Cell Injury and Repair Resulting from Sleep Loss and Sleep Recovery in Laboratory Rats
Open accessAbstract
STUDY OBJECTIVES: Increased cell injury would provide the type of change in constitution that would underlie sleep disruption as a risk factor for multiple diseases. The current study was undertaken to investigate cell injury and altered cell fate as consequences of sleep deprivation, which were predicted from systemic clues. DESIGN: Partial (35% sleep reduction) and total sleep deprivation were produced in rats for 10 days, which was tolerated and without overtly deteriorated health. Recovery rats were similarly sleep deprived for 10 days, then allowed undisturbed sleep for 2 days. The plasma, liver, lung, intestine, heart, and spleen were analyzed and compared to control values for damage to DNA, proteins, and lipids; apoptotic cell signaling and death; cell proliferation; and concentrations of glutathione peroxidase and catalase. MEASUREMENTS AND RESULTS: Oxidative DNA damage in totally sleep deprived rats was 139% of control values, with organ-specific effects in the liver (247%), lung (166%), and small intestine (145%). Overall and organ-specific DNA damage was also increased in partially sleep deprived rats. In the intestinal epithelium, total sleep deprivation resulted in 5.3-fold increases in dying cells and 1.5-fold increases in proliferating cells, compared with control. Recovery sleep restored the balance between DNA damage and repair, and resulted in normal or below-normal metabolic burdens and oxidative damage. CONCLUSIONS: These findings provide physical evidence that sleep loss causes cell damage, and in a manner expected to predispose to replication errors and metabolic abnormalities; thereby providing linkage between sleep loss and disease risk observed in epidemiological findings. Properties of recovery sleep include biochemical and molecular events that restore balance and decrease cell injury.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In rats, myeloperoxidase activity in the intestines was increased after recovery sleep compared with baseline and sleep-deprivation levels, suggesting ongoing reactive processes during recovery sleep subsequent to sleep deprivation.
“However, myeloperoxidase activity in the intestines was increased after recovery sleep compared with baseline and sleep-deprivation levels, suggesting ongoing reactive processes during recovery sleep subsequent to sleep deprivation (174).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [174]
In rats, 48 h of recovery sleep following 10 days of sleep deprivation restored sleep deprivation-induced increases of myeloperoxidase activity in the lung and liver.
“In rats, 48 h of recovery sleep following 10 days of sleep deprivation restored sleep deprivation-induced increases of myeloperoxidase activity (an enzyme constituent of neutrophils) in the lung and liver.”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [174]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
Ohkawa, H., Ohishi, N., & Yagi, K. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90738-3 · Cited by 29,460 · see citing works
Aebi, H. E. (1974) · Elsevier eBooks · doi:10.1016/b978-0-12-091302-2.50032-3 · Cited by 2,075 · see citing works
8-hydroxy-2′ -deoxyguanosine (8-OHdG): A Critical Biomarker of Oxidative Stress and Carcinogenesis
Valavanidis, A., Vlachogianni, T., & FIOTAKIS, C. (2009) · Journal of Environmental Science and Health Part C · doi:10.1080/10590500902885684 · Cited by 1,985 · see citing works
Sleep disturbances and chronic disease in older adults
Foley, D., Ancoli-Israel, S., Britz, P., & Walsh, J. (2004) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2004.02.010 · Cited by 1,203 · see citing works
Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk
Meier-Ewert, H. K., Ridker, P. M., Rifai, N., Regan, M. M., Price, N. J., Dinges, D. F., & Mullington, J. M. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.07.050 · Cited by 1,195 · see citing works
Adverse Effects of Modest Sleep Restriction on Sleepiness, Performance, and Inflammatory Cytokines
Vgontzas, A. N., Zoumakis, E., Bixler, E. O., Lin, H.-M., Follett, H., Kales, A., & Chrousos, G. P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031562 · Cited by 1,050 · see citing works
Measurement of F2-isoprostanes as an index of oxidative stress in vivo
Roberts, L. J., & Morrow, J. D. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00264-6 · Cited by 1,000 · see citing works
Wang (2012) · doi:10.1161/circresaha.111.261388 · Cited by 957 · see citing works
Cancer risk and oxidative DNA damage in man
Loft, S. H., & Poulsen, H. E. (1996) · Journal of Molecular Medicine · doi:10.1007/bf00207507 · Cited by 955 · see citing works
Life and Death: Metabolic Rate, Membrane Composition, and Life Span of Animals
Hulbert, A. J., Pamplona, R., Buffenstein, R., & Buttemer, W. A. (2007) · Physiological Reviews · doi:10.1152/physrev.00047.2006 · Cited by 926 · see citing works
Free radicals in biology and medicine
Lucy, J. A. (1985) · FEBS Letters · doi:10.1016/0014-5793(85)80903-0 · Cited by 908 · see citing works
Induction of intestinal epithelial proliferation by glucagon-like peptide 2.
