Aging and vascular endothelial function in humans

Seals, Douglas R.; Jablonski, Kristen L.; Donato, Anthony J.

doi:10.1042/cs20100476

Cited by 725Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionCardiovascular and exercise physiology

Aging and vascular endothelial function in humans

Open access

Seals, Douglas R., Jablonski, Kristen L., Donato, Anthony J.·2011·Clinical Science

DOI 10.1042/cs20100476PMC PMC3482987

Open this paper in CoChat — free account

Abstract

Advancing age is the major risk factor for the development of CVD (cardiovascular diseases). This is attributable, in part, to the development of vascular endothelial dysfunction, as indicated by reduced peripheral artery EDD (endothelium-dependent dilation) in response to chemical [typically ACh (acetylcholine)] or mechanical (intravascular shear) stimuli. Reduced bioavailability of the endothelium-synthesized dilating molecule NO (nitric oxide) as a result of oxidative stress is the key mechanism mediating reduced EDD with aging. Vascular oxidative stress increases with age as a consequence of greater production of reactive oxygen species (e.g. superoxide) without a compensatory increase in antioxidant defences. Sources of increased superoxide production include up-regulation of the oxidant enzyme NADPH oxidase, uncoupling of the normally NO-producing enzyme, eNOS (endothelial NO synthase) (due to reduced availability of the cofactor tetrahydrobiopterin) and increased mitochondrial synthesis during oxidative phosphorylation. Increased bioactivity of the potent endothelial-derived constricting factor ET-1 (endothelin-1), reduced endothelial production of/responsiveness to dilatory prostaglandins, the development of vascular inflammation, formation of AGEs (advanced glycation end-products), an increased rate of endothelial apoptosis and reduced expression of oestrogen receptor α (in postmenopausal females) also probably contribute to impaired EDD with aging. Several lifestyle and biological factors modulate vascular endothelial function with aging, including regular aerobic exercise, dietary factors (e.g. processed compared with non-processed foods), body weight/fatness, vitamin D status, menopause/oestrogen deficiency and a number of conventional and non-conventional risk factors for CVD. Given the number of older adults now and in the future, more information is needed on effective strategies for the prevention and treatment of vascular endothelial aging.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1042/cs20100476

