Privileged scaffolds for library design and drug discovery

The evolving role of natural products in drug discovery

Koehn, F. E., & Carter, G. T. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1657 · Cited by 2,579

Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery

Schreiber, S. L. (2000) · Science · doi:10.1126/science.287.5460.1964 · Cited by 2,571

Drugs for bad bugs: confronting the challenges of antibacterial discovery

Payne, D. J., Gwynn, M. N., Holmes, D. J., & Pompliano, D. L. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2201 · Cited by 2,512

A Planning Strategy for Diversity‐Oriented Synthesis

Burke, M. D., & Schreiber, S. L. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200300626 · Cited by 1,493

Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists

Evans, B., Rittle, K. E., Bock, M. G., DiPardo, R. M., Freidinger, R. M., Whitter, W. L., Lundell, G. F., Veber, D. F., Anderson, P., Chang, R. S. L., et al. (1988) · Journal of Medicinal Chemistry · doi:10.1021/jm00120a002 · Cited by 1,460

Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors

Gray, N. S., Wodicka, L. M., Thunnissen, A. M. W. H., Norman, T., Kwon, S., Espinoza, F. H., Morgan, D. O., Barnes, G., Leclerc, S., Meijer, L., et al. (1998) · Science · doi:10.1126/science.281.5376.533 · Cited by 808

From Nature to Drug Discovery: The Indole Scaffold as a ‘Privileged Structure’

Alves, F. R. S., Barreiro, E. J., & Fraga, C. A. M. (2009) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955709788452649 · Cited by 606

Diversity-oriented synthesis: Exploring the intersections between chemistry and biology

Tan, D. S. (2005) · Nature Chemical Biology · doi:10.1038/nchembio0705-74 · Cited by 605

Privileged Structures: Applications in Drug Discovery

DeSimone, R., Currie, K., Mitchell, S. A., Darrow, J. W., & Pippin, D. A. (2004) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207043328544 · Cited by 579

Towards the Optimal Screening Collection: A Synthesis Strategy

Nielsen, T. E., & Schreiber, S. L. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200703073 · Cited by 553

Chemoselective Diazine Dearomatization: The Catalytic Enantioselective Dearomatization of Pyrazine

Ketelboeter, D. R., Pappoppula, M., & Aponick, A. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.4c02979 · Cited by 17

N ‐Benzyl piperidine Fragment in Drug Discovery

Sharma, A., Sharma, M., & Bharate, S. B. (2024) · ChemMedChem · doi:10.1002/cmdc.202400384 · Cited by 17

Tuning the steric hindrance of alkylamines: a predictive model of steric editing of planar amines

Tomasini, M., Voccia, M., Caporaso, L., Szostak, M., & Poater, A. (2024) · Chemical Science · doi:10.1039/d4sc03873h · Cited by 17

Selective Synthesis of 5,6‐Dihydroindolo[1,2‐a]quinoxalines and 6,7‐Dihydroindolo[2,3‐c]quinolines by Orthogonal Copper and Palladium Catalysis

Zhang, L. J., Zhao, F., Zheng, M., Zhai, Y., Wang, J., & Liu, H. S. (2013) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201300667 · Cited by 17

Identification and synthesis of substituted pyrrolo[2,3-d]pyrimidines as novel firefly luciferase inhibitors

Liu, Y., Fang, J., Cai, H., Xiao, F., Ding, K., & Hu, Y. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.07.035 · Cited by 17

Heterocyclic Scaffolds in the Design of Peptidomimetic Integrin Ligands: Synthetic Strategies, Structural Aspects, and Biological Activity

Marco, R. D., Mazzotti, G., Greco, A., & Gentilucci, L. (2015) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026615666150812121614 · Cited by 17

Synthesis of indole-annulated sulfur heterocycles using copper-catalysed C–N coupling and palladium-catalysed direct arylation

Shelke, G. M., Jha, M., & Kumar, A. (2016) · Organic & Biomolecular Chemistry · doi:10.1039/c6ob00117c · Cited by 17

Synthesis and DNA‐binding study of imidazole linked thiazolidinone derivatives

War, J. A., Srivastava, S. K., & Srivastava, S. K. (2016) · Luminescence · doi:10.1002/bio.3156 · Cited by 17

