Pathways for repairing and tolerating the spectrum of oxidative DNA lesions

Berquist, Brian R.; Wilson, David M.

doi:10.1016/j.canlet.2012.02.001

Cited by 136DNA Repair MechanismsCarcinogens and Genotoxicity AssessmentDNA and Nucleic Acid Chemistry

Pathways for repairing and tolerating the spectrum of oxidative DNA lesions

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Berquist, Brian R., Wilson, David M.·2012·Cancer Letters

DOI 10.1016/j.canlet.2012.02.001PMC PMC3389563

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Abstract

Reactive oxygen species (ROS) arise from both endogenous and exogenous sources. These reactive molecules possess the ability to damage both the DNA nucleobases and the sugar phosphate backbone, leading to a wide spectrum of lesions, including non-bulky (8-oxoguanine and formamidopyrimidine) and bulky (cyclopurine and etheno adducts) base modifications, abasic sites, non-conventional single-strand breaks, protein-DNA adducts, and intra/interstrand DNA crosslinks. Unrepaired oxidative DNA damage can result in bypass mutagenesis during genome copying or gene expression, or blockage of the essential cellular processes of DNA replication or transcription. Such outcomes underlie numerous pathologies, including, but not limited to, carcinogenesis and neurodegeneration, as well as the aging process. Cells have adapted and evolved defense systems against the deleterious effects of ROS, and specifically devote a number of cellular DNA repair and tolerance pathways to combat oxidative DNA damage. Defects in these protective pathways trigger hereditary human diseases that exhibit increased cancer incidence, developmental defects, neurological abnormalities, and/or premature aging. We review herein classic and atypical oxidative DNA lesions, outcomes of encountering these damages during DNA replication and transcription, and the consequences of losing the ability to repair the different forms of oxidative DNA damage. We particularly focus on the hereditary human diseases Xeroderma Pigmentosum, Cockayne Syndrome and Fanconi Anemia, which may involve defects in the efficient repair of oxidative modifications to chromosomal DNA.

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During DNA replication, an oxidatively damaged site can be bypassed by inserting a mismatched deoxynucleotide such as 8-oxo-G:A.
“During DNA replication, an oxidatively damaged site may be bypassed by incorporating a mismatched deoxynucleotide (e.g., 8-oxo-G:A) [7].”
From Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress (2014) · cites this paper as [7]
Base excision repair/single-strand break repair, nucleotide excision repair, mismatch repair, homologous recombination, and nonhomologous end joining all participate in repairing oxidative DNA damage.
“Base excision repair (BER)/single-strand break repair (SSBR) (Fig. 3), nucleotide excision repair (NER) (Fig. 4), mismatch repair (MMR) (Fig. 5), homologous recombination (HR), and nonhomologous end joining (NHEJ) (Fig. 6) are all involved in the repair processes in response to oxidative DNA damage [7, 18].”
From Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress (2014) · cites this paper as [7]
To repair oxidative DNA damage, cells employ several DNA repair pathways including BER/SSBR, NER, MMR, HR, and NHEJ to maintain genome stability.
“To repair oxidative DNA damage, several DNA repair pathways, including BER/SSBR, NER, MMR, HR, and NHEJ, are employed by cells to maintain genome stability (Fig. 1) [7, 18].”
From Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress (2014) · cites this paper as [7]
DNA repair and DDR pathways evolved as two major cellular responses to oxidative stress-induced DNA damage that maintain genome stability.
“To maintain genome stability, DNA repair and DDR pathways have evolved as the two major cellular responses to oxidative stress-induced DNA damage [7, 31]”
From Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress (2014) · cites this paper as [7]

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Low, G. K. M., Fok, E. D. Z., Ting, A. P. L., & Hande, M. P. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.05.009 · Cited by 27 · see citing works
Review: DNA molecular electrostatic potential: novel perspectives for the mechanism of action of anticancer drugs involving electron transfer and oxidative stress.
