The interaction of flavonoids with mitochondria: effects on energetic processes
Abstract
The study addressed aspects of energetics of isolated rat liver mitochondria exposed to the flavonoids quercetin, taxifolin, catechin and galangin, taking into account influences of the 2,3 double bond/3-OH group and 4-oxo function on the C-ring, and o-di-OH on the B-ring of their structures, as well as mitochondrial mechanisms potentially involved in cell necrosis and apoptosis. The major findings/hypothesis, were: The 2,3 double bond/3-OH group in conjugation with the 4-oxo function on the C-ring in the flavonoid structure seems favour the interaction of these compounds with the mitochondrial membrane, decreasing its fluidity either inhibiting the respiratory chain of mitochondria or causing uncoupling; while the o-di-OH on the B-ring seems favour the respiratory chain inhibition, the absence of this structure seems favour the uncoupling activity. The flavonoids not affecting the respiration of mitochondria, induced MPT. The ability of flavonoids to induce the release of mitochondria-accumulated Ca(2+) correlated well with their ability to affect mitochondrial respiration on the one hand, and their inability to induce MPT, on the other. The flavonoids causing substantial respiratory chain inhibition or mitochondrial uncoupling, quercetin and galangin, respectively, also decreased the mitochondrial ATP levels, thus suggesting an apparent higher potential for necrosis induction in relation to the flavonoids inducing MPT, taxifolin and cathechin, which did not decrease significantly the ATP levels, rather suggesting an apparent higher potential for apoptosis induction.
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Quercetin can stimulate mitochondrial oxidative metabolism by directly decreasing ATP:AMP ratio, which activates AMPK and its downstream catabolic pathways.
“Furthermore, quercetin can stimulate mitochondria oxidative metabolism by directly decreasing ATP:AMP ratio, which in turn results in the activation of AMPK and its downstream catabolic pathways (Dorta et al., 2005).”
From Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet (2019) · cites this paper as Dorta et al., 2005
Cites
The Pathophysiology of Mitochondrial Cell Death
Green, D. R., & Kroemer, G. (2004) · Science · doi:10.1126/science.1099320 · Cited by 3,416 · see citing works
Regulation of cell death: the calcium–apoptosis link
Orrenius, S., Zhivotovsky, B., & Nicotera, P. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1150 · Cited by 2,990 · see citing works
The mitochondrial permeability transition
Zoratti, M., & Szabó, I. (1995) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(95)00003-a · Cited by 2,395 · see citing works
Lowe, S. W., & Lin, A. W. (2000) · Carcinogenesis · doi:10.1093/carcin/21.3.485 · Cited by 1,867 · see citing works
[36] Flavonoids as antioxidants: Determination of radical-scavenging efficiencies
Bors, W., Heller, W. E., Michel, C., & Sarán, M. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86128-i · Cited by 1,726 · see citing works
Lemasters, J. J., Nieminen, A.-L., Qian, T., Trost, L. C., Elmore, S. P., Nishimura, Y., Crowe, R. A., Cascio, W. E., Bradham, C. A., Brenner, D. A., et al. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00112-1 · Cited by 1,387 · see citing works
Galati, G., & O'Brien, P. J. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.034 · Cited by 1,101 · see citing works
The Ca2+-induced membrane transition in mitochondria
Hunter, D. R., & Haworth, R. A. (1979) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(79)90371-0 · Cited by 860 · see citing works
Crompton, M., Ellinger, H., & COSTI, A. (1988) · PubMed Central · Cited by 841 · see citing works
Mitochondrial permeability transition and oxidative stress
Kowaltowski, A. J., Castilho, R. F., & Vercesi, A. E. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02316-x · Cited by 832 · see citing works
Emaus, R. K., Grunwald, R., & Lemasters, J. J. (1986) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(86)90112-x · Cited by 805 · see citing works