Drucker, D. J., Erlich, P., Asa, S. L., & Brubaker, P. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7911 · Cited by 880 · see citing works
Luyster, F. S., Strollo, P. J., Zee, P. C., & Walsh, J. K. (2012) · SLEEP · doi:10.5665/sleep.1846 · Cited by 868 · see citing works
Haack, M., Sanchez, E., & Mullington, J. M. (2007) · Sleep · doi:10.1093/sleep/30.9.1145 · Cited by 615 · see citing works
Möller-Levet, C. S., Archer, S. N., Bucca, G., Laing, E. E., Slak, A., Kabiljo, R., Lo, J. C. Y., Santhi, N., von Schantz, M., Smith, C. P., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217154110 · Cited by 576 · see citing works
DNA‐damage repair; the good, the bad, and the ugly
Hakem, R. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.15 · Cited by 547 · see citing works
van Leeuwen, W. M. A., Lehto, M., Karisola, P., Lindholm, H., Luukkonen, R., Sallinen, M., Härmä, M., Porkka-Heiskanen, T., & Alenius, H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004589 · Cited by 483 · see citing works
Seril, D. N. (2003) · Carcinogenesis · doi:10.1093/carcin/24.3.353 · Cited by 467 · see citing works
Shearer, W. T., Reuben, J. M., Mullington, J. M., Price, N. J., Lee, B.-N., Smith, E. O., Szuba, M. P., Van Dongen, H. P. A., & Dinges, D. F. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.112270 · Cited by 455 · see citing works
Dissecting p53-dependent apoptosis
Chipuk, J. E., & Green, D. R. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401908 · Cited by 452 · see citing works
Dinges, D. F., Douglas, S. D., Zaugg, L., Campbell, D. E., McMann, J. M., Whitehouse, W. G., Orne, E. C., Kapoor, S. C., Icaza, E., & Orne, M. T. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117184 · Cited by 361 · see citing works
Romanovsky, A. A., Ivanov, A. I., & Shimansky, Y. P. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01173.2001 · Cited by 351 · see citing works
Stress-Induced Changes in Skin Barrier Function in Healthy Women
Altemus, M. M., Rao, B. K., Dhabhar, F. S., Ding, W., & Granstein, R. D. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2001.01373.x · Cited by 347 · see citing works
Sleep Deprivation in the Rat: III. Total Sleep Deprivation
Everson, C. A., Bergmann, B. M., & Rechtschaffen, A. (1989) · SLEEP · doi:10.1093/sleep/12.1.13 · Cited by 341 · see citing works
Self-citationQuantification of F2-isoprostanes as a biomarker of oxidative stress
Milne, G. L., Sanchez, S. C., Musiek, E. S., & Morrow, J. D. (2007) · Nature Protocols · doi:10.1038/nprot.2006.375 · Cited by 333 · see citing works
The effects of 40 hours of total sleep deprivation on inflammatory markers in healthy young adults
Frey, D. J., Fleshner, M., & Wright, K. P. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.04.003 · Cited by 330 · see citing works
The turnover and shedding of epithelial cells
Creamer, B., Shorter, R. G., & Bamforth, J. S. (1961) · Gut · doi:10.1136/gut.2.2.110 · Cited by 297 · see citing works