Kovacic, P., & Wakelin, L. P. G. (2002) · PubMed · Cited by 26 · see citing works
Complementation of the oxidatively damaged DNA repair defect in Cockayne syndrome A and B cells by Escherichia coli formamidopyrimidine DNA glycosylase
Ropolo, M., Degan, P., Foresta, M., D’Errico, M., Lasigliè, D., Eugenia Dogliotti, Y., Casartelli, G., Zupo, S., Poggi, A. D., & Fròsina, G. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.008 · Cited by 22 · see citing works
Impaired Repair of Ionizing Radiation-Induced DNA Damage in Cockayne Syndrome Cells
Cramers, P., Verhoeven, E. E. A., Filon, A. R., Rockx, D., Santos, S. J., van der Leer, A. A., Kleinjans, J. C. S., van Zeeland, A. A., & Mullenders, L. H. F. (2011) · Radiation Research · doi:10.1667/rr1972.1 · Cited by 21 · see citing works
Differential Blocking Effects of the Acetaldehyde-derived DNA Lesion N2-Ethyl-2′-deoxyguanosine on Transcription by Multisubunit and Single Subunit RNA Polymerases
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Impact of α‐hydroxy‐propanodeoxyguanine adducts on DNA duplex energetics: Opposite base modulation and implications for mutagenicity and genotoxicity
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Spinocerebellar Ataxia with Axonal Neuropathy
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Polymerization past the N2-isopropylguanine and the N6-isopropyladenine DNA lesions with the translesion synthesis DNA polymerases eta and iota and the replicative DNA polymerase alpha.
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Roles of specialized DNA polymerases in mutagenesis by oxidized guanine
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Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis
Smith, M. T., Guyton, K., Gibbons, C., Fritz, J. M., Portier, C., Rusyn, I., DeMarini, D., Caldwell, J., Kavlock, R., Lambert, P., et al. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1509912 · Cited by 599 · see citing works
Mitochondria as a Source of Reactive Oxygen and Nitrogen Species: From Molecular Mechanisms to Human Health
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Base excision repair: A critical player in many games
Wallace, S. S. (2014) · DNA Repair · doi:10.1016/j.dnarep.2014.03.030 · Cited by 401 · see citing works
PrimPol, an Archaic Primase/Polymerase Operating in Human Cells
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Ochratoxin A: Toxicity, oxidative stress and metabolism
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Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures
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A review of adaptive mechanisms in cell responses towards oxidative stress caused by dental resin monomers
Krifka, S., Spagnuolo, G., Schmalz, G., & Schweikl, H. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.03.019 · Cited by 289 · see citing works
Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress
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Oxidative DNA damage and nucleotide excision repair
Melis, J. P. M., van Steeg, H., & Luijten, M. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5036 · Cited by 234 · see citing works
A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells
Ahuja, A. K., Jodkowska, K., Teloni, F., Bizard, A. H., Zellweger, R., Herrador, R., Ortega, S., Hickson, I. D., Altmeyer, M., Méndez, J., et al. (2016) · Nature Communications · doi:10.1038/ncomms10660 · Cited by 202 · see citing works
A Review of the Application of Inflammatory Biomarkers in Epidemiologic Cancer Research
Brenner, D. R., Scherer, D., Muir, K. R., Schildkraut, J. M., Boffetta, P., Spitz, M. R., Marchand, L. L., Chan, A. T., Goode, E. L., Ulrich, C. M., et al. (2014) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-14-0064 · Cited by 163 · see citing works
