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Development and potential applications of CRISPR-Cas9 genome editing technology in sarcoma
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“Another example is the knockout of MDR1 in osteosarcoma cells with Cas9, which reduced cell resistance to chemotherapeutic agents [161].”
From CRISPR-Cas: Converting A Bacterial Defence Mechanism into A State-of-the-Art Genetic Manipulation Tool (2019) · cites this paper as [161]
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Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
Konermann, S., Brigham, M. D., Trevino, A. E., Joung, J., Abudayyeh, O. O., Barcena, C., Hsu, P. D., Habib, N., Gootenberg, J. S., Nishimasu, H., et al. (2015) · Nature · doi:10.1038/nature14136 · Cited by 2,825
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
Gilbert, L. A., Horlbeck, M. A., Adamson, B., Villalta, J. E., Chen, Y., Whitehead, E. H., Guimaraes, C., Panning, B., Ploegh, H. L., Bassik, M. C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.029 · Cited by 2,728
High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects
Kleinstiver, B. P., Pattanayak, V., Prew, M. S., Tsai, S. Q., Nguyen, N. T., Zheng, Z., & Joung, J. K. (2016) · Nature · doi:10.1038/nature16526 · Cited by 2,673
Rationally engineered Cas9 nucleases with improved specificity
Slaymaker, I. M., Gao, L., Zetsche, B., Scott, D. A., Yan, W. X., & Zhang, F. (2016) · Science · doi:10.1126/science.aad5227 · Cited by 2,414
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
Tsai, S. Q., Zheng, Z., Nguyen, N. T., Liebers, M., Topkar, V. V., Thapar, V., Wyvekens, N., Khayter, C., Iafrate, A. J., Le, L. P., et al. (2015) · Nature Biotechnology · doi:10.1038/nbt.3117 · Cited by 2,268
Cas9 as a versatile tool for engineering biology
Mali, P., Esvelt, K. M., & Church, G. M. (2013) · Nature Methods · doi:10.1038/nmeth.2649 · Cited by 1,197
Sequential cancer mutations in cultured human intestinal stem cells
Drost, J., van Jaarsveld, R. H., Ponsioen, B., Zimberlin, C., van Boxtel, R., Buijs, A., Sachs, N., Overmeer, R. M., Offerhaus, G. J., Begthel, H., et al. (2015) · Nature · doi:10.1038/nature14415 · Cited by 1,067
In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system
Maddalo, D., Manchado, E., Concepcion, C. P., Bonetti, C., Vidigal, J. A., Han, Y.-C., Ogrodowski, P., Crippa, A., Rekhtman, N., de Stanchina, E., et al. (2014) · Nature · doi:10.1038/nature13902 · Cited by 640
Heckl, D., Kowalczyk, M. S., Yudovich, D., Belizaire, R., Puram, R. V., McConkey, M. E., Thielke, A., Aster, J. C., Regev, A., & Ebert, B. L. (2014) · Nature Biotechnology · doi:10.1038/nbt.2951 · Cited by 555
Chromosomal Translocations in Human Cells Are Generated by Canonical Nonhomologous End-Joining
Ghezraoui, H., Piganeau, M., Renouf, B., Renaud, J.-B., Sallmyr, A., Ruis, B., Oh, S., Tomkinson, A. E., Hendrickson, E. A., Giovannangeli, C., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.002 · Cited by 351
Flagged first, then by citations
Research works printed but not linked: 78
- Borden, 2003, Soft tissue sarcomas of adults: state of the translational science, Clin. Cancer Res, 9, 1941
- Harwood, 2015, Targeted chemotherapy in bone and soft-tissue sarcoma, Orthop. Clin. North Am, 46, 587, 10.1016/j.ocl.2015.06.011 · DOI
- de Alava, 2007, Molecular pathology in sarcomas, Clin. Transl. Oncol, 9, 130, 10.1007/s12094-007-0027-2 · DOI
- Riggi, 2007, Sarcomas: genetics, signalling, and cellular origins. Part 1: the fellowship of TET, J. Pathol, 213, 4, 10.1002/path.2209 · DOI
- Movva, 2015, Multi-platform profiling of over 2000 sarcomas: identification of biomarkers and novel therapeutic targets, Oncotarget, 12234, 10.18632/oncotarget.3498 · DOI
- Taylor, 2011, Advances in sarcoma genomics and new therapeutic targets, Nat. Rev. Cancer, 11, 541, 10.1038/nrc3087 · DOI
- Demicco, 2012, New therapeutic targets in soft tissue sarcoma, Adv. Anat. Pathol, 19, 170, 10.1097/PAP.0b013e318253462f · DOI
- Zhang, 2014, Epigenetic regulators: new therapeutic targets for soft tissue sarcoma, Cancer Cell Microenviron, 1, e191
- Lu, 2015, Modeling cancer processes with CRISPR-Cas9, Trends Biotechnol, 33, 317, 10.1016/j.tibtech.2015.03.007 · DOI
- Agrawal, 2003, RNA interference: biology, mechanism, and applications, Microbiol. Mol. Biol. Rev, 67, 657, 10.1128/MMBR.67.4.657-685.2003 · DOI
- Wilson, 2001, The LoxP/CRE system and genome modification, Methods Mol. Biol, 158, 83
- Maizels, 2013, Genome engineering with Cre-loxP, J. Immunol, 191, 5, 10.4049/jimmunol.1301241 · DOI
- Barrangou, 2014, RNA events. Cas9 targeting and the CRISPR revolution, Science, 344, 707, 10.1126/science.1252964 · DOI
- Cong, 2013, Multiplex genome engineering using CRISPR/Cas systems, Science, 339, 819, 10.1126/science.1231143 · DOI · Paper page
- Bortesi, 2015, The CRISPR/Cas9 system for plant genome editing and beyond, Biotechnol. Adv, 33, 41, 10.1016/j.biotechadv.2014.12.006 · DOI
- Rath, 2015, The CRISPR-Cas immune system: biology, mechanisms and applications, Biochimie, 117, 119, 10.1016/j.biochi.2015.03.025 · DOI · Paper page
- Sanchez-Rivera, 2015, Applications of the CRISPR-Cas9 system in cancer biology, Nat. Rev. Cancer, 15, 387, 10.1038/nrc3950 · DOI · Paper page
- Wen, 2016, CRISPR-Cas9 systems: versatile cancer modelling platforms and promising therapeutic strategies, Int. J. Cancer, 138, 1328, 10.1002/ijc.29626 · DOI
- Xiao-Jie, 2015, CRISPR-Cas9: a new and promising player in gene therapy, J. Med. Genet, 52, 289, 10.1136/jmedgenet-2014-102968 · DOI · Paper page
- Zhang, 2014, CRISPR/Cas9 for genome editing: progress, implications and challenges, Hum. Mol. Genet, 23, R40, 10.1093/hmg/ddu125 · DOI
- Niu, 2014, Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos, Cell, 156, 836, 10.1016/j.cell.2014.01.027 · DOI · Paper page
- Sanchez-Rivera, 2014, Rapid modelling of cooperating genetic events in cancer through somatic genome editing, Nature, 516, 428, 10.1038/nature13906 · DOI
- Feldser, 2010, Stage-specific sensitivity to p53 restoration during lung cancer progression, Nature, 468, 572, 10.1038/nature09535 · DOI
- Gupta, 2014, Expanding the genetic editing tool kit: ZFNs, TALENs, and CRISPR-Cas9, J. Clin. Invest, 124, 4154, 10.1172/JCI72992 · DOI
- Matano, 2015, Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids, Nat. Med, 21, 256, 10.1038/nm.3802 · DOI · Paper page
- Wesche-Soldato, 2008, Hydrodynamic delivery of siRNA in a mouse model of sepsis, Methods Mol. Biol, 442, 67, 10.1007/978-1-59745-191-8_5 · DOI
- Xue, 2014, CRISPR-mediated direct mutation of cancer genes in the mouse liver, Nature, 514, 380, 10.1038/nature13589 · DOI · Paper page
- Platt, 2014, CRISPR-Cas9 knockin mice for genome editing and cancer modeling, Cell, 159, 440, 10.1016/j.cell.2014.09.014 · DOI · Paper page
- Albers, 2015, A versatile modular vector system for rapid combinatorial mammalian genetics, J. Clin. Invest, 125, 1603, 10.1172/JCI79743 · DOI
- Blasco, 2014, Simple and rapid in vivo generation of chromosomal rearrangements using CRISPR/Cas9 technology, Cell Rep, 9, 1219, 10.1016/j.celrep.2014.10.051 · DOI
- Choi, 2014, Targeted genomic rearrangements using CRISPR/Cas technology, Nat. Commun, 5, 3728, 10.1038/ncomms4728 · DOI
- Tschoep, 2007, Gene expression profiling in sarcomas, Crit. Rev. Oncol. Hematol, 63, 111, 10.1016/j.critrevonc.2007.04.001 · DOI
- Lagutina, 2015, Modeling of the human alveolar rhabdomyosarcoma Pax3-Foxo1 chromosome translocation in mouse myoblasts using CRISPR-Cas9 nuclease, PLoS Genet, 11, e1004951, 10.1371/journal.pgen.1004951 · DOI