Aging Impairs the Unfolded Protein Response to Sleep Deprivation and Leads to Proapoptotic Signaling
Naidoo, N. N., Ferber, M., Master, M., Zhu, Y., & Pack, A. I. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5685-07.2008 · Cited by 282 · see citing works
The flower pot technique of Rapid Eye Movement (REM) sleep deprivation
Mendelson, W. B., Guthrie, R. D., Canal-Frederick, G., & Wyatt, R. J. (1974) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(74)90018-5 · Cited by 264 · see citing works
von Ruesten, A., Weikert, C., Fietze, I., & Boeing, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030972 · Cited by 262 · see citing works
Circadian Desynchrony Promotes Metabolic Disruption in a Mouse Model of Shiftwork
Barclay, J. L., Husse, J., Bode, B., Naujokat, N., Meyer-Kovac, J., Schmid, S. M., Lehnert, H., & Oster, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037150 · Cited by 259 · see citing works
Halliwell, B. B. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00808-0 · Cited by 258 · see citing works
Sleep deprivation decreases superoxide dismutase activity in rat hippocampus and brainstem
Ramanathan, L., Gulyani, S., Nienhuis, R., & Siegel, J. M. (2002) · Neuroreport · doi:10.1097/00001756-200208070-00007 · Cited by 254 · see citing works
Sustained sleep deprivation impairs host defense
Everson, C. A. (1993) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1993.265.5.r1148 · Cited by 251 · see citing works
Self-citationEffects of sleep deprivation on human immune functions
Moldofsky, H., Lue, F. A., Davidson, J. R., & Gorczynski, R. (1989) · The FASEB Journal · doi:10.1096/fasebj.3.8.2785942 · Cited by 250 · see citing works
Oxidative DNA damage and cellular sensitivity to oxidative stress in human autoimmune diseases.
Bashir, S., Harris, G., Denman, M., Blake, D. R., & Winyard, P. G. (1993) · Annals of the Rheumatic Diseases · doi:10.1136/ard.52.9.659 · Cited by 250 · see citing works
Is the Mitochondrial Free Radical Theory of Aging Intact?
Sanz, A., Pamplona, R., & Barja, G. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.582 · Cited by 240 · see citing works
Matsui, A., Ikeda, T., Enomoto, K., Hosoda, K., Nakashima, H., Omae, K., Watanabe, M., Hibi, T., & Kitajima, M. (2000) · Cancer Letters · doi:10.1016/s0304-3835(99)00424-3 · Cited by 232 · see citing works
Effects of Method, Duration, and Sleep Stage on Rebounds from Sleep Deprivation in the Rat
Rechtschaffen, A., Bergmann, B. M., Gilliland, M. A., & Bauer, K. (1999) · SLEEP · doi:10.1093/sleep/22.1.11 · Cited by 231 · see citing works
Sleep duration versus sleep insufficiency as predictors of cardiometabolic health outcomes
Altman, N. G., Izci-Balserak, B., Schopfer, E., Jackson, N., Rattanaumpawan, P., Gehrman, P. R., Patel, N. P., & Grandner, M. A. (2012) · Sleep Medicine · doi:10.1016/j.sleep.2012.08.005 · Cited by 229 · see citing works
Suchecki, D., & Tufik, S. (2000) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00181-x · Cited by 220 · see citing works
