Cited by 392Heart Failure Treatment and ManagementSepsis Diagnosis and TreatmentCardiac Fibrosis and Remodeling

Elevated soluble CD14 receptors and altered cytokines in chronic heart failure

Anker, Stefan D., Egerer, Karl R., Volk, Hans-Dieter, Kox, Wolfgang J., Poole-Wilson, Philip A., Coats, Andrew J.S.·1997·The American Journal of Cardiology

Abstract

We hypothesized that in patients with chronic heart failure mesenteric venous congestion leads to increased bowel permeability, bacterial translocation, and thereby endotoxin release; the increased endotoxin challenge then causes immune activation with increased soluble CD14 levels and tumor necrosis factor (TNF)-alpha production. Patients with high soluble CD14 levels (indicative of endotoxin-cell interaction) have markedly increased plasma levels of TNF-alpha, soluble TNF receptors 1 and 2, and intracellular adhesion molecule-1, supporting this hypothesis.

Integrity signals

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Crossref · 10.1016/s0002-9149(97)00159-8

Cites

21 of 21 references verified0 citation errors · 0 not checkable

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Authors
Anker, S. D., Egerer, K. R., Volk, H.-D., Kox, W. J., Poole-Wilson, P. A., & Coats, A. J. S.
Affiliations
Humboldt-Universität zu Berlin (DE)
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
1997-05
Volume
79
Issue
10
Pages
1426-1430
ISSN
0002-9149 (ISSN-L)
OpenAlex
W2071209404
Cited by
392
References
21
Citations by year
2026: 2 · 2025: 7 · 2024: 9 · 2023: 14 · 2022: 10 · 2021: 13 · 2020: 8 · 2019: 11 · 2018: 12 · 2017: 11 · 2016: 9 · 2015: 10 · 2014: 10 · 2013: 12 · 2012: 13
FWCI
12.46
Type
journal article
Language
en
Open access
closed
Locations
  • The American Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords
chronic heart failure, soluble CD14, endotoxin, bacterial translocation, TNF-α, soluble TNF receptors, intracellular adhesion molecule-1, cytokines, immune activation
MeSH terms
Cardiac Output, Low, Chronic Disease, Female, Humans, Interferon-gamma, Interleukins, Male, Middle Aged, Tumor Necrosis Factor-alpha, Cytokines, Receptors, Tumor Necrosis Factor, Intercellular Adhesion Molecule-1, Lipopolysaccharide Receptors

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