Potential antioxidant and anticoagulant capacity of low molecular weight fucoidan fractions extracted from Laminaria japonica
Abstract
A low molecular weight fucoidan (DFPS), obtained from the brown seaweed Laminaria japonica, was separated into three fractions by anion-exchange column chromatography. All three fractions (DF1, DF2, DF3) predominantly contained variety fucose, galactose and sulfate group. The antioxidant and anticoagulant activities of these fractions were investigated. The results showed that all fractions possessed considerable antioxidant activities, DF1 was most active. All samples inhibited coagulant in APTT, TT and PT assays obviously. Available data presented the content of sulfate group, the molar ratio of sulfate/fucose and sulfate/total sugar, and the molecular weight played an important role on antioxidant and anticoagulant activity.
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Structural derivatives of FCSPs from Fucales and Laminariales exhibit anti-inflammatory, immunomodulatory, antiviral, and anticoagulant properties.
“Structural derivatives of fucose-containing sulfated polysaccharides (FCSPs), such as those originating from Fucales and Laminariales, exhibit anti-inflammatory, immunomodulatory, antiviral, and anticoagulant properties [2,3,4].”
From A Review on Fucoidan Structure, Extraction Techniques, and Its Role as an Immunomodulatory Agent (2022) · cites this paper as [4]
Cancer preventive action of fucoidans includes anti-inflammatory, anti-adhesive, antioxidant, and antiviral effects as well as capability to bind heavy metals.
“The cancer preventive action of fucoidans includes such useful properties as anti-inflammatory, anti-adhesive [72], antioxidant and antiviral effects [73,74,75,76] as well as their capability to bind heavy metals.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [75]
Algal fucoidans have diverse biological functions and possible therapeutic properties including antitumor, immunomodulatory, anti-inflammatory, antithrombotic, and anticoagulant effects.
“Algal fucoidans have been the subject of numerous scientific studies due to their diverse biological functions and possible therapeutic properties including antitumor, immunomodulatory, 45 anti-inflammatory, 6 antithrombotic, and anticoagulant effects.46”
From Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation (2013) · cites this paper as [46]
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Self-citation
- Authors
- Wang, J., Zhang, Q., Zhang, Z., Song, H., & Li, P.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- Zhang, Quanbin
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 46
- Issue
- 1
- Pages
- 6-12
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W1980000062
- Cited by
- 456
- References
- 30
- Citations by year
- 2026: 21 · 2025: 32 · 2024: 25 · 2023: 23 · 2022: 38 · 2021: 31 · 2020: 35 · 2019: 29 · 2018: 25 · 2017: 34 · 2016: 22 · 2015: 39 · 2014: 33 · 2013: 30 · 2012: 17
- FWCI
- 19.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chinese Academy of Sciences
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Health Sciences › Medicine › Pharmacology › Fungal Biology and Applications
- Keywords
- fucoidan, Laminaria japonica, low molecular weight fucoidan, antioxidant activity, anticoagulant activity, brown seaweed polysaccharides, fucose, sulfate content, molecular weight, coagulation inhibition, activated partial thromboplastin time, PT
- MeSH terms
- Anticoagulants, Antioxidants, Biphenyl Compounds, Humans, Laminaria, Molecular Weight, Magnetic Resonance Spectroscopy, Oxidation-Reduction, Picrates, Plant Extracts, Polysaccharides, Spectrophotometry, Infrared, Superoxides, Free Radical Scavengers, Hydroxyl Radical
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