Sleep Deprivation and Cellular Responses to Oxidative Stress
Gopalakrishnan, A., Ji, L. L., & Cirelli, C. (2004) · SLEEP · doi:10.1093/sleep/27.1.27 · Cited by 209 · see citing works
Heenan, E. J., & Sancar, A. (2008) · Wiley Encyclopedia of Chemical Biology · doi:10.1002/9780470048672.wecb131 · Cited by 209 · see citing works
Reductions in circulating anabolic hormones induced by sustained sleep deprivation in rats
Everson, C. A., & Crowley, W. R. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00553.2003 · Cited by 207 · see citing works
Self-citationEPITHELIAL CELL MIGRATION IN THE INTESTINE
Heath, J. P. (1996) · Cell Biology International · doi:10.1006/cbir.1996.0018 · Cited by 205 · see citing works
Changes in brain gene expression after long‐term sleep deprivation
Cirelli, C., Faraguna, U., & Tononi, G. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04058.x · Cited by 197 · see citing works
Antioxidant defense responses to sleep loss and sleep recovery
Everson, C. A., Laatsch, C. D., & Hogg, N. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00565.2004 · Cited by 192 · see citing works
Self-citationOxidative stress in ulcerative colitis: an old concept but a new concern
Jena, G., Trivedi, P. P., & Sandala, B. (2012) · Free Radical Research · doi:10.3109/10715762.2012.717692 · Cited by 177 · see citing works
CONTRIBUTION OF VISCERAL ORGANS TO ANIMAL ENERGY EXPENDITURES
Ferrell, C. L. (1988) · Journal of Animal Science · doi:10.1093/ansci/66.supplement_3.23 · Cited by 163 · see citing works
Terao, A., Steininger, T. L., Hyder, K., Apte-Deshpande, A. D., Ding, J., Rishipathak, D., Davis, R. W., Heller, H. C., & Kilduff, T. S. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00695-4 · Cited by 148 · see citing works
Everson, C. A. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00021.2005 · Cited by 141 · see citing works
Self-citationDNA damage and repair in atherosclerosis
Mahmoudi, M., MERCER, J., & Bennett, M. R. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.03.002 · Cited by 137 · see citing works
Pathways for repairing and tolerating the spectrum of oxidative DNA lesions
Berquist, B. R., & Wilson, D. M. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.02.001 · Cited by 136 · see citing works
Sleep Deprivation in the Rat: II. Methodology
Bergmann, B. M., Kushida, C. A., Everson, C. A., Gilliland, M. A., Obermeyer, W. H., & Rechtschaffen, A. (1989) · SLEEP · doi:10.1093/sleep/12.1.5 · Cited by 133 · see citing works
Self-citationThe Effects of Inanition and Malnutrition upon Growth and Structure.
Jackson, C. M. (1925) · JAMA · doi:10.1001/jama.1925.02660380053032 · Cited by 132 · see citing works
Oxidative stress in patients with primary insomnia
Güleç, M., Özkol, H., Selvı, Y., Tülüce, Y., Aydın, A., Beşiroğlu, L., & Özdemir, P. G. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.02.011 · Cited by 130 · see citing works
Response of the rat small-intestine epithelium to methotrexate.
