The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair
Open accessAbstract
Bone tissue has a remarkable ability to regenerate and heal itself. However, large bone defects and complex fractures still present a significant challenge to the medical community. Current treatments center on metal implants for structural and mechanical support and auto- or allo-grafts to substitute long bone defects. Metal implants are associated with several complications such as implant loosening and infections. Bone grafts suffer from donor site morbidity, reduced bioactivity, and risk of pathogen transmission. Surgical implants can be modified to provide vital biological cues, growth factors and cells in order to improve osseointegration and repair of bone defects. Here we review strategies and technologies to engineer metal surfaces to promote osseointegration with the host tissue. We also discuss strategies for modifying implants for cell adhesion and bone growth via integrin signaling and growth factor and cytokine delivery for bone defect repair.
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Cites
Keselowsky, B. G., Collard, D. M., & García, A. J. (2003) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.10537 · Cited by 949
Self-citationRepair of bone defects using synthetic mimetics of collagenous extracellular matrices
Lutolf, M. P., Weber, F. E., Schmoekel, H. G., Schense, J. C., Kohler, T., Müller, R., & Hubbell, J. A. (2003) · Nature Biotechnology · doi:10.1038/nbt818 · Cited by 850
Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation
Keselowsky, B. G., Collard, D. M., & García, A. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407356102 · Cited by 687
Self-citationMartino, M. M., Tortelli, F., Mochizuki, M., Traub, S., Ben-David, D., Kuhn, G. A., Müller, R., Livne, E., Eming, S. A., & Hubbell, J. A. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002614 · Cited by 459
Kim, S.-J., Shin, Y.-W., Yang, K.-H., Kim, S.-B., Yoo, M.-J., Han, S.-K., Im, S.-A., Won, Y.-D., Sung, Y.-B., Jeon, T.-S., et al. (2009) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-10-20 · Cited by 111
Cited by
Scaffolds for bone tissue engineering: state of the art and new perspectives
Roseti, L., Parisi, V., Petretta, M., Cavallo, C., Desando, G., Bartolotti, I., & Grigolo, B. (2017) · Materials Science and Engineering: C · doi:10.1016/j.msec.2017.05.017 · Cited by 1,320
Bioactive hydrogels for bone regeneration
Bai, X., Gao, M., Syed, S., Zhuang, J., Xu, X., & Zhang, X.-Q. (2018) · Bioactive Materials · doi:10.1016/j.bioactmat.2018.05.006 · Cited by 556
Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering
Narayanan, G., Vernekar, V. N., Kuyinu, E. L., & Laurencin, C. T. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.015 · Cited by 484
The application of hyaluronic acid in bone regeneration
Zhai, P., Peng, X., Li, B., Liu, Y., Sun, H., & Li, X. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.10.169 · Cited by 438
Zhang, K., Feng, Q., Fang, Z., Gu, L., & Bian, L. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00071 · Cited by 394
Metadata
- Authors
- Agarwal, R., & García, A. J.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 94
- Pages
- 53-62
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2081965734
- Cited by
- 789
- References
- 5
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
