Collagen accumulation and dysfunctional mucosal barrier of the small intestine in patients with chronic heart failure
Abstract
Chronic heart failure is a systemic disease with a devastating prognosis, which affects many organ systems other than the cardiovascular system. A total of 45 Chronic heart failure patients of ischemic etiology and 18 control subjects aged 45-65 years were recruited. All subjects underwent a physical examination by a qualified physician, echocardiography, an evaluation of the trophological status (including height and weight assessment) and net-of-fat body mass (NFBM) determination, an evaluation of intestinal functional activity based on fat and protein excretion with feces, and biopsy examination from the small intestine (see below). For all of them were performed functional tests of the small intestine and morphological examination of the small intestine and biopsy collection. Staining for collagen content of the mucosal wall showed that collagen content differed significantly between the four cohorts studied. In fact, relative collagen content was highest in advanced stages of the disease. However, patients with cardiac cachexia displayed even higher relative amounts of collagen than those of the same functional class without cardiac cachexia. Both fat loss and protein loss with the feces correlated with relative collagen area.
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Collagen content in mucosal walls is increased in proportion to the severity of heart failure.
“The collagen content in their mucosal walls is also increased, in proportion to the severity of heart failure35.”
From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [35]
Cites
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
Pitt, B., Zannad, F., Remme, W. J., Cody, R., Castaigne, A., Perez, A., Palensky, J., & Wittes, J. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411001 · Cited by 9,214 · see citing works
Durnin, J. V. G. A., & Womersley, J. (1974) · British Journal Of Nutrition · doi:10.1079/bjn19740060 · Cited by 6,343 · see citing works
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
Pitt, B., Zannad, F. M., Remme, W. J., Cody, R. J., Castaigne, A., Pérez, A. J. P., Palensky, J., & Wittes, J. T. (2000) · Survey of Anesthesiology · doi:10.1097/00132586-200006000-00059 · Cited by 2,927 · see citing works
RAPID METHOD FOR THE DETERMINATION OF FAT IN FECES
Kamer, J. H. V. D., Huinink, H. T. B., & Weyers, H. A. (1949) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)57092-7 · Cited by 1,865 · see citing works
Wasting as independent risk factor for mortality in chronic heart failure
Anker, S. D., Ponikowski, P. P., Varney, S. J., Chua, T. P., Clark, A. L., Webb-Peploe, K., Harrington, D., Kox, W. J., Poole-Wilson, P. A., & Coats, A. J. S. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07015-8 · Cited by 1,399 · see citing works
Packer, M. (1992) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(92)90167-l · Cited by 1,056 · see citing works
Zannad, F. M., Alla, F., Dousset, B., Pérez, A. J. P., & Pitt, B. (2000) · Circulation · doi:10.1161/01.cir.102.22.2700 · Cited by 946 · see citing works
Endotoxin and immune activation in chronic heart failure: a prospective cohort study
Niebauer, J., Volk, H.-D., Kemp, M., Dominguez, M., Schumann, R. R., Rauchhaus, M., Poole-Wilson, P. A., Coats, A. J., & Anker, S. D. (1999) · The Lancet · doi:10.1016/s0140-6736(98)09286-1 · Cited by 877 · see citing works
Alterations of skeletal muscle in chronic heart failure.
Drexler, H., Riede, U. N., Münzel, T. F., König, H., Funke, E., & Just, H. (1992) · Circulation · doi:10.1161/01.cir.85.5.1751 · Cited by 780 · see citing works
Inflammatory mediators in chronic heart failure: an overview
Anker, S. D., & von Haehling, S. (2004) · Heart · doi:10.1136/hrt.2002.007005 · Cited by 627 · see citing works
Elevated soluble CD14 receptors and altered cytokines in chronic heart failure
Anker, S. D., Egerer, K. R., Volk, H.-D., Kox, W. J., Poole-Wilson, P. A., & Coats, A. J. S. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00159-8 · Cited by 392 · see citing works
Abnormalities of skeletal muscle in patients with chronic heart failure
Lipkin, D. P., Jones, D. A., Round, J. M., & Poole-Wilson, P. A. (1988) · International Journal of Cardiology · doi:10.1016/0167-5273(88)90164-7 · Cited by 374 · see citing works
Kjeldahl Nitrogen Analysis as a Reference Method for Protein Determination in Dairy Products
Lynch, J. M., & Barbano, D. M. (1999) · Journal of AOAC International · doi:10.1093/jaoac/82.6.1389 · Cited by 345 · see citing works
The importance of the gastrointestinal system in the pathogenesis of heart failure
Krack, A., Sharma, R., Figulla, H. R., & Anker, S. D. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi389 · Cited by 280 · see citing works
The Pathogenesis of Cardiac Cachexia.
