Privileged scaffolds for library design and drug discovery

The evolving role of natural products in drug discovery

Koehn, F. E., & Carter, G. T. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1657 · Cited by 2,579

Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery

Schreiber, S. L. (2000) · Science · doi:10.1126/science.287.5460.1964 · Cited by 2,571

Drugs for bad bugs: confronting the challenges of antibacterial discovery

Payne, D. J., Gwynn, M. N., Holmes, D. J., & Pompliano, D. L. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2201 · Cited by 2,512

A Planning Strategy for Diversity‐Oriented Synthesis

Burke, M. D., & Schreiber, S. L. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200300626 · Cited by 1,493

Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists

Evans, B., Rittle, K. E., Bock, M. G., DiPardo, R. M., Freidinger, R. M., Whitter, W. L., Lundell, G. F., Veber, D. F., Anderson, P., Chang, R. S. L., et al. (1988) · Journal of Medicinal Chemistry · doi:10.1021/jm00120a002 · Cited by 1,460

Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors

Gray, N. S., Wodicka, L. M., Thunnissen, A. M. W. H., Norman, T., Kwon, S., Espinoza, F. H., Morgan, D. O., Barnes, G., Leclerc, S., Meijer, L., et al. (1998) · Science · doi:10.1126/science.281.5376.533 · Cited by 808

From Nature to Drug Discovery: The Indole Scaffold as a ‘Privileged Structure’

Alves, F. R. S., Barreiro, E. J., & Fraga, C. A. M. (2009) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955709788452649 · Cited by 606

Diversity-oriented synthesis: Exploring the intersections between chemistry and biology

Tan, D. S. (2005) · Nature Chemical Biology · doi:10.1038/nchembio0705-74 · Cited by 605

Privileged Structures: Applications in Drug Discovery

DeSimone, R., Currie, K., Mitchell, S. A., Darrow, J. W., & Pippin, D. A. (2004) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207043328544 · Cited by 579

Towards the Optimal Screening Collection: A Synthesis Strategy

Nielsen, T. E., & Schreiber, S. L. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200703073 · Cited by 553

Synthesis of Privileged Scaffolds by Using Diversity‐Oriented Synthesis

Surakanti, R., Sanivarapu, S., Thulluri, C., Iyer, P. S., Tangirala, R. S., Gundla, R., Addepally, U., Murthy, Y. L. N., Velide, L., & Sen, S. (2013) · Chemistry - An Asian Journal · doi:10.1002/asia.201201203 · Cited by 14

Domino [3+2+1] heterocyclization of isothiocyanates with aryl amidines leading to polysubstituted 1,3,5-triazine derivatives

Li, N., Tu, M., Jiang, B., Wang, X., & Tu, S. (2013) · Tetrahedron Letters · doi:10.1016/j.tetlet.2013.01.086 · Cited by 14

Recent advances in the annulative cyclization of 2-alkynylanilines: transition metal, metal-free, photoredox, and electrochemical approaches

Desai, K., Uppuluru, A., Hariprasath, K. R., Manikandan, R., Jayakumar, J., Padala, K., & Annamalai, P. (2025) · Chemical Communications · doi:10.1039/d5cc03457d · Cited by 13

Design, Synthesis and In Vitro Cytotoxic Activity of New 6,9-Disubstituted Purine Analogues

Küçükdumlu, A., Tunçbilek, M., Güven, E. B., & Çetin-Atalay, R. (2020) · Acta chimica slovenica · doi:10.17344/acsi.2019.5196 · Cited by 13

One-pot, three-component Fischer indolisation– N -alkylation for rapid synthesis of 1,2,3-trisubstituted indoles

Hughes‐Whiffing, C. A., & Perry, A. (2020) · Organic & Biomolecular Chemistry · doi:10.1039/d0ob02185g · Cited by 13

Scalable Synthesis of Piperazines Enabled by Visible‐Light Irradiation and Aluminum Organometallics

Suárez‐Pantiga, S., Colas, K., Johansson, M. J., & Mendoza, A. (2015) · Angewandte Chemie · doi:10.1002/ange.201505608 · Cited by 13

Iron‐Based Imidazolium Salt as Dual Lewis Acid and Redox Catalyst for the Aerobic Synthesis of Quinazolines

Martos, M., & Pastor, I. M. (2022) · European Journal of Organic Chemistry · doi:10.1002/ejoc.202200839 · Cited by 13

