Base excision repair and cancer

DNA Repair and Mutagenesis

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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

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Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

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Genome-wide association study identifies novel breast cancer susceptibility loci

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Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors

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Hereditary and Familial Colon Cancer

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Base-excision repair of oxidative DNA damage

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Single-strand break repair and genetic disease

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Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA

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Redox activation of Fos‐Jun DNA binding activity is mediated by a DNA repair enzyme.

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MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis

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The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings

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Requirement of mammalian DNA polymerase-β in base-excision repair

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Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

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Active DNA Demethylation Mediated by DNA Glycosylases

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Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells

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STRUCTURES OF TERNARY COMPLEXES OF RAT DNA POLYMERASE BETA, A DNA TEMPLATE-PRIMER, AND DDCTP

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Genome-wide association study identifies five new breast cancer susceptibility loci

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Excision of Deoxyribose Phosphate Residues by DNA Polymerase β During DNA Repair

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Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells

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The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites

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Human uracil–DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

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XRCC1 Polypeptide Interacts with DNA Polymerase and Possibly Poly (ADP-Ribose) Polymerase, and DNA Ligase III Is a Novel Molecular 'Nick-Sensor' In Vitro

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An N -Glycosidase from Escherichia coli That Releases Free Uracil from DNA Containing Deaminated Cytosine Residues

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XRCC1 and DNA strand break repair

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Cloning and characterization of hOGG1 , a human homolog of the OGG1 gene of Saccharomyces cerevisiae

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Structures of Ternary Complexes of Rat DNA Polymerase β, a DNA Template-Primer, and ddCTP

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DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice

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Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes.

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A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)

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Genetic Polymorphisms in the Base Excision Repair Pathway and Cancer Risk: A HuGE Review

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Going APE over ref-1

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An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III

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Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure.

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Uracil in DNA – occurrence, consequences and repair

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Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA

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AP Endonuclease-Independent DNA Base Excision Repair in Human Cells

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XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein–protein interactions

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Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA

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Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.

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A unified view of base excision repair: Lesion-dependent protein complexes regulated by post-translational modification

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Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

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Polymorphisms of DNA repair genes and risk of non-small cell lung cancer

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Molecular Cloning of the Human XRCC1 Gene, Which Corrects Defective DNA Strand Break Repair and Sister Chromatid Exchange

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Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C->T:A mutations

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The structural basis of specific base-excision repair by uracil–DNA glycosylase

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Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage

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The enzymology of apurinic/apyrimidinic endonucleases

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Base excision repair of DNA in mammalian cells

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Crystal structure and mutational analysis of human uracil-DNA glycosylase: Structural basis for specificity and catalysis

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Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase

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Opposite base‐dependent reactions of a human base excision repair enzyme on DNA containing 7,8‐dihydro‐8‐oxoguanine and abasic sites

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hUNG2 Is the Major Repair Enzyme for Removal of Uracil from U:A Matches, U:G Mismatches, and U in Single-stranded DNA, with hSMUG1 as a Broad Specificity Backup

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Mmh / Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice

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Expanded Extracolonic Tumor Spectrum in MUTYH-Associated Polyposis

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The lyase activity of the DNA repair protein β-polymerase protects from DNA-damage-induced cytotoxicity

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Repair of Oxidized Bases in DNA Bubble Structures by Human DNA Glycosylases NEIL1 and NEIL2

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Requirement for theXrcc1DNA Base Excision Repair Gene during Early Mouse Development

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Post‐replicative base excision repair in replication foci

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Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase

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Enzymatic Processing of Radiation-Induced Free Radical Damage in DNA

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A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII

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Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue.