Cites

193 of 193 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Age-related declines in endothelial function and NO bioavailability can impair neurovascular coupling, resulting in reduced cerebral perfusion and cognitive decline.
“age-related declines in endothelial function and NO bioavailability can impair this process, resulting in reduced cerebral perfusion and cognitive decline [168,169].”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [168]
The Summary and Conclusions (page not provided) links age-associated endothelial dysfunction to reduced NO bioavailability. The paper discusses peripheral vascular dilation, but the passages do not establish that these changes impair neurovascular coupling or lead to reduced cerebral perfusion and cognitive decline. (LLM, conf=0.88)
Experimental — accuracy not yet measured
This leads to peroxynitrite formation and endothelial damage.
“which leads to peroxynitrite formation and endothelial damage [168,232].”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [168]
The Oxidative stress section says superoxide could react with nitric oxide to form peroxynitrite, which oxidizes BH4 and may impair endothelium-dependent dilation. It also reports markers of oxidant damage in vascular endothelial cells, but does not establish the unqualified claim that this pathway leads to endothelial damage. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Ageing is associated with reduced eNOS activity, increased arginase activity, and enhanced oxidative degradation of NO.
“Ageing is associated with reduced eNOS activity, increased arginase activity, and enhanced oxidative degradation of NO”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [168]
The NO bioavailability and Oxidative stress sections support reduced NO availability with ageing and increased removal of NO by superoxide. But the NO bioavailability section reports increased eNOS phosphorylation in healthy older humans, suggesting greater—not reduced—enzyme activation. The ADMA and arginase section reports increased arginase activity in some ageing rat arteries, not a general finding in humans. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Structural vascular changes (intimal thickening and reduced capillary density) can restrict NO signalling in advanced disease.
“structural vascular changes (e.g., intimal thickening and reduced capillary density) can restrict NO signalling in advanced disease [168,244].”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [168]
The NO bioavailability section reports reduced NO-mediated dilation with aging, but attributes it to altered NO production or removal, not structural vascular changes. Searches for intimal thickening, reduced capillary density, and related vascular-structure terms found no passage linking those changes to restricted NO signalling in advanced disease; our copy is not truncated. (LLM, conf=0.75)
Experimental — accuracy not yet measured
The compensatory nitrate-nitrite-NO pathway may be particularly important for older adults.
“This compensatory pathway may be particularly important for older adults”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [168]
The NO bioavailability section reports reduced NO availability with aging and suggests that increased eNOS activation may compensate for it. However, searches for nitrate, nitrite, and a compensatory nitrate–nitrite–NO pathway found no passage addressing whether that pathway is particularly important for older adults. (LLM, conf=0.75)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064 · see citing works
Heart Disease and Stroke Statistics—2012 Update: A Report From the American Heart Association
Writing Group Members, Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31823ac046 · Cited by 7,333 · see citing works
Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: A Statement for Healthcare Professionals From the Centers for Disease Control and Prevention and the American Heart Association
Pearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon, R. O., Criqui, M., Fadl, Y. Y., Fortmann, S. P., Hong, Y., Myers, G. L., et al. (2003) · Circulation · doi:10.1161/01.cir.0000052939.59093.45 · Cited by 6,401 · see citing works
Heart Disease and Stroke Statistics—2010 Update: A Report From the American Heart Association
WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R. J., Brown, T. M., Carnethon, M., Dai, S., De Simone, G., Ferguson, T. B., Ford, E., Furie, K., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.192667 · Cited by 5,700 · see citing works
HEART DISEASE AND STROKE STATISTICS–2014 UPDATE: A REPORT FROM THE AMERICAN HEART ASSOCIATION
Tarver, T. (2014) · Journal of Consumer Health on the Internet · doi:10.1080/15398285.2014.902284 · Cited by 5,595 · see citing works
Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
Celermajer, D. S., Sorensen, K. E., Gooch, V. M., Spiegelhalter, D. J., Miller, O. I., Sullivan, I. D., Lloyd, J. K., & Deanfield, J. E. (1992) · The Lancet · doi:10.1016/0140-6736(92)93147-f · Cited by 4,742 · see citing works
Endothelial Function and Dysfunction: Testing and Clinical Relevance
Deanfield, J. E., Halcox, J. P., & Rabelink, T. J. (2007) · Circulation · doi:10.1161/circulationaha.106.652859 · Cited by 2,710 · see citing works
Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries
Ludmer, P. L., Selwyn, A. P., Shook, T., Wayne, R. R., Mudge, G. H., Alexander, R. W., & Ganz, P. (1986) · New England Journal of Medicine · doi:10.1056/nejm198610233151702 · Cited by 2,422 · see citing works
Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension
Panza, J. A., Quyyumi, A. A., Brush, J. E., & Epstein, S. E. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007053230105 · Cited by 2,366 · see citing works
Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises: Part I: Aging Arteries: A “Set Up” for Vascular Disease
Lakatta, E. G., & Levy, D. (2003) · Circulation · doi:10.1161/01.cir.0000048892.83521.58 · Cited by 2,244 · see citing works
Endothelial Dysfunction
Bonetti, P. O., Lerman, L. O., & Lerman, A. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000051384.43104.fc · Cited by 2,199 · see citing works
Close Relation of Endothelial Function in the Human Coronary and Peripheral Circulations
Anderson, T. J., Uehata, A., Gerhard, M. D., Meredith, I. T., Knab, S., Delagrange, D., Lieberman, E. H., Ganz, P., Creager, M. A., Yeung, A. C., et al. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00327-4 · Cited by 2,033 · see citing works
Endothelial Dysfunction, Oxidative Stress, and Risk of Cardiovascular Events in Patients With Coronary Artery Disease
Heitzer, T., Schlinzig, T., Krohn, K., Meinertz, T., & Münzel, T. (2001) · Circulation · doi:10.1161/hc4601.099485 · Cited by 1,961 · see citing works
The clinical implications of endothelial dysfunction
Widlansky, M. E., Gokce, N., Keaney, J. F., & Vita, J. A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00994-x · Cited by 1,749 · see citing works
Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance
Steinberg, H. O., Chaker, H., Leaming, R., Johnson, A., Brechtel, G., & Baron, A. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118709 · Cited by 1,687 · see citing works
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
Landmesser, U., Dikalov, S., Price, S. R., McCann, L. A., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci14172 · Cited by 1,660 · see citing works
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
Landmesser, U., Dikalov, S., Price, S. R., McCann, L., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200314172 · Cited by 1,660 · see citing works
Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults.
Celermajer, D. S., Sørensen, K. E., Georgakopoulos, D., Bull, C., Thomas, O., Robinson, J. T. C., & Deanfield, J. E. (1993) · Circulation · doi:10.1161/01.cir.88.5.2149 · Cited by 1,532 · see citing works
Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors
Vásquez-Vivar, J., Kalyanaraman, B., Martásek, P., Hogg, N., Masters, B. S. S., Karoui, H., Tordo, P., & Pritchard, K. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9220 · Cited by 1,484 · see citing works
Prognostic Value of Coronary Vascular Endothelial Dysfunction
Halcox, J. P. J., Schenke, W. H., Zalos, G., Mincemoyer, R., Prasad, A., Waclawiw, M. A., Nour, K. R. A., & Quyyumi, A. A. (2002) · Circulation · doi:10.1161/01.cir.0000025404.78001.d8 · Cited by 1,385 · see citing works
Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women
Celermajer, D. S., Sørensen, K. E., Spiegelhalter, D. J., Georgakopoulos, D., Robinson, J. T. C., & Deanfield, J. E. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90305-0 · Cited by 1,334 · see citing works
Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease.
Vita, J. A., Treasure, C. B., Nabel, E. G., McLenachan, J. M., Fish, R. D., Yeung, A. C., Vekshtein, V. I., Selwyn, A. P., & Ganz, P. (1990) · Circulation · doi:10.1161/01.cir.81.2.491 · Cited by 1,172 · see citing works
Prognostic Significance of Endothelial Dysfunction in Hypertensive Patients
Perticone, F., Ceravolo, R., Pujia, A., Ventura, G., Iacopino, S., Scozzafava, A., Ferraro, A., Chello, M., Mastroroberto, P., Verdecchia, P., et al. (2001) · Circulation · doi:10.1161/01.cir.104.2.191 · Cited by 1,059 · see citing works
Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans.
Creager, M. A., Cooke, J. P., Mendelsohn, M. E., Gallagher, S. J., Coleman, S. M., Loscalzo, J., & Dzau, V. J. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114688 · Cited by 1,017 · see citing works
Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis.
Zeiher, A. M., Drexler, H., Wollschläger, H., & Just, H. (1991) · Circulation · doi:10.1161/01.cir.83.2.391 · Cited by 994 · see citing works
Crucial role of endothelium in the vasodilator response to increased flow in vivo.
Pohl, U., Holtz, J., Busse, R., & Bassenge, E. (1986) · Hypertension · doi:10.1161/01.hyp.8.1.37 · Cited by 984 · see citing works
Regular Aerobic Exercise Prevents and Restores Age-Related Declines in Endothelium-Dependent Vasodilation in Healthy Men
DeSouza, C. A., Shapiro, L. F., Clevenger, C. M., Dinenno, F. A., Monahan, K. D., Tanaka, H., & Seals, D. R. (2000) · Circulation · doi:10.1161/01.cir.102.12.1351 · Cited by 896 · see citing works
Self-citation
Brachial Flow-Mediated Dilation Predicts Incident Cardiovascular Events in Older Adults
Yeboah, J., Crouse, J. R., Hsu, F., Burke, G. L., & Herrington, D. M. (2007) · Circulation · doi:10.1161/circulationaha.106.678276 · Cited by 890 · see citing works
Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture)
Félétou, M., & Vanhoutte, P. M. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00292.2006 · Cited by 818 · see citing works
Risk Stratification for Postoperative Cardiovascular Events via Noninvasive Assessment of Endothelial Function
Gokce, N., Keaney, J. F., Hunter, L. M., Watkins, M. T., Menzoı́an, J. O., & Vita, J. A. (2002) · Circulation · doi:10.1161/01.cir.0000012543.55874.47 · Cited by 782 · see citing works
Endothelial Function
Vita, J. A., & Keaney, J. F. (2002) · Circulation · doi:10.1161/01.cir.0000028581.07992.56 · Cited by 743 · see citing works
Aging and Endothelial Function in Normotensive Subjects and Patients With Essential Hypertension
Taddei, S., Virdis, A., Mattei, P., Ghiadoni, L., Gennari, A., Fasolo, C. B., Sudano, I., & Salvetti, A. (1995) · Circulation · doi:10.1161/01.cir.91.7.1981 · Cited by 710 · see citing works
Estrogen Improves Endothelium-Dependent, Flow-Mediated Vasodilation in Postmenopausal Women
Lieberman, E. H., Gerhard, M. D., Uehata, A., Walsh, B. W., Selwyn, A. P., Ganz, P., Yeung, A. C., & Creager, M. A. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-121-12-199412150-00005 · Cited by 701 · see citing works
Aging and proinflammatory cytokines
Bruunsgaard, H., Pedersen, M., & Pedersen, B. K. (2001) · Current Opinion in Hematology · doi:10.1097/00062752-200105000-00001 · Cited by 690 · see citing works
Acetylcholine releases endothelium‐derived hyperpolarizing factor and EDRF from rat blood vessels
Chen, G., Suzuki, H., & Weston, A. H. (1988) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1988.tb11752.x · Cited by 688 · see citing works
Enhanced Peroxynitrite Formation Is Associated with Vascular Aging
van der Loo, B., Labugger, R., Skepper, J. N., Bachschmid, M. M., Kilo, J., Powell, J. M., Palacios‐Callender, M., Erusalimsky, J. D., Quaschning, T., Maliñski, T., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.12.1731 · Cited by 674 · see citing works
Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension.
Zeiher, A. M., Drexler, H., Saurbier, B., & Just, H. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116634 · Cited by 671 · see citing works
Ultrasound Assessment of Flow-Mediated Dilation
Harris, R. A., Nishiyama, S. K., Wray, D. W., & Richardson, R. S. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.150821 · Cited by 671 · see citing works
Age-Related Reduction of NO Availability and Oxidative Stress in Humans
Taddei, S., Virdis, A., Ghiadoni, L., Salvetti, G., Bernini, G., Magagna, A., & Salvetti, A. (2001) · Hypertension · doi:10.1161/01.hyp.38.2.274 · Cited by 664 · see citing works
Effects of the DASH Diet Alone and in Combination With Exercise and Weight Loss on Blood Pressure and Cardiovascular Biomarkers in Men and Women With High Blood Pressure
Blumenthal, J. A. (2010) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.470 · Cited by 591 · see citing works
Aging-Induced Phenotypic Changes and Oxidative Stress Impair Coronary Arteriolar Function
Csiszár, A., Ungvari, Z. I., Edwards, J. G., Kaminski, P. M., Wolin, M. S., Koller, Á., & Kaley, G. (2002) · Circulation Research · doi:10.1161/01.res.0000020401.61826.ea · Cited by 565 · see citing works
Endothelial Function Testing as a Biomarker of Vascular Disease
