The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Bovine milk-derived exosomes for drug delivery
Open accessAbstract
Exosomes are biological nanovesicles that are involved in cell-cell communication via the functionally-active cargo (such as miRNA, mRNA, DNA and proteins). Because of their nanosize, exosomes are explored as nanodevices for the development of new therapeutic applications. However, bulk, safe and cost-effective production of exosomes is not available. Here, we show that bovine milk can serve as a scalable source of exosomes that can act as a carrier for chemotherapeutic/chemopreventive agents. Drug-loaded exosomes showed significantly higher efficacy compared to free drug in cell culture studies and against lung tumor xenografts in vivo. Moreover, tumor targeting ligands such as folate increased cancer-cell targeting of the exosomes resulting in enhanced tumor reduction. Milk exosomes exhibited cross-species tolerance with no adverse immune and inflammatory response. Thus, we show the versatility of milk exosomes with respect to the cargo it can carry and ability to achieve tumor targetability. This is the first report to identify a biocompatible and cost-effective means of exosomes to enhance oral bioavailability, improve efficacy and safety of drugs.
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Cites
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Extracellular vesicles as a next-generation drug delivery platform
Herrmann, I. K., Wood, M. J. A., & Fuhrmann, G. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00931-2 · Cited by 1,948
Targeting cancer stem cell pathways for cancer therapy
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RNA delivery by extracellular vesicles in mammalian cells and its applications
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Noncoding RNA therapeutics—Challenges and potential solutions
Winkle, M., El-Daly, S. M., Fabbri, M., & Calin, G. A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00219-z · Cited by 1,551
Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper
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Self-citation
Metadata
- Authors
- Munagala, R., Aqil, F., Jeyabalan, J., & Gupta, R. C.
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 371
- Issue
- 1
- Pages
- 48-61
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W2178935826
- Cited by
- 931
- References
- 6
- FWCI
- 15.95
- Type
- journal article
- Language
- en
- Open access
- green
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- Munagala, R., Aqil, F., Jeyabalan, J., & Gupta, R. C. (2016). Bovine milk-derived exosomes for drug delivery. Cancer Letters. https://doi.org/10.1016/j.canlet.2015.10.020
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