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Enhanced CpG Mutability and Tumorigenesis in MBD4-Deficient Mice

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MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily

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DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation

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Identification and Characterization of a Novel Human DNA Glycosylase for Repair of Cytosine-derived Lesions

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A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer

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Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase

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Structure and function in the uracil-DNA glycosylase superfamily

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Uracil-DNA Glycosylase (UNG)-Deficient Mice Reveal a Primary Role of the Enzyme during DNA Replication

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The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra‐helical deoxyribose at DNA abasic sites

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A CHO-cell strain having hypersensitivity to mutagens, a defect in DNA strand-break repair, and an extraordinary baseline frequency of sister-chromatid exchange

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New class of enzymes acting on damaged DNA

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Differential ability of polymorphic OGG1 proteins to suppress mutagenesis induced by 8-hydroxyguanine in human cell in vivo

Yamane, A. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh166 · Cited by 133

Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment

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Increased Colorectal Cancer Incidence in Obligate Carriers of Heterozygous Mutations in MUTYH

Jones, N., Vogt, S. L., Nielsen, M., Christian, D., Wark, P. A., Eccles, D., Edwards, E., Evans, D. G., Maher, E. R., Vasen, H. F. A., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.04.047 · Cited by 132

DNA repair activity of 8-oxoguanine DNA glycosylase 1 (OGG1) in human lymphocytes is not dependent on genetic polymorphism Ser326/Cys326

Janssen, K., Schlink, K., Götte, W., Hippler, B., Kaina, B., & Oesch, F. (2001) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(01)00096-9 · Cited by 127

Differential Specificity of Human and Escherichia coli Endonuclease III and VIII Homologues for Oxidative Base Lesions

Katafuchi, A., Nakano, T., Masaoka, A., Terato, H., Iwai, S., Hanaoka, F., & Ide, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400393200 · Cited by 127

Covalent Trapping of Human DNA Polymerase β by the Oxidative DNA Lesion 2-Deoxyribonolactone

DeMott, M. S., Beyret, E., Wong, D., Bales, B. C., Hwang, J.-T., Greenberg, M. M., & Demple, B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c100577200 · Cited by 127

Human Ape2 protein has a 3'-5' exonuclease activity that acts preferentially on mismatched base pairs

Burkovics, P., Szukacsov, V., Unk, I., & Haracska, L. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl259 · Cited by 127

Variation in base excision repair capacity

Wilson, D. M., Kim, D., Berquist, B. R., & Sigurdson, A. J. (2010) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2010.12.004 · Cited by 126

N-methylpurine DNA glycosylase and DNA polymerase β modulate BER inhibitor potentiation of glioma cells to temozolomide

Tang, J.-B., Svilar, D., Trivedi, R. N., Wang, X., Goellner, E. M., Moore, B., Hamilton, R. L., Banze, L. A., Brown, A. R., & Sobol, R. W. (2011) · Neuro-Oncology · doi:10.1093/neuonc/nor011 · Cited by 126

Structures of DNA Polymerase β with Active-Site Mismatches Suggest a Transient Abasic Site Intermediate during Misincorporation

Batra, V. K., Beard, W. A., Shock, D. D., Pedersen, L. C., & Wilson, S. H. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.02.025 · Cited by 125

Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition

Maiti, A., Morgan, M. T., Pozharski, E. V., & Drohat, A. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711061105 · Cited by 125

Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA

Chan, M. K., Ocampo-Hafalla, M. T., Vartanian, V. L., Jaruga, P., Kırkalı, G., Koenig, K. L., Brown, S. M., Lloyd, R. S., Dizdaroğlu, M., & Teebor, G. W. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.03.001 · Cited by 124

Effect of single mutations in the OGG1 gene found in human tumors on the substrate specificity of the Ogg1 protein

Audebert, M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.14.2672 · Cited by 124

Overexpression of N-methylpurine-DNA glycosylase in Chinese hamster ovary cells renders them more sensitive to the production of chromosomal aberrations by methylating agents — a case of imbalanced DNA repair

Coquerelle, T. M., Dösch, J., & Kaina, B. (1995) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(94)00035-5 · Cited by 123

cDNA cloning, sequencing, expression and possible domain structure of human APEX nuclease homologous to Escherichia coli exonuclease III

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Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis.