Verma, S., Buchanan, M. R., & Anderson, T. J. (2003) · Circulation · doi:10.1161/01.cir.0000089191.72957.ed · Cited by 565 · see citing works
Endothelial aging
BRANDES, R., FLEMING, I., & BUSSE, R. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.12.027 · Cited by 563 · see citing works
Direct Evidence of Endothelial Oxidative Stress With Aging in Humans
Donato, A. J., Eskurza, I., Silver, A., Levy, A., Pierce, G. L., Gates, P. E., & Seals, D. R. (2007) · Circulation Research · doi:10.1161/01.res.0000269183.13937.e8 · Cited by 558 · see citing works
Self-citation
Late prognostic value of flow-mediated dilation in the brachial artery of patients with chest pain
Neunteufl, T., Heher, S., Katzenschlager, R., Wölfl, G., Kostner, K., Maurer, G., & Weidinger, F. (2000) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)00857-2 · Cited by 553 · see citing works
Mechanisms of Vascular Aging: New Perspectives
Ungvari, Z. I., Kaley, G., de Cabo, R., Sonntag, W. E., & Csiszár, A. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq113 · Cited by 534 · see citing works
The importance of endothelin-1 for vascular dysfunction in cardiovascular disease
Böhm, F., & Pernow, J. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.06.004 · Cited by 518 · see citing works
Does accumulation of advanced glycation end products contribute to the aging phenotype?
Semba, R. D., Nicklett, E. J., & Ferrucci, L. (2010) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glq074 · Cited by 490 · see citing works
Arginase Reciprocally Regulates Nitric Oxide Synthase Activity and Contributes to Endothelial Dysfunction in Aging Blood Vessels
Berkowitz, D. E., White, R., Li, D., Minhas, K. M., Cernetich, A., Kim, S., Burke, S., Shoukas, A. A., Nyhan, D., Champion, H. C., et al. (2003) · Circulation · doi:10.1161/01.cir.0000092948.04444.c7 · Cited by 486 · see citing works
Menopause Is Associated With Endothelial Dysfunction in Women
Taddei, S., Virdis, A., Ghiadoni, L., Mattei, P., Sudano, I., Bernini, G., Pinto, S., & Salvetti, A. (1996) · Hypertension · doi:10.1161/01.hyp.28.4.576 · Cited by 472 · see citing works
Aging Progressively Impairs Endothelium-Dependent Vasodilation in Forearm Resistance Vessels of Humans
Gerhard, M. D., Roddy, M.-A., Creager, S. J., & Creager, M. A. (1996) · Hypertension · doi:10.1161/01.hyp.27.4.849 · Cited by 465 · see citing works
Physical Activity Prevents Age-Related Impairment in Nitric Oxide Availability in Elderly Athletes
Taddei, S., Galetta, F., Virdis, A., Ghiadoni, L., Salvetti, G., Franzoni, F., Giusti, C., & Salvetti, A. (2000) · Circulation · doi:10.1161/01.cir.101.25.2896 · Cited by 460 · see citing works
Endothelium-dependent flow-mediated vasodilation in coronary and brachial arteries in suspected coronary artery disease
Takase, B., Uehata, A., Akima, T., Nagai, T., Nishioka, T., Hamabe, A., Satomura, K., Ohsuzu, F., & Kurita, A. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00702-4 · Cited by 453 · see citing works
Inflammation and endothelial dysfunction during aging: role of NF-κB
Csiszar, A., Wang, M., Lakatta, E. G., & Ungvari, Z. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90470.2008 · Cited by 441 · see citing works
Superoxide Excess in Hypertension and Aging
Hamilton, C., Brosnan, M. J., McIntyre, M., Graham, D., & Dominiczak, A. F. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.529 · Cited by 438 · see citing works
Trunk Fat and Leg Fat Have Independent and Opposite Associations With Fasting and Postload Glucose Levels
Snijder, M. B., Dekker, J. M., Visser, M., Bouter, L. M., Stehouwer, C. D. A., Yudkin, J. S., Heine, R. J., Nijpels, G., & Seidell, J. C. (2004) · Diabetes Care · doi:10.2337/diacare.27.2.372 · Cited by 423 · see citing works
Atherosclerosis impairs flow-mediated dilation of coronary arteries in humans.
Cox, D. A., Vita, J. A., Treasure, C. B., Fish, R. D., Alexander, R. W., Ganz, P., & Selwyn, A. P. (1989) · Circulation · doi:10.1161/01.cir.80.3.458 · Cited by 413 · see citing works
Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans.
Egashira, K., Inou, T., Hirooka, Y., Kai, H., Sugimachi, M., Suzuki, S., Kuga, T., Urabe, Y., & Takeshita, A. (1993) · Circulation · doi:10.1161/01.cir.88.1.77 · Cited by 394 · see citing works
Habitual exercise and arterial aging
Seals, D. R., DeSouza, C. A., Donato, A. J., & Tanaka, H. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90553.2008 · Cited by 379 · see citing works
Self-citation
eNOS uncoupling and endothelial dysfunction in aged vessels
Yang, Y., Huang, A., Kaley, G., & Sun, D. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00230.2009 · Cited by 370 · see citing works
A Comparison of Three Different Methods to Evaluate Endothelium-Dependent Vasodilation in the Elderly
Lind, L., Fors, N., Hall, J., Marttala, K., & Stenborg, A. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000184769.22061.da · Cited by 364 · see citing works
25-Hydroxyvitamin D Deficiency Is Associated With Inflammation-Linked Vascular Endothelial Dysfunction in Middle-Aged and Older Adults
Jablonski, K., Chonchol, M., Pierce, G. L., Walker, A. E., & Seals, D. R. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.160929 · Cited by 360 · see citing works
Self-citation
Serum Total Cholesterol Concentrations and Awareness, Treatment, and Control of Hypercholesterolemia Among US Adults
Ford, E. S., Mokdad, A. H., Giles, W. H., & Mensah, G. A. (2003) · Circulation · doi:10.1161/01.cir.0000066320.27195.b4 · Cited by 355 · see citing works
Venous occlusion plethysmography in cardiovascular research: methodology and clinical applications
Wilkinson, I. B., & Webb, D. J. (2001) · British Journal of Clinical Pharmacology · doi:10.1046/j.0306-5251.2001.01495.x · Cited by 355 · see citing works
Increased mitochondrial H 2 O 2 production promotes endothelial NF-κB activation in aged rat arteries
Ungvari, Z. I., Orosz, Z. Z., Labinskyy, N., Rivera, A., Xiangmin, Z., Smith, K. E., & Csiszár, A. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01346.2006 · Cited by 348 · see citing works
Effect of acute and chronic ascorbic acid on flow‐mediated dilatation with sedentary and physically active human ageing
Eskurza, I., Monahan, K. D., Robinson, J. A., & Seals, D. R. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.057042 · Cited by 341 · see citing works
Self-citation
Obesity and Body Fat Distribution Induce Endothelial Dysfunction by Oxidative Stress
Perticone, F., Ceravolo, R., Candigliota, M., Ventura, G., Iacopino, S., Sinopoli, F., & Mattioli, P. L. (2001) · Diabetes · doi:10.2337/diabetes.50.1.159 · Cited by 336 · see citing works
Role of shear stress and endothelial prostaglandins in flow- and viscosity-induced dilation of arterioles in vitro.
Koller, Á., Sun, D., & Kaley, G. (1993) · Circulation Research · doi:10.1161/01.res.72.6.1276 · Cited by 331 · see citing works
Responses of angiographically normal human coronary arteries to intracoronary injection of acetylcholine by age and segment. Possible role of early coronary atherosclerosis.
Yasue, H., Matsuyama, K., Matsuyama, K., Okumura, K., Morikami, Y., & Ogawa, H. (1990) · Circulation · doi:10.1161/01.cir.81.2.482 · Cited by 324 · see citing works
Hot Flashes and Subclinical Cardiovascular Disease
Thurston, R. C., Sutton-Tyrrell, K., Everson‐Rose, S. A., Hess, R., & Matthews, K. A. (2008) · Circulation · doi:10.1161/circulationaha.108.776823 · Cited by 323 · see citing works
Flow-induced vasodilation of the human brachial artery is impaired in patients < 40 years of age with coronary artery disease
Lieberman, E. H., Gerhard, M. D., Uehata, A., Selwyn, A. P., Ganz, P., Yeung, A. C., & Creager, M. A. (1996) · The American Journal of Cardiology · doi:10.1016/s0002-9149(96)00597-8 · Cited by 318 · see citing works
Vascular endothelial dysfunction with aging: endothelin-1 and endothelial nitric oxide synthase
Donato, A. J., Gano, L. B., Eskurza, I., Silver, A., Gates, P. E., Jablonski, K., & Seals, D. R. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00689.2008 · Cited by 318 · see citing works
Self-citation
Hypertension Causes Premature Aging of Endothelial Function in Humans
Taddei, S., Virdis, A., Mattei, P., Ghiadoni, L., Fasolo, C. B., Sudano, I., & Salvetti, A. (1997) · Hypertension · doi:10.1161/01.hyp.29.3.736 · Cited by 315 · see citing works
Endothelial Function Predicts Progression of Carotid Intima-Media Thickness
Halcox, J., Donald, A. E., Ellins, E. A., Witte, D. R., Shipley, M. J., Brunner, E. J., Marmot, M. G., & Deanfield, J. E. (2009) · Circulation · doi:10.1161/circulationaha.108.765701 · Cited by 315 · see citing works
Expression of Constitutive and Inducible Nitric Oxide Synthases in the Vascular Wall of Young and Aging Rats
Cernadas, M. R., de Miguel, L. S., Garcı́a-Durán, M., González-Fernández, F., Millás, I., Montón, M., Rodrigo, J., Rico, L., Fernández, A. P., de Frutos, T., et al. (1998) · Circulation Research · doi:10.1161/01.res.83.3.279 · Cited by 310 · see citing works
Deletion of p66 <sup>shc</sup> Gene Protects Against Age-Related Endothelial Dysfunction
Francia, P., delli Gatti, C., Bachschmid, M., Martin-Padura, I., Savoia, C., Migliaccio, E., Pelicci, P. G., Schiavoni, M., Lüscher, T. F., Volpe, M., et al. (2004) · Circulation · doi:10.1161/01.cir.0000147731.24444.4d · Cited by 298 · see citing works
Estradiol Therapy Combined With Progesterone and Endothelium-Dependent Vasodilation in Postmenopausal Women
Gerhard, M. D., Walsh, B. W., Tawakol, A. A., Haley, E. A., Creager, S. J., Seely, E. W., Ganz, P., & Creager, M. A. (1998) · Circulation · doi:10.1161/01.cir.98.12.1158 · Cited by 296 · see citing works
Call to Action on Use and Reimbursement for Home Blood Pressure Monitoring: Executive Summary: A Joint Scientific Statement From the American Heart Association, American Society of Hypertension, and Preventive Cardiovascular Nurses Association
Pickering, T. G., Miller, N. H., Ogedegbe, G., Krakoff, L. R., Artinian, N. T., & Goff, D. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.189011 · Cited by 294 · see citing works
Peripheral Adiposity Exhibits an Independent Dominant Antiatherogenic Effect in Elderly Women
Tankó, L. B., Bagger, Y. Z., Alexandersen, P., Larsen, P. J., & Christiansen, C. (2003) · Circulation · doi:10.1161/01.cir.0000057974.74060.68 · Cited by 270 · see citing works
Proinflammatory Profile Within the Grossly Normal Aged Human Aortic Wall
Wang, M., Zhang, J., Jiang, L.-Q., Spinetti, G., Pintus, G., Monticone, R. E., Kolodgie, F. D., Virmani, R., & Lakatta, E. G. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.089409 · Cited by 269 · see citing works
Aging‐induced proinflammatory shift in cytokine expression profile in rat coronary arteries
Csiszár, A., Ungvari, Z. I., Koller, Á., Edwards, J. G., & Kaley, G. (2003) · The FASEB Journal · doi:10.1096/fj.02-1049fje · Cited by 266 · see citing works
Nuclear Factor-κB Activation Contributes to Vascular Endothelial Dysfunction via Oxidative Stress in Overweight/Obese Middle-Aged and Older Humans
Pierce, G. L., Lesniewski, L. A., Lawson, B. R., Beske, S. D., & Seals, D. R. (2009) · Circulation · doi:10.1161/circulationaha.108.804294 · Cited by 262 · see citing works
Self-citation
Effect of age on kinetics of nitric oxide release in rat aorta and pulmonary artery.
Tschudi, M. R., Barton, M., Bersinger, N. A., Moreau, P. R., Cosentino, F., Noll, G., Maliñski, T., & Lüscher, T. F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118872 · Cited by 260 · see citing works
Body fat distribution predicts the degree of endothelial dysfunction in uncomplicated obesity
Arcaro, G., Zamboni, M. M., Rossi, L., Turcato, E., Covi, G., Armellini, F., Bosello, O., & Lechi, A. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0801022 · Cited by 258 · see citing works
Prognostic Value of Systemic Endothelial Dysfunction in Patients With Acute Coronary Syndromes
Fichtlscherer, S., Breuer, S., & Zeiher, A. M. (2004) · Circulation · doi:10.1161/01.cir.0000143378.58099.8c · Cited by 251 · see citing works
Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1
Csiszár, A., Labinskyy, N., Jiménez, R., Pinto, J. T., Ballabh, P., Losonczy, G., Pearson, K. J., de Cabo, R., & Ungvari, Z. I. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.06.004 · Cited by 248 · see citing works
Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down‐regulation of NADPH oxidase
Durrant, J., Seals, D. R., Connell, M. L., Russell, M. J., Lawson, B. R., Folian, B. J., Donato, A. J., & Lesniewski, L. A. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.169771 · Cited by 244 · see citing works
Self-citation
Mechanisms Underlying Caloric Restriction and Lifespan Regulation
Ungvari, Z. I., Parrado‐Fernández, C., Csiszár, A., & de Cabo, R. (2008) · Circulation Research · doi:10.1161/circresaha.107.168369 · Cited by 239 · see citing works
Aging impairs endothelium-dependent vasodilation in rat skeletal muscle arterioles
Muller‐Delp, J. M., Spier, S. A., Ramsey, M. W., & Delp, M. D. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00004.2002 · Cited by 238 · see citing works
Aging is associated with greater nuclear NFκB, reduced IκBα, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans
Donato, A. J., Black, A. D., Jablonski, K. L., Gano, L. B., & Seals, D. R. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00438.x · Cited by 237 · see citing works
Self-citation
Aging Increases Aortic MMP-2 Activity and Angiotensin II in Nonhuman Primates
Wang, M., Takagi, G., Asai, K., Resuello, R. G., Natividad, F. F., Vatner, D. E., Vatner, S. F., & Lakatta, E. G. (2003) · Hypertension · doi:10.1161/01.hyp.0000073843.56046.45 · Cited by 235 · see citing works
Changes in biomechanical properties, composition of collagen and elastin, and advanced glycation endproducts of the rat aorta in relation to age
Brüel, A., & Oxlund, H. (1996) · Atherosclerosis · doi:10.1016/s0021-9150(96)05947-3 · Cited by 232 · see citing works