Intramolecular Photoreactions of (5S)-5-Oxymethyl-2(5H)-furanones as a Tool for the Stereoselective Generation of Diverse Polycyclic Scaffolds

Lejeune, G., Font, J., Parella, T., Alibés, R., & Figueredo, M. (2015) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.5b01354 · Cited by 17

Oxidative C–H functionalization of N-carbamoyl 1,2-dihydroquinolines

Liu, Z., Chen, L., Li, J., Liu, K., Zhao, J., Xu, M., Feng, L., Wan, R., Li, W., & Liu, L. (2017) · Organic & Biomolecular Chemistry · doi:10.1039/c7ob01793f · Cited by 17

Structure Optimization of Aloperine Derivatives as HIV-1 Entry Inhibitors

Dang, Z., Xie, H., Zhu, L., Zhang, Q., Li, Z., Huang, L., & Chen, C. (2017) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.7b00376 · Cited by 17

Application of “Smart” Amine Donors for Rapid Screening and Scale‐Up of Transaminase‐Mediated Biotransformations

Gomm, A., Grigoriou, S., Peel, C., Ryan, J., Mujtaba, N., Clarke, T., Kulcinskaja, E., & O’Reilly, E. (2018) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201800799 · Cited by 17

The Azoles in Pharmacochemistry: Perspectives on the Synthesis of New Compounds and Chemoinformatic Contributions

Viana, J. D. O., Monteiro, A., Barbosa‐Filho, J. M., Scotti, L., & Scotti, M. T. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191125090700 · Cited by 17

Metal-Free Tandem Approach for Triazole-Fused Diazepinone Scaffolds via [3 + 2]Cycloaddition/C–N Coupling Reaction

Majeed, K., Wang, L., Liu, B., Guo, Z., Zhou, F., & Zhang, Q. (2020) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.0c02022 · Cited by 17

Cryptosporidium parvum Pyruvate Kinase Inhibitors With in vivo Anti-cryptosporidial Efficacy

Khan, S. M., Zhang, X., & Witola, W. H. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.800293 · Cited by 17

Synthesis and biological evaluation of tetrahydroisoquinoline-derived antibacterial compounds

Payne, M. S., Bottomley, A. L., Och, A., Hiscocks, H. G., Asmara, A. P., Harry, E. J., & Ung, A. T. (2022) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2022.116648 · Cited by 17

Synthesis of Atropisomerically Defined, Highly Substituted Biaryl Scaffolds through Catalytic Enantioselective Bromination and Regioselective Cross‐Coupling

Gustafson, J. L., Lim, D., Barrett, K. T., & Miller, S. J. (2011) · Angewandte Chemie · doi:10.1002/ange.201101147 · Cited by 17

New Hybrid Molecules Based on Sulfur-Containing Nicotinonitriles: Synthesis, Analgesic Activity in Acetic Acid-Induced Writhing Test, and Molecular Docking Studies

Krivokolysko, D. S., Dotsenko, V. V., Bibik, E. Y., Samokish, A. A., Venidiktova, Y. S., Фролов, К. А., Krivokolysko, S. G., Pankov, A. A., Aksenov, N. A., & Aksenova, I. V. (2022) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162022030104 · Cited by 17

Exploring the Chemical Space around the Privileged Pyrazolo[3,4-d]pyrimidine Scaffold: Toward Novel Allosteric Inhibitors of T315I-Mutated Abl

Vignaroli, G., Mencarelli, M., Sementa, D., Crespan, E., Kiššová, M., Maga, G., Schenone, S., Radi, M., & Botta, M. (2014) · ACS Combinatorial Science · doi:10.1021/co500004e · Cited by 17

Naturally Inspired Molecules as Multifunctional Agents for Alzheimer’s Disease Treatment

Rampa, A., Tarozzi, A., Mancini, F. R., Pruccoli, L., Martino, R. M. C. D., Gobbi, S., Bisi, A., Simone, A. D., Palomba, F., Zaccheroni, N., et al. (2016) · Molecules · doi:10.3390/molecules21050643 · Cited by 17

