Cited by 142Pharmacogenetics and Drug MetabolismGlutathione Transferases and PolymorphismsDrug Transport and Resistance Mechanisms

Function and organization of the human cytosolic sulfotransferase (SULT) family

Coughtrie, Michael W.H.·2016·Chemico-Biological Interactions

Abstract

The sulfuryl transfer reaction is of fundamental biological importance. One of the most important manifestations of this process are the reactions catalyzed by members of the cytosolic sulfotransferase (SULT) superfamily. These enzymes transfer the sulfuryl moiety from the universal donor PAPS (3'-phosphoadenosine 5'-phosphosulfate) to a wide variety of substrates with hydroxyl- or amino-groups. Normally a detoxification reaction this facilitates the elimination of a multitude of xenobiotics, although for some molecules sulfation is a bioactivation step. In addition, sulfation plays a key role in endocrine and other signalling pathways since many steroids, sterols, thyroid hormones and catecholamines exist primarily as sulfate conjugates in humans. This article summarizes much of our current knowledge of the organization and function of the human cytosolic sulfotransferases and highlights some of the important interspecies differences that have implications for, among other things, drug development and chemical safety analysis.

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Crossref · 10.1016/j.cbi.2016.05.005

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Authors
Coughtrie, M. W. H.
Affiliations
University of British Columbia (CA)
Corresponding author
Coughtrie, Michael W.H.
Venue
Chemico-Biological Interactions
Publisher
Elsevier BV
Published
2016-11
Volume
259
Issue
Pt A
Pages
2-7
ISSN
0009-2797 (ISSN-L)
OpenAlex
W2346100651
Cited by
142
References
86
Citations by year
2026: 11 · 2025: 11 · 2024: 14 · 2023: 19 · 2022: 14 · 2021: 19 · 2020: 13 · 2019: 18 · 2018: 12 · 2017: 8 · 2016: 3
FWCI
2.45
Type
journal article
Language
en
Open access
closed
Locations
  • Chemico-Biological Interactions (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords
cytosolic sulfotransferases, sulfation, PAPS, xenobiotic detoxification, metabolic activation, species differences, drug development, chemical safety
MeSH terms
Humans, Inactivation, Metabolic, Phosphoadenosine Phosphosulfate, Substrate Specificity, Sulfates, Sulfotransferases

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