Synthesis, structural characterization, and antimicrobial activity of novel ferrocene-N-acyl hydrazones designed by means of molecular simplification strategy Celebrating the 100th anniversary of the birth of Professor Paulo Freire

Filho, J. M. D. S., & Castro, M. V. B. D. S. (2022) · Journal of Organometallic Chemistry · doi:10.1016/j.jorganchem.2022.122488 · Cited by 13

Verification of preparations of (1H-indol-3-yl)methyl electrophiles and development of their microflow rapid generation and substitution

Masui, H., Kanda, S., & Fuse, S. (2023) · Communications Chemistry · doi:10.1038/s42004-023-00837-1 · Cited by 13

Arylcyanomethylenequinone Oximes: An Overview of Synthesis, Chemical Transformations, and Biological Activity

Kula, K., Nagatsky, R., Sadowski, M., Siumka, Y., & Demchuk, O. M. (2023) · Molecules · doi:10.3390/molecules28135229 · Cited by 13

Benzo‐fused Nitrogen Heterocycles by Asymmetric Ring Expansion and Stereochemically Retentive Re‐contraction of Cyclic Ureas

Mallick, R. K., Žabka, M., & Clayden, J. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202318417 · Cited by 13

Discovery and Optimization of Tetrahydroisoquinoline Derivatives To Enhance Lysosome Biogenesis as Preclinical Candidates for the Treatment of Alzheimer’s Disease

Zhou, J., Wang, N., Wang, M., Hu, Y., Zhang, Z., Gu, Z., Wang, J., Shou, H., Cheng, X., Liu, H., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00159 · Cited by 14

Organocatalytic[3 + 2]Cycloaddition: Synthesis of Quinazoline Containing Sulfonyl 1,2,3‐Triazoles as Potent EGFR Targeting Anti‐Breast Cancer Agents

Dodlapati, V. R., Sucharitha, E. R., Palabindela, R., Kapavarapu, R., Kavela, S., & Narsimha, S. (2024) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.4905 · Cited by 13

DiffMC‐Gen: A Dual Denoising Diffusion Model for Multi‐Conditional Molecular Generation

Yang, Y., Gu, S., Liu, B., Gong, X., Lu, R., Qiu, J., Yao, X., & Liu, H. (2025) · Advanced Science · doi:10.1002/advs.202417726 · Cited by 15

Solid Phase Synthesis of 1,5-Diarylpyrazole-4-carboxamides: Discovery of Antagonists of the CB-1 Receptor

Pendri, A., Dodd, D. S., Chen, J., Cvijic, M. E., Kang, L., Baska, R. A. F., Carlson, K. E., Burford, N. T., Sun, C., Ewing, W. R., et al. (2012) · ACS Combinatorial Science · doi:10.1021/co200147y · Cited by 13

Structural and Functional Diversities of the Hexadecahydro‐1H‐cyclopenta[a]phenanthrene Framework, a Ubiquitous Scaffold in Steroidal Hormones

Choudhury, C., Priyakumar, U. D., & Sastry, G. N. (2016) · Molecular Informatics · doi:10.1002/minf.201600005 · Cited by 13

Facile entry into structurally diverse, privileged, (hetero)arene-fused N-alkoxy 3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-ones

Sapegin, A., Reutskaya, E., Смирнов, А. В., Korsakov, M. K., & Krasavin, M. (2016) · Tetrahedron Letters · doi:10.1016/j.tetlet.2016.11.064 · Cited by 13

Synthesis of 2H-pyrano[3,2-g]quinolin-2-ones containing a pyrimidinone moiety and characterization of their anticoagulant activity via inhibition of blood coagulation factors Xa and XIa

Potapov, A. Y., Paponov, B. V., Podoplelova, N. A., Panteleev, M. A., Potapov, M. A., Ledenyova, I. V., Stolpovskaya, N. V., & Shikhaliev, K. S. (2021) · Chemistry of Heterocyclic Compounds · doi:10.1007/s10593-021-02945-z · Cited by 13

Regioselective Hydrodebromination of Polybrominated Indoles

Chelucci, G., Pinna, G. A., & Pinna, G. (2014) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201400032 · Cited by 13

Library of diversely substituted 2-(quinolin-4-yl)imidazolines delivers novel non-cytotoxic antitubercular leads

Krasavin, M., Mujumdar, P., Parchinsky, V. Z., Vinogradova, T. I., Manicheva, O. A., & Догонадзе, М. З. (2015) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2015.1101094 · Cited by 13

