Cited by 1,509Computational Drug Discovery MethodsChemical Synthesis and AnalysisHeterocyclic Compound Synthesis and Bioactivity

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Privileged scaffolds for library design and drug discovery

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Welsch, Matthew E, Snyder, Scott A, Stockwell, Brent R·2010·Current Opinion in Chemical Biology

DOI 10.1016/j.cbpa.2010.02.018PMC PMC2908274

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Abstract

This review explores the concept of using privileged scaffolds to identify biologically active compounds through building chemical libraries. We hope to accomplish three main objectives: to provide one of the most comprehensive listings of privileged scaffolds; to reveal through four selected examples the present state of the art in privileged scaffold library synthesis (in hopes of inspiring new and even more creative approaches); and also to offer some thoughts on how new privileged scaffolds might be identified and exploited.

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Authors: Welsch, M. E., Snyder, S. A., & Stockwell, B. R.
Affiliations: Columbia University (US)
Howard Hughes Medical Institute (US)
Corresponding author: Snyder, Scott A
Stockwell, Brent R
ORCID: Snyder, Scott A
Stockwell, Brent R
Venue: Current Opinion in Chemical Biology
Publisher: Elsevier BV
Published: 2010-06
Volume: 14
Issue: 3
Pages: 347-361
ISSN: 1367-5931 (ISSN-L)
DOI: 10.1016/j.cbpa.2010.02.018
PMC: PMC2908274
OpenAlex: W2162106505
Cited by: 1,509
References: 49
Citations by year: 2026: 83 · 2025: 84 · 2024: 97 · 2023: 101 · 2022: 111 · 2021: 102 · 2020: 109 · 2019: 119 · 2018: 108 · 2017: 114 · 2016: 104 · 2015: 96 · 2014: 91 · 2013: 69 · 2012: 53
FWCI: 5.29
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Current Opinion in Chemical Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
Arnold and Mabel Beckman Foundation
Research Corporation for Science Advancement
Eli Lilly and Company
National Cancer Institute (RC2CA148308, R01CA097061)
National Institute of General Medical Sciences (R01GM084994, R01GM085081, R01-GM84994)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Computational Drug Discovery Methods
Physical Sciences › Chemistry › Organic Chemistry › Chemical Synthesis and Analysis
Physical Sciences › Chemistry › Organic Chemistry › Heterocyclic Compound Synthesis and Bioactivity
Keywords: privileged scaffolds, chemical libraries, library design, drug discovery, scaffold-based drug design, chemical library synthesis, bioactive compounds
MeSH terms: Pharmaceutical Preparations, Humans, Models, Chemical, Protein Binding, Drug Delivery Systems, Receptors, Cytoplasmic and Nuclear, Small Molecule Libraries, Drug Discovery

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