The DOI matches its Crossref record; 138 of the 138 references it cites were found in a registry or an index.
Applications of chitin and chitosan nanofibers in bone regenerative engineering
Abstract
Promoting bone regeneration and repairing defects are urgent and critical challenges in orthopedic clinical practice. Research on bone substitute biomaterials is essential for improving the treatment strategies for bone regeneration. Chitin and its derivative, chitosan, are among the most abundant natural biomaterials and widely found in the shells of crustaceans. Chitin and chitosan are non-toxic, antibacterial, biocompatible, degradable, and have attracted significant attention in bone substitute biomaterials. Chitin/chitosan nanofibers and nanostructured scaffolds have large surface area to volume ratios and high porosities. These scaffolds can be fabricated by electrospinning, thermally induced phase separation and self-assembly, and are widely used in biomedical applications such as biological scaffolds, drug delivery, bacterial inhibition, and wound dressing. Recently, some chitin/chitosan-based nanofibrous scaffolds have been found structurally similar to bone's extracellular matrix and can assist in bone regeneration. This review outlines the biomedical applications and biological properties of chitin/chitosan-based nanofibrous scaffolds in bone tissue engineering.
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Cites
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Cited by
A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds
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Unraveling of Advances in 3D-Printed Polymer-Based Bone Scaffolds
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Cellulose-based composite scaffolds for bone tissue engineering and localized drug delivery
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Metadata
- Authors
- Tao, F., Cheng, Y., Shi, X., Zheng, H., Du, Y., Xiang, W., & Deng, H.
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 230
- Pages
- 115658
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W2990682151
- Cited by
- 341
- References
- 138
- FWCI
- 12.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tao, F., Cheng, Y., Shi, X., Zheng, H., Du, Y., Xiang, W., & Deng, H. (2020). Applications of chitin and chitosan nanofibers in bone regenerative engineering. Carbohydrate Polymers. https://doi.org/10.1016/j.carbpol.2019.115658
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