Photophysical, Electrochemical Studies of Novel Pyrazol‐4‐yl‐2,3‐dihydroquinazolin‐4(1 H )‐ones and Their Anticancer Activity

Kamble, A. A., Kamble, R. R., Chougala, L. S., Kadadevarmath, J. S., Maidur, S. R., Patil, P. S., Kumbar, M. N., & Marganakop, S. B. (2017) · ChemistrySelect · doi:10.1002/slct.201700498 · Cited by 13

Direct oxidative C–H alkynylation of N -carbamoyl tetrahydroisoquinolines and dihydroisoquinolines

Chen, L., Sun, C., Feng, G., Cao, M. H., Zhao, S.-L., Yan, J. Y., Wan, R., & Liu, L. (2018) · Organic & Biomolecular Chemistry · doi:10.1039/c8ob00373d · Cited by 13

Stereoselective Construction of Spiro‐Indolenine Frameworks through a Prins/Friedel–Crafts Cyclization Cascade Reaction

Chandrashekhar, R., Vemulapalli, S. P. B., Sridhar, B., & Reddy, B. V. S. (2018) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201701812 · Cited by 13

Synthesis and antitumor evaluation of novel 4‐anilino‐7,8‐dihydropyrido[4,3‐d]pyrimidine‐6(5H)‐carboxylate derivatives as potential EGFR inhibitors

Zhang, D., Yan, Y., Jin, G., Liu, B., Ma, X., Han, D., & Jia, X. (2018) · Archiv der Pharmazie · doi:10.1002/ardp.201800110 · Cited by 13

Toward development of generic inhibitors against the 3C proteases of picornaviruses

Banerjee, K., Bhat, R., Rao, V. U. B., Nain, A., Rallapalli, K. L., Gangopadhyay, S., Singh, R. P., Banerjee, M., & Jayaram, B. (2018) · FEBS Journal · doi:10.1111/febs.14707 · Cited by 13

A biocatalytic redox cascade approach for one-pot deracemization of carboxyl-substituted tetrahydroisoquinolines by stereoinversion

Ju, S., Qian, M., Li, J., Xu, G., Yang, L., & Wu, J. (2019) · Green Chemistry · doi:10.1039/c9gc02795e · Cited by 13

Fe3O4@SiO2‐CeCl3 Catalyzed Chemoselective Synthesis of Functionalized 3‐Substituted‐1,5‐Benzodiazepines via One‐pot Multicomponent and Domino Reactions

Zhou, L., Wang, M., Wang, K., Wen, T., & Wang, L. (2020) · Applied Organometallic Chemistry · doi:10.1002/aoc.5707 · Cited by 13

AIScaffold: A Web-Based Tool for Scaffold Diversification Using Deep Learning

Lai, J., Li, X., Wang, Y., Yin, S., Zhou, J., & Liu, Z. (2020) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.0c00867 · Cited by 13

Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase

Linsky, T. W., & Fast, W. L. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.07.022 · Cited by 13

Nervous System

Jeschke, P., Nauen, R., Sparks, T. C., Loso, M. R., Watson, G. B., Babcock, J. M., Kramer, V. J., Zhu, Y., Nugent, B. M., Thomas, J. D., et al. (2011) · Wiley eBooks · doi:10.1002/9783527644179.ch32 · Cited by 13

Synthetic Approaches to the Resveratrol‐Based Family of Oligomeric Natural Products

Snyder, S. A. (2011) · Wiley eBooks · doi:10.1002/9783527634606.ch19 · Cited by 13

Advances in Copper and Nickel C─N and C─O Cross‐Couplings of (Hetero)Aryl Chlorides Enabled by Ancillary Ligand Development

Morrison, K. M., & Stradiotto, M. (2025) · Chemistry - A European Journal · doi:10.1002/chem.202501858 · Cited by 12

Tf2O-Mediated Cyclization of α-Acyl-β-(2-aminopyridinyl)acrylamides: Access to N-Substituted 4H-Pyrido[1,2-a]pyrimidin-4-imines

Rao, C. B., Zhang, N., Hu, J., Wang, Y., Liang, Y., Zhang, R., Yuan, J., & Dong, D. (2020) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.9b03495 · Cited by 12

Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target

Liao, Y., Chan, S. C., Welsh, E. A., Fang, B., Sun, L., Schönbrunn, E., Koomen, J. M., Duckett, D. R., Haura, E. B., Monastyrskyi, A., et al. (2023) · ACS Chemical Biology · doi:10.1021/acschembio.2c00587 · Cited by 12

Synthesis of tetracyclic dibenzo[ b , f ][1,4]oxazepine-fused β-lactams via visible-light-induced Staudinger annulation

Wang, J., Zhao, Y., Li, W., Kong, X., Yao, C., & Zhang, K. (2023) · Organic & Biomolecular Chemistry · doi:10.1039/d3ob01078c · Cited by 12

Synthesis and cytotoxic evaluation of heterocyclic compounds by vinylic substitution of ketene dithioacetals

Baliza, L. R. S. P., Freitas, T. R., Gonçalves, E. K. S., Antunes, G. R., Souza, A. J. F., Yoneda, J. D., Duarte, C. L., Andrade, S. N., Sabino, A. D. P., Varotti, F. D. P., et al. (2024) · Chemical Biology & Drug Design · doi:10.1111/cbdd.14581 · Cited by 12

A multi-component synthetic route for 2-pyrazolines via acceptorless dehydrogenation of alcohols using homogeneous Ni( ii ) catalysts

Kukreti, P., Chauhan, R., Panwar, A., & Ghosh, K. (2024) · Organic & Biomolecular Chemistry · doi:10.1039/d4ob01352b · Cited by 12

Proteome-Wide Discovery of Degradable Proteins Using Bifunctional Molecules

Forrest, I., Conway, L. P., Gathmann, C., Jadhav, A. M., Chiu, T.-Y., Chaheine, C. M., Estrada, M. A., Shrestha, A., Sarris, K., Reitsma, J. M., et al. (2025) · ACS Central Science · doi:10.1021/acscentsci.5c01594 · Cited by 12

Exploration of Scaffolds from Natural Products with Antiplasmodial Activities, Currently Registered Antimalarial Drugs and Public Malarial Screen Data

Egieyeh, S. A., Syce, J. A., Christoffels, A. G., & Malan, S. F. (2016) · Molecules · doi:10.3390/molecules21010104 · Cited by 12

On the nonadditivity of the substituent effect in homo-disubstituted pyridines

Hęclik, K., & Dobrowolski, J. C. (2016) · Journal of Physical Organic Chemistry · doi:10.1002/poc.3656 · Cited by 12

Synthesis and supramolecular self-assembly of thioxothiazolidinone derivatives driven by H-bonding and diverse π–hole interactions: A combined experimental and theoretical analysis

Andleeb, H., Khan, I. A., Bauzá, A., Tahir, M. N., Simpson, J., Hameed, S., & Frontera, A. (2017) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2017.03.046 · Cited by 12

Chemoenzymatic synthesis of cytokinins from nucleosides: ribose as a blocking group

Oslovsky, V. E., Solyev, P. N., Polyakov, K. M., Alexeev, C. S., & Mikhailov, S. N. (2018) · Organic & Biomolecular Chemistry · doi:10.1039/c8ob00223a · Cited by 12

Silver-catalyzed cascade reactions of 3-cyanochromone with 1,1-enediamines: synthesis of highly functionalized 2-(pyridin-3-yl)-chromeno[2,3- d ]pyrimidines

Xiao, Q., Liu, J., Nie, J., Kong, L., Lin, J., & Yan, S. (2020) · Organic Chemistry Frontiers · doi:10.1039/d0qo00388c · Cited by 12

Electrochemically induced assembling of isatins, kojic acid, and malonic acid derivatives into substituted spiro[indole‐3,4′‐pyran]‐2( 1 H)‐one scaffold and predicting potential protein targets

Elinson, M. N., Ryzhkova, Y. E., Vereshchagin, A. N., Ryzhkov, F. V., Kalashnikova, V. M., Korolev, V. A., & Egorov, M. P. (2022) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.4579 · Cited by 12

Tandem InCl 3 -Promoted Hydroperoxide Rearrangements and Nucleophilic Additions: A Straightforward Entry to Benzoxacycles

Bosnidou, A. E., Fayet, A., Cheibas, C., Gayraud, O., Bourcier, S., Frison, G., & Nay, B. (2023) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.3c00845 · Cited by 12

Structure–activity relationship study of E6 as a novel necroptosis inducer

Mou, J., Park, A., Cai, Y. C., Yuan, J., & Yuan, C. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.04.038 · Cited by 12