Flavonoids as antioxidant agents: Importance of their interaction with biomembranes
Saija, A., Scalese, M., Lanza, M., Marzullo, D., Bonina, F., & Castelli, F. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00240-k · Cited by 701 · see citing works
Absorption and metabolism of flavonoids
Walle, T. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.01.002 · Cited by 622 · see citing works
Modulation of Liposomal Membrane Fluidity by Flavonoids and Isoflavonoids
Arora, A., Byrem, T. M., Nair, M. G., & Strasburg, G. M. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1525 · Cited by 595 · see citing works
Mitochondria as all‐round players of the calcium game
Rizzuto, R., Bernardi, P., & Pozzan, T. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00037.x · Cited by 562 · see citing works
Arora, A., Nair, M. G., & Strasburg, G. M. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00458-9 · Cited by 562 · see citing works
Agullo, G., Gamet‐Payrastre, L., Manenti, S., Viala, C., Rémésy, C., Chap, H., & Payrastre, B. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)82453-7 · Cited by 535 · see citing works
Costantini, P., Chernyak, B. V., Petronilli, V., & Bernardi, P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.12.6746 · Cited by 516 · see citing works
Firuzi, O., Lacanna, A., Petrucci, R., Marrosu, G., & Saso, L. (2004) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2004.11.001 · Cited by 487 · see citing works
Calcium signaling and apoptosis
Hajnóczky, G., Davies, E., & Madesh, M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00616-8 · Cited by 462 · see citing works
The Ca2+-induced membrane transition in mitochondria
Hunter, D. R., & Haworth, R. A. (1979) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(79)90373-4 · Cited by 459 · see citing works
Pedersen, P. L., Greenawalt, J. W., Reynafarje, B., Hullihen, J. M., Decker, G. L., Soper, J. W., & Bustamente, E. (1978) · Methods in cell biology · doi:10.1016/s0091-679x(08)62030-0 · Cited by 445 · see citing works
Gunter, T. E., Yule, D. I., Gunter, K. K., Eliseev, R. A., & Salter, J. D. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.03.071 · Cited by 409 · see citing works
Structure-antioxidant Activity Relationships of Flavonoids: A Re-examination
Silva, M. M., Santos, M., Caroço, G., Rocha, R., Justino, G. C., & Mira, L. (2002) · Free Radical Research · doi:10.1080/198-1071576021000016472 · Cited by 375 · see citing works
[27] Measurements of cation transport with metallochromic indicators
Scarpa, A. (1979) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(79)56030-3 · Cited by 255 · see citing works
Flavonoids and the inhibition of PKC and PI 3-kinase
Gamet‐Payrastre, L., Manenti, S., Gratacap, M., Tulliez, J. E., Chap, H., & Payrastre, B. (1999) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(98)00220-1 · Cited by 255 · see citing works
Bondar, V. M., Sweeney‐Gotsch, B., Andreeff, M., Mills, G. B., & McConkey, D. J. (2002) · PubMed · Cited by 234 · see citing works
Flavonoids and isoflavones: absorption, metabolism, and bioactivity
Rice-Evans, C. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.12.012 · Cited by 231 · see citing works
Electrochemistry of flavonoids
Hodnick, W. F., MllosavljeviĆ, E. B., Nelson, J. H., & Pardini, R. S. (1988) · Biochemical Pharmacology · doi:10.1016/0006-2952(88)90253-5 · Cited by 219 · see citing works
dos Santos, A. C., Uyemura, S. A., Lopes, J. L. C., Bazon, J. N., Mingatto, F. E., & Curti, C. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00003-3 · Cited by 188 · see citing works
Yu, B. P., Suescun, E. A., & Yang, S. Y. (1992) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(92)90123-u · Cited by 184 · see citing works
The uncoupling efficiency and affinity of flavonoids for vesicles
Cees van, D. I. J. K., Driessen, A. J. M., & Recourt, K. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00488-3 · Cited by 149 · see citing works
Inhibition of proliferation and induction of apoptosis by genistein in colon cancer HT-29 cells
Yu, Z., Li, W., & Liu, F. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.06.010 · Cited by 134 · see citing works