Ligand-free Pd-catalysed decarboxylative arylation of imidazo[1,2-a]pyridine-3-carboxylic acids with aryl bromides

Karale, U. B., Kalari, S., Shivakumar, J., Makane, V. B., Babar, D. A., Thakare, R., Babu, B. N., Chopra, S., & Rode, H. B. (2016) · RSC Advances · doi:10.1039/c6ra12166g · Cited by 17

A practical oxidative C–H functionalization of N-carbamoyl tetrahydro-β-carbolines with diverse potassium trifluoroborates

Sun, Y., Wang, G., Chen, J., Liu, C., Cai, M., Zhu, R., Huang, H., Li, W., & Liu, L. (2016) · Organic & Biomolecular Chemistry · doi:10.1039/c6ob01171c · Cited by 17

Mechanism of irreversible inhibition of Mycobacterium tuberculosis shikimate kinase by ilimaquinone

Simithy, J., Fuanta, R., Hobrath, J. V., Kochanowska-Karamyan, A. J., Hamann, M. T., Goodwin, D. C., & Calderón, Á. I. (2018) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2018.04.007 · Cited by 17

A skeletally diverse library of bioactive natural-product-like compounds enabled by late-stage P450-catalyzed oxyfunctionalization

Bortz, A. R., Bennett, J. M., & Fasan, R. (2024) · Chem · doi:10.1016/j.chempr.2024.08.003 · Cited by 16

Synthetic approach to skeletally diverse nitrogen heterocycles from dicyano-2-methylenebut-3-enoates

Zhang, X., Huang, Q., Zou, W., Li, Q., Feng, X., Jia, Z.-Q., Liu, Y., Li, J., & Wang, Q. (2019) · Organic Chemistry Frontiers · doi:10.1039/c9qo00509a · Cited by 16

Systematic comparison of competitive and allosteric kinase inhibitors reveals common structural characteristics

Hu, H., Laufkötter, O., Miljković, F. N., & Bajorath, J. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113206 · Cited by 16

Discovery of indolizine lactones as anticancer agents and their optimization through late-stage functionalization

da Silva, T. S., Souza, M. S., Andricopulo, A. D., & Coelho, F. (2023) · RSC Advances · doi:10.1039/d3ra03395c · Cited by 16

Efficient construction of functionalized pyrroloindolines through cascade radical cyclization/intermolecular coupling

Jiang, Y., Liu, D., Zhang, L., Qin, C., Li, H., Yang, H., Walsh, P. J., & Yang, X. (2024) · Chemical Science · doi:10.1039/d3sc05210a · Cited by 16

Recent Developments and Future Perspectives of Purine Derivatives as a Promising Scaffold in Drug Discovery

Rana, N., Grover, P., & Singh, H. (2024) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266290152240110074034 · Cited by 18

An Air-Stable, Single-Component Iridium Precatalyst for the Borylation of C–H Bonds on Large to Miniaturized Scales

D’Angelo, K. A., La, C., Kotecki, B., Wilson, J. W., Karmel, C., Swiatowiec, R., Tu, N. P., Shekhar, S., & Hartwig, J. F. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.4c12333 · Cited by 16

The chemistry and pharmacology of privileged pyrroloquinazolines

Chao, B., Li, B. X., & Xiao, X. (2014) · MedChemComm · doi:10.1039/c4md00485j · Cited by 16

Organocatalytic one-pot asymmetric synthesis of 2-aryl-2,3-dihydro-4-quinolones

Pan, G., Su, L., Zhang, Y., Guo, S., & Wang, Y. (2016) · RSC Advances · doi:10.1039/c6ra01247g · Cited by 16

Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor

Musella, S., Sarno, V. D., Ciaglia, T., Sala, M., Spensiero, A., Scala, M. C., Ostacolo, C., Andreï, G., Balzarini, J. M., Snoeck, R., et al. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.09.014 · Cited by 16

Discovery and Optimization of Novel 5-Indolyl-7-arylimidazo[1,2-a]pyridine-8-carbonitrile Derivatives as Potent Antitubulin Agents Targeting Colchicine-binding Site

Zhai, X., Wang, X., Wang, J., Liu, J., Zuo, D., Jiang, N., Zeng, T., Yang, X., Jing, T., & Gong, P. (2017) · Scientific Reports · doi:10.1038/srep43398 · Cited by 16

