Anatomy and development of the nervous system of Nematostella vectensis , an anthozoan cnidarian

Marlow, Heather Q.; Srivastava, Mansi; Matus, David Q.; Rokhsar, Daniel; Martindale, Mark Q.

doi:10.1002/dneu.20698

Cited by 248Marine Invertebrate Physiology and EcologyDevelopmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanisms

Anatomy and development of the nervous system of Nematostella vectensis , an anthozoan cnidarian

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Marlow, Heather Q., Srivastava, Mansi, Matus, David Q., Rokhsar, Daniel, Martindale, Mark Q.·2009·Developmental Neurobiology

DOI 10.1002/dneu.20698

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Abstract

Nematostella vectensis , an anthozoan cnidarian, whose genome has been sequenced and is suitable for developmental and ecological studies, has a complex neural morphology that is modified during development from the larval to adult form. N. vectensis ' nervous system is a diffuse nerve net with both ectodermal sensory and effector cells and endodermal multipolar ganglion cells. This nerve net consists of several distinct neural territories along the oral–aboral axis including the pharyngeal and oral nerve rings, and the larval apical tuft. These neuralized regions correspond to expression of conserved bilaterian neural developmental regulatory genes including homeodomain transcription factors and NCAMs . Early neurons and stem cell populations identified with NvMsi , NvELAV , and NvGCM , indicate that neural differentiation occurs throughout the animal and initiates prior to the conclusion of gastrulation. Neural specification in N. vectensis appears to occur through an independent mechanism from that in the classical cnidarian model Hydra . © 2009 Wiley Periodicals, Inc. Develop Neurobiol, 2009

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There is a discrepancy between bioinformatic data and empirical data, specifically the lack of serotonin orthologues in reference [37] with serotonin immunostaining in reference [26] in Nematostella.
“Also, one has to take into account the discrepancy of bioinformatic data with the empirical data (lack of serotonin orthologues in reference [37], with serotonin immunostaining in reference [26] in Nematostella).”
From Evolution of eumetazoan nervous systems: insights from cnidarians (2015) · cites this paper as [26]

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Developmental Neurobiology 1932846x, 2009, 4, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/dneu.20698, Wiley Online Library on [14/08/2023]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License Developmental Neurobiology 1932846x, 2009, 4, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/dneu.20698, Wiley Online Library on [14/08/2023]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License
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Matus DQ, Pang K, Marlow H, Dunn CW, Thomsen GH, Martindale MQ. 2006a. Deep evolutionary roots for bilaterality in the metazoa. Proc Natl Acad Sci USA, in press.
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Authors: Marlow, H. Q., Srivastava, M., Matus, D. Q., Rokhsar, D., & Martindale, M. Q.
Affiliations: University of Hawaiʻi at Mānoa (US)
University of California, Berkeley (US)
Duke University (US)
Corresponding author: Martindale, Mark Q.
ORCID: Marlow, Heather Q.
Srivastava, Mansi
Matus, David Q.
Rokhsar, Daniel
Martindale, Mark Q.
Venue: Developmental Neurobiology
Publisher: Wiley
Published: 2009-01-23
Volume: 69
Issue: 4
Pages: 235-254
ISSN: 1932-8451 (ISSN-L)
1932-846X
DOI: 10.1002/dneu.20698
OpenAlex: W2023007715
Cited by: 247
References: 108
Citations by year: 2026: 7 · 2025: 15 · 2024: 19 · 2023: 8 · 2022: 13 · 2021: 13 · 2020: 5 · 2019: 15 · 2018: 14 · 2017: 10 · 2016: 15 · 2015: 21 · 2014: 17 · 2013: 15 · 2012: 21
FWCI: 15.28
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Developmental Neurobiology (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: Nematostella vectensis, cnidarian nervous system, nerve net, neural development, homeodomain transcription factor, CD56, neural stem cells, oral-aboral axis, apical tuft, gastrulation, neural specification
MeSH terms: Animals, Cell Differentiation, Immunohistochemistry, Molecular Sequence Data, Nervous System, Neurons, Stem Cells, Polymerase Chain Reaction, Neural Cell Adhesion Molecules, Anthozoa

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Anatomy and development of the nervous system of Nematostella vectensis , an anthozoan cnidarian

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