacintov, N. E. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.507 · Cited by 59
The DNA Glycosylase NEIL2 Suppresses Fusobacterium-Infection-Induced Inflammation and DNA Damage in Colonic Epithelial Cells
Sayed, I. M., Chakraborty, A., El‐Hafeez, A. A. A., Sharma, A., Sahan, A. Z., Huang, W. J. M., Sahoo, D., Ghosh, P., Hazra, T. K., & Das, S. (2020) · Cells · doi:10.3390/cells9091980 · Cited by 57
Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine
Duclos, S., Aller, P., Jaruga, P., Dizdaroğlu, M., Wallace, S. S., & Doublié, S. (2012) · DNA repair · doi:10.1016/j.dnarep.2012.06.004 · Cited by 57
Self-citation
Roles for the 8-Oxoguanine DNA Repair System in Protecting Telomeres From Oxidative Stress
Rosa, M. D., Johnson, S. A., & Opresko, P. L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.758402 · Cited by 58
Viral inactivation by light
Sadraeian, M., Zhang, L., Aavani, F., Biazar, E., & Jin, D. (2022) · eLight · doi:10.1186/s43593-022-00029-9 · Cited by 53
Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation
Galick, H. A., Kathe, S. D., Liu, M., Robey-Bond, S. M., Kidane, D., Wallace, S. S., & Sweasy, J. B. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306752110 · Cited by 52
Self-citation
Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1
Zou, Z., Dong, L., Wang, H., Niu, J., Zou, M., Wu, N., Yu, D., & Wang, Y. (2015) · OncoTargets and Therapy · doi:10.2147/ott.s94513 · Cited by 53
The Pivotal Role of DNA Repair in Infection Mediated-Inflammation and Cancer
Sahan, A. Z., Hazra, T. K., & Das, S. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00663 · Cited by 56
The Therapeutic Potential of DNA Damage Repair Pathways and Genomic Stability in Lung Cancer
Burgess, J. T., Rose, M., Boucher, D., Plowman, J., Molloy, C., Fisher, M. A., O’Leary, C. G., Richard, D. J., O'Byrne, K. J., & Bolderson, E. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01256 · Cited by 58
NTHL1 in genomic integrity, aging and cancer
Das, L., Quintana, V., & Sweasy, J. B. (2020) · DNA repair · doi:10.1016/j.dnarep.2020.102920 · Cited by 48
Self-citation
Reactive oxygen species and gastric carcinogenesis: The complex interaction between Helicobacter pylori and host
Wu, S., Chen, Y., Chen, Z., Wei, F., Zhou, Q., Li, P., & Gu, Q. (2023) · Helicobacter · doi:10.1111/hel.13024 · Cited by 47
Advances in single‐molecule fluorescent nanosensors
Liu, M., Qiu, J., Ma, F., & Zhang, C. (2021) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1716 · Cited by 48
Telomeric injury by KML001 in human T cells induces mitochondrial dysfunction through the p53-PGC-1α pathway
Schank, M., Zhao, J., Wang, L., Li, Z., Cao, D., Nguyen, L. N., Dang, X., Khanal, S., Nguyen, L. N. T., Thakuri, B. K. C., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03238-7 · Cited by 47
NMR and computational methods for molecular resolution of allosteric pathways in enzyme complexes
East, K. W., Skeens, E., Cui, J. Y., Belato, H. B., Mitchell, B. P., Hsu, R. V., Batista, V. S., Palermo, G., & Lisi, G. P. (2019) · Biophysical Reviews · doi:10.1007/s12551-019-00609-z · Cited by 45
Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: Activity, structure, and the effect of editing
Prakash, A., Carroll, B. L., Sweasy, J. B., Wallace, S. S., & Doublié, S. (2014) · DNA repair · doi:10.1016/j.dnarep.2013.12.003 · Cited by 46
Self-citation
Initiation of the ATM-Chk2 DNA damage response through the base excision repair pathway
Chou, W., Hu, L., Hsiung, C., & Shen, C. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv079 · Cited by 49
When DNA repair goes wrong: BER-generated DNA-protein crosslinks to oxidative lesions
Quiñones, J. L., & Demple, B. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.05.014 · Cited by 43
The Biochemical Role of the Human NEIL1 and NEIL3 DNA Glycosylases on Model DNA Replication Forks
Albelazi, M. S., Martin, P. R., Mohammed, S., Mutti, L., Parsons, J. L., & Elder, R. H. (2019) · Genes · doi:10.3390/genes10040315 · Cited by 43