Anticancer drugs of tomorrow: apoptotic pathways as targets for drug design
Łoś, M., Burek, C. J., Stroh, C., Benedyk, K., Hug, H., & Mackiewicz, A. A. (2003) · Drug Discovery Today · doi:10.1016/s1359-6446(02)02563-1 · Cited by 123 · see citing works
Genistein Induces Apoptosis of RPE-J Cells by Opening Mitochondrial PTP
Yoon, H. S., Moon, S. C., Kim, N. D., Park, B.-S., Jeong, M. H., & Yoo, Y. H. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3445 · Cited by 116 · see citing works
Skulachev, V. P. (2000) · IUBMB Life · doi:10.1080/152165400410209 · Cited by 113 · see citing works
Hsu, Y., Kuo, P., & Lin, C. (2003) · Biochemical Pharmacology · doi:10.1016/j.bcp.2003.09.042 · Cited by 108 · see citing works
Ca2+ signalling in mitochondria: mechanism and role in physiology and pathology
Brini, M. (2003) · Cell Calcium · doi:10.1016/s0143-4160(03)00145-3 · Cited by 108 · see citing works
Lemasters, J. J., & Hackenbrock, C. R. (1976) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1976.tb10625.x · Cited by 103 · see citing works
Salvi, M., Brunati, A. M., Clari, G., & Toninello, A. (2002) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(02)00361-4 · Cited by 96 · see citing works
Calcium uptake in isolated brush-border vesicles from rat small intestine
Miller, A. K., & Bronner, F. (1981) · Biochemical Journal · doi:10.1042/bj1960391 · Cited by 96 · see citing works
Otake, Y., & Walle, T. (2002) · Drug Metabolism and Disposition · doi:10.1124/dmd.30.2.103 · Cited by 87 · see citing works
Overview on the mechanisms of drug-induced liver cell death
Grattagliano, I., Portincasa, P., Palmieri, V. O., & Palasciano, G. (2002) · Annals of Hepatology · doi:10.1016/s1665-2681(19)32160-x · Cited by 36 · see citing works
Uncoupling activity of a series of flavones and flavonols on isolated plant mitochondria
Ravanel, P. (1986) · Phytochemistry · doi:10.1016/s0031-9422(00)81546-0 · Cited by 33 · see citing works
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2 of the 46 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Flavonoids as Anticancer Agents
Kopustinskienė, D. M., Jakštas, V., Savickas, A., & Bernatonienė, J. (2020) · Nutrients · doi:10.3390/nu12020457 · Cited by 1,313 · see citing works
The Role of Catechins in Cellular Responses to Oxidative Stress
Bernatonienė, J., & Kopustinskienė, D. M. (2018) · Molecules · doi:10.3390/molecules23040965 · Cited by 704 · see citing works
Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance
Davis, J. M., Murphy, E. A., Carmichael, M. D., & Davis, B. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90925.2008 · Cited by 486 · see citing works
Granado‐Serrano, A. B., Martiín, M. A., Bravo, L., Goya, L., & Ramos, S. (2006) · Journal of Nutrition · doi:10.1093/jn/136.11.2715 · Cited by 374 · see citing works
Sergi, D., Naumovski, N., Heilbronn, L. K., Abeywardena, M., O’Callaghan, N., Lionetti, L., & Luscombe-Marsh, N. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00532 · Cited by 347 · see citing works
Sandoval-Acuña, C., Ferreira, J., & Speisky, H. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.05.017 · Cited by 285 · see citing works
Quercetin and the mitochondria: A mechanistic view
de Oliveira, M. R., Nabavi, S. M., Braidy, N., Setzer, W. N., Ahmed, T., & Nabavi, S. F. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.12.014 · Cited by 252 · see citing works
Targeting Inflammatory Pathways by Flavonoids for Prevention and Treatment of Cancer
Prasad, S., Phromnoi, K., Yadav, V. R., Chaturvedi, M. M., & Aggarwal, B. B. (2010) · Planta Medica · doi:10.1055/s-0030-1250111 · Cited by 229 · see citing works
Eid, H. M., Martineau, L. C., Saleem, A., Muhammad, A., Vallerand, D., Benhaddou-Andaloussi, A., Nistor, L., Afshar, A., Arnason, J. T., & Haddad, P. S. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900218 · Cited by 218 · see citing works
Forbes-Hernández, T. Y., Giampieri, F., Gasparrini, M., Mazzoni, L., Quiles, J. L., Álvarez-Suárez, J. M., & Battino, M. A. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.03.017 · Cited by 200 · see citing works
Dihydroquercetin: More than just an impurity?