Bergoglio, V., Pillaire, M., Lacroix‐Triki, M., Raynaud‐Messina, B., Canitrot, Y., Bieth, A., Garès, M., Wright, M., Delsol, G., Loeb, L. A., et al. (2002) · PubMed · Cited by 121

High accumulation of oxidative DNA damage, 8-hydroxyguanine, in Mmh/Ogg1 deficient mice by chronic oxidative stress

Arai, T. (2002) · Carcinogenesis · doi:10.1093/carcin/23.12.2005 · Cited by 120

Single Qdot-labeled glycosylase molecules use a wedge amino acid to probe for lesions while scanning along DNA

Dunn, A. R., Kad, N. M., Nelson, S. R., Warshaw, D. M., & Wallace, S. S. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr459 · Cited by 118

Genetic regulation of ionizing radiation sensitivity and breast cancer risk

Hu, J. J., Smith, T. R., Miller, M. S., Lohman, K., & Case, L. D. (2002) · Environmental and Molecular Mutagenesis · doi:10.1002/em.10058 · Cited by 118

Second human protein with homology to the Escherichia coli abasic endonuclease exonuclease III

Hadi, M. Z., & Wilson, D. M. (2000) · Environmental and Molecular Mutagenesis · doi:10.1002/1098-2280(2000)36:4 · Cited by 116

Distinct Repair Activities of Human 7,8-Dihydro-8-oxoguanine DNA Glycosylase and Formamidopyrimidine DNA Glycosylase for Formamidopyrimidine and 7,8-Dihydro-8-oxoguanine

Asagoshi, K., Yamada, T., Terato, H., Ohyama, Y., Monden, Y., Arai, T., Nishimura, S., Aburatani, H., Lindahl, T. L., & Ide, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.7.4956 · Cited by 115

Early Embryonic Lethality Due to Targeted Inactivation of DNA Ligase III

Puebla‐Osorio, N., Lacey, D. B., Alt, F. W., & Zhu, C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.10.3935-3941.2006 · Cited by 114

Alkylpurine–DNA–N-Glycosylase Knockout Mice Show Increased Susceptibility to Induction of Mutations by Methyl Methanesulfonate

Elder, R. H., Jansen, J. G., Weeks, R. J., Willington, M. A., Deans, B., Watson, A. J., Mynett, K. J., Bailey, J., Cooper, D. P., Rafferty, J. A., et al. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.10.5828 · Cited by 114

Expression of DNA polymerase β cancer-associated variants in mouse cells results in cellular transformation

Sweasy, J. B., Lang, T., Starcevic, D., Sun, K.-W., Lai, C., DiMaio, D., & Dalal, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505166102 · Cited by 112

Identification and Characterization of Inhibitors of Human Apurinic/apyrimidinic Endonuclease APE1

Simeonov, A. M., Kulkarni, A., Dorjsuren, D. G., Jadhav, A., Shen, M., McNeill, D. R., Austin, C. P., & Wilson, D. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005740 · Cited by 111

Base Excision Repair

Krokan, H. E., & Bjoras, M. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012583 · Cited by 1,322

The impact of oxidative DNA damage and stress on telomere homeostasis

Barnes, R. P., Fouquerel, E., & Opresko, P. L. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.03.013 · Cited by 585

Base excision repair: A critical player in many games

Wallace, S. S. (2014) · DNA Repair · doi:10.1016/j.dnarep.2014.03.030 · Cited by 401

DNA Damage Response Genes and the Development of Cancer Metastasis

Broustas, C. G., & Lieberman, H. B. (2014) · Radiation Research · doi:10.1667/rr13515.1 · Cited by 284

DNA Damage and Associated DNA Repair Defects in Disease and Premature Aging

Tiwari, V., & Wilson, D. M. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.06.005 · Cited by 244

Base excision repair and the role of MUTYH

Kairupan, C. F., & Scott, R. J. (2007) · Hereditary Cancer in Clinical Practice · doi:10.1186/1897-4287-5-4-199 · Cited by 39

Colorectal cancer and inherited mutations in base-excision repair

Chow, E. C., Thirlwell, C., Macrae, F., & Lipton, L. R. (2004) · The Lancet Oncology · doi:10.1016/s1470-2045(04)01595-5 · Cited by 59

Variant base excision repair proteins: Contributors to genomic instability

Nemec, A. A., Wallace, S. S., & Sweasy, J. B. (2010) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.10.010 · Cited by 77

Exposing the MYtH about base excision repair and human inherited disease

Cheadle, J. P., & Sampson, J. R. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg259 · Cited by 92

CommentaryDNA Base Excision Repair Defects in Human Pathologies

Fròsina, G. (2004) · Free Radical Research · doi:10.1080/10715760400011445 · Cited by 36