Cnidarian chemical neurotransmission, an updated overview

Kass-Simon, G.; Pierobon, Paola

doi:10.1016/j.cbpa.2006.09.008

Cited by 150Marine Invertebrate Physiology and EcologyNeuropeptides and Animal PhysiologyNeuroscience and Neuropharmacology Research

Cnidarian chemical neurotransmission, an updated overview

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Kass-Simon, G., Pierobon, Paola·2007·Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology

DOI 10.1016/j.cbpa.2006.09.008

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Abstract

The ultrastructural, histochemical, immunocytochemical, biochemical, molecular, behavioral and physiological evidence for non-peptidergic and peptidergic chemical neurotransmission in the Anthozoa, Hydrozoa, Scyphozoa and Cubozoa is surveyed. With the possible exception of data for the catecholamines and peptides in some animals, the set of cumulative data - the evidence from all methodologies - is incomplete. Taken together, the evidence from all experimental approaches suggests that both classical fast (acetylcholine, glutamate, GABA, glycine) and slow (catecholamines and serotonin) transmitters, as well as neuropeptides, are involved in cnidarian neurotransmission. Ultrastructural evidence for peptidergic, serotonergic, and catecholaminergic synaptic localization is available, but the presence of clear and dense-cored synaptic vesicles also suggests both fast and slow classical transmission. Immunocytochemical studies, in general, reveal a continuous, non-localized distribution of neuropeptides, suggesting a neuromodulatory role for them. Immunocytochemical and biochemical studies indicate the presence of glutamate, GABA, serotonin, catecholamines (and/or their receptors), RFamides, nitric oxide and eicosanoids in cnidarian neurons and tissues. Gene sequences for peptidergic preprohormones have been reported; putative gene homologies to receptor proteins for vertebrate transmitters have been found in Hydra. Behavioral and physiological studies implicate classical transmitters, neuropeptides, eicosanoids and nitric oxide in the coordination of the neuroeffector systems.

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Histochemical, biochemical, and functional data indicate the presence of small molecule neurotransmitters such as catecholamines, serotonin, acetylcholine, glutamate, and GABA in Cnidaria.
“Ample histochemical, biochemical and functional data have been accumulated, indicating the presence of different small molecule neurotransmitters, such as catecholamines, serotonin, acetylcholine, glutamate and GABA in Cnidaria [48,49].”
From Back to the Basics: Cnidarians Start to Fire (2017) · cites this paper as [48]

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Genomic Organization and Splicing Variants of a Peptidylglycine α-Hydroxylating Monooxygenase from Sea Anemones
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Evidence for a Common Pattern of Peptidergic Innervation of Cnidocytes
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Antho-RFamide Immunoreactivity in Neuronal Synaptic and Nonsynaptic Vesicles of Sea Anemones
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The occurrence in and actions of amino acids on isolated supra oral sphincter preparations of the sea anemone Actinia equina
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Two types of surface amine receptors modulating the feeding response inHydra japonica: the depressing action of dopamine and related amines
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Different roles of GABA and glycine in the modulation of chemosensory responses in Hydra vulgaris (Cnidaria, Hydrozoa)
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Monoamine release by neurons of a primitive nervous system: an amperometric study
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Identification of a novel aminergic-like G protein-coupled receptor in the cnidarian Renilla koellikeri
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Authors: Kass-Simon, G., & Pierobon, P.
Affiliations: Istituto di Cibernetica “Eduardo Caianiello” (IT)
Venue: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
Publisher: Elsevier BV
Published: 2007-01
Volume: 146
Issue: 1
Pages: 9-25
ISSN: 1095-6433 (ISSN-L)
DOI: 10.1016/j.cbpa.2006.09.008
OpenAlex: W2069471505
Cited by: 150
References: 210
Citations by year: 2026: 4 · 2025: 10 · 2024: 8 · 2023: 5 · 2022: 5 · 2021: 12 · 2020: 6 · 2019: 13 · 2018: 10 · 2017: 7 · 2016: 8 · 2015: 12 · 2014: 5 · 2013: 7 · 2012: 6
FWCI: 0.58
Type: journal article
Language: en
Open access: green
digitalcommons.uri.edu
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology (publishedVersion)
PubMed (publishedVersion)
Journal of Media Literacy Education (submittedVersion, cc-by)
Funders: Ministero dell’Istruzione, dell’Università e della Ricerca (1105/02, 44)
Topics: Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: chemical neurotransmission, neuropeptides, acetylcholine, glutamate, GABA, glycine, catecholamines, serotonin, RFamide, nitric oxide, eicosanoids, synaptic vesicles, neuromodulation, Hydra, Anthozoa, Hydrozoa, Scyphozoa, Cubozoa
MeSH terms: Animals, Cnidaria, Electrophysiology, Histocytochemistry, Immunohistochemistry, Synaptic Transmission, Neurotransmitter Agents

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Cnidarian chemical neurotransmission, an updated overview

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