Long-term association of brachial artery flow-mediated vasodilation and cardiovascular events in middle-aged subjects with no apparent heart disease
Shechter, M., Issachar, A., Marai, I., Koren‐Morag, N., Freinark, D., Shahar, Y., Shechter, A., & Feinberg, M. S. (2008) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.01.021 · Cited by 231 · see citing works
Anatomic Heterogeneity of Vascular Aging
Barton, M., Cosentino, F., Brandes, R. P., Moreau, P. R., Shaw, S., & Lüscher, T. F. (1997) · Hypertension · doi:10.1161/01.hyp.30.4.817 · Cited by 222 · see citing works
Aging and plasminogen activator inhibitor-1 (PAI-1) regulation: implication in the pathogenesis of thrombotic disorders in the elderly
YAMAMOTO, K., TAKESHITA, K., KOJIMA, T., TAKAMATSU, J., & SAITO, H. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.11.013 · Cited by 214 · see citing works
Vasculoprotective Effects of Anti-Tumor Necrosis Factor-α Treatment in Aging
Csiszár, A., Labinskyy, N., Smith, K. E., Rivera, A., Orosz, Z. Z., & Ungvari, Z. I. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060708 · Cited by 214 · see citing works
Effects of ageing and exercise training on endothelium‐dependent vasodilatation and structure of rat skeletal muscle arterioles
Spier, S. A., Delp, M. D., Meininger, C. J., Donato, A. J., Ramsey, M. W., & Muller‐Delp, J. M. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.060301 · Cited by 209 · see citing works
Self-citation
Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension
Zieman, S. J., Melenovský, V., Clattenburg, L., Corretti, M. C., Capriotti, A. R., Gerstenblith, G., & Kass, D. A. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e328013e7dd · Cited by 209 · see citing works
Sex-specific effects of habitual aerobic exercise on brachial artery flow-mediated dilation in middle-aged and older adults
Pierce, G. L., Eskurza, I., Walker, A. E., Fay, T. N., & Seals, D. R. (2010) · Clinical Science · doi:10.1042/cs20100174 · Cited by 209 · see citing works
Self-citation
Impact of age, sex, and exercise on brachial artery flow-mediated dilatation
Black, M. A., Cable, N. T., Thijssen, D. H. J., & GREEN, D. J. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00226.2009 · Cited by 205 · see citing works
Brachial Artery Vasodilator Function and Systemic Inflammation in the Framingham Offspring Study
Vita, J. A., Keaney, J. F., Larson, M. G., Keyes, M. J., Massaro, J. M., Lipinska, I., Lehman, B. T., Fan, S., Osypiuk, E. W., Wilson, P. W. F., et al. (2004) · Circulation · doi:10.1161/01.cir.0000148821.97162.5e · Cited by 204 · see citing works
Oral L-arginine improves endothelial function in healthy individuals older than 70 years
Bode‐Böger, S. M., Muke, J., Surdacki, A., Brabant, G. E., Böger, R. H., & Frölich, J. C. (2003) · Vascular Medicine · doi:10.1191/1358863x03vm474oa · Cited by 198 · see citing works
Endothelial function and inflammation in coronary artery disease
Tousoulis, D., Charakida, M., & Stefanadis, C. (2005) · Postgraduate Medical Journal · doi:10.1136/hrt.2005.066936 · Cited by 195 · see citing works
Vascular Endothelial Estrogen Receptor α Is Modulated by Estrogen Status and Related to Endothelial Function and Endothelial Nitric Oxide Synthase in Healthy Women
Gavin, K. M., Seals, D. R., Silver, A., & Moreau, K. L. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0278 · Cited by 195 · see citing works
Self-citation
Physical activity, plasma antioxidant capacity, and endothelium-dependent vasodilation in young and older men
Franzoni, F., Ghiadoni, L., Galetta, F., PLANTINGA, Y., Lubrano, V., Huang, Y., Salvetti, G., Regoli, F., Taddei, S., & Santoro, G. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.11.006 · Cited by 193 · see citing works
Peripheral Vascular Endothelial Dysfunction and Apoptosis in Old Monkeys
Asai, K., Kudej, R. K., Shen, Y.-T., Yang, G.-P., Takagi, G., Kudej, A. B., Geng, Y., Sato, N., Nazareno, J. B., Vatner, D. E., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1493 · Cited by 189 · see citing works
Randomized, Double-Blind, Placebo-Controlled Study on Effects of Raloxifene and Hormone Replacement Therapy on Plasma NO Concentrations, Endothelin-1 Levels, and Endothelium-Dependent Vasodilation in Postmenopausal Women
Saitta, A., Altavilla, D., Cucinotta, D., Morabito, N., Frisina, N., Corrado, F., D’Anna, R., Lasco, A., Squadrito, G., Gaudio, A., et al. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0901.095565 · Cited by 188 · see citing works
Inducible NO Synthase–DependentS-Nitrosylation and Activation of Arginase1 Contribute to Age-Related Endothelial Dysfunction
Santhanam, L., Lim, H. K., Lim, H. K., Miriel, V. A., Brown, T. R., Patel, M. D., Balanson, S., Ryoo, S., Anderson, M., Irani, K., et al. (2007) · Circulation Research · doi:10.1161/circresaha.107.157727 · Cited by 184 · see citing works
Gene expression changes of prostanoid synthases in endothelial cells and prostanoid receptors in vascular smooth muscle cells caused by aging and hypertension
Tang, E. H. C., & Vanhoutte, P. M. (2007) · Physiological Genomics · doi:10.1152/physiolgenomics.00136.2007 · Cited by 182 · see citing works
Knockdown of Arginase I Restores NO Signaling in the Vasculature of Old Rats
White, A. R., Ryoo, S., Li, D., Champion, H. C., Steppan, J., Wang, D., Nyhan, D. P., Shoukas, A. A., Hare, J. M., & Berkowitz, D. E. (2005) · Hypertension · doi:10.1161/01.hyp.0000198543.34502.d7 · Cited by 179 · see citing works
Regional fat distribution in women and risk of cardiovascular disease
Williams, M., Hunter, G., Kekes-Szabo, T., Snyder, S., & Treuth, M. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.3.855 · Cited by 178 · see citing works
From Belfast to Mayo and beyond: the use and future of plethysmography to study blood flow in human limbs
Joyner, M. J., Dietz, N. M., & Shepherd, J. T. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.6.2431 · Cited by 177 · see citing works
Habitual exercise and vascular ageing
Seals, D. R., Walker, A. E., Pierce, G. L., & Lesniewski, L. A. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.178822 · Cited by 173 · see citing works
Self-citation
Mechanisms Responsible for Endothelial Dysfunction Associated With Acute Estrogen Deprivation in Normotensive Women
Virdis, A., Ghiadoni, L., Pinto, S., Lombardo, M., Petraglia, F., Gennazzani, A., Buralli, S., Taddei, S., & Salvetti, A. (2000) · Circulation · doi:10.1161/01.cir.101.19.2258 · Cited by 173 · see citing works
Tetrahydrobiopterin augments endothelium‐dependent dilatation in sedentary but not in habitually exercising older adults
Eskurza, I., Myerburgh, L. A., Kahn, Z. D., & Seals, D. R. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.092734 · Cited by 172 · see citing works
Self-citation
Reactive Oxygen Species Mediate Endothelium-Dependent Relaxations in Tetrahydrobiopterin-Deficient Mice
Cosentino, F., Barker, J. E., Brand, M. P., Heales, S., Werner, E. R., Tippins, J. R., West, N. E. J., Channon, K. M., Volpe, M., & Lüscher, T. F. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.4.496 · Cited by 171 · see citing works
Reduced release of nitric oxide to shear stress in mesenteric arteries of aged rats
Sun, D., Huang, A., Yan, E. H., Wu, Z., Yan, C., Kaminski, P. M., Oury, T. D., Wolin, M. S., & Kaley, G. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00854.2003 · Cited by 167 · see citing works
Endothelin-1 Vasoconstrictor Tone Increases With Age in Healthy Men But Can Be Reduced by Regular Aerobic Exercise
Guilder, G. P. V., Westby, C. M., Greiner, J. J., Stauffer, B. L., & DeSouza, C. A. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.088294 · Cited by 167 · see citing works
Weight Loss Alone Improves Conduit and Resistance Artery Endothelial Function in Young and Older Overweight/Obese Adults
Pierce, G. L., Beske, S. D., Lawson, B. R., Southall, K. L., Benay, F. J., Donato, A. J., & Seals, D. R. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.111427 · Cited by 167 · see citing works
Self-citation
Arginase and vascular aging
Santhanam, L., Christianson, D. W., Nyhan, D. P., & Berkowitz, D. E. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90627.2008 · Cited by 166 · see citing works
Tetrahydrobiopterin-dependent formation of endothelium-derived relaxing factor (nitric oxide) in aortic endothelial cells
Schmidt, K., Werner, E. R., Mayer, B., WACHTER, H., & Kukovetz, W. R. (1992) · Biochemical Journal · doi:10.1042/bj2810297 · Cited by 164 · see citing works
Endothelial Apoptosis
Štefanec, T. (2000) · CHEST Journal · doi:10.1378/chest.117.3.841 · Cited by 163 · see citing works
Dietary Intake of Fruits and Vegetables Improves Microvascular Function in Hypertensive Subjects in a Dose-Dependent Manner
McCall, D. O., McGartland, C. P., McKinley, M. C., Patterson, C. C., Sharpe, P., McCance, D. R., Young, I. S., & Woodside, J. V. (2009) · Circulation · doi:10.1161/circulationaha.108.831297 · Cited by 161 · see citing works
Ageing diminishes endothelium‐dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles
Delp, M. D., Behnke, B. J., Spier, S. A., Wu, G., & Muller‐Delp, J. M. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.147686 · Cited by 160 · see citing works
Short‐term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress
Rippe, C., Lesniewski, L. A., Connell, M. L., LaRocca, T. J., Donato, A. J., & Seals, D. R. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00557.x · Cited by 158 · see citing works
Self-citation
Effects of ageing and exercise training on eNOS uncoupling in skeletal muscle resistance arterioles
Sindler, A. L., Delp, M. D., Reyes, R., Wu, G., & Muller‐Delp, J. M. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.172221 · Cited by 156 · see citing works
Combined Hormone Replacement Therapy Does Not Protect Women Against the Age-Related Decline in Endothelium-Dependent Vasomotor Function
Sørensen, K. E., Dørup, I., Hermann, A. P., & Mosekilde, L. (1998) · Circulation · doi:10.1161/01.cir.97.13.1234 · Cited by 151 · see citing works
Endothelial Function, But Not Carotid Intima-Media Thickness, Is Affected Early in Menopause and Is Associated with Severity of Hot Flushes
Bechlioulis, A., Kalantaridou, S., Naka, K. Κ., Chatzikyriakidou, A., Calis, K. A., Makrigiannakis, A., Papanikolaou, O., Kaponis, A. I., Katsouras, C. S., Georgiou, I. A., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2262 · Cited by 146 · see citing works
Effects of a low-salt diet on flow-mediated dilatation in humans
Dickinson, K. M., Keogh, J. B., & Clifton, P. M. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26856 · Cited by 145 · see citing works
Methods for Evaluating Endothelial Function in Humans
Barac, A., Campia, U., & Panza, J. A. (2007) · Hypertension · doi:10.1161/01.hyp.0000259601.38807.a6 · Cited by 142 · see citing works
Mechanisms of estrogen action in the cardiovascular system
Mendelsohn, M. E. (2000) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(00)00110-2 · Cited by 140 · see citing works
Estrogen Replacement and Brachial Artery Flow-Mediated Vasodilation in Older Women
Herrington, D. M., Espeland, M. A., Crouse, J. R., Robertson, J., Riley, W. A., McBurnie, M. A., & Burke, G. L. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq1201.100241 · Cited by 140 · see citing works
Effects of the Menopause, Gender, and Estrogen Replacement Therapy on Vascular Nitric Oxide Activity
Majmudar, N. G., Robson, S. C., & Ford, G. A. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.4.6530 · Cited by 140 · see citing works
Effects of estrogen replacement therapy on peripheral vasomotor function in postmenopausal women
Gilligan, D. M., Badar, D. M., Panza, J. A., Quyyumi, A. A., & Cannon, R. O. (1995) · The American Journal of Cardiology · doi:10.1016/0002-9149(95)80033-o · Cited by 137 · see citing works
The endothelium: a new target for therapy
Cooke, J. P. (2000) · Vascular Medicine · doi:10.1177/1358836x0000500108 · Cited by 132 · see citing works
Effect of resistance training on arterial wave reflection and brachial artery reactivity in normotensive postmenopausal women
Casey, D. P., Pierce, G. L., Howe, K. S., Mering, M. C., & Braith, R. W. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0447-2 · Cited by 128 · see citing works
Aging induces muscle-specific impairment of endothelium-dependent dilation in skeletal muscle feed arteries
Woodman, C. R., Price, E. M., & Laughlin, M. H. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00461.2002 · Cited by 119 · see citing works
Differential Effects of Oral and Transdermal Estrogen Replacement Therapy on Endothelial Function in Postmenopausal Women
Vehkavaara, S., Hakala‐Ala‐Pietilä, T., Virkamäki, A., Bergholm, R., Ehnholm, C., Hovatta, O., Taskinen, M., & Yki‐Järvinen, H. (2000) · Circulation · doi:10.1161/01.cir.102.22.2687 · Cited by 119 · see citing works
Does arterial shear explain the magnitude of flow-mediated dilation?: a comparison between young and older humans
Thijssen, D. H. J., Bullens, L. M., van Bemmel, M. M., Dawson, E. A., Hopkins, N. D., Tinken, T. M., Black, M. A., Hopman, M. T. E., Cable, N. T., & GREEN, D. J. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00980.2008 · Cited by 117 · see citing works
Testing for endothelial dysfunction
Raitakari, O. T., & Celermajer, D. S. (2000) · Annals of Medicine · doi:10.3109/07853890008995931 · Cited by 116 · see citing works
Reduced Nitric Oxide Causes Age-Associated Impairment of Circadian Rhythmicity
Kunieda, T., Minamino, T., Miura, K., Katsuno, T., Tateno, K., Miyauchi, H., Kaneko, S., Bradfield, C. A., FitzGerald, G. A., & Komuro, I. (2008) · Circulation Research · doi:10.1161/circresaha.107.162230 · Cited by 115 · see citing works
Endothelial Dysfunction and Subsequent Decline in Glomerular Filtration Rate in Hypertensive Patients
Perticone, F., Maio, R., Perticone, M., Sciacqua, A., Shehaj, E., Naccarato, P., & Sesti, G. (2010) · Circulation · doi:10.1161/circulationaha.110.940932 · Cited by 111 · see citing works