Weidmann, A. E. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.03.035 · Cited by 197 · see citing works
Quercetin's Influence on Exercise Performance and Muscle Mitochondrial Biogenesis
NIEMAN, D. C., WILLIAMS, A. S., SHANELY, R. A., JIN, F., MCANULTY, S. R., TRIPLETT, N. T., AUSTIN, M. D., & HENSON, D. A. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181b18fa3 · Cited by 194 · see citing works
Fiorani, M., Guidarelli, A., Blasa, M., Azzolini, C., Candiracci, M., Piatti, E., & Cantoni, O. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.01.014 · Cited by 171 · see citing works
Lagoa, R., Graziani, I., López‐Sánchez, C., García‐Martínez, V., & Gutiérrez‐Merino, C. (2011) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2011.09.022 · Cited by 164 · see citing works
López-Revuelta, A., Sánchez-Gallego, J. I., Hernández‐Hernández, Á., Sánchez‐Yagüe, J., & Llanillo, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2006.03.004 · Cited by 158 · see citing works
Natural Compounds Modulating Mitochondrial Functions
Gibellini, L., Bianchini, E., Biasi, S. D., Nasi, M., Cossarizza, A., & Pinti, M. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/527209 · Cited by 158 · see citing works
Structure–activity relationships of flavonoid-induced cytotoxicity on human leukemia cells
Plochmann, K., Korte, G., Koutsilieri, E., Richling, E., Riederer, P. F., Rethwilm, A., Schreier, P. H., & Scheller, C. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.02.003 · Cited by 157 · see citing works
The Dietary Flavonoid Quercetin Increases VO2max and Endurance Capacity
Davis, J. M., Carlstedt, C. J., Chen, S., Carmichael, M. D., & Murphy, E. A. (2010) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.20.1.56 · Cited by 146 · see citing works
Flavonoids and Mitochondria: Activation of Cytoprotective Pathways?
Kicińska, A., & Jarmuszkiewicz, W. (2020) · Molecules · doi:10.3390/molecules25133060 · Cited by 134 · see citing works
Polyphenols as mitochondria-targeted anticancer drugs
Gorlach, S., Fichna, J., & Lewandowska, U. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.07.004 · Cited by 133 · see citing works
Quercetin attenuates vascular calcification by inhibiting oxidative stress and mitochondrial fission
Cui, L., Li, Z., Chang, X., Cong, G., & Hao, L. (2016) · Vascular Pharmacology · doi:10.1016/j.vph.2016.11.006 · Cited by 120 · see citing works
The effect of flavonoids on rat heart mitochondrial function
Trumbeckaitė, S., Bernatonienė, J., Majienė, D., Jakštas, V., Savickas, A., & Toleikis, A. (2006) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2006.04.003 · Cited by 111 · see citing works
Antiproliferative effect of quercetin in the human U138MG glioma cell line
Braganhol, E., Zamin, L. L., Cañedo, A. D., Horn, F., Tamajusuku, A. S. K., Wink, M. R., Salbego, C. G., & Battastini, A. M. O. (2006) · Anti-Cancer Drugs · doi:10.1097/01.cad.0000215063.23932.02 · Cited by 107 · see citing works
Ruan, D., Wang, W., Lin, C., Fouad, A. M., Chen, W., Xia, W., Wang, S., Luo, X., Zhang, W. H., Yan, S., et al. (2018) · animal · doi:10.1017/s1751731118000678 · Cited by 104 · see citing works
Silva, B., Oliveira, P. J., Dias, A. C. P., & Malva, J. O. (2008) · Neurotoxicity Research · doi:10.1007/bf03033510 · Cited by 101 · see citing works
Bioactive Compounds in Phytomedicine
Rasooli, I. (2012) · InTech eBooks · doi:10.5772/2374 · Cited by 97 · see citing works
Usta, J. A., Kreydiyyeh, S. I., Knio, K., Barnabe, P., Yolla, B., & Dagher, S. (2009) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2009.02.012 · Cited by 98 · see citing works
Plant bioactives and redox signaling: (–)-Epicatechin as a paradigm
Fraga, C. G., Oteiza, P. I., & Galleano, M. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.01.007 · Cited by 94 · see citing works
Ramos, A. M., & Aller, P. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.02.007 · Cited by 94 · see citing works
Su, K., Yu, C. Y., Chen, Y., Huang, Y., Chen, C., Wu, H., & Chen, Y. S. (2014) · International Journal of Medical Sciences · doi:10.7150/ijms.8220 · Cited by 90 · see citing works
Dietary Polyphenols and Mitochondrial Function: Role in Health and Disease
