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Microwave assisted extraction of sulfated polysaccharides (fucoidan) from Ascophyllum nodosum and its antioxidant activity
Abstract
Sulfated polysaccharides (fucoidan) from brown seaweed Ascophyllum nodosum were extracted by microwave assisted extraction (MAE) technology. Different conditions of temperature (90-150°C), extraction time (5-30 min) were evaluated and optimal fucoidan yield was 16.08%, obtained from 120°C for 15 min's extraction. Compositional analysis, GPC, HPAEC and IR analysis were employed for characterization of extracted sulfated polysaccharides. Fucose was the main monosaccharide of fucoidan extracted at 90°C while glucuronic acid was the main monosaccharide of fucoidan extracted at 150°C. Both the molecular weight and sulfate content of extracted fucoidan increased with decreasing extraction temperature. All fucoidans exhibited antioxidant activities as measured by DPPH scavenging and reducing power, among which fucoidan extracted at 90°C was highest. This study shows that MAE is an efficient technology to extract sulfated polysaccharides from seaweed and Ascophyllum nodosum could potentially be a resource for natural antioxidants.
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“Low molecular weight products of polysaccharides showed higher antiproliferative activity and those with higher sulfate content exhibited strong antioxidant activity [80,81].”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [81]
In the citing paper
“The increased temperature affected the sulfate content of fucoidan, it decreased with the extraction temperature [81].”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [81]
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Metadata
- Authors
- Yuan, Y., & Macquarrie, D.
- Affiliations
- University of York (GB)
- Corresponding author
- Macquarrie, Duncan
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 129
- Pages
- 101-107
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W317714569
- Semantic Scholar
- fe72b2f1446aba29dd8e23236f0f0027211ea81a
- Cited by
- 371
- References
- 50
- Citations by year
- 2026: 23 · 2025: 45 · 2024: 39 · 2023: 43 · 2022: 35 · 2021: 44 · 2020: 36 · 2019: 31 · 2018: 25 · 2017: 25 · 2016: 16 · 2015: 9
- FWCI
- 38.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Carbohydrate Polymers (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
- Keywords
- fucoidan, sulfated polysaccharides, Ascophyllum nodosum, brown algae, microwave-assisted extraction, extraction temperature, extraction time, fucose, glucuronic acid, sulfate content, molecular weight, antioxidant activity, DPPH radical scavenging, reducing power, natural antioxidants
- MeSH terms
- Antioxidants, Biphenyl Compounds, Carbohydrates, Microwaves, Oxidation-Reduction, Picrates, Polysaccharides, Temperature, Time Factors, Uronic Acids, Free Radical Scavengers, Ascophyllum
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