Tetrahydrobiopterin improves aging-related impairment of endothelium-dependent vasodilation through increase in nitric oxide production
Higashi, Y., Sasaki, S., Nakagawa, K., Kimura, M., Noma, K., Hara, K., Jitsuiki, D., Goto, C., Oshima, T., Chayama, K., et al. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.07.025 · Cited by 109 · see citing works
Ageing is associated with impairment of nitric oxide and prostanoid dilator pathways in the human forearm
Singh, N., Prasad, S., Singer, D. R. J., & ALLISTER, R. J. M. (2002) · Clinical Science · doi:10.1042/cs1020595 · Cited by 107 · see citing works
Impaired flow-mediated dilation with age is not explained by l -arginine bioavailability or endothelial asymmetric dimethylarginine protein expression
Gates, P. E., Boucher, M. L., Silver, A., Monahan, K. D., & Seals, D. R. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00660.2006 · Cited by 107 · see citing works
Self-citation
Endogenous Estrogen and Acetylcholine-Induced Vasodilation in Normotensive Women
Pinto, S., Virdis, A., Ghiadoni, L., Bernini, G., Lombardo, M., Petraglia, F., Genazzani, A. R., Taddei, S., & Salvetti, A. (1997) · Hypertension · doi:10.1161/01.hyp.29.1.268 · Cited by 106 · see citing works
Mechanisms of aging-induced impairment of endothelium-dependent relaxation: role of tetrahydrobiopterin
Blackwell, K. A., Sorenson, J. P., Richardson, D. M., Smith, L. A., Suda, O., Nath, K. A., & Katušić, Z. S. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00248.2004 · Cited by 106 · see citing works
Circulating and cellular markers of endothelial dysfunction with aging in rats
Challah, M., Nadaud, S., Philippe, M., Battle, T., Soubrier, F., Corman, B., & Michel, J. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.4.h1941 · Cited by 104 · see citing works
Flow-mediated dilatation in human circulation: diagnostic and therapeutic aspects
Kelm, M. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2002.282.1.h1 · Cited by 104 · see citing works
Aging and Severity of Hypertension Attenuate Endothelium-Dependent Renal Vascular Relaxation in Humans
Higashi, Y., Oshima, T., Ozono, R., Matsuura, H., & Kajiyama, G. (1997) · Hypertension · doi:10.1161/01.hyp.30.2.252 · Cited by 102 · see citing works
Effect of Medroxyprogesterone Acetate on Endothelium-Dependent Vasodilation in Postmenopausal Women Receiving Estrogen
Wakatsuki, A., Okatani, Y., Ikenoue, N., & Fukaya, T. (2001) · Circulation · doi:10.1161/hc4001.097035 · Cited by 99 · see citing works
Xanthine oxidase does not contribute to impaired peripheral conduit artery endothelium‐dependent dilatation with ageing
Eskurza, I., Kahn, Z. D., & Seals, D. R. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.102566 · Cited by 98 · see citing works
Self-citation
Pick your Poiseuille: normalizing the shear stimulus in studies of flow-mediated dilation
Parker, B. A., Trehearn, T. L., & Meendering, J. R. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91302.2009 · Cited by 98 · see citing works
Age Moderates the Short-Term Effects of Transdermal 17β-Estradiol on Endothelium-Dependent Vascular Function in Postmenopausal Women
Sherwood, A., Bower, J. K., McFetridge-Durdle, J., Blumenthal, J. A., Newby, L. K., & Hinderliter, A. L. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.145383 · Cited by 97 · see citing works
Time Since Menopause Influences the Acute and Chronic Effect of Estrogens on Endothelial Function
Vitale, C., Mercuro, G. G., Cerquetani, E., Marazzi, G., Patrizi, R., Pelliccia, F., Volterrani, M., Fini, M., Collins, P. D., & Rosano, G. M. C. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.158634 · Cited by 96 · see citing works
Enhanced endothelin-1-mediated leg vascular tone in healthy older subjects
Thijssen, D. H. J., Rongen, G. A. P. J. M., van Dijk, A. P. J., Smits, P., & Hopman, M. T. E. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00357.2007 · Cited by 93 · see citing works
Shear stress induces eNOS mRNA expression and improves endothelium-dependent dilation in senescent soleus muscle feed arteries
Woodman, C. R., Price, E. M., & Laughlin, M. H. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00408.2004 · Cited by 92 · see citing works
B6D2F1 Mice Are a Suitable Model of Oxidative Stress-Mediated Impaired Endothelium-Dependent Dilation With Aging
Lesniewski, L. A., Connell, M., Durrant, J., Folian, B. J., Anderson, M. C., Donato, A. J., & Seals, D. R. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln049 · Cited by 91 · see citing works
Self-citation
Arterial Destiffening With Atorvastatin in Overweight and Obese Middle-Aged and Older Adults
Orr, J. S., Dengo, A. L., Rivero, J. M., & Davy, K. P. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.138248 · Cited by 83 · see citing works
Aging Is Associated With Reduced Prostacyclin-Mediated Dilation in the Human Forearm
Nicholson, W. T., Stelling, B. E. V., Hesse, C., Eisenach, J. H., & Joyner, M. J. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.121483 · Cited by 81 · see citing works
Sedentary aging increases resting and exercise-induced intramuscular free radical formation
Bailey, D. M., McEneny, J., Mathieu-Costello, O. A., Henry, R. R., James, P. E., McCord, J. M., Pietri, S., Young, I. S., & Richardson, R. S. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00354.2010 · Cited by 80 · see citing works
Heterogeneous vasodilator responses of human limbs: influence of age and habitual endurance training
Newcomer, S. C., Leuenberger, U. A., Hogeman, C. S., & Proctor, D. N. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01151.2004 · Cited by 77 · see citing works
Evidence for agonist‐specific endothelial vasodilator dysfunction with ageing in healthy humans
DeSouza, C. A., Clevenger, C. M., Greiner, J. J., Smith, D. T., Hoetzer, G. L., Manning, L. S., & Stauffer, B. L. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.019166 · Cited by 76 · see citing works
Aging affects vascular structure and function in a limb-specific manner
Nishiyama, S. K., Wray, D. W., & Richardson, R. S. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90612.2008 · Cited by 75 · see citing works
Short-Term Estrogen Augments Both Nitric Oxide-Mediated and Non-Nitric Oxide-Mediated Endothelium-Dependent Forearm Vasodilation in Postmenopausal Women
Tagawa, H., Shimokawa, H., Tagawa, T., Kuroiwa‐Matsumoto, M., Hirooka, Y., & Takeshita, A. (1997) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199710000-00012 · Cited by 74 · see citing works
Exercise training reverses age-related decrements in endothelium-dependent dilation in skeletal muscle feed arteries
Trott, D. W., Gündüz, F., Laughlin, M. H., & Woodman, C. R. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91232.2008 · Cited by 73 · see citing works
Pharmacologic versus flow-mediated assessments of peripheral vascular endothelial vasodilatory function in humans
Eskurza, I., Seals, D. R., DeSouza, C. A., & Tanaka, H. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)01997-x · Cited by 71 · see citing works
Self-citation
Increased Endothelial Exocytosis and Generation of Endothelin-1 Contributes to Constriction of Aged Arteries
Goel, A., Su, B. Y., Flavahan, S., Lowenstein, C. J., Berkowitz, D. E., & Flavahan, N. A. (2010) · Circulation Research · doi:10.1161/circresaha.109.210229 · Cited by 65 · see citing works
Selected Contribution: Aging impairs nitric oxide and prostacyclin mediation of endothelium-dependent dilation in soleus feed arteries
Woodman, C. R., Price, E. M., & Laughlin, M. H. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01073.2002 · Cited by 62 · see citing works
Aging Increases PGHS-2–Dependent Vasoconstriction in Rat Mesenteric Arteries
Stewart, K., Zhang, Y., & Davidge, S. T. (2000) · Hypertension · doi:10.1161/01.hyp.35.6.1242 · Cited by 59 · see citing works
Gene transfer of extracellular superoxide dismutase protects against vascular dysfunction with aging
Brown, K. A., Chu, Y., Lund, D. D., Heistad, D. D., & Faraci, F. M. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00676.2005 · Cited by 57 · see citing works
Low dietary sodium intake is associated with enhanced vascular endothelial function in middle-aged and older adults with elevated systolic blood pressure
Jablonski, K., Gates, P. E., Pierce, G. L., & Seals, D. R. (2009) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944709345790 · Cited by 52 · see citing works
Self-citation
Effect of losartan in aging-related endothelial impairment
Rajagopalan, S., Brook, R. D., Mehta, R. H., Supiano, M. A., & Pitt, B. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)02297-4 · Cited by 51 · see citing works
The L-arginine: nitric oxide pathway, cellular transduction and immunological roles.
Moncada, S. (1993) · PubMed · Cited by 49 · see citing works
Effects of a 'healthy' diet and of acute and long-term vitamin C on vascular function in healthy older subjects
Singh, N. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00514-x · Cited by 48 · see citing works
Modulation of Vascular Endothelial Function by Low-Density Lipoprotein Cholesterol With Aging: Influence of Habitual Exercise
Walker, A. E., Eskurza, I., Pierce, G. L., Gates, P. E., & Seals, D. R. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2008.353 · Cited by 48 · see citing works
Self-citation
Neurogenic and myogenic control of conduit coronary a.: A possible interference
Gerová, M., GERO, J., Bárta, E., Dolezel, S., Smieško, V., & Levický, V. (1981) · Basic Research in Cardiology · doi:10.1007/bf01908351 · Cited by 48 · see citing works
Vascular Endothelial Function Is Related to White Blood Cell Count and Myeloperoxidase Among Healthy Middle-Aged and Older Adults
Walker, A. E., Seibert, S. M., Donato, A. J., Pierce, G. L., & Seals, D. R. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.145870 · Cited by 48 · see citing works
Self-citation
Hormone therapy and antioxidant vitamins do not improve endothelial vasodilator function in postmenopausal women with established coronary artery disease: a substudy of the Women's Angiographic Vitamin and Estrogen (WAVE) trial
Kelemen, M. D., Vaidya, D. M., Waters, D. D., Howard, B. V., Cobb, F. R., Younes, N., Tripputti, M., & Ouyang, P. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.09.021 · Cited by 47 · see citing works
Nitric oxide-dependent vasodilation in human subjects
Vita, J. A. (2002) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(02)59183-7 · Cited by 44 · see citing works
Endothelin. Immunohistologic localization in aorta and biosynthesis by cultured human aortic endothelial cells.
Tokunaga, O., Fan, J., Watanabe, T., Kobayashi, M., Kumazaki, T., & Mitsui, Y. (1992) · PubMed · Cited by 43 · see citing works
Fenofibrate improves endothelial function in the brachial artery and forearm resistance arterioles of statin-treated Type 2 diabetic patients
Hamilton, S. J., Chew, G. T., Davis, T. M. E., & Watts, G. F. (2010) · Clinical Science · doi:10.1042/cs20090568 · Cited by 42 · see citing works
Tumor Necrosis Factor-α and Vascular Angiotensin II in Estrogen-Deficient Rats
Arenas, I. A., Armstrong, S. J., Xu, Y., & Davidge, S. T. (2006) · Hypertension · doi:10.1161/01.hyp.0000235865.03528.f1 · Cited by 39 · see citing works
Niacin improves small artery vasodilatory function and compliance in statin-treated type 2 diabetic patients
Hamilton, S. J., Chew, G. T., Davis, T. M. E., & Watts, G. F. (2010) · Diabetes and Vascular Disease Research · doi:10.1177/1479164110376206 · Cited by 34 · see citing works
Ageing is associated with impairment of nitric oxide and prostanoid dilator pathways in the human forearm
SINGH, N., Prasad, S., SINGER, D. R. J., et al. (2002) · Clinical Science · doi:10.1042/cs20010262 · Cited by 34 · see citing works
Ageing alters aortic antioxidant enzyme activities in Fischer‐344 rats
Demaree, Lawler, Linehan, & Delp (1999) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1999.00552.x · Cited by 33 · see citing works
A change in the redox environment and thromboxane A2 production precede endothelial dysfunction in mice
Gendron, M.-È., & Thorin, É. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00352.2007 · Cited by 32 · see citing works
Placebo-controlled trial of transdermal estrogen therapy alone in postmenopausal women: effects on arterial compliance and endothelial function
Teede, H. J., Liang, Y.-L., Kotsopoulos, D., Zoungas, S., Craven, R., & McGrath, B. P. (2002) · Climacteric · doi:10.1080/cmt.5.2.160.169 · Cited by 32 · see citing works
Tempol improves vascular function in the mesenteric vascular bed of senescent rats
Tatchum‐Talom, R., & Martin, D. S. (2004) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y04-010 · Cited by 30 · see citing works
Cytochrome P-450 2C9 signaling does not contribute to age-associated vascular endothelial dysfunction in humans
Donato, A. J., Eskurza, I., Jablonski, K., Gano, L. B., Pierce, G. L., & Seals, D. R. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90629.2008 · Cited by 27 · see citing works
Self-citation
Evaluation of endothelial function in hypertensive elderly patients by high‐resolution ultrasonography
Wang, X., Deng, Y., Zhang, Q., Li, C., Zhang, Y., & Guirong, L. (1999) · Clinical Cardiology · doi:10.1002/clc.4960221105 · Cited by 27 · see citing works
Effect Of Anti-Oxidant Treatment And Cholesterol Lowering On Resting Arterial Tone, Metabolic Vasodilation And Endothelial Function In The Human Forearm: A Randomized, Placebo-Controlled Study
Duffy, S. J., O’Brien, R. C., New, G., Harper, R. W., & Meredith, I. T. (2001) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2001.03458.x · Cited by 20 · see citing works
[Variation in the plasma endothelin levels in relation to age].
Battistelli, S., Gori, S., Borgogni, T., & Manasse, G. (1996) · PubMed · Cited by 12 · see citing works