A natural product based DOS library of hybrid systems

Prabhu, G., Agarwal, S., Sharma, V., Madurkar, S. M., Munshi, P., Singh, S., & Sen, S. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.03.023 · Cited by 12

Atropisomerization of 8-Membered Dibenzolactam: Experimental NMR and Theoretical DFT Study

Buevich, A. V. (2015) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.5b02321 · Cited by 12

C–H Bond Functionalization of Tetrahydropyridopyrimidines and Other Related Hetereocycles

Cheng, Z., Yu, Z., Yang, S., Shen, H. C., Zhao, W., & Zhong, S. (2017) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.7b02382 · Cited by 12

Green and Eco-Friendly Synthesis of Quinoxalines by Brönsted Acidic Ionic Liquid Supported on Nano-SiO 2 under Solvent-Free Conditions

Daragahi, S. A. H., Mohebat, R., & MOSSLEMIN, M. H. (2018) · Organic Preparations and Procedures International · doi:10.1080/00304948.2018.1462056 · Cited by 12

Regiodivergent Trifluoromethanesulfonic Acid‐Promoted Cycloisomerizations of Ynenamines to Fused Indoles

Alam, K., Kim, J. G., Kang, D. Y., & Park, J. K. (2019) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201801506 · Cited by 12

An approach to dihydroisoindolobenzodiazepinones—three-dimensional molecular frameworks

Yaremenko, A. G., Shelyakin, V. V., Volochnyuk, D. M., Rusanov, E. B., & Grygorenko, O. O. (2012) · Tetrahedron Letters · doi:10.1016/j.tetlet.2012.12.065 · Cited by 12

Water-triggered union of multi-component reactions towards the synthesis of a 4 H -chromene hybrid scaffold

Kumaravel, K., Rajarathinam, B., & Vasuki, G. (2020) · RSC Advances · doi:10.1039/d0ra05105e · Cited by 12

The interaction of 4-thiazolidinone derivatives containing indolin-2-one moiety with P-glycoprotein studied using K562 cell lines

Wang, F., Liu, Z., Wang, J., Tao, J., Gong, P., Bao, X., Zhao, Y., & Wang, Y. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.06.002 · Cited by 12

Modulating Prins Cyclization versus Tandem Prins Processes for the Synthesis of Hexahydro‐1H‐pyrano[3,4‐c]chromenes

Satteyyanaidu, V., Chandrashekhar, R., Reddy, B. V. S., & Lalli, C. (2020) · European Journal of Organic Chemistry · doi:10.1002/ejoc.202000220 · Cited by 11

Insights into solvation, chemical reactivity, structural, vibrational and anti-hypertensive properties of a thiazolopyrimidine derivative by DFT and MD simulations

Al-Otaibi, J. S., Costa, R. A., Costa, E. V., Tananta, V. L., Mary, Y. S., & Mary, Y. S. (2022) · Structural Chemistry · doi:10.1007/s11224-022-01931-1 · Cited by 11

Highly Diastereoselective Synthesis of Oxindoles Containing Vicinal Quaternary and Tertiary Stereocenters by a Domino Heck/Decarboxylative Alkynylation Sequence

Wang, D., Wu, P., Du, P.-Y., Qu, G., & Guo, H. (2022) · Organic Letters · doi:10.1021/acs.orglett.2c01517 · Cited by 11

Highly Active and Stable Bis Imidazolium-Based Copper N-heterocyclic Carbene Modified Graphene Oxide for O-arylation and N-arylation Reactions in Water

Imanpour, M., Lamei, K., & Eshghi, H. (2022) · Catalysis Letters · doi:10.1007/s10562-022-04074-4 · Cited by 11

Mechanism of Co( iii )-catalyzed annulation of N -chlorobenzamide with styrene and origin of cyclopentadienyl ligand-controlled enantioselectivity

Gao, H., Wang, W., Lv, X., Lü, G., & Li, Y. (2023) · Organic Chemistry Frontiers · doi:10.1039/d3qo00038a · Cited by 11

Organocatalyzed Asymmetric Michael Addition of 3-Fluorooxindole to Vinylidene Bisphosphonates

Jin, Y., Wang, X., Ning, L.-W., Wang, R.-J., Li, Y., Zhang, Y., & Chen, L. (2024) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.4c00289 · Cited by 12