Mild C(sp)–H functionalization of dihydrosanguinarine and dihydrochelerythrine for development of highly cytotoxic derivatives

Romo‐Pérez, A., Miranda, L. D., Chávez-Blanco, A. D., Dueñas‐González, A., Camacho‐Corona, M. D. R., Huerta, A. A., & García, A. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.06.021 · Cited by 16

Enzymology of Anthraquinone‐γ‐Pyrone Ring Formation in Complex Aromatic Polyketide Biosynthesis

Hou, X., Song, Y., Zhang, M., Lan, W., Meng, S., Wang, C., Pan, H., Cao, C., & Tang, G. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201806729 · Cited by 16

Synthesis of poly-substituted pyrazolo[1,5-a]quinolines through one-pot two component cascade reaction

Kato, J., Ijuin, R., Aoyama, H., & Yokomatsu, T. (2014) · Tetrahedron · doi:10.1016/j.tet.2014.02.081 · Cited by 16

Novel 4-(1H-1,2,3-triazol-4-yl)methoxy)cinnolines as potent antibacterial agents: Synthesis and molecular docking study

Bommagani, M. B., Mokenapelli, S., Yerrabelly, J. R., Boda, S. K., & Chitneni, P. R. (2020) · Synthetic Communications · doi:10.1080/00397911.2020.1728333 · Cited by 16

Privileged Scaffold Analysis of Natural Products with Deep Learning‐based Indication Prediction Model

Lai, J., Hu, J., Wang, Y., Zhou, X., Li, Y., Zhang, L., & Liu, Z. (2020) · Molecular Informatics · doi:10.1002/minf.202000057 · Cited by 16

A New Smoothened Antagonist Bearing the Purine Scaffold Shows Antitumour Activity In Vitro and In Vivo

Zárate, A. M., Espinosa‐Bustos, C., Guerrero, S., Fierro, A., Oyarzun-Ampuero, F. A., Quest, A. F. G., Marcotullio, L. D., Loricchio, E., Caimano, M., Calcaterra, A., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168372 · Cited by 17

Synthesis and Cytotoxic Activity of Novel Indole Derivatives and Their in silico Screening on Spike Glycoprotein of SARS-CoV-2

Gobinath, P., Packialakshmi, P., Vijayakumar, K., Abdellattif, M. H., Shahbaaz, M., Idhayadhulla, A., & Surendrakumar, R. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.637989 · Cited by 16

Synthesis and diverse biological activity profile of triethylammonium isatin-3-hydrazones

Bogdanov, A. V., Tsivileva, O. M., Voloshina, A. D., Lyubina, A. P., Amerhanova, S. K., Burtceva, E., Бухаров, С. В., Самородов, А. В., & Павлов, В. Н. (2022) · ADMET & DMPK · doi:10.5599/admet.1179 · Cited by 16

Metal‐Free [3+2] Tandem Cyclization Synthesis of Unique 11H‐Pyrido[3′,2′:4,5]Pyrrolo[3,2‐b]Indolizine from 7‐Azaindoles and Pyridotriazoles

Zhang, G., Zhang, J., Xu, Y., & Dong, L. (2018) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201800764 · Cited by 16

CuI catalyzed domino coupling–cyclization of 2-iodo-phenols and 1-alkynes to the synthesis of 2-substituted benzo[b]furans/furo-pyridines

Chen, Z.-P., Zhou, Y., Shui, M., & Liu, F. (2018) · Tetrahedron Letters · doi:10.1016/j.tetlet.2018.11.076 · Cited by 16

Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity

Froux, L., Elbahnsi, A., Boucherle, B., Billet, A., Baatallah, N., Hoffmann, B., Alliot, J., Zelli, R., Zeinyeh, W., Haudecoeur, R., et al. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112116 · Cited by 16

Facile synthesis of 2,5,7-trisubstituted oxazolo[5,4-d]pyrimidines via copper-catalyzed intramolecular C–O bond formation

Xu, D., Sun, L., & You, Q. (2012) · Tetrahedron · doi:10.1016/j.tet.2012.03.080 · Cited by 16

