Cathepsin B: A sellsword of cancer progression
Open accessAbstract
Clinical, biochemical and molecular biology studies have identified lysosome-encapsulated cellular proteases as critical risk factors for cancer progression. Cathepsins represent a group of such proteases aimed at maintenance of cellular homeostasis. Nevertheless, recent reports suggest that Cathepsin B executes other cellular programs such as controlling tumor growth, migration, invasion, angiogenesis, and metastases development. In fact, elevated levels of Cathepsins are found under different pathological conditions including inflammation, infection, neurodegenerative disease, and cancer. Furthermore, the discovery of Cathepsin B secretion and function as an extracellular matrix protein has broadened our appreciation for the impact of Cathepsin B on cancer progression. Underneath a façade of an intracellular protease with limited therapeutic potential hides a central role of cathepsins in extracellular functions. Moreover, this role is incredibly diverse from one condition to the next - from driving caspase-dependent apoptosis to facilitating tumor neovascularization and metastasis. Here we discuss the role of Cathepsin B in the oncogenic process and perspective the use of Cathepsin B for diagnostic and therapeutic applications.
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The role of cathepsin B in cells is to drive caspase-dependent apoptosis and promote tumor invasion, metastasis and angiogenesis.
“The role of cathepsin B in cells is to drive caspase-dependent apoptosis and promote tumor invasion, metastasis and angiogenesis.147”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [147]
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Liow, K. Y., & Chow, S. C. (2017) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-017-1436-6 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
- Authors
- Mijanović, O., Branković, A., Panin, A. N., Savchuk, S., Timashev, P., Ulasov, I., & Lesniak, M. S.
- Affiliations
- Sechenov University (RU)
- Kriminalističko-policijski univerzitet (RS)
- Northwestern University (US)
- Corresponding author
- Lesniak, Maciej S.
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 449
- Pages
- 207-214
- ISSN
- 0304-3835 (ISSN-L)
- PMC
- PMC6488514
- OpenAlex
- W2916664436
- Cited by
- 205
- References
- 104
- Citations by year
- 2026: 24 · 2025: 33 · 2024: 36 · 2023: 40 · 2022: 39 · 2021: 23 · 2020: 7 · 2019: 2 · 2018: 1
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Letters (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Jakov (University of Criminalistic and Police Studies, Belgrade, Serbia) (submittedVersion)
- Jakov (University of Criminalistic and Police Studies, Belgrade, Serbia) (submittedVersion, cc-by-nc-nd)
- Funders
- Russian academic excellence project (5-100)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Health Sciences › Medicine › Oncology › Peptidase Inhibition and Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Calpain Protease Function and Regulation
- Keywords
- cathepsin B, lysosomal proteases, tumor progression, extracellular matrix, metastasis, tumor angiogenesis, tumor invasion, caspase-dependent apoptosis, tumor markers, cancer therapeutics
- MeSH terms
- RNAi Therapeutics, Animals, Antineoplastic Agents, Autophagy, Cathepsin B, Cell Movement, Humans, Neoplasm Invasiveness, Neoplasms, Protease Inhibitors, Biomarkers, Tumor, Signal Transduction, Apoptosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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