Flagged first, then by citations

Sorted by citations

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease
Iadecola, C. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.030 · Cited by 2,480 · see citing works
Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease
Steven, S., Frenis, K., Oelze, M. W., Kalinovic, S., Kuntić, M., Jiménez, M. T. B., Vujačić-Mirski, K., Helmstädter, J., Kröller‐Schön, S., Münzel, T. F., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7092151 · Cited by 729 · see citing works
Cellular and molecular biology of aging endothelial cells
Donato, A. J., Morgan, R. G., Walker, A. E., & Lesniewski, L. A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.01.021 · Cited by 538 · see citing works
Self-citation
Ageing, metabolism and cardiovascular disease
Costantino, S., Paneni, F., & Cosentino, F. (2015) · The Journal of Physiology · doi:10.1113/jp270538 · Cited by 465 · see citing works
Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice
Picciotto, N. E., Gano, L. B., Johnson, L. C., Martens, C. R., Sindler, A. L., Mills, K. F., Imai, S., & Seals, D. R. (2016) · Aging Cell · doi:10.1111/acel.12461 · Cited by 396 · see citing works
Self-citation
Management of Acute Coronary Syndrome in the Older Adult Population: A Scientific Statement From the American Heart Association
Damluji, A. A., Forman, D. E., Wang, T. Y., Chikwe, J., Kunadian, V., Rich, M. W., Young, B. A., Page, R. L., II, DeVon, H. A., & Alexander, K. P. (2022) · Circulation · doi:10.1161/cir.0000000000001112 · Cited by 381 · see citing works
Exercise modulates oxidative stress and inflammation in aging and cardiovascular diseases
Sallam, N., & Laher, I. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/7239639 · Cited by 334 · see citing works
Arterial ageing: from endothelial dysfunction to vascular calcification
Tesauro, M., Mauriello, A., Rovella, V., Annicchiarico‐Petruzzelli, M., Cardillo, C., Melino, G., & Daniele, N. D. (2017) · Journal of Internal Medicine · doi:10.1111/joim.12605 · Cited by 325 · see citing works
Endothelial Dysfunction: Is There a Hyperglycemia-Induced Imbalance of NOX and NOS?
Meza, C. A., La Favor, J. D., Kim, D.-H., & Hickner, R. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153775 · Cited by 323 · see citing works
Dysfunction of the neurovascular unit in ischemic stroke and neurodegenerative diseases: An aging effect
Cai, W., Zhang, K., Li, P., Zhu, L., Xu, J., Yang, B., Hu, X., Lu, Z., & Chen, J. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.006 · Cited by 288 · see citing works
Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress
Ke, Y., Li, D., Zhao, M., Liu, C., Liu, J., Zeng, A., Shi, X., Cheng, S., Pan, B., Zheng, L., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.01.007 · Cited by 285 · see citing works
Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans
Brunt, V. E., Gioscia‐Ryan, R. A., Casso, A. G., VanDongen, N. S., Ziemba, B. P., Sapinsley, Z. J., Richey, J. J., Zigler, M. C., Neilson, A. P., Davy, K. P., et al. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.14759 · Cited by 285 · see citing works
Self-citation
Oxidative Stress and New Pathogenetic Mechanisms in Endothelial Dysfunction: Potential Diagnostic Biomarkers and Therapeutic Targets
Scioli, M. G., Storti, G., D’Amico, F., Rodríguez Guzmán, R., Centofanti, F., Doldo, E., Céspedes Miranda, E. M., & Orlandi, A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061995 · Cited by 281 · see citing works
The effect of diet and exercise on intestinal integrity and microbial diversity in mice
Campbell, S. C., Wisniewski, P. J., Noji, M., McGuinness, L. R., Häggblom, M. M., Lightfoot, S. A., Joseph, L. B., & Kerkhof, L. J. (2016) · PLOS ONE · doi:10.1371/journal.pone.0150502 · Cited by 268 · see citing works
SIRT‐1 and vascular endothelial dysfunction with ageing in mice and humans
Donato, A. J., Magerko, K. A., Lawson, B. R., Durrant, J., Lesniewski, L. A., & Seals, D. R. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.211219 · Cited by 270 · see citing works
Self-citation
The protective role of Sirt1 in vascular tissue: its relationship to vascular aging and atherosclerosis
Kitada, M., Ogura, Y., & Koya, D. (2016) · Aging · doi:10.18632/aging.101068 · Cited by 270 · see citing works
Translational evidence that impaired autophagy contributes to arterial ageing
LaRocca, T. J., Henson, G. D., Thorburn, A. M., Sindler, A. L., Pierce, G. L., & Seals, D. R. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.229690 · Cited by 255 · see citing works
Self-citation
Peripheral Circulation
Laughlin, M. H., Davis, M. J., Secher, N. H., LIESHOUT, J. J. V., Arce‐Esquivel, A. A., Simmons, G. H., Bender, S. B., Padilla, J., Bache, R. J., Merkus, D., et al. (2012) · Comprehensive physiology · doi:10.1002/cphy.c100048 · Cited by 264 · see citing works
Effects of short-term, medium-term and long-term resistance exercise training on cardiometabolic health outcomes in adults: systematic review with meta-analysis
Ashton, R. E. M., Tew, G. A., Aning, J. J., Gilbert, S. E., Lewis, L. S., & Saxton, J. (2018) · British Journal of Sports Medicine · doi:10.1136/bjsports-2017-098970 · Cited by 254 · see citing works
Mitochondrial Oxidative Stress, Mitochondrial DNA Damage and Their Role in Age-Related Vascular Dysfunction
Mikhed, Y., Daiber, A., & Steven, S. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160715918 · Cited by 257 · see citing works
Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and relation to vascular endothelial function
Rossman, M. J., Kaplon, R. E., Hill, S. D., McNamara, M. N., Santos-Parker, J. R., Pierce, G. L., Seals, D. R., & Donato, A. J. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00416.2017 · Cited by 232 · see citing works
Self-citation
Pharmacologic Options for the Treatment of Sarcopenia
Morley, J. E. (2016) · Calcified Tissue International · doi:10.1007/s00223-015-0022-5 · Cited by 225 · see citing works
Aerobic exercise training and vascular function with ageing in healthy men and women
Seals, D. R., Nagy, E., & Moreau, K. L. (2019) · The Journal of Physiology · doi:10.1113/jp277764 · Cited by 231 · see citing works
Self-citation
Arterial structure and function in vascular ageing: are you as old as your arteries?
Thijssen, D. H. J., Carter, S. E., & GREEN, D. J. (2015) · The Journal of Physiology · doi:10.1113/jp270597 · Cited by 218 · see citing works
Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging: Sodium nitrite and vascular dysfunction with aging
Sindler, A. L., Fleenor, B. S., Calvert, J. W., Marshall, K. D., Zigler, M. L., Lefer, D. J., & Seals, D. R. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00679.x · Cited by 218 · see citing works
Self-citation
Elevated Circulating Trimethylamine N-Oxide Levels Contribute to Endothelial Dysfunction in Aged Rats through Vascular Inflammation and Oxidative Stress
Li, T., Chen, Y., Gua, C., & Li, X. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00350 · Cited by 216 · see citing works
Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights
Mason, S. A., Trewin, A. J., Parker, L., & Wadley, G. D. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101471 · Cited by 226 · see citing works
Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress
Santos‐Parker, J. R., Strahler, T. R., Bassett, C. J., Bispham, N. Z., Chonchol, M. B., & Seals, D. R. (2017) · Aging · doi:10.18632/aging.101149 · Cited by 214 · see citing works
Self-citation
The autophagy enhancer spermidine reverses arterial aging
LaRocca, T. J., Gioscia‐Ryan, R. A., Hearon, C. M., & Seals, D. R. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.04.004 · Cited by 207 · see citing works
Self-citation
Role of sphingolipids in senescence: implication in aging and age-related diseases
Trayssac, M., Hannun, Y. A., & Obeid, L. M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97949 · Cited by 205 · see citing works
Polyamines: Functions, Metabolism, and Role in Human Disease Management
Sagar, N. A., Tarafdar, S., Agarwal, S., Tarafdar, A., & Sharma, S. (2021) · Medical Sciences · doi:10.3390/medsci9020044 · Cited by 210 · see citing works
SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: Implications for vascular aging
Zarzuelo, M. J., López-Sepúlveda, R., Sánchez, M., Romero, M., Gómez-Guzmán, M., Ungvary, Z., Pérez-Vizcaíno, F., Jiménez, R., & Duarte, J. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.02.015 · Cited by 202 · see citing works
Suppression of the gut microbiome ameliorates age‐related arterial dysfunction and oxidative stress in mice
Brunt, V. E., Gioscia‐Ryan, R. A., Richey, J. J., Zigler, M. C., Cuevas, L. M., Gonzalez, A., Vázquez‐Baeza, Y., Battson, M. L., Smithson, A. T., Gilley, A. D., et al. (2019) · The Journal of Physiology · doi:10.1113/jp277336 · Cited by 182 · see citing works
Self-citation
Vitamin D deficiency and risk of cardiovascular diseases: a narrative review
Kheiri, B., Abdalla, A., Osman, M., Ahmed, S. A., Hassan, M., & Bachuwa, G. I. (2018) · Clinical Hypertension · doi:10.1186/s40885-018-0094-4 · Cited by 174 · see citing works
Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice
Donato, A. J., Walker, A. E., Magerko, K. A., Bramwell, R. C., Black, A. D., Henson, G. D., Lawson, B. R., Lesniewski, L. A., & Seals, D. R. (2013) · Aging Cell · doi:10.1111/acel.12103 · Cited by 169 · see citing works
Self-citation
Dietary Sodium Restriction Reverses Vascular Endothelial Dysfunction in Middle-Aged/Older Adults With Moderately Elevated Systolic Blood Pressure
Jablonski, K., Racine, M. L., Geolfos, C. J., Gates, P. E., Chonchol, M., McQueen, M. B., & Seals, D. R. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.09.010 · Cited by 169 · see citing works
Self-citation
Cold‐induced cutaneous vasoconstriction in humans: Function, dysfunction and the distinctly counterproductive
Alba, B. K., Castellani, J. W., & Charkoudian, N. (2019) · Experimental Physiology · doi:10.1113/ep087718 · Cited by 169 · see citing works
Revisiting pharmacology of oxidative stress and endothelial dysfunction in cardiovascular disease: Evidence for redox-based therapies
Daiber, A., & Chłopicki, S. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.02.026 · Cited by 169 · see citing works
Dietary rapamycin supplementation reverses age‐related vascular dysfunction and oxidative stress, while modulating nutrient‐sensing, cell cycle, and senescence pathways
Lesniewski, L. A., Seals, D. R., Walker, A. E., Henson, G. D., Blimline, M., Trott, D. W., Bosshardt, G. C., LaRocca, T. J., Lawson, B. R., Zigler, M. C., et al. (2016) · Aging Cell · doi:10.1111/acel.12524 · Cited by 167 · see citing works
Self-citation
Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases
de Almeida, A. J. P. O., Rezende, M. S. D. A., Dantas, S. H., Silva, S. D. L., de Oliveira, J. C. P. L., de Azevedo, F. D. L. A. A., Alves, R. M. F. R., de Menezes, G. M. S., dos Santos, P. F., Gonçalves, T. A. F., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1954398 · Cited by 167 · see citing works
Dietary Nitrate and Nitric Oxide Metabolism: Mouth, Circulation, Skeletal Muscle, and Exercise Performance
Jones, A. M., Vanhatalo, A., Seals, D. R., Rossman, M. J., Piknova, B., & Jonvik, K. L. (2021) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002470 · Cited by 156 · see citing works
Self-citation
The problems of vitamin d insufficiency in older people.
Boucher, B. J. (2012) · Europe PMC (PubMed Central) · Cited by 155 · see citing works
Curcumin ameliorates arterial dysfunction and oxidative stress with aging
Fleenor, B. S., Sindler, A. L., Marvi, N. K., Howell, K. L., Zigler, M. L., Yoshizawa, M., & Seals, D. R. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.10.008 · Cited by 145 · see citing works
Self-citation
Aerobic exercise and other healthy lifestyle factors that influence vascular aging
Santos‐Parker, J. R., LaRocca, T. J., & Seals, D. R. (2014) · AJP Advances in Physiology Education · doi:10.1152/advan.00088.2014 · Cited by 141 · see citing works
Self-citation
You're Only as Old as Your Arteries: Translational Strategies for Preserving Vascular Endothelial Function with Aging
Seals, D. R., Kaplon, R. E., Gioscia‐Ryan, R. A., & LaRocca, T. J. (2014) · Physiology · doi:10.1152/physiol.00059.2013 · Cited by 138 · see citing works
Self-citation
Vascular Aging in Women: is Estrogen the Fountain of Youth?
Novella, S., Dantas, A. P., Segarra, G., Medina, P., & Hermenegildo, C. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00165 · Cited by 135 · see citing works
Ageing and microvasculature
Scioli, M. G., Bielli, A., Arcuri, G., Ferlosio, A., & Orlandi, A. (2014) · Vascular Cell · doi:10.1186/2045-824x-6-19 · Cited by 132 · see citing works
The Causal Relationship between Endothelin-1 and Hypertension: Focusing on Endothelial Dysfunction, Arterial Stiffness, Vascular Remodeling, and Blood Pressure Regulation
Kostov, K. G. (2021) · Life · doi:10.3390/life11090986 · Cited by 126 · see citing works
Inflammation, Oxidative Stress, Vascular Aging and Atherosclerotic Ischemic Stroke
Koutsaliaris, I. K., Moschonas, I. C., Pechlivani, L., Tsouka, A. N., & Tselepis, A. D. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210921161711 · Cited by 120 · see citing works
Differential Modulation of Nitric Oxide Synthases in Aging: Therapeutic Opportunities
Cáu, S. B. D. A., Carneiro, F. S., & Tostes, R. C. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00218 · Cited by 121 · see citing works
Atherothrombosis and Oxidative Stress: Mechanisms and Management in Elderly
Violi, F., Loffredo, L., Carnevale, R., Pignatelli, P., & Pastori, D. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6963 · Cited by 121 · see citing works
Time‐Efficient Inspiratory Muscle Strength Training Lowers Blood Pressure and Improves Endothelial Function, NO Bioavailability, and Oxidative Stress in Midlife/Older Adults With Above‐Normal Blood Pressure