Taminiau, J., Gall, D., & Hamilton, J. R. (1980) · Gut · doi:10.1136/gut.21.6.486 · Cited by 128 · see citing works
Karthikeyan, K., Bai, B. R. S., Gauthaman, K., Sathish, K., & Devaraj, S. N. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00671-4 · Cited by 123 · see citing works
Prevention of type 1 diabetes: from the view point of β cell damage
Kawasaki, E., Abiru, N., & Eguchi, K. (2004) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2003.09.015 · Cited by 123 · see citing works
Sleep disturbances after open heart surgery
Orr, W. C., & Stahl, M. L. (1977) · The American Journal of Cardiology · doi:10.1016/s0002-9149(77)80191-4 · Cited by 119 · see citing works
The effects of inanition and malnutrition upon growth and structure
Jackson, C. M. (1925) · doi:10.5962/bhl.title.6431 · Cited by 112 · see citing works
Hu, J., Chen, Z., Gorczynski, C. P., Gorczynski, L. Y., Kai, Y., Lee, L., Manuel, J., & Gorczynski, R. M. (2003) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2003.03.001 · Cited by 101 · see citing works
Everson, C., Smith, C., & Sokoloff, L. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-11-06769.1994 · Cited by 96 · see citing works
Self-citationKotani, J. (1999) · Archives of Surgery · doi:10.1001/archsurg.134.3.287 · Cited by 94 · see citing works
Early Oxidative DNA Damages and Late Development of Lung Cancer in Diesel Exhaust-Exposed Rats
Iwai, K., Adachi, S., Takahashi, M., Möller, L., Udagawa, T., Mizuno, S., & Sugawara, I. (2000) · Environmental Research · doi:10.1006/enrs.2000.4072 · Cited by 92 · see citing works
Endl, E., & Gerdes, J. (2000) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(200003)182:3 · Cited by 89 · see citing works
Nutritional and metabolic adaptations to prolonged sleep deprivation in the rat
Everson, C. A., & Wehr, T. A. (1993) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1993.264.2.r376 · Cited by 88 · see citing works
Self-citationGopaul, N. K., Halliwell, B. B., & Änggård, E. (2000) · Free Radical Research · doi:10.1080/10715760000300671 · Cited by 83 · see citing works
Klein, R. M., & McKenzie, J. C. (1983) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-198302010-00004 · Cited by 72 · see citing works
Sleep Deprivation in the Rat: IX. Recovery
Everson, C. A., Gilliland, M. A., Kushida, C. A., Pilcher, J. J., Fang, V. S., Refetoff, S., Bergmann, B. M., & Rechtschaffen, A. (1989) · SLEEP · doi:10.1093/sleep/12.1.60 · Cited by 65 · see citing works
Self-citationDistinct effects of acute and chronic sleep loss on DNA damage in rats
Andersen, M. L., Ribeiro, D. A., Bergamaschi, C. T., Alvarenga, T. A., Silva, A., Zager, A., Campos, R. R., & Tufik, S. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.02.014 · Cited by 60 · see citing works
Oxidative-stress-induced epigenetic changes in chronic diabetic complications
Feng, B., Ruiz, M. A., & Chakrabarti, S. (2012) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2012-0251 · Cited by 59 · see citing works
Okayasu, I. (2012) · Pathology International · doi:10.1111/j.1440-1827.2012.02807.x · Cited by 59 · see citing works
(1969) · PubMed · Cited by 58 · see citing works
Role of DNA damage in atherosclerosis—Bystander or participant?
Gray, K., & Bennett, M. R. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.06.025 · Cited by 57 · see citing works
Everson, C. A., & Szabó, A. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00230.2009 · Cited by 57 · see citing works
Self-citationChang, H., Mai, F., Chen, B., Wu, U., Huang, Y., Lan, C., & Ling, Y. (2008) · Journal of Anatomy · doi:10.1111/j.1469-7580.2008.00860.x · Cited by 54 · see citing works
Mistlberger, R. E., Belcourt, J., & Antle, M. C. (2002) · Journal of Biological Rhythms · doi:10.1177/07430402017003006 · Cited by 51 · see citing works
Gut stem cells in tissue renewal and disease: methods, markers, and myths
Rizk, P., & Barker, N. (2012) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1176 · Cited by 44 · see citing works
Sleep Deprivation Alters Gene Expression and Antioxidant Enzyme Activity in Mice Splenocytes
Lungato, L., Marques, M. S., Pereira, V. G., Hix, S., Gazarini, M. L., Tufik, S. B., & D’Almeida, V. (2013) · Scandinavian Journal of Immunology · doi:10.1111/sji.12029 · Cited by 37 · see citing works
Everson, C. A., Thalacker, C. D., & Hogg, N. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90623.2008 · Cited by 35 · see citing works
Self-citationRenes, I. B., Verburg, M., Bulsing, N. P., et al. (2002) · The Journal of Pathology · doi:10.1002/path.1183 · Cited by 33 · see citing works
Everson, C. A., & Reed, H. L. (1995) · Endocrinology · doi:10.1210/endo.136.4.7895653 · Cited by 32 · see citing works
Self-citationEverson, C. A., & Nowak, T. S. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00558.2001 · Cited by 31 · see citing works
Self-citationCell proliferation induced by laxatives and related compounds in the rat intestine
Toyoda, K., Nishikawa, A., Furukawa, F., et al. (1994) · Cancer Letters · doi:10.1016/0304-3835(94)90297-6 · Cited by 20 · see citing works
Sleep Deprivation in the Rat: XVI. Effects in a Light-Dark Cycle
Tsai, L., Bergmann, B. M., & Rechtschaffen, A. (1992) · SLEEP · doi:10.1093/sleep/15.6.537 · Cited by 16 · see citing works
Rat splanchnic net oxygen consumption, energy implications.