Discovery of Schaeffer’s Acid Analogues as Lead Structures of Mycobacterium tuberculosis Type II Dehydroquinase Using a Rational Drug Design Approach

Schmidt, M. F., Korb, O., Howard, N., Dias, M. V. B., Blundell, T. L., & Abell, C. (2012) · ChemMedChem · doi:10.1002/cmdc.201200508 · Cited by 11

Synthesis of novel glycosyl-1,2,3-1H-triazolyl methyl quinazolin-4(3H)-ones and their effect on GLUT4 translocation

Ramakrishna, K. K. G., Thakur, R. K., Pasam, V. R., Pandey, J., Mahar, R., Shukla, S. K., Tamrakar, A. K., & Tripathi, R. P. (2016) · Tetrahedron · doi:10.1016/j.tet.2016.11.074 · Cited by 11

Application of diazonium chemistry in purine modifications: A focused review

Sengupta, S., & Das, P. (2021) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.4352 · Cited by 11

Consecutive Ring Expansion and Contraction for the Synthesis of 1‐Aryl Tetrahydroisoquinolines and Tetrahydrobenzazepines from Readily Available Heterocyclic Precursors

Hill, J., Matlock, J. V., Lefebvre, Q., Cooper, K. G., & Clayden, J. (2018) · Angewandte Chemie · doi:10.1002/ange.201802188 · Cited by 11

Synthesis, Computational Insights, and Anticancer Activity of Novel Indole–Schiff Base Derivatives

Trivedi, K. M., Patel, U. P., Dabhi, R. C., & Maru, J. J. (2022) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162022030116 · Cited by 11

C–H Alkenylation of Indoles through a Dual 1,3-Sulfur Migration Process

Li, J., Dong, K., Deng, X., Li, R., Liu, J., Wang, X., & Tang, S. (2022) · Organic Letters · doi:10.1021/acs.orglett.2c03052 · Cited by 11

Exploring quantum computational, molecular docking, and molecular dynamics simulation with MMGBSA studies of ethyl-2-amino-4-methyl thiophene-3-carboxylate

Fatima, A., Khanum, G., Srivastava, S. K., Bhattacharya, P., Ali, A., Arora, H., Siddiqui, N., & Javed, S. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2180667 · Cited by 11

Bis-aryloxadiazoles as effective activators of the aryl hydrocarbon receptor

Basham, K. J., Bhonde, V. R., Kieffer, C., Mack, J. B. C., Hess, M., Welm, B. E., & Looper, R. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.04.013 · Cited by 11

Synthesis of enones, pyrazolines and pyrrolines with gem-difluoroalkyl side chains

Dine, A. N. E., Khalaf, A., Gree, D. M., Tasseau, O., Farès, F., Jaber, N., Lesot, P., Hachem, A., & Gree, R. L. (2013) · Beilstein Journal of Organic Chemistry · doi:10.3762/bjoc.9.230 · Cited by 11

Metal‐Free Selective Synthesis of 1,4‐Dihydropyridazines from Hydroxypyrrolines and Hydrazines

Shabalin, D. A., Dvorko, M. Y., Zolotareva, E. E., Ushakov, I. A., Vashchenko, A. V., Schmidt, E. Y., & Trofimov, B. A. (2017) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201700589 · Cited by 11

Tricyclic heterocycles display diverse sensitivity to the A147T TSPO polymorphism

Sokias, R., Werry, E. L., Cheng, H. W. A., Lloyd, J. H., Sohler, G., Danon, J. J., Montgomery, A. P., Du, J. J., Gao, Q., Hibbs, D. E., et al. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112725 · Cited by 11

R-group Replacement Database for Medicinal Chemistry

Takeuchi, K., Kunimoto, R., & Bajorath, J. (2021) · Future Science OA · doi:10.2144/fsoa-2021-0062 · Cited by 11

An in silico pipeline for the discovery of multitarget ligands: A case study for epi-polypharmacology based on DNMT1/HDAC2 inhibition

Prieto-Martínez, F. D., Gortari, E. F., Medina‐Franco, J. L., & Espinoza‐Fonseca, L. M. (2021) · Artificial Intelligence in the Life Sciences · doi:10.1016/j.ailsci.2021.100008 · Cited by 10

Evaluation of HIV-1 inhibition by stereoisomers and analogues of the sesquiterpenoid hydroquinone peyssonol A

Treitler, D. S., Li, Z., Krystal, M., Meanwell, N. A., & Snyder, S. A. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.01.098 · Cited by 11