Craighead, D. H., Heinbockel, T. C., Freeberg, K. A., Rossman, M. J., Jackman, R. A., Jankowski, L. R., Hamilton, M. N., Ziemba, B. P., Reisz, J. A., D’Alessandro, A., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.020980 · Cited by 119 · see citing works
Self-citation
The interactions of oxidative stress and inflammation with vascular dysfunction in ageing: the vascular health triad
Wadley, A. J., Zanten, J. V., & Aldred, S. (2012) · AGE · doi:10.1007/s11357-012-9402-1 · Cited by 118 · see citing works
Reference intervals for brachial artery flow-mediated dilation and the relation with cardiovascular risk factors
Holder, S. M., Bruno, R. M., Shkredova, D. A., Dawson, E. A., Jones, H., Hopkins, N. D., Hopman, M. T. E., Bailey, T. G., Coombes, J. S., Askew, C. D., et al. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.15754 · Cited by 118 · see citing works
Edward F. Adolph Distinguished Lecture: The remarkable anti-aging effects of aerobic exercise on systemic arteries
Seals, D. R. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00362.2014 · Cited by 118 · see citing works
Self-citation
Heat therapy: mechanistic underpinnings and applications to cardiovascular health
Brunt, V. E., & Minson, C. T. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00141.2020 · Cited by 121 · see citing works
Aging-induced biological changes and cardiovascular diseases.
Fajemiroye, J. O., Cunha, L. C. D., Saavedra-Rodríguez, R., Rodrigues, K. L., Naves, L. M., Mourão, A. A., Silva, E. F. D., Williams, N. E. E., Martins, J. L. R., Sousa, R. B., et al. (2018) · BioMed Research International · doi:10.1155/2018/7156435 · Cited by 109 · see citing works
High intensity interval training (HIIT) improves resting blood pressure, metabolic (MET) capacity and heart rate reserve without compromising cardiac function in sedentary aging men
Grace, F., Herbert, P., Elliott, A. D., Richards, J., Beaumont, A. J., & Sculthorpe, N. F. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.05.010 · Cited by 108 · see citing works
Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence
Mahoney, S. A., Venkatasubramanian, R., Darrah, M. A., Ludwig, K. R., VanDongen, N. S., Greenberg, N., Longtine, A. G., Hutton, D. A., Brunt, V. E., Campisi, J., et al. (2023) · Aging Cell · doi:10.1111/acel.14060 · Cited by 107 · see citing works
Self-citation
Skeletal Muscle Circulation
Korthuis, R. J. (2011) · Colloquium Series on Integrated Systems Physiology From Molecule to Function · doi:10.4199/c00035ed1v01y201106isp023 · Cited by 104 · see citing works
Endoplasmic reticulum stress and the development of endothelial dysfunction.
Battson, M. L., Lee, D. M., & Gentile, C. (2017) · American Journal of Physiology. Heart and Circulatory Physiology · doi:10.1152/ajpheart.00437.2016 · Cited by 104 · see citing works
COVID-19 Vasculopathy: Mounting Evidence for an Indirect Mechanism of Endothelial Injury
Nicosia, R. F., Ligresti, G., Caporarello, N., Akilesh, S., & Ribatti, D. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.05.007 · Cited by 102 · see citing works
Advanced glycation end products upregulate lysyl oxidase and endothelin-1 in human aortic endothelial cells via parallel activation of ERK1/2–NF-κB and JNK–AP-1 signaling pathways
Adamopoulos, C., Piperi, C., Gargalionis, A. N., Dalagiorgou, G., Spilioti, E., Korkolopoulou, P. A., Diamanti‐Kandarakis, E., & Papavassiliou, A. G. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2091-z · Cited by 101 · see citing works
Effects of Estrogen on Vascular Inflammation
Novella, S., Heras, M., Hermenegildo, C., & Dantas, A. P. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.250308 · Cited by 100 · see citing works
Brachial artery endothelial function is stable across a menstrual and oral contraceptive pill cycle but lower in premenopausal women than in age-matched men
Shenouda, N., Priest, S. E., Rizzuto, V. I., & MacDonald, M. J. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00102.2018 · Cited by 99 · see citing works
Microparticles Induce Cell Cycle Arrest Through Redox‐Sensitive Processes in Endothelial Cells: Implications in Vascular Senescence
Burger, D. E., Kwart, D. G., Montezano, A. C. I., Read, N. C., Kennedy, C., Thompson, C. S., & Touyz, R. M. (2012) · Journal of the American Heart Association · doi:10.1161/jaha.112.001842 · Cited by 99 · see citing works
The Vitamin D Receptor as a Potential Target for the Treatment of Age-Related Neurodegenerative Diseases Such as Alzheimer’s and Parkinson’s Diseases: A Narrative Review
Lasoń, W., Jantas, D., Leśkiewicz, M., Regulska, M., & Basta‐Kaim, A. (2023) · Cells · doi:10.3390/cells12040660 · Cited by 96 · see citing works
Physiological adaptations to resistance exercise as a function of age
Phillips, B., Williams, J. P., Greenhaff, P., Smith, K., & Atherton, P. (2017) · JCI Insight · doi:10.1172/jci.insight.95581 · Cited by 86 · see citing works
Impaired Hydrogen Sulfide–Mediated Vasodilation Contributes to Microvascular Endothelial Dysfunction in Hypertensive Adults
Greaney, J. L., Kutz, J. L., Shank, S. W., Jandu, S., Santhanam, L., & Alexander, L. M. (2017) · Hypertension · doi:10.1161/hypertensionaha.116.08964 · Cited by 93 · see citing works
CORP: Ultrasound assessment of vascular function with the passive leg movement technique
Gifford, J. R., & Richardson, R. S. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00557.2017 · Cited by 93 · see citing works
Cellular Senescence Contributes to Large Elastic Artery Stiffening and Endothelial Dysfunction With Aging: Amelioration With Senolytic Treatment
Clayton, Z. S., Rossman, M. J., Mahoney, S. A., Venkatasubramanian, R., Maurer, G. S., Hutton, D. A., VanDongen, N. S., Greenberg, N. T., Longtine, A. G., Ludwig, K. R., et al. (2023) · Hypertension · doi:10.1161/hypertensionaha.123.21392 · Cited by 84 · see citing works
“Excess superoxide-related oxidative stress can directly contribute to endothelial dysfunction with aging, 43 as superoxide can scavenge NO and ultimately reduce its bioavailability.”
BackgroundSelf-citation
Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis
Caporarello, N., Lee, J., Pham, T. X., Jones, D. L., Guan, J., Link, P. A., Meridew, J. A., Marden, G., Yamashita, T., Osborne, C. A., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31890-4 · Cited by 92 · see citing works
Role of microRNAs in endothelial inflammation and senescence
Qin, B., Yang, H., & Xiao, B. (2011) · Molecular Biology Reports · doi:10.1007/s11033-011-1241-0 · Cited by 91 · see citing works
Dicarbonyl Stress at the Crossroads of Healthy and Unhealthy Aging
Nigro, C., Leone, A., Fiory, F., Prevenzano, I., Nicolò, A., Mirra, P., Bèguinot, F., & Miele, C. (2019) · Cells · doi:10.3390/cells8070749 · Cited by 91 · see citing works
Cerebral Small Vessel Disease: a Review of the Pathophysiological Mechanisms
Hannawi, Y. (2023) · Translational Stroke Research · doi:10.1007/s12975-023-01195-9 · Cited by 92 · see citing works
Coenzyme Q10 Prevents Senescence and Dysfunction Caused by Oxidative Stress in Vascular Endothelial Cells
Huo, J., Xu, Z., Hosoe, K., Kubo, H., Miyahara, H., Dai, J., Mori, M., Sawashita, J., & Higuchi, K. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/3181759 · Cited by 87 · see citing works
Vascular effects of dietary salt
Edwards, D. G., & Farquhar, W. B. (2014) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000089 · Cited by 89 · see citing works
Nutrition and other lifestyle influences on arterial aging
LaRocca, T. J., Martens, C. R., & Seals, D. R. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.002 · Cited by 83 · see citing works
Self-citation
Oral trehalose supplementation improves resistance artery endothelial function in healthy middle-aged and older adults
Kaplon, R. E., Hill, S. D., Bispham, N. Z., Santos‐Parker, J. R., Nowlan, M. J., Snyder, L. L., Chonchol, M., LaRocca, T. J., McQueen, M. B., & Seals, D. R. (2016) · Aging · doi:10.18632/aging.100962 · Cited by 84 · see citing works
Self-citation
Healthy lifestyle-based approaches for successful vascular aging
Rossman, M. J., LaRocca, T. J., Martens, C. R., & Seals, D. R. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00521.2018 · Cited by 82 · see citing works
Self-citation
Mechanisms underlying the influence of oestrogen on cardiovascular physiology in women
Novella, S., Pérez‐Cremades, D., Mompeón, A., & Hermenegildo, C. (2019) · The Journal of Physiology · doi:10.1113/jp278063 · Cited by 83 · see citing works
Accelerated Aging and Age-Related Diseases (CVD and Neurological) Due to Air Pollution and Traffic Noise Exposure
Hahad, O., Frenis, K., Kuntić, M., Daiber, A., & Münzel, T. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052419 · Cited by 83 · see citing works
Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults
DeVan, A. E., Johnson, L. C., Brooks, F. A., Evans, T. D., Justice, J. N., Cruickshank-Quinn, C. I., Reisdorph, N. A., Bryan, N. S., McQueen, M. B., Santos‐Parker, J. R., et al. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00879.2015 · Cited by 82 · see citing works
Self-citation
Endothelial Aging Associated with Oxidative Stress Can Be Modulated by a Healthy Mediterranean Diet
Marı́n, C., Yubero‐Serrano, E. M., López‐Miranda, J., & Pérez‐Jiménez, F. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14058869 · Cited by 80 · see citing works
Vascular dysfunction in aged mice contributes to persistent lung fibrosis
Caporarello, N., Meridew, J. A., Aravamudhan, A., Jones, D. L., Austin, S. A., Pham, T. X., Haak, A. J., Choi, K. M., Tan, Q., Haresi, A. J., et al. (2020) · Aging Cell · doi:10.1111/acel.13196 · Cited by 78 · see citing works
Developmental aspects of a life course approach to healthy ageing
Hanson, M., Cooper, C., Sayer, A., Eendebak, R. J., Clough, G., & Beard, J. (2016) · Journal of Physiology · doi:10.1113/jp270579 · Cited by 71 · see citing works
Aging in blood vessels. Medicinal agents FOR systemic arterial hypertension in the elderly
Rubio-Ruiz, M. E., Pérez-Torres, I., Soto, M. E., Pastelı́n, G., & Guarner‐Lans, V. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.10.001 · Cited by 78 · see citing works
Ginsenoside Rb1 Prevents H2O2-Induced HUVEC Senescence by Stimulating Sirtuin-1 Pathway
Song, Z., Liu, Y., Hao, B., Yu, S., Zhang, H., Liu, D., Zhou, B., Wu, L., Wang, M., Xiong, Z., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112699 · Cited by 76 · see citing works
Aging Impairs Electrical Conduction Along Endothelium of Resistance Arteries Through Enhanced Ca2+-Activated K + Channel Activation
Behringer, E. J., Shaw, R. L., Westcott, E. B., Socha, M. J., & Segal, S. S. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.301514 · Cited by 76 · see citing works
Protective Role of Endogenous Kallistatin in Vascular Injury and Senescence by Inhibiting Oxidative Stress and Inflammation
Chao, J., Guo, Y., & Chao, L. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/4138560 · Cited by 72 · see citing works
ACE2‐EPC‐EXs protect ageing ECs against hypoxia/reoxygenation‐induced injury through the miR‐18a/Nox2/ROS pathway
Zhang, C., Wang, J., Ma, X., Wang, W., Zhao, B., Chen, Y., Chen, C., & Bihl, J. C. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13471 · Cited by 74 · see citing works
Vascular autophagy in health and disease
Hughes, W. E., Beyer, A., & Gutterman, D. D. (2020) · Basic Research in Cardiology · doi:10.1007/s00395-020-0802-6 · Cited by 74 · see citing works
Melatonin as an Anti-Aging Therapy for Age-Related Cardiovascular and Neurodegenerative Diseases
Giménez, V. M. M., Heras, N. D. L., Lahera, V., Tresguerres, J. A. F., Reiter, R. J., & Manucha, W. A. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.888292 · Cited by 73 · see citing works
Assessment of dynamic cerebral autoregulation and cerebrovascular CO 2 reactivity in ageing by measurements of cerebral blood flow and cortical oxygenation
Oudegeest‐Sander, M. H., van Beek, A. H. E. A., Abbink, K., Rikkert, M. G. M. O., Hopman, M. T. E., & Claassen, J. A. H. R. (2013) · Experimental Physiology · doi:10.1113/expphysiol.2013.076455 · Cited by 74 · see citing works
Kidney and epigenetic mechanisms of salt-sensitive hypertension
Kawarazaki, W., & Fujita, T. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-021-00399-2 · Cited by 73 · see citing works
Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging
Clayton, Z. S., Hutton, D. A., Brunt, V. E., VanDongen, N. S., Ziemba, B. P., Casso, A. G., Greenberg, N., Mercer, A. N., Rossman, M. J., Campisi, J., et al. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00118.2021 · Cited by 73 · see citing works
Self-citation
Integration and Modulation of Intercellular Signaling Underlying Blood Flow Control
Segal, S. S. (2015) · Journal of Vascular Research · doi:10.1159/000439112 · Cited by 73 · see citing works
Gut-Flora-Dependent Metabolite Trimethylamine-N-Oxide Promotes Atherosclerosis-Associated Inflammation Responses by Indirect ROS Stimulation and Signaling Involving AMPK and SIRT1
Zhou, S., Xue, J., Shan, J., Hong, Y., Zhu, W., Nie, Z., Zhang, Y., Ji, N., Luo, X., Zhang, T., et al. (2022) · Nutrients · doi:10.3390/nu14163338 · Cited by 72 · see citing works
The effect of an advanced glycation end-product crosslink breaker and exercise training on vascular function in older individuals: A randomized factorial design trial
Oudegeest‐Sander, M. H., Rikkert, M. G. M. O., Smits, P., Thijssen, D. H. J., van Dijk, A. P. J., Levine, B. D., & Hopman, M. T. E. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.10.009 · Cited by 71 · see citing works
The role of senescence, telomere dysfunction and shelterin in vascular aging
Liu, Y., Bloom, S. I., & Donato, A. J. (2018) · Microcirculation · doi:10.1111/micc.12487 · Cited by 70 · see citing works
Self-citation