Cellular Responses to Widespread DNA Replication Stress
Nickoloff, J. A., Jaiswal, A. S., Sharma, N., Williamson, E. A., Tran, M. T., Arris, D., Yang, M., & Hromas, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316903 · Cited by 46
SUMOylation coordinates BERosome assembly in active DNA demethylation during cell differentiation
Steinacher, R., Barekati, Z., Botev, P., Kuśnierczyk, A., Slupphaug, G., & Schär, P. (2018) · The EMBO Journal · doi:10.15252/embj.201899242 · Cited by 41
Haloferax volcanii —a model archaeon for studying DNA replication and repair
Pérez-Arnaiz, P., Dattani, A., Smith, V., & Allers, T. (2020) · Open Biology · doi:10.1098/rsob.200293 · Cited by 46
Targeting abasic site-containing DNA with annelated quinolizinium derivatives: the influence of size, shape and substituents
Benner, K., Ihmels, H., Kölsch, S., & Pithan, P. M. (2014) · Organic & Biomolecular Chemistry · doi:10.1039/c3ob42140f · Cited by 41
Molecular Mechanisms of H. pylori-Induced DNA Double-Strand Breaks
Kidane, D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102891 · Cited by 42
The impact of rare germline variants on human somatic mutation processes
Vali-Pour, M., Park, S., Espinosa‐Carrasco, J., Ortiz-Martínez, D., Lehner, B., & Supek, F. (2022) · Nature Communications · doi:10.1038/s41467-022-31483-1 · Cited by 39
Human Variation in DNA Repair, Immune Function, and Cancer Risk
Cheong, A. W. Y., & Nagel, Z. D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.899574 · Cited by 38
MicroRNA binding site polymorphisms as biomarkers in cancer management and research
Landi, S., Gemignani, F., & Cipollini, M. (2014) · Pharmacogenomics and Personalized Medicine · doi:10.2147/pgpm.s61693 · Cited by 36
Transcription coupled base excision repair in mammalian cells: So little is known and so much to uncover
Chakraborty, A., Tapryal, N., Islam, A., MITRA, S. P., & Hazra, T. K. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103204 · Cited by 39
MUTYH-associated tumor syndrome: The other face of MAP
Magrin, L., Fanale, D., Brando, C., Corsini, L. R., Randazzo, U., Piazza, M. D., Gurrera, V., Pedone, E., Russo, T. D. B., Vieni, S., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02304-y · Cited by 37
DNA polymerase β deficiency is linked to aggressive breast cancer: A comprehensive analysis of gene copy number, mRNA and protein expression in multiple cohorts
Abdel-Fatah, T. M. A., Russell, R., Agarwal, D., Moseley, P. M., Abayomi, M., Perry, C., Albarakati, N., Ball, G., Chan, S. Y. T., Caldas, C., et al. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.01.001 · Cited by 34
Contribution of DNA unwrapping from histone octamers to the repair of oxidatively damaged DNA in nucleosomes
Maher, R. L., Prasad, A., Rizvanova, O., Wallace, S. S., & Pederson, D. S. (2013) · DNA repair · doi:10.1016/j.dnarep.2013.08.010 · Cited by 34
Self-citation
Apurinic/apyrimidinic endonuclease 1 induced upregulation of fibroblast growth factor 2 and its receptor 3 induces angiogenesis in human osteosarcoma cells
Ren, T., Qing, Y., Dai, N., Li, M., Qian, C., Yang, Y., Cheng, Y., Li, Z., Zhang, S., Zhong, Z., et al. (2013) · Cancer Science · doi:10.1111/cas.12334 · Cited by 34
Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice
Kay, J. E., Corrigan, J. J., Armijo, A. L., Nazari, I. S., Kohale, I. N., Torous, D. K., Avlasevich, S. L., Croy, R. G., Wadduwage, D. N., Carrasco, S. E., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108864 · Cited by 34
NAPTUNE: nucleic acids and protein biomarkers testing via ultra-sensitive nucleases escalation
Hu, T., Ke, X., Yu, Y., Feng, H., Zhang, S., Cui, Y., Zhang, B., He, M., Tang, Y., Liu, L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56653-9 · Cited by 34
Oxidatively-induced DNA damage and base excision repair in euthymic patients with bipolar disorder