Congenericity of Claimed Compounds in Patent Applications

Falaguera, M. J., & Mestres, J. (2021) · Molecules · doi:10.3390/molecules26175253 · Cited by 12

Sulphur ylide-mediated cyclopropanation and subsequent spirocyclopropane rearrangement reactions

Dai, Q., Li, J., Wang, Q., Yang, S.-L., Tao, Y.-M., He, M.-H., Li, Q., Han, B., & Zhang, X. (2022) · Organic & Biomolecular Chemistry · doi:10.1039/d2ob00466f · Cited by 15

Design, Synthesis, In Silico Studies and Inhibitory Activity towards Bcr-Abl, BTK and FLT3-ITD of New 2,6,9-Trisubstituted Purine Derivatives as Potential Agents for the Treatment of Leukaemia

Bertrand, J., Dostálová, H., Kryštof, V., Jorda, R., Delgado, T., Castro‐Álvarez, A., Mella, J., Cabezas, D., Faúndez, M., Espinosa‐Bustos, C., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061294 · Cited by 15

Synthesis of Spiro[indole-3,3′-pyrrolidine]-2′-(thi)ones

Yasui, M., Ohbu, H., Ishikawa, M., Yoshida, T., Takeda, N., Hirao, S., Abe, T., & Ueda, M. (2022) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.2c02561 · Cited by 15

Acceptorless cross-dehydrogenative coupling for C(sp3)-H heteroarylation mediated by a heterogeneous GaN/ketone photocatalyst/photosensitizer system

Kang, H., Tan, L., Han, J., Huang, C., Su, H. L., Kavun, A. M., & LI, C. ‐. (2023) · Communications Chemistry · doi:10.1038/s42004-023-00947-w · Cited by 15

Green preparation of new pyrimidine triazole derivatives via one-pot multicomponent reactions of guanidine

Hezarcheshmeh, N. K., Godarzbod, F., Abdullah, M. N., & Hossaini, Z. (2023) · Molecular Diversity · doi:10.1007/s11030-023-10754-z · Cited by 15

Imidazolidinones Derivatives As Pioneering Anticancer Agents: Unraveling Insights Through synthesis And Structure‐Activity Exploration

Dewangan, S., Rawat, V., & Thakur, A. S. (2024) · ChemistrySelect · doi:10.1002/slct.202401379 · Cited by 15

Synthesis of Benzimidazole‐Substituted Arylboronic Acids via Aerobic Oxidation of 1,2‐Arylenediamines and Formyl‐Substituted Aryl MIDA Boronates using Potassium Iodide as a Catalyst

Lee, Y., & Cheon, C. (2015) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201500302 · Cited by 15

Pd-Catalyzed Ligand-Free Synthesis of Arylated Heteroaromatics by Coupling of N-Heteroaromatic Bromides with Iodobenzene Diacetate, Iodosobenzene, or Diphenyliodonium Salts

Wang, X., He, Y., Ren, M., Shengkang, L., Liu, H., & Huang, G. (2016) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.6b01103 · Cited by 15

Intramolecular Diaza‐Diels–Alder Protocol: A New Diastereoselective and Modular One‐Step Synthesis of Constrained Polycyclic Frameworks

Srinivasulu, V., Reddy, A., Mazitschek, R., Lukens, A. K., Wirth, D. F., Li, L., Naumov, P., O’Connor, M. J., & Al‐Tel, T. H. (2016) · Chemistry - A European Journal · doi:10.1002/chem.201605231 · Cited by 15

Versatility of the Biginelli reaction: Synthesis of new biphenyl dihydropyrimidin-2-thiones using different ketones as building blocks

Gonçalves, I. L., Davi, L., Rockenbach, L., das Neves, G. M., Kagami, L. P., Canto, R. F. S., Figueiró, F., Battastini, A. M. O., & Eifler-Lima, V. L. (2018) · Tetrahedron Letters · doi:10.1016/j.tetlet.2018.06.006 · Cited by 15

Synthesis and antimycobacterial activity of (+)‐usnic acid conjugates

Cirillo, D. M., Borroni, E., Festoso, I., Monti, D., Romeo, S., Mazier, D., & Verotta, L. (2018) · Archiv der Pharmazie · doi:10.1002/ardp.201800177 · Cited by 15

