The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Platelet-derived microparticles induce angiogenesis and stimulate post-ischemic revascularization
Abstract
OBJECTIVE: Platelet activation is accompanied by the release of microparticles. However, little is known about the role of platelet-derived microparticles (PMP) in the regulation of angiogenesis and related clinical situations. The aim of our study was to evaluate the effect of PMP on angiogenesis and to analyze its mechanisms. METHODS: Both in vitro (rat aortic ring model, cell invasion test) and in vivo (agarose bead transplantation, artificial cardiac ischemia in Sabra rats) approaches were used in the study. RESULTS: A dose-dependent pro-angiogenic effect of PMP was observed in the rat aortic ring model. This effect could be eliminated by inhibition of VEGF, bFGF, and PDGF, but not heparanase. PMP exerted their effect via PI 3-kinase, Src kinase, and ERK, whereas protein kinase C and p38 were not involved. Moreover, PMP induced invasion of endothelial cells through a layer of matrigel. This effect was mediated by VEGF, heparanase, and PDGF, but not bFGF. Furthermore, PMP induced angiogenesis in an in vivo model in which agarose beads containing PMP were transplanted subcutaneously into mice. In addition, the effect of PMP on angiogenesis was evaluated in the model of in vivo chronic myocardial ischemia in rats. Ischemia induced a decrease in the number of functioning capillaries (34+/-21.5 vs. 157+/-42.0 per view field), but their amount increased after injection of PMP into the myocarium (97+/-27.3; p<0.001 vs. ischemia without PMP). CONCLUSIONS: PMP induce angiogenesis both in vitro and in vivo. Injection of PMP into the ischemic myocardium might improve the process of revascularization after chronic ischemia.
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Cites
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“Platelets accumulate at the sites of vascular injury or disturbances in blood flow, where they activate and release various granular mediators [1].”
BackgroundModulation of monocyte-endothelial cell interactions by platelet microparticles.
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Cellular microparticles: what are they bad or good for?
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Cited by
Microparticles: Protagonists of a Novel Communication Network for Intercellular Information Exchange
Mause, S. F., & Weber, C. (2010) · Circulation Research · doi:10.1161/circresaha.110.226456 · Cited by 786
Bian, S., Zhang, L., Duan, L., Wang, X., Min, Y., & Yu, H. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1110-5 · Cited by 710
Extracellular vesicles in physiological and pathological conditions
Yuana, Y., Sturk, A., & Nieuwland, R. (2013) · Blood Reviews · doi:10.1016/j.blre.2012.12.002 · Cited by 569
Human platelet lysate: Replacing fetal bovine serum as a gold standard for human cell propagation?
Burnouf, T., Strunk, D., Koh, M. B. C., & Schallmoser, K. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2015.10.065 · Cited by 521
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Metadata
- Authors
- BRILL, A., DASHEVSKY, O., RIVO, J., GOZAL, Y., & VARON, D.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-07-01
- Volume
- 67
- Issue
- 1
- Pages
- 30-38
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2004653956
- Cited by
- 433
- References
- 29
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- BRILL, A., DASHEVSKY, O., RIVO, J., GOZAL, Y., & VARON, D. (2005). Platelet-derived microparticles induce angiogenesis and stimulate post-ischemic revascularization. Cardiovascular Research. https://doi.org/10.1016/j.cardiores.2005.04.007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