- Torres, 2014, Engineering human tumour-associated chromosomal translocations with the RNA-guided CRISPR-Cas9 system, Nat. Commun, 5, 3964, 10.1038/ncomms4964 · DOI
- Aubrey, 2015, An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo, Cell Rep, 10, 1422, 10.1016/j.celrep.2015.02.002 · DOI
- Chen, 2015, Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis, Cell, 160, 1246, 10.1016/j.cell.2015.02.038 · DOI · Paper page
- Post, 2012, Mouse models of sarcomas: critical tools in our understanding of the pathobiology, Clin. Sarcoma Res, 2, 20, 10.1186/2045-3329-2-20 · DOI
- Suva, 2007, Sarcomas: genetics, signalling, and cellular origins. Part 2: TET-independent fusion proteins and receptor tyrosine kinase mutations, J. Pathol, 213, 117, 10.1002/path.2208 · DOI
- Lang, 2004, Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome, Cell, 119, 861, 10.1016/j.cell.2004.11.006 · DOI · Paper page
- Donehower, 1992, Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours, Nature, 356, 215, 10.1038/356215a0 · DOI · Paper page
- Lin, 2009, Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice, Carcinogenesis, 30, 1789, 10.1093/carcin/bgp180 · DOI
- Rauch, 2010, The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice, PLoS ONE, 5, 10.1371/journal.pone.0015755 · DOI
- Ng, 2012, Genetically engineered mouse models and human osteosarcoma, Clin. Sarcoma Res, 2, 19, 10.1186/2045-3329-2-19 · DOI
- Lagutina, 2002, Pax3-FKHR knock-in mice show developmental aberrations but do not develop tumors, Mol. Cell. Biol, 22, 7204, 10.1128/MCB.22.20.7204-7216.2002 · DOI
- Keller, 2004, Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin, Genes Dev, 18, 2608, 10.1101/gad.1243904 · DOI
- Keller, 2004, Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function, Genes Dev, 18, 2614, 10.1101/gad.1244004 · DOI
- Rubin, 2011, Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma, Cancer Cell, 19, 177, 10.1016/j.ccr.2010.12.023 · DOI
- Tsumura, 2006, Cooperation of oncogenic K-ras and p53 deficiency in pleomorphic rhabdomyosarcoma development in adult mice, Oncogene, 25, 7673, 10.1038/sj.onc.1209749 · DOI
- Doyle, 2010, p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma, J. Pathol, 222, 129, 10.1002/path.2748 · DOI
- Haldar, 2007, A conditional mouse model of synovial sarcoma: insights into a myogenic origin, Cancer Cell, 11, 375, 10.1016/j.ccr.2007.01.016 · DOI
- Charytonowicz, 2012, PPARgamma agonists enhance ET-743-induced adipogenic differentiation in a transgenic mouse model of myxoid round cell liposarcoma, J. Clin. Invest, 122, 886, 10.1172/JCI60015 · DOI
- Joseph, 2008, The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells, Cancer Cell, 13, 129, 10.1016/j.ccr.2008.01.003 · DOI
- Hayashi, 2011, Molecular approach to uterine leiomyosarcoma: LMP2-deficient mice as an animal model of spontaneous uterine leiomyosarcoma, Sarcoma, 2011, 476498, 10.1155/2011/476498 · DOI
- Strizzi, 2007, Development of leiomyosarcoma of the uterus in MMTV-CR-1 transgenic mice, J. Pathol, 211, 36, 10.1002/path.2083 · DOI
- Xing, 2009, A role for BRCA1 in uterine leiomyosarcoma, Cancer Res, 69, 8231, 10.1158/0008-5472.CAN-09-2543 · DOI
- Mou, 2015, Precision cancer mouse models through genome editing with CRISPR-Cas9, Genome Med, 7, 53, 10.1186/s13073-015-0178-7 · DOI
- Malina, 2013, Repurposing CRISPR/Cas9 for in situ functional assays, Genes Dev, 27, 2602, 10.1101/gad.227132.113 · DOI
- Feng, 2015, Targeting CDK11 in osteosarcoma cells using the CRISPR-Cas9 system, J. Orthop. Res, 33, 199, 10.1002/jor.22745 · DOI
- Duan, 2012, Systematic kinome shRNA screening identifies CDK11 (PITSLRE) kinase expression is critical for osteosarcoma cell growth and proliferation, Clin. Cancer Res, 18, 4580, 10.1158/1078-0432.CCR-12-1157 · DOI