The diversity‐oriented synthesis of pteridines—achievements and potential for development

Suckling, C. J. (2013) · IUBMB Life · doi:10.1002/iub.1148 · Cited by 11

A novel quinazolinone derivative induces cytochrome c interdependent apoptosis and autophagy in human leukemia MOLT-4 cells

Kumar, S. G., Guru, S. K., Pathania, A. S., Mupparapu, N., Kumar, A., Malik, F. A., Bharate, S. B., Ahmed, Q. N., Vishwakarma, R. A., & Bhushan, S. (2014) · Toxicology Reports · doi:10.1016/j.toxrep.2014.07.018 · Cited by 11

Pharmacophore inference and its application to computational drug discovery

Wallach, I. (2010) · Drug Development Research · doi:10.1002/ddr.20398 · Cited by 11

Diastereoselective construction of syn-α-oxyamines via three-component α-oxyaldehyde–dibenzylamine–alkyne coupling reaction: application in the synthesis of (+)-β-conhydrine and its analogues

Deshmukh, S. C., Roy, A., & Talukdar, P. (2012) · Organic & Biomolecular Chemistry · doi:10.1039/c2ob26007g · Cited by 11

Milde Cobalt‐katalysierte Negishi‐Kreuzkupplungen von (Hetero‐)Arylzinkreagentien mit (Hetero‐)Arylhalogeniden

Haas, D., Hammann, J. M., Lutter, F. H., & Knochel, P. (2016) · Angewandte Chemie · doi:10.1002/ange.201510665 · Cited by 11

A new CAN-catalyzed domino process related to the Nenitzescu reaction: very concise access to fused ortho-indolequinones from simple precursors

Suryavanshi, P. A., Sridharan, V., & Menéndez, J. C. (2013) · Tetrahedron · doi:10.1016/j.tet.2013.04.101 · Cited by 11

Evolution of 3-(4-hydroxyphenyl)indoline-2-one as a scaffold for potent and selective anticancer activity

Boudreau, M. W., & Hergenrother, P. J. (2022) · RSC Medicinal Chemistry · doi:10.1039/d2md00110a · Cited by 10

Deoxygenation of oximes for the synthesis of pyrrolines via hydroimination cyclization

Han, W., Liu, W.-D., Su, J., & Zhao, J. (2023) · Organic & Biomolecular Chemistry · doi:10.1039/d3ob00072a · Cited by 10

Visible‐Light‐Induced Metal‐Free Three‐Component Amidoheteroarylation of Alkenes to Synthesize β‐(Hetero)arylethylamines

Feng, Q., Wang, H., Liu, Y., Wei, L., Sun, J., Wang, X., Sun, R., Wang, Y., & Li, L. (2024) · European Journal of Organic Chemistry · doi:10.1002/ejoc.202400185 · Cited by 10

Synthesis of Some New Coumarin-thiazolidine-2,4-dione-1,2,3-triazole Hybrids as Tubulin Targeting Anti-Lung Cancer Agents

Ramakrishna, B., Bokkala, K., Kumar, B. A., & Kumar, T. K. (2024) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162024020109 · Cited by 10

GPCRSPACE: A New GPCR Real Expanded Library Based on Large Language Models Architecture and Positive Sample Machine Learning Strategies

Chen, S., & Zhong, F. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c01983 · Cited by 10

Synthesis of Indol-3-yl Morpholino Derivatives Containing a Hydrazone Moiety as Potential Antiplant Virus Agents

Sun, P., Huang, Y., Yang, X., Ma, X., Xia, Z., Yang, Z., & Wu, J. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c05642 · Cited by 10

Pyridazine: A privileged scaffold in the development of 21st-century pesticides

Chen, C., Wang, G., Li, K., Lei, Q., Jin, Z., & Gan, X. (2025) · Chinese Chemical Letters · doi:10.1016/j.cclet.2025.110902 · Cited by 10

Sources for Leads: Natural Products and Libraries

van Herwerden, E. F., & Süßmuth, R. D. (2015) · Handbook of experimental pharmacology · doi:10.1007/164_2015_19 · Cited by 10

Synthesis of a biological active β-hairpin peptide by addition of two structural motifs

Fischer, S., Lamping, M., Gold, M., Roettger, Y., Brödje, D., Dodel, R. C., Frantz, R., Mraheil, M. A., Chakraborty, T., & Geyer, A. (2016) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2016.11.022 · Cited by 10

