The DOI matches its Crossref record.
Endothelial aging
Abstract
Aging is considered to be the major risk factor for the development of atherosclerosis and, therefore, for coronary artery disease. Apart from age-associated remodeling of the vascular wall, which includes luminal enlargement, intimal and medial thickening, and increased vascular stiffness, endothelial function declines with age. This is most obvious from the attenuation of endothelium-dependent dilator responses, which is a consequence of the alteration in the expression and/or activity of the endothelial NO synthase, upregulation of the inducible NO synthase, and increased formation of reactive oxygen species. Aging is also associated with a reduction in the regenerative capacity of the endothelium and endothelial senescence, which is characterized by an increased rate of endothelial cell apoptosis.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“we used a well-established model for endothelial aging57,58 by generating human induced pluripotent stem cells (hiPSCs) from fibroblasts obtained from five independent human donors59 and subsequently differentiated them into endothelial cells (hiPSC-ECs)60.”
From An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging (2021) · cites this paper as [58]
Citations
Cited by
Sorted by citations
Satellite Cells and the Muscle Stem Cell Niche
Yin, H., Price, F., & Rudnicki, M. A. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2011 · Cited by 2,166
The intersection between aging and cardiovascular disease
North, B. J., & Sinclair, D. A. (2012) · Circulation Research · doi:10.1161/circresaha.111.246876 · Cited by 1,585
Ungvari, Z., Tarantini, S., Donato, A. J., Galvan, V., & Csiszar, A. (2018) · Circulation Research · doi:10.1161/circresaha.118.311378 · Cited by 919
Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture)
Félétou, M., & Vanhoutte, P. M. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00292.2006 · Cited by 818
“Senescent endothelial cells are altered morphologically, have an increased generation of reactive oxygen species, have a decreased production of NO, and are more sensitive to apoptotic stimuli (18, 82, 159).”
BackgroundAging and vascular endothelial function in humans
Seals, D. R., Jablonski, K. L., & Donato, A. J. (2011) · Clinical Science · doi:10.1042/cs20100476 · Cited by 725
Metadata
- Authors
- BRANDES, R., FLEMING, I., & BUSSE, R.
- Affiliations
- Goethe University Frankfurt (DE)
- Corresponding author
- BRANDES, R
- ORCID
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-05-01
- Volume
- 66
- Issue
- 2
- Pages
- 286-294
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W4256530495
- Cited by
- 563
- References
- 0
- Citations by year
- 2026: 13 · 2025: 19 · 2024: 23 · 2023: 23 · 2022: 38 · 2021: 31 · 2020: 27 · 2019: 26 · 2018: 20 · 2017: 26 · 2016: 32 · 2015: 33 · 2014: 35 · 2013: 25 · 2012: 41
- FWCI
- 12.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cardiovascular Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Keywords
- endothelial aging, endothelial function, atherosclerosis, coronary artery disease, nitric oxide synthase, inducible nitric oxide synthase, reactive oxygen species, endothelial cell senescence, endothelial cell apoptosis, vascular remodeling, vascular stiffness
- MeSH terms
- Aged, Aging, Coronary Disease, Endothelium, Vascular, Humans, Vasodilation, Cellular Senescence, Apoptosis, Reactive Oxygen Species, Oxidative Stress, Nitric Oxide Synthase, Nitric Oxide Synthase Type II, Nitric Oxide Synthase Type III
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