- Zhou, 2015, Cyclin-dependent kinase 11(p110) (CDK11(p110)) is crucial for human breast cancer cell proliferation and growth, Sci. Rep, 5, 10433, 10.1038/srep10433 · DOI
- Takahashi, 2015, Significance of polypyrimidine tract-binding protein 1 expression in colorectal cancer, Mol. Cancer Ther, 14, 1705, 10.1158/1535-7163.MCT-14-0142 · DOI
- Jia, 2014, Cyclin-dependent kinase 11 (CDK11) is crucial in the growth of liposarcoma cells, Cancer Lett, 342, 104, 10.1016/j.canlet.2013.08.040 · DOI
- Susa, 2010, Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma, PLoS ONE, 5, 10.1371/journal.pone.0010764 · DOI
- Kasap, 2014, DrugTargetSeqR: a genomics- and CRISPR-Cas9-based method to analyze drug targets, Nat. Chem. Biol, 10, 626, 10.1038/nchembio.1551 · DOI
- Neggers, 2015, Identifying drug-target selectivity of small-molecule CRM1/XPO1 inhibitors by CRISPR/Cas9 genome editing, Chem. Biol, 22, 107, 10.1016/j.chembiol.2014.11.015 · DOI
- Yao, 2009, The expression of CRM1 is associated with prognosis in human osteosarcoma, Oncol. Rep, 21, 229
- Kazim, 2015, Selective nuclear export inhibitor KPT-330 enhances the antitumor activity of gemcitabine in human pancreatic cancer, Mol. Cancer Ther, 14, 1570, 10.1158/1535-7163.MCT-15-0104 · DOI
- De Cesare, 2015, Anti-tumor activity of selective inhibitors of XPO1/CRM1-mediated nuclear export in diffuse malignant peritoneal mesothelioma: the role of survivin, Oncotarget, 6, 13119, 10.18632/oncotarget.3761 · DOI
- Rath, 2012, Kinesins and cancer, Nat. Rev. Cancer, 12, 527, 10.1038/nrc3310 · DOI
- Houghton, 2007, The pediatric preclinical testing program: description of models and early testing results, Pediatr. Blood Cancer, 49, 928, 10.1002/pbc.21078 · DOI · Paper page
- Souid, 2010, A pediatric phase I trial and pharmacokinetic study of ispinesib: a Children's Oncology Group phase I consortium study, Pediatr. Blood Cancer, 55, 1323, 10.1002/pbc.22609 · DOI
- O'Malley, 2015, Evidence of BRAF V600E in indeterminate cell tumor and interdigitating dendritic cell sarcoma, Ann. Diagn. Pathol, 19, 113, 10.1016/j.anndiagpath.2015.02.008 · DOI
- Chen, 2013, Langerhans cell sarcoma arising from chronic lymphocytic lymphoma/small lymphocytic leukemia: lineage analysis and BRAF V600E mutation study, N. Am. J. Med. Sci, 5, 386, 10.4103/1947-2714.114172 · DOI
- Idbaih, 2014, Dramatic response of a BRAF V600E-mutated primary CNS histiocytic sarcoma to vemurafenib, Neurology, 83, 1478, 10.1212/WNL.0000000000000880 · DOI
- Kopetz, 2015, Phase II pilot study of vemurafenib in patients with metastatic BRAF-mutated colorectal cancer, J. Clin. Oncol, 33, 4032, 10.1200/JCO.2015.63.2497 · DOI · Paper page
- Shalem, 2014, Genome-scale CRISPR-Cas9 knockout screening in human cells, Science, 343, 84, 10.1126/science.1247005 · DOI · Paper page
- Cho, 2014, Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases, Genome Res, 24, 132, 10.1101/gr.162339.113 · DOI · Paper page
- Zhang, 2015, CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs, Sci. Rep, 5, 16277, 10.1038/srep16277 · DOI
Cited by
Sorted by citations
Loureiro, A., & da Silva, G. J. (2019) · Antibiotics · doi:10.3390/antibiotics8010018 · Cited by 129
Metadata
- Authors
- Liu, T., Shen, J. K., Li, Z., Choy, E., Hornicek, F. J., & Duan, Z.
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 373
- Issue
- 1
- Pages
- 109-118
- ISSN
- 0304-3835
- PMC
- PMC4772675
- Cited by
- 30
- References
- 11
- Language
- en
- Funders
- Gattegno and Wechsler funds
- Kenneth Stanton Fund
- Jennifer Hunter Yates Foundation
- Sarcoma Foundation of America
- National Cancer Institute (UO1, CA 151452-01)
- Sarcoma SPORE (5U54 CA168512-02)
- Academic Enrichment Fund of MGH Orthopaedics
- China Scholarship Council
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