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A comparative study of the anticoagulant activities of eleven fucoidans
Abstract
Seven fucoidans that differed only with respect to the average molecular weight and four fucoidans that differed with respect to both the molar ratio of fucose to galactose and the average molecular weight were obtained. The anticoagulant activities of these fucoidans were determined in order to understand the effects of the average molecular weight and the content of galactose. Fucoidans Y5-Y11, with the average molecular weight in the range of 50.1-8.4 kDa, showed decreasing activity at three concentrations and dose-dependent activity in the APTT and TT assays. Y1-Y4, which differed with respect to the average molecular weight and the molar ratio of fucose to galactose, exhibited complicated results in the APTT and TT assays. It was shown that not only the average molecular weight but also the molar ratio of fucose to galactose affected the anticoagulant activity of fucoidans.
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“These macroalgal polysaccharides, particularly fucoidan and laminarin, show a wide range of biological activities such as antiinflammatory, antimicrobial, anticoagulant, antiadhesive, antioxidant, antiviral, antipeptic, antitumour, antiapoptosis, antiproliferative and immunostimulatory in in vitro and in vivo model systems”
From Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification (2017) · cites this paper as Jin et al., 2013
In the citing paper
“O-sulphated 3-linked αgalactans and 3-O-sulphation at C-3 of 4-α-L-fucose-1 → units (in fucoidan) is mainly responsible for its anticoagulant activity”
From Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification (2017) · cites this paper as Jin et al., 2013
In the citing paper
“These sulphate linked sugar units increased the inhibition of factors Xa, IIa and thrombin with the help of antithrombin and heparin cofactor II in blood coagulation intrinsic pathway”
From Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification (2017) · cites this paper as Jin et al., 2013
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Metadata
- Authors
- Jin, W., Zhang, Q., Wang, J., & Zhang, W.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- Zhang, Quanbin
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 91
- Issue
- 1
- Pages
- 1-6
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W2080388593
- Cited by
- 114
- References
- 26
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 9 · 2023: 10 · 2022: 11 · 2021: 12 · 2020: 11 · 2019: 10 · 2018: 11 · 2017: 8 · 2016: 9 · 2015: 4 · 2014: 5 · 2013: 5
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Carbohydrate Polymers (publishedVersion)
- PubMed (publishedVersion)
- Funders
- State Oceanic Administration of the People's Republic of China (201005024)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
- Keywords
- fucoidan, anticoagulant activity, molecular weight, activated partial thromboplastin time, thrombin time, sulfated polysaccharides, dose-dependent activity
- MeSH terms
- Anticoagulants, Molecular Weight, Partial Thromboplastin Time, Polysaccharides, Prothrombin Time, Thrombin Time
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