Oxidative stress in thyroid carcinomas: biological and clinical significance
Hassani, R. A. E., Buffet, C., Leboulleux, S., & Dupuy, C. (2019) · Endocrine Related Cancer · doi:10.1530/erc-18-0476 · Cited by 140 · see citing works
Cell Injury and Repair Resulting from Sleep Loss and Sleep Recovery in Laboratory Rats
Everson, C. A., Henchen, C. J., Szabo, A., & Hogg, N. (2014) · Sleep · doi:10.5665/sleep.4244 · Cited by 136 · see citing works
Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells
Nassour, J., Martien, S., Martin, N., Deruy, E., Tomellini, E., Malaquin, N., Bouali, F., Sabatier, L., Wernert, N., Pinte, S., et al. (2016) · Nature Communications · doi:10.1038/ncomms10399 · Cited by 124 · see citing works
The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them
Smith, M. T., Guyton, K. Z., Kleinstreuer, N., Borrel, A., Cárdenas, A., Chiu, W. A., Felsher, D. W., Gibbons, C. F., Goodson, W. H., Houck, K. A., et al. (2020) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-19-1346 · Cited by 117 · see citing works
Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease
Wang, Y., Chakravarty, P., Ranes, M., Kelly, G. P., Brooks, P. J., Neilan, E. G., Stewart, A., Schiavo, G., & Svejstrup, J. Q. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412569111 · Cited by 109 · see citing works
Novel method for site-specific induction of oxidative DNA damage reveals differences in recruitment of repair proteins to heterochromatin and euchromatin
Lan, L., Nakajima, S., Wei, L., Sun, L., Hsieh, C.-L., Sobol, R. W., Bruchez, M. P., Houten, B. V., Yasui, A., & Levine, A. S. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1233 · Cited by 98 · see citing works
NADPH oxidases: new actors in thyroid cancer?
Hassani, R. A. E., Schlumberger, M. J., & Dupuy, C. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.64 · Cited by 92 · see citing works
Blinded by the UV light: How the focus on transcription-coupled NER has distracted from understanding the mechanisms of Cockayne syndrome neurologic disease
Brooks, P. J. (2013) · DNA repair · doi:10.1016/j.dnarep.2013.04.018 · Cited by 82 · see citing works
Oxidative Stress, Bone Marrow Failure, and Genome Instability in Hematopoietic Stem Cells
Richardson, C., Yan, S., & Vestal, C. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16022366 · Cited by 81 · see citing works
Widespread transcriptional gene inactivation initiated by a repair intermediate of 8-oxoguanine
Allgayer, J., Kitsera, N., Bartelt, S., Epe, B., & Khobta, A. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw473 · Cited by 77 · see citing works
Targeted DNA damage at individual telomeres disrupts their integrity and triggers cell death
Sun, L., Tan, R., Xu, J., LaFace, J., Gao, Y. D., Xiao, Y., Attar, M. A., Neumann, C. A., Li, G., Su, B., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv598 · Cited by 75 · see citing works
The Emerging Role of QSOX1 in Cancer
Lake, D. F., & Faigel, D. O. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5572 · Cited by 69 · see citing works
ATM-dependent pathways of chromatin remodelling and oxidative DNA damage responses
Berger, N. D., Stanley, F. K. T., Moore, S., & Goodarzi, A. A. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0283 · Cited by 65 · see citing works
Beneficial and paradoxical roles of selenium at nutritional levels of intake in healthspan and longevity
Zhang, L., Zeng, H., & Cheng, W. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.05.067 · Cited by 66 · see citing works
CSB interacts with SNM1A and promotes DNA interstrand crosslink processing
Iyama, T., Lee, S. Y., Berquist, B. R., Gileadi, O., Bohr, V. A., Seidman, M. M., McHugh, P. J., & Wilson, D. M. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1279 · Cited by 61 · see citing works