Pittman, J., & COHEN, P. (1966) · Annals of Internal Medicine · doi:10.7326/0003-4819-64-2-481_1 · Cited by 210 · see citing works
The Pathogenesis of Cardiac Cachexia
Pittman, J. G., & Cohen, P. (1964) · New England Journal of Medicine · doi:10.1056/nejm196408202710807 · Cited by 201 · see citing works
Packer, M. (1993) · The American Journal of Cardiology · doi:10.1016/0002-9149(93)90081-m · Cited by 139 · see citing works
Tumour necrosis factor-? and the failing heart
von Haehling, S., Jankowska, E. A., & Anker, S. D. (2004) · Basic Research in Cardiology · doi:10.1007/s00395-003-0433-8 · Cited by 121 · see citing works
Cachexia: a therapeutic approach beyond cytokine antagonism
von Haehling, S., Genth‐Zotz, S., Anker, S. D., & Volk, H. (2002) · International Journal of Cardiology · doi:10.1016/s0167-5273(02)00245-0 · Cited by 85 · see citing works
The Pathogenesis of Cardiac Cachexia
Pittman, J. G., & Cohen, P. (1964) · New England Journal of Medicine · doi:10.1056/nejm196408272710908 · Cited by 76 · see citing works
VARRÓ, V., Blaho, G., CSERNAY, L., Jung, I., & Szarvas, F. (1965) · Digestive Diseases and Sciences · doi:10.1007/bf02236670 · Cited by 62 · see citing works
Cachexia in heart failure is bad for you.
Anker, S. D., & Coats, A. J. S. (1998) · PubMed · Cited by 24 · see citing works
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Dietary metabolism, the gut microbiome, and heart failure
Tang, W. H. W., Li, D. Y., & Hazen, S. L. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0108-7 · Cited by 789 · see citing works
Intersections Between Microbiome and Heart Failure: Revisiting the Gut Hypothesis
Nagatomo, Y., & Tang, W. H. W. (2015) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2015.09.017 · Cited by 259 · see citing works
Genton, L., Cani, P. D., & Schrenzel, J. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2014.10.003 · Cited by 148 · see citing works
Muscle Wasting in Ageing and Chronic Illness
Ebner, N., Sliziuk, V., Scherbakov, N., & Sandek, A. (2015) · ESC Heart Failure · doi:10.1002/ehf2.12033 · Cited by 61 · see citing works
Mamic, P., Heidenreich, P. A., Hedlin, H., Tennakoon, L., & Staudenmayer, K. L. (2016) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2016.06.005 · Cited by 59 · see citing works
- Authors
- Arutyunov, G. P., Kostyukevich, O. I., Serov, R. A., Rylova, N. V., & Bylova, N. A.
- Affiliations
- Bakulev Scientific Center for Cardiovascular Surgery Russian Academy of Medical Sciences (RU)
- Venue
- International Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 125
- Issue
- 2
- Pages
- 240-245
- ISSN
- 0167-5273 (ISSN-L)
- OpenAlex
- W1965049855
- Cited by
- 103
- References
- 22
- Citations by year
- 2025: 7 · 2024: 6 · 2023: 9 · 2022: 5 · 2021: 9 · 2020: 7 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 9 · 2015: 7 · 2014: 4 · 2013: 7 · 2012: 4
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- chronic heart failure, collagen deposition, small intestine, intestinal barrier, cardiac cachexia, ischemic heart failure, intestinal dysfunction, intestinal mucosa histology
- MeSH terms
- Aged, Chronic Disease, Collagen, Female, Heart Failure, Humans, Intestinal Absorption, Intestinal Mucosa, Intestine, Small, Male, Middle Aged, Cohort Studies
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