Ceylan, D., Tuna, G., Kırkalı, G., Tunca, Z., Can, G., Arat, H. E., Kant, M., Dizdaroğlu, M., & Özerdem, A. (2018) · DNA repair · doi:10.1016/j.dnarep.2018.03.006 · Cited by 32
Base excision repair capacity as a determinant of prognosis and therapy response in colon cancer patients
Vodenková, S., Jirásková, K., Urbanova, M., Kroupa, M., Slyšková, J., Schneiderová, M., Levý, M., Büchler, T., Liška, V., Vodičková, Ľ., et al. (2018) · DNA repair · doi:10.1016/j.dnarep.2018.09.006 · Cited by 33
Chromatin recruitment of OGG1 requires cohesin and mediator and is essential for efficient 8-oxoG removal
Lebraud, E., Pinna, G., Siberchicot, C., Dépagne, J., Busso, D., Fantini, D., Irbah, L., Robeska, E., Kratassiouk, G., Ravanat, J., et al. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa611 · Cited by 35
DNA repair pathways and their roles in drug resistance for lung adenocarcinoma
Kara, A., Özgür, A., Nalbantoğlu, S., & Karadağ, A. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06314-z · Cited by 35
A Zinc Linchpin Motif in the MUTYH Glycosylase Interdomain Connector Is Required for Efficient Repair of DNA Damage
Engstrom, L. M., Brinkmeyer, M. K., Ha, Y., Raetz, A. G., Hedman, B., Hodgson, K. O., Solomon, E. I., & David, S. S. (2014) · Journal of the American Chemical Society · doi:10.1021/ja502942d · Cited by 32
Base Excision Repair Variants in Cancer
Marsden, C. G., Dragon, J. A., Wallace, S. S., & Sweasy, J. B. (2017) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2017.03.003 · Cited by 32
Self-citation
Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies
Moshawih, S., Fern, L. A., Ardianto, C., Goh, K. W., Kifli, N., Goh, H. P., Jarrar, Q., & Ming, L. C. (2022) · Biomolecules · doi:10.3390/biom12070878 · Cited by 32
Chromatin associated mechanisms in base excision repair - nucleosome remodeling and DNA transcription, two key players
Menoni, H., Mascio, P. D., Cadet, J., Dimitrov, S. I., & Angelov, D. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.026 · Cited by 29
The ligation of pol β mismatch insertion products governs the formation of promutagenic base excision DNA repair intermediates
Çağlayan, M. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa151 · Cited by 30
The scaffold protein XRCC1 stabilizes the formation of polβ/gap DNA and ligase IIIα/nick DNA complexes in base excision repair
Tang, Q., & Çağlayan, M. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101025 · Cited by 30
Exploiting base excision repair to improve therapeutic approaches for pancreatic cancer
Sharbeen, G. (2015) · Frontiers in Nutrition · doi:10.3389/fnut.2015.00010 · Cited by 30
Radiation induced base excision repair (BER): A mechanistic mathematical approach
Rahmanian, S., Taleei, R., & Nikjoo, H. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.07.011 · Cited by 30
Single nucleotide polymorphisms in DNA glycosylases: From function to disease
D’Errico, M., Parlanti, E., Pascucci, B., Fortini, P., Baccarini, S., Simonelli, V., & Dogliotti, E. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.002 · Cited by 30
The NEIL1 G83D germline DNA glycosylase variant induces genomic instability and cellular transformation
Galick, H. A., Marsden, C. G., Kathe, S. D., Dragon, J. A., Volk, L. B., Nemec, A. A., Wallace, S. S., Prakash, A., Doublié, S., & Sweasy, J. B. (2017) · Oncotarget · doi:10.18632/oncotarget.20716 · Cited by 31
Self-citation
Targeting the DNA damage response in cancer
Guffanti, F., Chiappa, M., & Damia, G. L. M. (2024) · MedComm · doi:10.1002/mco2.788 · Cited by 30
Acetylation of the histone H3 tail domain regulates base excision repair on higher-order chromatin structures
Banerjee, D. R., Deckard, C. E., Zeng, Y., & Sczepanski, J. T. (2019) · Scientific Reports · doi:10.1038/s41598-019-52340-0 · Cited by 27
New perspectives in cancer biology from a study of canonical and non-canonical functions of base excision repair proteins with a focus on early steps
Malfatti, M. C., Antoniali, G., Codrich, M., Burra, S., Mangiapane, G., Dalla, E., & Tell, G. (2019) · Mutagenesis · doi:10.1093/mutage/gez051 · Cited by 26