Use of 3-(trifluoromethyl)-1H-pyrazolo-[3,4-b]pyridine as a versatile building block

Schirok, H., Griebenow, N., Fürstner, C., & Dilmaç, A. M. (2015) · Tetrahedron · doi:10.1016/j.tet.2015.06.050 · Cited by 10

Catalytic C–C coupling of diazo compounds with arylboronic acids: using surface modified sewage sludge as catalyst

Zhang, Z., Yu, Y., Xie, Y., Hughes, T. C., Xu, J., Huang, F., & Huang, H. (2020) · Green Chemistry · doi:10.1039/d0gc00317d · Cited by 10

Sequential four-component protocol for the synthesis of pyrido[1,2-a]pyrimidin-6-one derivatives in water

Rezvanian, A., Amoozadkhalili, F., & Roosta, A. (2021) · Chemical Papers · doi:10.1007/s11696-020-01450-5 · Cited by 10

Synthesis of a DNA‐Encoded Library of Pyrrolo[2,3‐d]pyrimidines

Park, J., Wang, H. M., Shin, M. H., & Lim, H. (2021) · Bulletin of the Korean Chemical Society · doi:10.1002/bkcs.12243 · Cited by 10

A Brønsted acid catalyzed tandem reaction for the diastereoselective synthesis of cyclobuta-fused tetrahydroquinoline carboxylic esters

Marras, V., Caboni, P., Secci, F., Guillot, R., Aitken, D. J., & Frongia, A. (2021) · Organic & Biomolecular Chemistry · doi:10.1039/d1ob01518d · Cited by 10

Highly Stereoselective Synthesis of Natural‐Product‐Like Hybrids by an Organocatalytic/Multicomponent Reaction Sequence

Echemendía, R., de la Torre, A. F., Monteiro, J. L., Pila, M., Corrêa, A. G., Westermann, B., Rivera, D. G., & Paixão, M. W. (2015) · Angewandte Chemie · doi:10.1002/ange.201412074 · Cited by 10

Tandem imine generation/N-cyclization/C-alkylation sequence to access N-functionalized indoles featuring an aza-quaternary carbon

Tian, J., Tu, Z., Zhou, F., Yu, J., & Zhou, J. E. (2023) · Organic Chemistry Frontiers · doi:10.1039/d3qo00114h · Cited by 10

Two New Chromones from Cassia auriculata and Their Antiviral Activity

Liu, X., Zheng, J.-N., Shen, S., Xiong, W., Li, S.-S., Ma, X., Li, Y.-K., Zhou, M., Gong, D., Hu, Q., et al. (2023) · Chemistry of Natural Compounds · doi:10.1007/s10600-023-04025-4 · Cited by 10

The Experimentalist’s Guide to Machine Learning for Small Molecule Design

Lindley, S. E., Lu, Y., & Shukla, D. (2023) · ACS Applied Bio Materials · doi:10.1021/acsabm.3c00054 · Cited by 11

Refine and Strengthen SAR-Based Read-Across by Considering Bioactivation and Modes of Action

Yan, G., Rose, J. L., Ellison, C. A., Mudd, A. M., Zhang, X., & Wu, S. (2023) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.3c00156 · Cited by 10

A systematic study of two complementary protocols allowing the general, mild and efficient deprotection of N-pivaloylindoles

Ruiz, M., Sánchez, J. D., López‐Alvarado, P., & Menéndez, J. C. (2011) · Tetrahedron · doi:10.1016/j.tet.2011.10.098 · Cited by 10

Privileged heterocyclic scaffolds in chemical biology and drug discovery: synthesis and bioactivity

Altomare, C. (2017) · Chemistry of Heterocyclic Compounds · doi:10.1007/s10593-017-2046-4 · Cited by 8

Privileged Structures Revisited

Schneider, P., & Schneider, G. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201702816 · Cited by 127

Privileged Structures and Motifs (Synthetic and Natural Scaffolds)

Jones, A. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.12316-9 · Cited by 4

Privileged Structures: Applications in Drug Discovery

DeSimone, R., Currie, K., Mitchell, S. A., Darrow, J. W., & Pippin, D. A. (2004) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207043328544 · Cited by 579

Scaffold composition and biological relevance of screening libraries

Shelat, A. A., & Guy, R. K. (2007) · Nature Chemical Biology · doi:10.1038/nchembio0807-442 · Cited by 170