Cited by 456Seaweed-derived Bioactive CompoundsPolysaccharides Composition and ApplicationsFungal Biology and Applications

Potential antioxidant and anticoagulant capacity of low molecular weight fucoidan fractions extracted from Laminaria japonica

Wang, Jing, Zhang, Quanbin, Zhang, Zhongshan, Song, Houfang, Li, Pengcheng·2010·International Journal of Biological Macromolecules

Abstract

A low molecular weight fucoidan (DFPS), obtained from the brown seaweed Laminaria japonica, was separated into three fractions by anion-exchange column chromatography. All three fractions (DF1, DF2, DF3) predominantly contained variety fucose, galactose and sulfate group. The antioxidant and anticoagulant activities of these fractions were investigated. The results showed that all fractions possessed considerable antioxidant activities, DF1 was most active. All samples inhibited coagulant in APTT, TT and PT assays obviously. Available data presented the content of sulfate group, the molar ratio of sulfate/fucose and sulfate/total sugar, and the molecular weight played an important role on antioxidant and anticoagulant activity.

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Crossref · 10.1016/j.ijbiomac.2009.10.015

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  • Structural derivatives of FCSPs from Fucales and Laminariales exhibit anti-inflammatory, immunomodulatory, antiviral, and anticoagulant properties.

    “Structural derivatives of fucose-containing sulfated polysaccharides (FCSPs), such as those originating from Fucales and Laminariales, exhibit anti-inflammatory, immunomodulatory, antiviral, and anticoagulant properties [2,3,4].”
  • Cancer preventive action of fucoidans includes anti-inflammatory, anti-adhesive, antioxidant, and antiviral effects as well as capability to bind heavy metals.

    “The cancer preventive action of fucoidans includes such useful properties as anti-inflammatory, anti-adhesive [72], antioxidant and antiviral effects [73,74,75,76] as well as their capability to bind heavy metals.”
  • Algal fucoidans have diverse biological functions and possible therapeutic properties including antitumor, immunomodulatory, anti-inflammatory, antithrombotic, and anticoagulant effects.

    “Algal fucoidans have been the subject of numerous scientific studies due to their diverse biological functions and possible therapeutic properties including antitumor, immunomodulatory, 45 anti-inflammatory, 6 antithrombotic, and anticoagulant effects.46”

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Authors
Wang, J., Zhang, Q., Zhang, Z., Song, H., & Li, P.
Affiliations
Chinese Academy of Sciences (CN)
Corresponding author
Zhang, Quanbin
Venue
International Journal of Biological Macromolecules
Publisher
Elsevier BV
Published
2010-01
Volume
46
Issue
1
Pages
6-12
ISSN
0141-8130 (ISSN-L)
OpenAlex
W1980000062
Cited by
456
References
30
Citations by year
2026: 21 · 2025: 32 · 2024: 25 · 2023: 23 · 2022: 38 · 2021: 31 · 2020: 35 · 2019: 29 · 2018: 25 · 2017: 34 · 2016: 22 · 2015: 39 · 2014: 33 · 2013: 30 · 2012: 17
FWCI
19.87
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Biological Macromolecules (publishedVersion)
  • PubMed (publishedVersion)
Funders
Chinese Academy of Sciences
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
  • Health Sciences › Medicine › Pharmacology › Fungal Biology and Applications
Keywords
fucoidan, Laminaria japonica, low molecular weight fucoidan, antioxidant activity, anticoagulant activity, brown seaweed polysaccharides, fucose, sulfate content, molecular weight, coagulation inhibition, activated partial thromboplastin time, PT
MeSH terms
Anticoagulants, Antioxidants, Biphenyl Compounds, Humans, Laminaria, Molecular Weight, Magnetic Resonance Spectroscopy, Oxidation-Reduction, Picrates, Plant Extracts, Polysaccharides, Spectrophotometry, Infrared, Superoxides, Free Radical Scavengers, Hydroxyl Radical

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