Synthesis and identification of heteroaromatic N -benzyl sulfonamides as potential anticancer agents

Hopkins, M. D., Abebe, F. A., Scott, K. A., Ozmer, G. L., Sheir, A. A., Schroeder, L. J., Sheaff, R. J., & Lamar, A. A. (2019) · Organic & Biomolecular Chemistry · doi:10.1039/c9ob01694e · Cited by 15

Modulation of Pharmacologically Relevant Properties of Piperidine Derivatives by Functional Groups in an Equatorial or Axial β‐Position to the Amino Group

Schnider, P., Dolente, C., Stalder, H., Martin, R. E., Reinmüller, V., Marty, R., Gramberg, C. W., Wagner, B., Fischer, H., Alker, A., et al. (2019) · ChemBioChem · doi:10.1002/cbic.201900474 · Cited by 15

Drugs, host proteins and viral proteins: how their promiscuities shape antiviral design

Gupta, M. N., & Roy, I. (2020) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12652 · Cited by 15

Photoinitiated multicomponent cascade reaction of Nheteroarenes with unactivated alkenes and trimethylsilyl azide

Shen, J., He, L., Liang, C., Ouyang, Y., Yue, X., Wu, H., Xu, J., Liu, X., Zhu, Q. X., & Zhang, P. (2022) · Molecular Catalysis · doi:10.1016/j.mcat.2022.112330 · Cited by 15

Catalytic Synthesis of N‐Unprotected Piperazines, Morpholines, and Thiomorpholines from Aldehydes and SnAP Reagents

Luescher, M. U., & Bode, J. W. (2015) · Angewandte Chemie · doi:10.1002/ange.201505167 · Cited by 15

Lead Discovery and Lead Modification

Silverman, R. B., & Holladay, M. W. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-382030-3.00002-7 · Cited by 17

Synthesis of Oxazolo[5,4‐d][1,2,4]triazolo[4,3‐a]pyrimidines as a New Class of Heterocyclic Compounds

Akbarzadeh, M., Bakavoli, M., Eshghi, H., & Shiri, A. (2015) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.2346 · Cited by 15

Organocatalytic Enantioselective Synthesis of Trifluoromethyl‐Containing Tetralin Derivatives by Sequential (Hetero)Michael Reaction–Intramolecular Nitrone Cycloaddition

Rabasa‐Alcañiz, F., Torres, J., Sánchez‐Roselló, M., Tejero, T., Merino, P., Fustero, S., & del Pozo, C. (2017) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201700975 · Cited by 15

Palladium-catalyzed C–H alkenylation of quinoxaline N-oxide enabled by a mono-N-protected amino acid

Franco, M. S. F., de Paula, M. H., Glowacka, P. C., Fumagalli, F., Clososki, G. C., & Emery, F. D. S. (2018) · Tetrahedron Letters · doi:10.1016/j.tetlet.2018.05.054 · Cited by 15

Stereospecific assembly of tetrahydroquinolines via tandem ring-opening/oxidative cyclization of donor–acceptor cyclopropanes with N -alkyl anilines

Das, B. K., Pradhan, S., & Punniyamurthy, T. (2019) · Chemical Communications · doi:10.1039/c9cc04042k · Cited by 15

Synthesis of pyrazolo[3,4-b]azepines and their antioxidant and antibacterial studies

Romo, P., Isaza, J. H., Braulio Insuasty, O., Abonı́a, R., del Crespo, M. P., & Jairo Quiroga, P. (2019) · Monatshefte für Chemie - Chemical Monthly · doi:10.1007/s00706-019-02479-3 · Cited by 15

Mechanism and Origins of Enantio- and Regioselectivities in Catalytic Asymmetric Minisci-Type Addition to Heteroarenes

Feng, A., Yang, Y., Liu, Y., Geng, C., Zhu, R., & Zhang, D. (2020) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.0c00597 · Cited by 15

Pharmacologic Profiling of Phosphoinositide 3-Kinase Inhibitors as Mitigators of Ionizing Radiation–Induced Cell Death