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Distinctive adaptive response to repeated exposure to hydrogen peroxide associated with upregulation of DNA repair genes and cell cycle arrest
Santa-González, G. A., Gómez-Molina, A., Arcos‐Burgos, M., Meyer, J. N., & Camargo, M. (2016) · Redox Biology · doi:10.1016/j.redox.2016.07.004 · Cited by 61 · see citing works
Transcription-Associated Genome Instability
Gaillard, H., Herrera‐Moyano, E., & Aguilera, A. (2013) · Chemical Reviews · doi:10.1021/cr400017y · Cited by 60 · see citing works
Oxidatively damaged DNA and its repair in colon carcinogenesis
Tudek, B., & Speina, E. (2012) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2012.04.003 · Cited by 55 · see citing works
NBS1 is required for macrophage homeostasis and functional activity in mice
Pereira‐Lopes, S., Tur, J., Calatayud-Subias, J. A., Lloberas, J., Stracker, T. H., & Celada, A. (2015) · Blood · doi:10.1182/blood-2015-04-637371 · Cited by 50 · see citing works
Evaluation of DNA damage and physiological responses in Nile tilapia, Oreochromis niloticus (Linnaeus, 1758) exposed to sub-lethal diclofenac (DCF)
Pandey, P. K., Ajima, M. N. O., Kumar, K., Poojary, N., & Kumar, S. (2017) · Aquatic Toxicology · doi:10.1016/j.aquatox.2017.03.007 · Cited by 50 · see citing works
AOP report: Development of an adverse outcome pathway for oxidative DNA damage leading to mutations and chromosomal aberrations
Cho, E., Allemang, A., Audebert, M., Chauhan, V., Dertinger, S. D., Hendriks, G., Luijten, M., Marchetti, F., Minocherhomji, S., Pfuhler, S., et al. (2022) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22479 · Cited by 48 · see citing works
Comprehensive DNA Adduct Analysis Reveals Pulmonary Inflammatory Response Contributes to Genotoxic Action of Magnetite Nanoparticles
Ishino, K., Kato, T., Kato, M., Shibata, T., Watanabe, M., Wakabayashi, K., Nakagama, H., & Totsuka, Y. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16023474 · Cited by 49 · see citing works
Oxidative stress as a plausible mechanism for zearalenone to induce genome toxicity
Feng, Y., Zhao, A., Wang, J., Tian, Y., Yan, Z., Dri, M., Shen, W., Felici, M. D., & Li, L. (2022) · Gene · doi:10.1016/j.gene.2022.146511 · Cited by 48 · see citing works
Plant organellar DNA polymerases are replicative and translesion DNA synthesis polymerases
Baruch‐Torres, N., & Brieba, L. G. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx744 · Cited by 48 · see citing works
Commentary on the utility of the National Toxicology Program study on cell phone radiofrequency radiation data for assessing human health risks despite unfounded criticisms aimed at minimizing the findings of adverse health effects
Melnick, R. L. (2018) · Environmental Research · doi:10.1016/j.envres.2018.09.010 · Cited by 48 · see citing works
Base excision repair capacity in informing healthspan
Brenerman, B. M., Illuzzi, J. L., & Wilson, D. M. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu225 · Cited by 47 · see citing works
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Coordination of DNA repair by NEIL1 and PARP-1: a possible link to aging
Noren Hooten, N., Fitzpatrick, M., Kompaniez, K., Jacob, K. D., Moore, B. R., Nagle, J., Barnes, J., Lohani, A., & Evans, M. K. (2012) · Aging · doi:10.18632/aging.100492 · Cited by 44 · see citing works
Leukemogenic rearrangements at the mixed lineage leukemia gene (MLL)—multiple rather than a single mechanism
Gole, B., & Wiesmüller, L. (2015) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2015.00041 · Cited by 43 · see citing works
Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions
Daley, J. M., Tomimatsu, N., Hooks, G. M., Wang, W., Miller, A. S., Xue, X., Nguyen, K. A., Kaur, H., Williamson, E. A., Mukherjee, B., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16903-4 · Cited by 42 · see citing works
IARC use of oxidative stress as key mode of action characteristic for facilitating cancer classification: Glyphosate case example illustrating a lack of robustness in interpretative implementation
Bus, J. S. (2017) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2017.03.004 · Cited by 41 · see citing works
Mapping the key characteristics of carcinogens for glyphosate and its formulations: A systematic review
Rana, I., Nguyen, P. K., Rigutto, G., Louie, A., Lee, J. E., Smith, M. T., & Zhang, L. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.139572 · Cited by 39 · see citing works
TiO2 Nanoparticles Caused DNA Damage in Lung and Extra-Pulmonary Organs Through ROS-Activated FOXO3a Signaling Pathway After Intratracheal Administration in Rats
Han, B., Pei, Z., Shi, L., Wang, Q., Li, C., Zhang, B., Su, X., Zhang, N., Zhou, L., Zhao, B., et al. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s254969 · Cited by 38 · see citing works
Mycobacterium smegmatis DinB2 misincorporates deoxyribonucleotides and ribonucleotides during templated synthesis and lesion bypass
Ordonez, H., & Shuman, S. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1027 · Cited by 37 · see citing works
FANCI is a negative regulator of Akt activation
Zhang, X., Lu, X., Akhter, S., Georgescu, M.-M., & Legerski, R. J. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1158375 · Cited by 36 · see citing works
Persistent damaged bases in DNA allow mutagenic break repair in Escherichia coli
Moore, J. M., Correa, R., Rosenberg, S. M., & Hastings, P. J. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006733 · Cited by 36 · see citing works
OECD Series on Adverse Outcome Pathways
OECD (2016) · OECD series on adverse outcome pathways · doi:10.1787/2415170x · Cited by 36 · see citing works
Mitochondrial DNA Instability in Mammalian Cells
Carvalho, G., Repolês, B. M., Mendes, I. C., & Wanrooij, P. H. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0091 · Cited by 34 · see citing works
DNA Repair Protein Expression and Oxidative/Nitrosative Stress in Ulcerative Colitis and Sporadic Colorectal Cancer
Angelis, P. M. D., Dorg, L. T., Pham, S., & Andersen, S. N. (2021) · Anticancer Research · doi:10.21873/anticanres.15112 · Cited by 35 · see citing works
Assessment of HEMA and TEGDMA induced DNA damage by multiple genotoxicological endpoints in human lymphocytes
Ginzkey, C., Zinnitsch, S., Steußloff, G., Koehler, C. J., Hackenberg, S., Hagen, R., Kleinsasser, N. H., & Froelich, K. (2015) · Dental Materials · doi:10.1016/j.dental.2015.04.009 · Cited by 35 · see citing works
Contribution of DNA unwrapping from histone octamers to the repair of oxidatively damaged DNA in nucleosomes
Maher, R. L., Prasad, A., Rizvanova, O., Wallace, S. S., & Pederson, D. S. (2013) · DNA repair · doi:10.1016/j.dnarep.2013.08.010 · Cited by 34 · see citing works
Oxidative DNA damage is involved in ochratoxin A-induced G2 arrest through ataxia telangiectasia-mutated (ATM) pathways in human gastric epithelium GES-1 cells in vitro
Cui, J., Liu, J., Wu, S., Wang, Y., Shen, H., Xing, L., Wang, J., Yan, X., & Zhang, X. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1043-3 · Cited by 33 · see citing works
The AEG-1-USP10-PARP1 axis confers radioresistance in esophageal squamous cell carcinoma via facilitating homologous recombination-dependent DNA damage repair
Zhao, X., Ma, Y., Li, J., Sun, X., Sun, Y., Qu, F., Shi, X., Xie, Y., Liu, S., Ma, Y., et al. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216440 · Cited by 33 · see citing works