Teixeira, J., Chavarria, D., Borges, F., Wojtczak, L., Wieckowski, M. R., Karkucińska‐Więckowska, A., & Oliveira, P. J. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170529101810 · Cited by 87 · see citing works
Quercetin Induces Mitochondrial Biogenesis through Activation of HO-1 in HepG2 Cells
Rayamajhi, N., Kim, S., Go, H., Joe, Y., Callaway, Z., Kang, J., Ryter, S. W., & Chung, H. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/154279 · Cited by 87 · see citing works
Zhang, Y., Chen, S., Wei, C., Rankin, G. O., Ye, X., & Chen, Y. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.01.084 · Cited by 85 · see citing works
Antioxidant activity of flavonoids in isolated mitochondria
Dorta, D. J., Pigoso, A. A., Mingatto, F. E., Rodrigues, T., Pestana, C. R., Uyemura, S. A., dos Santos, A. C., & Curti, C. (2008) · Phytotherapy Research · doi:10.1002/ptr.2441 · Cited by 85 · see citing works
Effects of quercetin on the apoptosis of the human gastric carcinoma cells
Wang, P., Zhang, K., Zhang, Q., Mei, J., Chen, C., Feng, Z., & Yu, D. (2011) · Toxicology in Vitro · doi:10.1016/j.tiv.2011.11.015 · Cited by 81 · see citing works
Flavonoids and mitochondrial pharmacology: A new paradigm for cardioprotection
Testai, L. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.04.017 · Cited by 77 · see citing works
The Effects of Quercetin Supplementation on Eccentric Exercise-Induced Muscle Damage
Bazzucchi, I., Patrizio, F., Ceci, R., Duranti, G., Sgrò, P., Sabatini, S., Luigi, L. D., Sacchetti, M., & Felici, F. (2019) · Nutrients · doi:10.3390/nu11010205 · Cited by 71 · see citing works
Houghton, M. J., Kerimi, A., Tumova, S., Boyle, J. P., & Williamson, G. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.037 · Cited by 68 · see citing works
Chronic quercetin exposure affects fatty acid catabolism in rat lung
de Boer, V. C. J., van Schothorst, E. M., Dihal, A. A., van der Woude, H., Arts, I. C. W., Rietjens, I. M. C. M., Hollman, P. C. H., & Keijer, J. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6316-z · Cited by 64 · see citing works
Zhang, J., Souders, C. L., Denslow, N. D., & Martyniuk, C. J. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.04.024 · Cited by 63 · see citing works
Quercetin Impacts Expression of Metabolism- and Obesity-Associated Genes in SGBS Adipocytes
Leiherer, A., Stoemmer, K., Muendlein, A., Saely, C. H., Kinz, E., Brandtner, E. M., Fraunberger, P., & Drexel, H. (2016) · Nutrients · doi:10.3390/nu8050282 · Cited by 59 · see citing works
Amigo‐Benavent, M., Wang, S., Mateos, R., Sarriá, B., & Bravo, L. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.05.019 · Cited by 59 · see citing works
Yu, T., Dohl, J., Chen, Y., Gasier, H. G., & Deuster, P. A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28006 · Cited by 56 · see citing works
Valdecantos, M. P., Pérez‐Matute, P., González‐Muniesa, P., Prieto-Hontoria, P. L., Moreno-Aliaga, M. J., & Martínez, J. A. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.11.011 · Cited by 53 · see citing works
Effect of Dietary Bioactive Compounds on Mitochondrial and Metabolic Flexibility
Serrano, J. C. E., Cassanyé, A., Martin‐Garí, M., Granado‐Serrano, A. B., & Portero‐Otín, M. (2016) · Diseases · doi:10.3390/diseases4010014 · Cited by 51 · see citing works
Băran, I., Ganea, C., Scordino, A., Musumeci, F., Barresi, V., Tudisco, S. S., Privitera, S., Grasso, R., Condorelli, D. F., Ursu, I., et al. (2010) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-010-9104-1 · Cited by 49 · see citing works
Poór, M., Veres, B., Jakus, P., Antus, C., Montskó, G., Zrínyi, Z., Vladimir‐Knežević, S., Petrik, J., & Kőszegi, T. (2014) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2014.01.016 · Cited by 49 · see citing works
Ortega, R., & Garcı́a, N. (2009) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-009-9198-6 · Cited by 49 · see citing works
Duranti, G., Ceci, R., Patrizio, F., Sgrò, P., Luigi, L. D., Sabatini, S., Felici, F., & Bazzucchi, I. (2017) · Nutrition Research · doi:10.1016/j.nutres.2017.12.002 · Cited by 48 · see citing works
Effect of Ginkgo biloba extract on the rat heart mitochondrial function