Lazo, J. S., Sharlow, E. R., Epperly, M. W., Lira, A. K., Leimgruber, S., Skoda, E. M., Wipf, P., & Greenberger, J. S. (2013) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.208421 · Cited by 15

Discovery of a potent anti-tumor agent through regioselective mono-N-acylation of 7H-pyrrolo[3,2-f]quinazoline-1,3-diamine

Chen, J., Kassenbrock, A. R., Li, B. X., & Xiao, X. (2013) · MedChemComm · doi:10.1039/c3md00134b · Cited by 15

Design, synthesis and antitrypanosomatid activity of 2-nitroimidazole-3,5-disubstituted isoxazole compounds based on benznidazole

Carvalho, D. B., Costa, P. A. N., Portapilla, G. B., das Neves, A. R., Shiguemoto, C. Y. K., Pelizaro, B. I., Silva, F., Piranda, E. M., Arruda, C. C. P., Gaspari, P. D. M., et al. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115451 · Cited by 15

Promoting GAINs (Give Attention to Limitations in Assays) over PAINs Alerts: no PAINS, more GAINs

Choo, M. Z. Y., & Chai, C. L. L. (2022) · ChemMedChem · doi:10.1002/cmdc.202100710 · Cited by 15

Cu-Catalyzed tandem cyclization and coupling of enynones with enaminones for multisubstituted furans & furano-pyrroles

Dattatri, Singam, M. K. R., Nanubolu, J. B., & Reddy, M. S. (2022) · Organic & Biomolecular Chemistry · doi:10.1039/d2ob00839d · Cited by 14

Iridium-Catalyzed Enantioselective Direct α-C–H Alkylation of Saturated Cyclic Amines with Alkenes

Yamauchi, D., Yamakawa, K., & Nishimura, T. (2022) · Organic Letters · doi:10.1021/acs.orglett.2c02733 · Cited by 14

Base-Promoted Tandem Synthesis of 3,4-Dihydroisoquinolones

Li, J., Wang, H., Jin, H., Xiang, Z., Chen, L., Walsh, P. J., & Liang, G. (2022) · Organic Letters · doi:10.1021/acs.orglett.2c03167 · Cited by 14

Green synthesis and investigation of antioxidant and antibacterial activity of new derivatives of chromenoazepines employing CuO/TiO2@MWCNTs

Hasani, L., Ezzatzadeh, E., & Hossaini, Z. (2024) · Molecular Diversity · doi:10.1007/s11030-023-10803-7 · Cited by 14

Recent advancements on biological activity of indole and their derivatives: A review

Kumar, P., Ahma, M. I., Singh, S., Pratam, M. R. F., & Mishra, A. K. (2022) · The Thai Journal of Pharmaceutical Sciences · doi:10.56808/3027-7922.2567 · Cited by 14

Synthesis of 3‐Fluoro‐2‐hetarylindoles and 3,3‐Difluoro‐2‐hetarylindolines through Lewis Acid‐Catalyzed Formation of 3,3‐Difluoroindolium Ions

Fong, J. Z. M., Choo, S. S. S., Richard, J., Garland, M., Guo, L., Johannes, C. W., & Nguyen, T. M. (2015) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201403443 · Cited by 14

Applications of Multicomponent Assembly Processes to the Facile Syntheses of Diversely Functionalized Nitrogen Heterocycles

Martin, S. F., Donald, J. R., Granger, B. A., Hardy, S., & Sahn, J. J. (2011) · Heterocycles · doi:10.3987/com-11-s(p)92 · Cited by 14

Druggable chemical space and enumerative combinatorics

Yu, M. J. (2013) · Journal of Cheminformatics · doi:10.1186/1758-2946-5-19 · Cited by 14

A Mild Lewis‐Acid‐Catalyzed Method for Head‐to‐Tail Dimerization or Cyclization of tert‐Alcohols

Ramulu, B. V., Mahendar, L., & Satyanarayana, G. (2015) · Asian Journal of Organic Chemistry · doi:10.1002/ajoc.201500456 · Cited by 14

Enriching biologically relevant chemical space around 2-aminothiazole template for anticancer drug development