Genomic amplification of Fanconi anemia complementation group A (FancA) in head and neck squamous cell carcinoma (HNSCC): Cellular mechanisms of radioresistance and clinical relevance
Heß, J., Unger, K., Orth, M., Schötz, U., Schüttrumpf, L., Zangen, V., Gimenez-Aznar, I., Michna, A., Schneider, L., Stamp, R., et al. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.11.014 · Cited by 30 · see citing works
From clinical description, to in vitro and animal studies, and backward to patients: Oxidative stress and mitochondrial dysfunction in Fanconi anemia
Pagano, G., Talamanca, A. A., Castello, G., d’Ischia, M., Pallardó, F. V., Petrović, S. Ž., Porto, B., Tiano, L., & Zatterale, A. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.01.015 · Cited by 30 · see citing works
Benzyl isothiocyanate promotes apoptosis of oral cancer cells via an acute redox stress-mediated DNA damage response
Yeh, Y., Hsu, Y.-N., Huang, S.-Y., Lin, J.-S., Zi-Feng, C., Chow, N.-H., Su, S.-H., Shyu, H.-W., Lin, C., Huang, W.-T., et al. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.09.028 · Cited by 31 · see citing works
GSE4 peptide suppresses oxidative and telomere deficiencies in ataxia telangiectasia patient cells
Pintado‐Berninches, L., Fernández-Varas, B., Benitéz‐Buelga, C., Manguán-García, C., Serrano-Benítez, A., Iarriccio, L., Carrillo, J., Güenechea, G., Egusquiaguirre, S. P., Pedraz, J. L., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-018-0272-7 · Cited by 30 · see citing works
The Ageing Process Affects the Antioxidant Defences and the Poly (ADPribosyl)ation Activity in Cistus Incanus L. Leaves
Arena, C., Vitale, L., Bianchi, A. R., Mistretta, C., Vitale, E., Parisi, C., Guerriero, G., Magliulo, V., & Maio, A. D. (2019) · Antioxidants · doi:10.3390/antiox8110528 · Cited by 30 · see citing works
Exogenous melatonin enhances soybean ( Glycine max (L.) Merr.) seedling tolerance to saline‐alkali stress by regulating antioxidant response and DNA damage repair
Zhao, Q., Chen, S., Wang, G., Du, Y., Zhang, Z., Yu, G., Ren, C., Zhang, Y., & Du, J. (2022) · Physiologia Plantarum · doi:10.1111/ppl.13731 · Cited by 30 · see citing works
Genetic damage and potential mechanism exploration under different air pollution patterns by multi-omics
Xu, J., Zhang, Q., Su, Z., Liu, Y., Yan, T., Zhang, Y., Wang, T., Wei, X., Chen, Z., Hu, G., et al. (2022) · Environment International · doi:10.1016/j.envint.2022.107636 · Cited by 30 · see citing works
Replication Fork Remodeling and Therapy Escape in DNA Damage Response-Deficient Cancers
Liptay, M., Barbosa, J. S., & Rottenberg, S. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00670 · Cited by 29 · see citing works
Pre-Replicative Repair of Oxidized Bases Maintains Fidelity in Mammalian Genomes: The Cowcatcher Role of NEIL1 DNA Glycosylase
Rangaswamy, S., Pandey, A., MITRA, S. P., & Hegde, M. L. (2017) · Genes · doi:10.3390/genes8070175 · Cited by 26 · see citing works
The Cockayne syndrome group A and B proteins are part of a ubiquitin–proteasome degradation complex regulating cell division
Paccosi, E., Costanzo, F., Costantino, M., Balzerano, A., Monteonofrio, L., Soddu, S., Prantera, G., Brancorsini, S., Egly, J., & Proietti‐De‐Santis, L. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2006543117 · Cited by 25 · see citing works
Expression of DNA repair genes in burned skin exposed to low-level red laser
Trajano, E. T. L., Mencalha, A. L., Monte‐Alto‐Costa, A., Pôrto, L. C., & da Fonseca, A. D. S. (2014) · Lasers in Medical Science · doi:10.1007/s10103-014-1612-6 · Cited by 25 · see citing works
Arsenite induces premature senescence via p53/p21 pathway as a result of DNA damage in human malignant glioblastoma cells