Trumbeckaitė, S., Bernatonienė, J., Majienė, D., Jakštas, V., Savickas, A., & Toleikis, A. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.12.028 · Cited by 47 · see citing works
Tundis, R., Iacopetta, D., Sinicropi, M. S., Bonesi, M., Leporini, M., PASSALACQUA, N. G., Ceramella, J., Menichini, F., & Loizzo, M. R. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.05.040 · Cited by 47 · see citing works
Utilizing small nutrient compounds as enhancers of exercise-induced mitochondrial biogenesis
Craig, D. M., Ashcroft, S. P., Belew, M. Y., Stocks, B., Currell, K., Baar, K., & Philp, A. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00296 · Cited by 45 · see citing works
Pazin, M., Pereira, L. C., & Dorta, D. J. (2014) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2014.974233 · Cited by 44 · see citing works
Elingold, I., Isollabella, M. P., Casanova, M. B., Celentano, A. M., Pérez, C., Cabrera, J. L., Diez, R. A., & Dubin, M. (2007) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2007.10.005 · Cited by 44 · see citing works
Nutritional supplementation in the treatment of glaucoma: A systematic review
Loskutova, E., O'Brien, C. J., Loskutov, I. A., & Loughman, J. (2018) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2018.09.005 · Cited by 44 · see citing works
Brisdelli, F., Coccia, C., Cinque, B., Cifone, M. G., & Bozzi, A. (2006) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-006-9307-3 · Cited by 44 · see citing works
Xi, Y., Yu, H., Ma, W., Ding, B., Ding, J., Yuan, L., Feng, J., & Xiao, R. (2011) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-011-9362-7 · Cited by 42 · see citing works
Gao, C., Chen, X., Li, J., Li, Y., Tang, Y., Liu, L., Chen, S., Yu, H., Liu, L., & Yao, P. (2013) · European Journal of Applied Physiology · doi:10.1007/s00421-013-2802-9 · Cited by 42 · see citing works
Quercetin’s effect on cycling efficiency and substrate utilization
Dumke, C. L., Nieman, D. C., Utter, A. C., Rigby, M. D., Quindry, J. C., Triplett, N. T., McAnulty, S. R., & McAnulty, L. S. (2009) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h09-099 · Cited by 41 · see citing works
Cytotoxic and Apoptotic Activities of Prunus spinosa Trigno Ecotype Extract on Human Cancer Cells
Meschini, S., Pellegrini, E., Condello, M., Occhionero, G., Delfine, S., Condello, G., & Mastrodonato, F. (2017) · Molecules · doi:10.3390/molecules22091578 · Cited by 39 · see citing works
Flavonoids and cellular stress: a complex interplay affecting human health
Vissenaekens, H., Criel, H., Grootaert, C., Raes, K., Smagghe, G. J., & Camp, J. V. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1929822 · Cited by 38 · see citing works
Dietary bioactive compounds as modulators of mitochondrial function
Vásquez-Reyes, S., Velázquez-Villegas, L. A., Vargas-Castillo, A., Noriega, L. G., Torres, N., & Tovar, A. R. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108768 · Cited by 35 · see citing works
Seydi, E., Mehrpouya, L., Sadeghi, H., Rahimi, S., & Pourahmad, J. (2021) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2021.104785 · Cited by 35 · see citing works
Guzy, J., Vašková, J., Rozmer, Z., Fodor, K., Mareková, M., Poškrobová, M., & Perjési, P. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.11.098 · Cited by 34 · see citing works
Escobar, S. J. D. M., Fong, G. M., Winnischofer, S. M. B., Simone, M., Munoz, L., Dennis, J. M., Rocha, M. E. M., & Witting, P. K. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.11.022 · Cited by 33 · see citing works
Martineau, L. C. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.11.012 · Cited by 33 · see citing works
Sgrò, P., Ceci, R., Lista, M., Patrizio, F., Sabatini, S., Felici, F., Sacchetti, M., Bazzucchi, I., Duranti, G., & Luigi, L. D. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.745959 · Cited by 33 · see citing works
Effects of α-mangostin on mitochondrial energetic metabolism
Abundis, E. M., Garcı́a, N., Correa, F., Hernández‐Reséndiz, S., Pedraza‐Chaverrí, J., & Zazueta, C. (2009) · Mitochondrion · doi:10.1016/j.mito.2009.12.140 · Cited by 32 · see citing works
Ristivojević, M. K., Stojadinović, M., Smiljanić, K., Stanić-Vučinić, D., & Veličković, T. Ć. (2014) · RSC Advances · doi:10.1039/c4ra13230k · Cited by 32 · see citing works
Fungitoxicity against Botrytis cinerea of a Flavonoid Isolated from Pseudognaphalium robustum
Cotoras, M., Mendoza, L., Munoz, A. Y., Yáñez, K. P., Castro, P. D. T. O. E., & Aguirre, M. J. (2011) · Molecules · doi:10.3390/molecules16053885 · Cited by 32 · see citing works
The multifaceted role of quercetin derived from its mitochondrial mechanism
Carrillo-Garmendia, A., Pérez, L. A. M., & Regalado‐González, C. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04833-w · Cited by 35 · see citing works
Epicatechin regulation of mitochondrial structure and function is opioid receptor dependent
Panneerselvam, M., Ali, S. S., Finley, J. C., Kellerhals, S. E., Migita, M. Y., Head, B. P., Patel, P. M., Roth, D. M., & Patel, H. H. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300026 · Cited by 31 · see citing works
Jofré, I., Cuevas, M., de Castro, L. S., Losano, J. D. D. A., Torres, M. A., Marysol Alvear, Z., Scheuermann, E., de Andrade, A. F. C., Nichi, M., Assumpção, M. E. O. D., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/2917513 · Cited by 30 · see citing works
Chain Breaking Antioxidant Activity of Heavy (S, Se, Te) Chalcogens Substituted Polyphenols
Viglianisi, C., & Menichetti, S. (2019) · Antioxidants · doi:10.3390/antiox8100487 · Cited by 30 · see citing works
Chudapongse, N., Kamkhunthod, M., & Poompachee, K. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.05.010 · Cited by 30 · see citing works
Martineau, L., Adeyiwola-Spoor, D. C. A., Vallerand, D., Afshar, A., Arnason, J., & Haddad, P. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.10.026 · Cited by 42 · see citing works
Citrus Flavonoid Supplementation Improves Exercise Performance in Trained Athletes.
Overdevest, E., Wouters, J. A., Wolfs, K. H. M., van Leeuwen, J. J. M., & Possemiers, S. (2018) · Europe PMC (PubMed Central) · Cited by 29 · see citing works
Antifungal activity of honey from stingless bee Melipona beecheii against Candida albicans
Hau-Yama, N. E., Magaña-Ortíz, D., Oliva, A. I., & Ortíz‐Vázquez, E. (2019) · Journal of Apicultural Research · doi:10.1080/00218839.2019.1665247 · Cited by 29 · see citing works
Zymonė, K., Benetis, R., Trumbeckas, D., Basevičienė, I., & Trumbeckaitė, S. (2022) · Molecules · doi:10.3390/molecules27196377 · Cited by 29 · see citing works
Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice
Ruíz, L. M., Salazar, C., Jensen, E. L., Ruiz, P. A., Tiznado, W., Quintanilla, R. A., Barreto, M., & Elorza, Á. A. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/836301 · Cited by 29 · see citing works
Eid, H. M., Vallerand, D., Muhammad, A., Durst, T., Haddad, P., & Martineau, L. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.08.026 · Cited by 31 · see citing works
Băran, I., Ganea, C., Privitera, S., Scordino, A., Barresi, V., Musumeci, F., Mocanu, M., Condorelli, D. F., Ursu, I., Grasso, R., et al. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/498914 · Cited by 29 · see citing works
Moresco, K. S., Silveira, A., Schnorr, C. E., Zeidán‐Chuliá, F., Bortolin, R. C., Bittencourt, L. D. S., Mingori, M. R., Heimfarth, L., Rabelo, T. K., Morrone, M. D. S., et al. (2017) · Biomedicines · doi:10.3390/biomedicines5030053 · Cited by 28 · see citing works
Woodman, O. L., Long, R., Pons, S., Eychenne, N., Berdeaux, A., & Morin, D. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.01.004 · Cited by 28 · see citing works
Signaling Proteins and Pathways Affected by Flavonoids in Leukemia Cells
Liu, X., Ye, F., Wu, J. W., How, B., Li, W., & Zhang, D. Y. (2015) · Nutrition and Cancer · doi:10.1080/01635581.2015.989372 · Cited by 28 · see citing works
Chen, Y., Chen, H.-Y., Hsu, C., & Yen, G. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf063118t · Cited by 28 · see citing works
Debnath, I., Ghosh, S., Jha, S. K., Bhunia, S., Nayak, A., Basak, S., Nandi, S., & Bhattacharjee, S. (2025) · BIO Integration · doi:10.15212/bioi-2025-0073 · Cited by 30 · see citing works
Changes of metabolic profiles in urine after oral administration of quercetin in rats
