Cited by 205Protease and Inhibitor MechanismsPeptidase Inhibition and AnalysisCalpain Protease Function and Regulation

Cathepsin B: A sellsword of cancer progression

Open access
Mijanović, Olja, Branković, Ana, Panin, Alexander N., Savchuk, Solomiia, Timashev, Peter, Ulasov, Ilya, Lesniak, Maciej S.·2019·Cancer Letters

Abstract

Clinical, biochemical and molecular biology studies have identified lysosome-encapsulated cellular proteases as critical risk factors for cancer progression. Cathepsins represent a group of such proteases aimed at maintenance of cellular homeostasis. Nevertheless, recent reports suggest that Cathepsin B executes other cellular programs such as controlling tumor growth, migration, invasion, angiogenesis, and metastases development. In fact, elevated levels of Cathepsins are found under different pathological conditions including inflammation, infection, neurodegenerative disease, and cancer. Furthermore, the discovery of Cathepsin B secretion and function as an extracellular matrix protein has broadened our appreciation for the impact of Cathepsin B on cancer progression. Underneath a façade of an intracellular protease with limited therapeutic potential hides a central role of cathepsins in extracellular functions. Moreover, this role is incredibly diverse from one condition to the next - from driving caspase-dependent apoptosis to facilitating tumor neovascularization and metastasis. Here we discuss the role of Cathepsin B in the oncogenic process and perspective the use of Cathepsin B for diagnostic and therapeutic applications.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.canlet.2019.02.035

Cites

104 of 104 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The role of cathepsin B in cells is to drive caspase-dependent apoptosis and promote tumor invasion, metastasis and angiogenesis.

    “The role of cathepsin B in cells is to drive caspase-dependent apoptosis and promote tumor invasion, metastasis and angiogenesis.147”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [147]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

9 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Mijanović, O., Branković, A., Panin, A. N., Savchuk, S., Timashev, P., Ulasov, I., & Lesniak, M. S.
Affiliations
  • Sechenov University (RU)
  • Kriminalističko-policijski univerzitet (RS)
  • Northwestern University (US)
Corresponding author
Lesniak, Maciej S.
Venue
Cancer Letters
Publisher
Elsevier BV
Published
2019-05
Volume
449
Pages
207-214
ISSN
0304-3835 (ISSN-L)
OpenAlex
W2916664436
Cited by
205
References
104
Citations by year
2026: 24 · 2025: 33 · 2024: 36 · 2023: 40 · 2022: 39 · 2021: 23 · 2020: 7 · 2019: 2 · 2018: 1
FWCI
1.80
Type
journal article
Language
en
Open access
Locations
  • Cancer Letters (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Jakov (University of Criminalistic and Police Studies, Belgrade, Serbia) (submittedVersion)
  • Jakov (University of Criminalistic and Police Studies, Belgrade, Serbia) (submittedVersion, cc-by-nc-nd)
Funders
Russian academic excellence project (5-100)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
  • Health Sciences › Medicine › Oncology › Peptidase Inhibition and Analysis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Calpain Protease Function and Regulation
Keywords
cathepsin B, lysosomal proteases, tumor progression, extracellular matrix, metastasis, tumor angiogenesis, tumor invasion, caspase-dependent apoptosis, tumor markers, cancer therapeutics
MeSH terms
RNAi Therapeutics, Animals, Antineoplastic Agents, Autophagy, Cathepsin B, Cell Movement, Humans, Neoplasm Invasiveness, Neoplasms, Protease Inhibitors, Biomarkers, Tumor, Signal Transduction, Apoptosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review