Ninomiya, Y., Cui, X., Yasuda, T., Wang, B., Yu, D. H., Sekine‐Suzuki, E., & Nenoi, M. (2014) · BMB Reports · doi:10.5483/bmbrep.2014.47.10.254 · Cited by 25 · see citing works
WRN is recruited to damaged telomeres via its RQC domain and tankyrase1-mediated poly-ADP-ribosylation of TRF1
Sun, L., Nakajima, S., Teng, Y., Chen, H., Yang, L., Chen, X., Gao, B., Levine, A. S., & Lan, L. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx065 · Cited by 25 · see citing works
Chromosome-wide histone deacetylation by sirtuins prevents hyperactivation of DNA damage-induced signaling upon replicative stress
Simoneau, A., Ricard, É., Weber, S., Hammond-Martel, I., Wong, L. H., Sellam, A., Giaever, G. N., Nislow, C., Raymond, M., & Würtele, H. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1537 · Cited by 24 · see citing works
Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription
Sengupta, S., Wang, H., Yang, C., Szczęsny, B., Hegde, M. L., & MITRA, S. P. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1919445117 · Cited by 23 · see citing works
SARS-CoV-2 and the DNA damage response
Grand, R. J. A. (2023) · Journal of General Virology · doi:10.1099/jgv.0.001918 · Cited by 23 · see citing works
Cell-free Xenopus egg extracts for studying DNA damage response pathways
Cupello, S., Richardson, C. A., & Yan, S. (2016) · The International Journal of Developmental Biology · doi:10.1387/ijdb.160113sy · Cited by 24 · see citing works
Biochemical Characterization of the Human Mitochondrial Replicative Twinkle Helicase
Khan, I., Crouch, J. D., Bharti, S. K., Sommers, J. A., Carney, S. M., Yakubovskaya, E., García–Díaz, M., Trakselis, M. A., & Brosh, R. M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.712026 · Cited by 23 · see citing works
Transcription Blockage by DNA Damage in Nucleotide Excision Repair-Related Neurological Dysfunctions
Kajitani, G. S., Nascimento, L. L. D. S., Neves, M. R. D. C., Leandro, G. D. S., Garcia, C. C. M., & Menck, C. F. M. (2021) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2020.10.009 · Cited by 22 · see citing works
Impact of Age-Associated Cyclopurine Lesions on DNA Repair Helicases
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Authors: Berquist, B. R., & Wilson, D. M.
Affiliations: Texas A&M Health Science Center (US)
National Institutes of Health (US)
Corresponding author: Wilson, David M.
ORCID: Berquist, Brian R.
Wilson, David M.
Venue: Cancer Letters
Publisher: Elsevier BV
Published: 2012-12
Volume: 327
Issue: 1-2
Pages: 61-72
ISSN: 0304-3835 (ISSN-L)
DOI: 10.1016/j.canlet.2012.02.001
PMC: PMC3389563
OpenAlex: W2149489809
Cited by: 136
References: 165
Citations by year: 2026: 1 · 2025: 5 · 2024: 3 · 2023: 6 · 2022: 8 · 2021: 8 · 2020: 9 · 2019: 8 · 2018: 7 · 2017: 10 · 2016: 17 · 2015: 19 · 2014: 18 · 2013: 12 · 2012: 4
FWCI: 1.55
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cancer Letters (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Aging (ZIAAG000743)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords: oxidative DNA damage, DNA repair, reactive oxygen species, 8-oxoguanine, OGG1, abasic sites, DNA cross-links, DNA replication, transcription, xeroderma pigmentosum, Cockayne syndrome, Fanconi anemia, carcinogenesis, aging, neurodegeneration
MeSH terms: Animals, Cockayne Syndrome, DNA Damage, DNA-Directed DNA Polymerase, DNA Repair, DNA Replication, Fanconi Anemia, Gene Expression Regulation, Humans, DNA-Directed RNA Polymerases, Xeroderma Pigmentosum, Mutagenesis, Reactive Oxygen Species, Oxidative Stress, Genetic Predisposition to Disease, Heredity

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Pathways for repairing and tolerating the spectrum of oxidative DNA lesions

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