An, D., Zhang, Q., Wu, S., Wei, J., Yang, J., Dong, F., Yan, X., & Guo, C. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.03.019 · Cited by 27 · see citing works
Role of Flavonoids in Modulation of Mitochondria Dynamics during Oxidative Stress
Kumar, S., Chhabra, V., Shenoy, S., Daksh, R., Ravichandiran, V., Swamy, R. S., & Kumar, N. (2023) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/0113895575259219230920093214 · Cited by 28 · see citing works
Dąbrowska, A., Zając, M., Bednarczyk, P., & Łukasiak, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010638 · Cited by 26 · see citing works
Pardo‐Andreu, G. L., Dorta, D. J., Delgado, R., Cavalheiro, R. A., dos Santos, A. C., Vercesi, A. E., & Curti, C. (2005) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.10.109 · Cited by 26 · see citing works
Caruso, F., Berinato, M., Hernandez, M., Belli, S. L., Smart, C., & Rossi, M. (2022) · PLoS ONE · doi:10.1371/journal.pone.0267624 · Cited by 24 · see citing works
Gabrielová, E., Jabůrek, M., Gažák, R., Vostálová, J., Ježek, J., Vladimír Křen, A., & Modrianský, M. (2010) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-010-9319-2 · Cited by 24 · see citing works
Sánchez-Muñoz, M. A., Valdez-Solana, M. A., Campos-Almazán, M. I., Flores-Herrera, Ó., Esparza-Perusquía, M., Olvera-Sánchez, S., García‐Arenas, G., Avitia-Domínguez, C. I., Téllez‐Valencia, A., & Sierra‐Campos, E. (2018) · Biochemistry Research International · doi:10.1155/2018/5681081 · Cited by 24 · see citing works
Mitochondrial respiratory complex I probed by delayed luminescence spectroscopy
Băran, I., Ionescu, D. N., Privitera, S., Scordino, A., Mocanu, M., Musumeci, F., Grasso, R., Gulino, M., Iftime, A., Tofolean, I. T., et al. (2013) · Journal of Biomedical Optics · doi:10.1117/1.jbo.18.12.127006 · Cited by 24 · see citing works
Effects of Ginkgo biloba extract on heart and liver mitochondrial functions: mechanism(s) of action
Baliūtytė, G., Banienė, R., Trumbeckaitė, S., Borutaitė, V., & Toleikis, A. (2010) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-010-9275-x · Cited by 23 · see citing works
Cálgaro-Helena, A. F., Vicentine, K. F. D., Rodrigues, T., Dorta, D. J., Raddi, M. S. G., Vilegas, W., Uyemura, S. A., dos Santos, A. C., & Curti, C. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2006.04.006 · Cited by 23 · see citing works
Cheng, M.-Y., Cheng, Y.-W., Yan, J. X., Hu, X., Zhang, H., Wang, Z., Yin, Q., & Cheng, W. (2016) · PubMed Central · Cited by 22 · see citing works
Selective toxicity of chrysin on mitochondria isolated from liver of a HCC rat model
Seydi, E., Rahimpour, Z., Salimi, A., & Pourahmad, J. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.115163 · Cited by 22 · see citing works
- Authors
- Dorta, D. J., Pigoso, A. A., Mingatto, F. E., Rodrigues, T., Prado, I. M. R., Helena, A. F. C., Uyemura, S. A., Santos, A. C., & Curti, C.
- Affiliations
- Universidade de São Paulo (BR)
- Corresponding author
- Curti, Carlos
- ORCID
- Venue
- Chemico-Biological Interactions
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 152
- Issue
- 2-3
- Pages
- 67-78
- ISSN
- 0009-2797 (ISSN-L)
- OpenAlex
- W2042065066
- Cited by
- 165
- References
- 46
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 8 · 2021: 6 · 2020: 7 · 2019: 13 · 2018: 11 · 2017: 10 · 2016: 6 · 2015: 9 · 2014: 11 · 2013: 4 · 2012: 8
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemico-Biological Interactions (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade de São Paulo
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- flavonoids, mitochondria, quercetin, taxifolin, catechins, galangin, mitochondrial permeability transition, mitochondrial uncoupling, electron transport inhibition, mitochondrial membrane fluidity, mitochondrial calcium release, mitochondrial ATP, apoptosis, necrosis, structure-activity relationship, liver mitochondria
- MeSH terms
- Adenosine Triphosphate, Animals, Calcium, Catechin, Flavonoids, Intracellular Membranes, Luminescent Measurements, Male, Membrane Fluidity, Mitochondria, Liver, Polarography, Quercetin, Structure-Activity Relationship, Rats, Wistar, Cell Respiration, Flavonols, Rats
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