Targeting the DNA Damage Response Machinery for Lung Cancer Treatment
Venugopala, K. N. (2022) · Pharmaceuticals · doi:10.3390/ph15121475 · Cited by 27
Functional Polymorphisms in DNA Repair Genes Are Associated with Sporadic Colorectal Cancer Susceptibility and Clinical Outcome
Jirásková, K., Hughes, D. J., Brezina, S., Gumpenberger, T., Veškrňová, V., Büchler, T., Schneiderová, M., Levý, M., Liška, V., Vodenková, S., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010097 · Cited by 26
Caught in motion: human NTHL1 undergoes interdomain rearrangement necessary for catalysis
Carroll, B. L., Zahn, K. E., Hanley, J. P., Wallace, S. S., Dragon, J. A., & Doublié, S. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab1162 · Cited by 26
Self-citation
The Base Excision Repair Pathway in the Nematode Caenorhabditis elegans
Elsakrmy, N., Zhang-Akiyama, Q.-M., & Ramotar, D. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.598860 · Cited by 28
Glycosidic Bond Cleavage in DNA Nucleosides: Effect of Nucleobase Damage and Activation on the Mechanism and Barrier
Lenz, S. A. P., Kellie, J. L., & Wetmore, S. D. (2015) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.5b10337 · Cited by 24
PARP‑1 inhibition sensitizes temozolomide‑treated glioblastoma cell lines and decreases drug resistance independent of MGMT activity and PTEN proficiency
Montaldi, A. P., de Lima, S. C. G., Godoy, P. R. D. V., Xavier, D. P., & Sakamoto‐Hojo, E. T. (2020) · Oncology Reports · doi:10.3892/or.2020.7756 · Cited by 24
Targeting Replication Stress Response Pathways to Enhance Genotoxic Chemo- and Radiotherapy
Nickoloff, J. A. (2022) · Molecules · doi:10.3390/molecules27154736 · Cited by 30
Research progress on the role and mechanism of DNA damage repair in germ cell development
Wang, Y., Su, M., Chen, Y., Huang, X., Ruan, L., Lv, Q., & Li, L. L. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1234280 · Cited by 25
Gene-gene interactions in gastrointestinal cancer susceptibility
Kim, J., Yum, S., Kang, C., & Kang, S. (2016) · Oncotarget · doi:10.18632/oncotarget.11701 · Cited by 24
Regulation of DNA repair by non-coding miRNAs
Natarajan, V. (2016) · Non-coding RNA Research · doi:10.1016/j.ncrna.2016.10.002 · Cited by 24
The C-terminal tail of the NEIL1 DNA glycosylase interacts with the human mitochondrial single-stranded DNA binding protein
Sharma, N., Chakravarthy, S., Longley, M. J., Copeland, W. C., & Prakash, A. (2018) · DNA repair · doi:10.1016/j.dnarep.2018.02.012 · Cited by 25

Authors: Wallace, S. S., Murphy, D. L., & Sweasy, J. B.
Affiliations: University of Vermont (US)
Yale University (US)
Corresponding author: Wallace, Susan S.
ORCID: Wallace, Susan S.
Sweasy, Joann B.
Venue: Cancer Letters
Publisher: Elsevier BV
Published: 2012-12
Volume: 327
Issue: 1-2
Pages: 73-89
ISSN: 0304-3835 (ISSN-L)
DOI: 10.1016/j.canlet.2011.12.038
PMC: PMC3361536
OpenAlex: W1985323804
Cited by: 329
References: 357
Citations by year: 2026: 17 · 2025: 21 · 2024: 17 · 2023: 32 · 2022: 34 · 2021: 34 · 2020: 26 · 2019: 27 · 2018: 26 · 2017: 15 · 2016: 23 · 2015: 14 · 2014: 25 · 2013: 16 · 2012: 2
FWCI: 1.66
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cancer Letters (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (P01CA098993, R01CA080830, R01 CA33657, P01CA129186, R01CA033657)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Keywords: base excision repair, short-patch repair, DNA repair deficiency, cancer susceptibility, MUTYH, biallelic variants, mouse model, endogenous DNA damage, neurological disorders
MeSH terms: Animals, Cell Transformation, Neoplastic, DNA Damage, DNA Repair, Humans, Neoplasms, Phenotype, Gene Expression Regulation, Neoplastic, Genetic Predisposition to Disease, DNA Repair Enzymes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Base excision repair and cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks