Dietary bioactive compounds as modulators of mitochondrial function
Abstract
The increase in incidence and prevalence of metabolic diseases, such as diabetes, obesity, and metabolic syndrome, is a health problem worldwide. Nutritional strategies that can impact on mitochondrial activity represent a novel and effective option to modulate energy expenditure and energetic metabolism in cells and tissues and could be used as adjuvant treatments for metabolic-associated disorders. Dietary bioactive compounds also known as "food bioactives" have proven to exert multiple health benefits and counteract metabolic alterations. In the last years, it has been consistently reported that the modulation of mitochondrial function represents one of the mechanisms behind the bioactive compounds-dependent health improvements. In this review, we focus on gathering, summarizing, and discussing the evidence that supports the effect of dietary bioactive compounds on mitochondrial activity and the relation of these effects in the pathological context. Despite the evidence presented here on in vivo and in vitro effects, more studies are needed to determine their effectiveness in humans.
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Caloric restriction and natural compounds elicit changes in cellular mitochondrial content and mitigate mitochondrial ROS production.
“A common theme emerging from studies is that caloric restriction and these natural compounds elicit changes in cellular mitochondrial content and mitigates mitochondrial ROS production [69].”
From Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds (2024) · cites this paper as [69]
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“SIRT1 has a variety of functions and can interact with proteins related to a variety of signaling pathways to deacetylate histones, lysine residues and transcription factors and play a role in gene regulation (Vasquez-Reyes et al. 2021; Maissan et al. 2021).”
BackgroundExtraction and encapsulation of bioactive compounds: A review
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“Emerging evidence shows dietary bioactive compounds modulate gut health, intestinal barrier function [9,10], and mitochondrial activity, representing a novel option to modulate energy expenditure and energetic metabolism in cells and tissues [5,11].”
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“With this in mind, we tested the efficacy of the prolonged in vivo administration of a standardized green tea extract (GTE) in preventing the initial functional changes occurring in the diabetic heart, given the documented effect of this compound in promoting mitochondrial function, even in the normal heart [16,25,34]…”
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Brown Adipose Tissue, Batokines, and Bioactive Compounds in Foods: An Update
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Amazonian Fruits for Treatment of Non-Communicable Diseases
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“Mitochondria are essential organelles involved in energy production and cellular oxidative metabolism, generating approximately 90% of cellular ATP through oxidative phosphorylation complexes (OXPHOS) [21].”
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Healthy Aging in Times of Extreme Temperatures: Biomedical Approaches
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“One aspect of the microbiome’s contribution to human health and well-being is its interaction with dietary intake, leading to physiological effects such as the alteration of the chemical structure of ingested food components and the modulation of human metabolism in the body (1).”
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Bioactive compounds of forest fungi for diverse biotechnological applications
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Osteogenic Effects of Bioactive Compounds Found in Fruits on Mesenchymal Stem Cells: A Review
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New insights into molecular mechanisms behind the anti-aging effects of dietary bioactive components
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93Chapter 5 Molecular, biochemical, and metabolic approaches to functional foods
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Functional foods and their potential impact on women’s health in Chile
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- Authors
- Vásquez-Reyes, S., Velázquez-Villegas, L. A., Vargas-Castillo, A., Noriega, L. G., Torres, N., & Tovar, A. R.
- Affiliations
- Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX)
- Corresponding author
- Tovar, Armando R.
- Venue
- The Journal of Nutritional Biochemistry
- Publisher
- Elsevier BV
- Published
- 2021-10
- Volume
- 96
- Pages
- 108768
- ISSN
- 0955-2863 (ISSN-L)
- OpenAlex
- W3160956896
- Cited by
- 35
- References
- 177
- Citations by year
- 2026: 2 · 2025: 14 · 2024: 8 · 2023: 4 · 2022: 7
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- The Journal of Nutritional Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Consejo Nacional de Ciencia y Tecnología (261843)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- dietary bioactive compounds, mitochondrial function, metabolic disorders, diabetes mellitus, obesity, metabolic syndrome, energy expenditure, energy metabolism, adjuvant therapy
- MeSH terms
- Gastrointestinal Microbiome, Animals, Humans, Mitochondria, Oxygen Consumption, Thermogenesis, AMP-Activated Protein Kinases, Functional Food, Sirtuin 1
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