Casado, J. F., Fernández–Löpez, J., Esteve, M., et al. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018347 · Cited by 12 · see citing works
Clinical Manifestations of Prolonged Sleep Deprivation
Everson, C. A. (1997) · KARGER eBooks · doi:10.1159/000061563 · Cited by 10 · see citing works
Self-citationGuo, J., Chau, J. F. L., Xi Zhong, S. H. E. N., et al. (2004) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520410004523 · Cited by 10 · see citing works
Dotan, I., & Mayer, L. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6189-2.00002-0 · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 14
- Morgulis S. Fasting and Undernutrition. New York: Dutton, 1923. Downloaded from https://academic.oup.com/sleep/article/37/12/1929/2416803 by guest on 28 August 2023 Sleep Loss is a State of Cell Injury-Everson et al.
- Kleitman N. Sleep and Wakefulness. Chicago, IL: University of Chicago Press, 1963.
- Gilliland M, Wold L, Wollmann R, Eschenbach K, Rechtschaffen A. Pathology in sleep deprived rats is not reflected in histologic abnormalities (Abstract). Sleep Res 1984;13:190.
- National Research Council of the National Academies. Committee for the Update of the Guide for the Care and Use of Laboratory Animals. Guide for the Care and Use of Laboratory Animals. 8th ed. Washington, DC: The National Academies Press, 2011.
- Aebi H. Catalase. In: Bergmeyer HU, ed. Methods of Enzymatic Analysis. New York: Academic Press, 1974:673-84.
- Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol 2000;182:311-22.
- Halliwell B. Effect of diet on cancer development: is oxidative DNA damage a biomarker? Free Radic Biol Med 2002;32:968-74.
- Everson CA, Laatsch CD, Hogg N. Antioxidant defense responses to sleep loss and sleep recovery. Am J Physiol Regul Integr Comp Physiol 2005;288:374-83.
- Everson CA, Thalacker CD, Hogg N. Phagocyte migration and cellular stress induced in liver, lung, and intestine during sleep loss and sleep recovery. Am J Physiol Regul Integr Comp Physiol 2008;295:2067-74.
- Everson CA, Bergmann BM, Rechtschaffen A. Sleep deprivation in the rat. III. Total sleep deprivation. Sleep 1989;12:13-21.
- Everson CA, Crowley WR. Reductions in circulating anabolic hormones induced by sustained sleep deprivation in rats. Am J Physiol Endocrinol Metab 2004;286:1060-70.
- Everson CA, Reed HL. Pituitary and peripheral thyroid hormone responses to thyrotropin-releasing hormone during sustained sleep deprivation in freely moving rats. Endocrinology 1995;136:1426-34.
- Everson CA, Smith CB, Sokoloff L. Effects of prolonged sleep deprivation on local rates of cerebral energy metabolism in freely moving rats. J Neurosci 1994;14:6769-78.
- Everson CA, Wehr TA. Nutritional and metabolic adaptations to prolonged sleep deprivation in the rat. Am J Physiol Regul Integr Comp Physiol 1993;264:R376-87. Downloaded from https://academic.oup.com/sleep/article/37/12/1929/2416803 by guest on 28 August 2023
Cited by
Sorted by citations
The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479 · see citing works
“In this study, cell injury was most pronounced in the intestine (173), which could result in increased intestinal permeability (leaky gut) and, together with the impairment of host defense following sleep loss, to a translocation of commensal bacteria and PAMP-driven systemic inflammation (175, 303) (see also sect.”
BackgroundTouitou, Y., Reinberg, A., & Touitou, D. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.02.008 · Cited by 738 · see citing works
Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut
Vaccaro, A., Kaplan Dor, Y., Nambara, K., Pollina, E. A., Lin, C., Greenberg, M. E., & Rogulja, D. (2020) · Cell · doi:10.1016/j.cell.2020.04.049 · Cited by 541 · see citing works
Aging and Alzheimer's disease: comparison and associations from molecular to system level
Xia, X., Jiang, Q., McDermott, J., & Han, J. J. (2018) · Aging Cell · doi:10.1111/acel.12802 · Cited by 301 · see citing works
Carroll, J. E., Irwin, M. R., Levine, M., Seeman, T. E., Absher, D., Assimes, T., & Horvath, S. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.07.008 · Cited by 173 · see citing works
Carroll, J. E., Cole, S. W., Seeman, T. E., Breen, E. C., Witarama, T., Arevalo, J. M. G., Ma, J., & Irwin, M. R. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.08.024 · Cited by 129 · see citing works
Insomnia and Telomere Length in Older Adults
Carroll, J. E., Esquivel, S., Goldberg, A., Seeman, T. E., Effros, R. B., Dock, J., Olmstead, R., Breen, E. C., & Irwin, M. R. (2016) · Sleep · doi:10.5665/sleep.5526 · Cited by 85 · see citing works
Shimizu, Y., Yamamura, R., Yokoi, Y., Ayabe, T., Ukawa, S., Nakamura, K., Okada, E., Imae, A., Nakagawa, T., Tamakoshi, A., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2190306 · Cited by 53 · see citing works
- Authors
- Everson, C. A., Henchen, C. J., Szabo, A., & Hogg, N.
- Affiliations
- Medical College of Wisconsin (US)
- Department of Population Health, The Medical College of Wisconsin, Milwaukee, WI
- Corresponding author
- Everson, Carol A.
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-12-01
- Volume
- 37
- Issue
- 12
- Pages
- 1929-1940
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- PMC
- PMC4548518
- OpenAlex
- W2331378898
- Cited by
- 136
- References
- 90
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 12 · 2023: 16 · 2022: 10 · 2021: 10 · 2020: 10 · 2019: 15 · 2018: 11 · 2017: 7 · 2016: 11 · 2015: 5
- FWCI
- 10.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- SLEEP (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- Vanderbilt University
- Medical College of Wisconsin
- National Institutes of Health (UL1TR000055)
- National Heart, Lung, and Blood Institute (HL086447, R01HL086447, R01HL080744, HL080744)
- National Center for Advancing Translational Sciences
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep deprivation, sleep recovery, cell damage, oxidative DNA damage, apoptosis, cell proliferation, intestinal epithelium, oxidative stress, glutathione peroxidase, catalase, liver, lung, small intestine, heart, spleen
- MeSH terms
- Animals, Antioxidants, Catalase, Disease Susceptibility, DNA Damage, DNA Repair, Glutathione Peroxidase, Intestine, Small, Liver, Lung, Male, Organ Specificity, Sleep, Sleep Deprivation, Signal Transduction, Cell Death, Oxidative Stress, Cell Proliferation, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
