The DOI matches its Crossref record; 351 of the 357 references it cites were found in a registry or an index.
Base excision repair and cancer
Open accessAbstract
Base excision repair is the system used from bacteria to man to remove the tens of thousands of endogenous DNA damages produced daily in each human cell. Base excision repair is required for normal mammalian development and defects have been associated with neurological disorders and cancer. In this paper we provide an overview of short patch base excision repair in humans and summarize current knowledge of defects in base excision repair in mouse models and functional studies on short patch base excision repair germ line polymorphisms and their relationship to cancer. The biallelic germ line mutations that result in MUTYH-associated colon cancer are also discussed.
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“Defective DNA repair and DDR pathways may lead to several human diseases, such as cancer and neurodegenerative diseases [6, 33–38]”
From Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress (2014) · cites this paper as [33]
In the citing paper
“Dysfunctions in these pathways are linked to cancer and neurodegenerative diseases [6, 33–38]”
From Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress (2014) · cites this paper as [33]
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Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA
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Cited by
Sorted by citations
Krokan, H. E., & Bjoras, M. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012583 · Cited by 1,322
The impact of oxidative DNA damage and stress on telomere homeostasis
Barnes, R. P., Fouquerel, E., & Opresko, P. L. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.03.013 · Cited by 585
Base excision repair: A critical player in many games
Wallace, S. S. (2014) · DNA Repair · doi:10.1016/j.dnarep.2014.03.030 · Cited by 401
Self-citationDNA Damage Response Genes and the Development of Cancer Metastasis
Broustas, C. G., & Lieberman, H. B. (2014) · Radiation Research · doi:10.1667/rr13515.1 · Cited by 284
DNA Damage and Associated DNA Repair Defects in Disease and Premature Aging
Tiwari, V., & Wilson, D. M. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.06.005 · Cited by 244
Metadata
- Authors
- Wallace, S. S., Murphy, D. L., & Sweasy, J. B.
- Affiliations
- University of Vermont (US)
- Yale University (US)
- Corresponding author
- Wallace, Susan S.
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 327
- Issue
- 1-2
- Pages
- 73-89
- ISSN
- 0304-3835 (ISSN-L)
- PMC
- PMC3361536
- OpenAlex
- W1985323804
- Cited by
- 329
- References
- 357
- Citations by year
- 2026: 17 · 2025: 21 · 2024: 17 · 2023: 32 · 2022: 34 · 2021: 34 · 2020: 26 · 2019: 27 · 2018: 26 · 2017: 15 · 2016: 23 · 2015: 14 · 2014: 25 · 2013: 16 · 2012: 2
- FWCI
- 1.66
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Letters (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P01CA098993, R01CA080830, R01 CA33657, P01CA129186, R01CA033657)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Keywords
- base excision repair, short-patch repair, DNA repair deficiency, cancer susceptibility, MUTYH, biallelic variants, mouse model, endogenous DNA damage, neurological disorders
- MeSH terms
- Animals, Cell Transformation, Neoplastic, DNA Damage, DNA Repair, Humans, Neoplasms, Phenotype, Gene Expression Regulation, Neoplastic, Genetic Predisposition to Disease, DNA Repair Enzymes
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