Elevated soluble CD14 receptors and altered cytokines in chronic heart failure
Abstract
We hypothesized that in patients with chronic heart failure mesenteric venous congestion leads to increased bowel permeability, bacterial translocation, and thereby endotoxin release; the increased endotoxin challenge then causes immune activation with increased soluble CD14 levels and tumor necrosis factor (TNF)-alpha production. Patients with high soluble CD14 levels (indicative of endotoxin-cell interaction) have markedly increased plasma levels of TNF-alpha, soluble TNF receptors 1 and 2, and intracellular adhesion molecule-1, supporting this hypothesis.
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Heart failure is associated with altered intestinal function.
“It has long been recognized that heart failure is associated with altered intestinal function3,4.”
From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [3]
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Self-citation
- Authors
- Anker, S. D., Egerer, K. R., Volk, H.-D., Kox, W. J., Poole-Wilson, P. A., & Coats, A. J. S.
- Affiliations
- Humboldt-Universität zu Berlin (DE)
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 1997-05
- Volume
- 79
- Issue
- 10
- Pages
- 1426-1430
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2071209404
- Cited by
- 392
- References
- 21
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 9 · 2023: 14 · 2022: 10 · 2021: 13 · 2020: 8 · 2019: 11 · 2018: 12 · 2017: 11 · 2016: 9 · 2015: 10 · 2014: 10 · 2013: 12 · 2012: 13
- FWCI
- 12.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- chronic heart failure, soluble CD14, endotoxin, bacterial translocation, TNF-α, soluble TNF receptors, intracellular adhesion molecule-1, cytokines, immune activation
- MeSH terms
- Cardiac Output, Low, Chronic Disease, Female, Humans, Interferon-gamma, Interleukins, Male, Middle Aged, Tumor Necrosis Factor-alpha, Cytokines, Receptors, Tumor Necrosis Factor, Intercellular Adhesion Molecule-1, Lipopolysaccharide Receptors
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