Aging and Vascular Endothelial Dysfunction
Seals, D. R. (2009) · The FASEB Journal · doi:10.1096/fasebj.23.1_supplement.414.2
Self-citation
Endothelial dysfunction and aging: An update
Herrera, M. D., Mingorance, C., Rodríguez‐Rodríguez, R., & de Sotomayor, M. Á. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.07.002 · Cited by 322 · see citing works
Mechanisms Involved in the Aging-Induced Vascular Dysfunction
Fuente, M. E. A. D. L., Angulo, J., Fernán, S. E., Peiró, C., Sánchez‐Ferrer, C. F., & Rodríguez‐Mañas, L. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00132 · Cited by 226 · see citing works
Ageing, exercise and cardiovascular health: good and bad news
Calbet, J. A. L. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.244400 · Cited by 5 · see citing works
Oxidative stress and vascular inflammation in aging
Assar, M. E., Angulo, J., & Rodríguez‐Mañas, L. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.07.003 · Cited by 576 · see citing works

Authors: Seals, D. R., Jablonski, K. L., & Donato, A. J.
Affiliations: University of Colorado Boulder (US)
ORCID: Seals, Douglas R.
Donato, Anthony J.
Venue: Clinical Science
Publisher: Portland Press Ltd.
Published: 2011-01-18
Volume: 120
Issue: 9
Pages: 357-375
ISSN: 0143-5221 (ISSN-L)
1470-8736
DOI: 10.1042/cs20100476
PMC: PMC3482987
OpenAlex: W1983986440
Cited by: 725
References: 191
Citations by year: 2026: 63 · 2025: 49 · 2024: 45 · 2023: 52 · 2022: 66 · 2021: 58 · 2020: 48 · 2019: 49 · 2018: 49 · 2017: 39 · 2016: 44 · 2015: 46 · 2014: 35 · 2013: 28 · 2012: 40
FWCI: 25.52
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Clinical Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Aging (AG022241, K01AG029337, AG031141, AG-006537, R01AG031141, AG 029337, F31AG033994, R01AG022241, AG-000279, R37AG013038, R01AG013038, R01AG040297, R01AG006537, AG-013038, AG033994, T32AG000279)
National Center for Research Resources (RR-00051, M01RR000051)
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords: vascular aging, endothelial dysfunction, endothelium-dependent dilation, nitric oxide bioavailability, oxidative stress, superoxide, NADPH oxidase, endothelial nitric oxide synthase, tetrahydrobiopterin, endothelin-1, advanced glycation end products, vascular inflammation, endothelial cell apoptosis, estrogen receptor alpha, menopause, aerobic exercise, dietary factors, vitamin D, cardiovascular risk
MeSH terms: Aging, Cardiovascular Diseases, Endothelium, Vascular, Humans, Inflammation, Nitric Oxide, Vasodilation, Exercise, Oxidative Stress

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Aging and vascular endothelial function in humans

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks