Cited by 35Adipose Tissue and MetabolismMitochondrial Function and PathologyPhytochemicals and Antioxidant Activities

Dietary bioactive compounds as modulators of mitochondrial function

Vásquez-Reyes, Sarai, Velázquez-Villegas, Laura A., Vargas-Castillo, Ariana, Noriega, Lilia G., Torres, Nimbe, Tovar, Armando R.·2021·The Journal of Nutritional Biochemistry

Abstract

The increase in incidence and prevalence of metabolic diseases, such as diabetes, obesity, and metabolic syndrome, is a health problem worldwide. Nutritional strategies that can impact on mitochondrial activity represent a novel and effective option to modulate energy expenditure and energetic metabolism in cells and tissues and could be used as adjuvant treatments for metabolic-associated disorders. Dietary bioactive compounds also known as "food bioactives" have proven to exert multiple health benefits and counteract metabolic alterations. In the last years, it has been consistently reported that the modulation of mitochondrial function represents one of the mechanisms behind the bioactive compounds-dependent health improvements. In this review, we focus on gathering, summarizing, and discussing the evidence that supports the effect of dietary bioactive compounds on mitochondrial activity and the relation of these effects in the pathological context. Despite the evidence presented here on in vivo and in vitro effects, more studies are needed to determine their effectiveness in humans.

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Crossref · 10.1016/j.jnutbio.2021.108768

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Research works printed but not linked: 5

  1. Bernhoft, 2010, A brief review on bioactive compounds in plants, 11
  2. Khan, 2020, Chapter 1. Extraction of bioactive molecules: convenctional versus novel methods
  3. Palacios-González, 2019, Genistein increases the thermogenic program of subcutaneous WAT and increase energy expenditure in mice, J Nutr Biochem, 68, 59, 10.1016/j.jnutbio.2019.03.012 · DOI
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Authors
Vásquez-Reyes, S., Velázquez-Villegas, L. A., Vargas-Castillo, A., Noriega, L. G., Torres, N., & Tovar, A. R.
Affiliations
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX)
Corresponding author
Tovar, Armando R.
Venue
The Journal of Nutritional Biochemistry
Publisher
Elsevier BV
Published
2021-10
Volume
96
Pages
108768
ISSN
0955-2863 (ISSN-L)
OpenAlex
W3160956896
Cited by
35
References
177
Citations by year
2026: 2 · 2025: 14 · 2024: 8 · 2023: 4 · 2022: 7
FWCI
0.63
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Nutritional Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
Consejo Nacional de Ciencia y Tecnología (261843)
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
dietary bioactive compounds, mitochondrial function, metabolic disorders, diabetes mellitus, obesity, metabolic syndrome, energy expenditure, energy metabolism, adjuvant therapy
MeSH terms
Gastrointestinal Microbiome, Animals, Humans, Mitochondria, Oxygen Consumption, Thermogenesis, AMP-Activated Protein Kinases, Functional Food, Sirtuin 1

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