Titus, S., & Sreejalekshmi, K. G. (2017) · Medicinal Chemistry Research · doi:10.1007/s00044-017-2039-y · Cited by 14

BF3 etherate-mediated microwave-assisted facile synthesis of thiopyrano[2,3-b]indol-2-one

Jha, M., Davis, C., Fazzari, J., & Vitali, M. (2014) · Tetrahedron Letters · doi:10.1016/j.tetlet.2014.10.131 · Cited by 14

Prospects for Discovering the Secondary Metabolites of Cordyceps Sensu Lato by the Integrated Strategy

Bibi, S., Wang, Y., Tang, D., Kamal, M. A., & Yu, H. (2019) · Medicinal Chemistry · doi:10.2174/1573406416666191227120425 · Cited by 14

Integration of ion exchange resin materials for a downstream‐processing approach of an imine reductase‐catalyzed reaction

Meyer, L., Brundiek, H. B., & von Langermann, J. (2020) · Biotechnology Progress · doi:10.1002/btpr.3024 · Cited by 14

Synthesis and biological evaluation of thiazolidinedione derivatives with high ligand efficiency to P. aeruginosa PhzS

Froes, T. Q., Chaves, B. T., Mendes, M. S., Ximenes, R. M., da Silva, I. M., da Silva, P. B. G., de Albuquerque, J. F. C., & Castilho, M. S. (2021) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2021.1931165 · Cited by 14

Synthesis, Structure, and Analgesic Activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic Acids Ethyl Esters

Krivokolysko, D. S., Dotsenko, V. V., Bibik, E. Y., Miazina, A. V., Krivokolysko, S. G., Vasilin, V. K., Pankov, A. A., Aksenov, N. A., & Aksenova, I. V. (2021) · Russian Journal of General Chemistry · doi:10.1134/s1070363221120306 · Cited by 14

Construction of Benzimidazolone Derivatives via Aryl Iodide Catalyzed Intramolecular Oxidative C–H Amination

Wang, Y., Sun, Y., Cui, Y.-M., Yu, Y.-X., & Wu, Z. (2022) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.1c02929 · Cited by 14

Cp*RhIII-Catalyzed Cascade Annulation of Arylimidates with Pyridotriazoles toward Isoquinolin-3-ol Derivatives

Yan, W., Luo, H., Wu, Q., Liu, L., Li, J., & Wei, J. (2022) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.2c01164 · Cited by 14

Synthetic pregnenolone derivatives as antiviral agents against acyclovir-resistant isolates of Herpes Simplex Virus Type 1

Dávola, M. E., Mazaira, G. I., Galigniana, M. D., Alché, L. E., Ramirez, J. A., & Barquero, A. A. (2015) · Antiviral Research · doi:10.1016/j.antiviral.2015.08.002 · Cited by 14

A simple copper-catalyzed two-step one-pot synthesis of indolo[1,2-a]quinazoline

Li, C., Zhang, L. J., Shu, S., & Liu, H. S. (2014) · Beilstein Journal of Organic Chemistry · doi:10.3762/bjoc.10.254 · Cited by 14

Mini-ISES identifies promising carbafructopyranose-based salens for asymmetric catalysis: Tuning ligand shape via the anomeric effect

Karukurichi, K. R., Fei, X., Swyka, R. A., Broussy, S., Shen, W., Dey, S., Roy, S. K., & Berkowitz, D. B. (2015) · Science Advances · doi:10.1126/sciadv.1500066 · Cited by 14

Modular access to functionalized 5–8–5 fused ring systems via a photoinduced cycloisomerization reaction

Salvati, A. E., Law, J. A., Liriano, J., & Frederich, J. H. (2018) · Chemical Science · doi:10.1039/c8sc00999f · Cited by 14

Unusually Reactive Cyclic Anhydride Expands the Scope of the Castagnoli–Cushman Reaction

Chizhova, M., Khoroshilova, O. V., Dar’in, D. V., & Krasavin, M. (2018) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.8b02164 · Cited by 14

Kinase Inhibitors of Novel Pyridopyrimidinone Candidates: Synthesis and In Vitro Anticancer Properties

Khalifa, N. M., Al-Omar, M. A., Alkahtani, H. M., & Bakheit, A. H. (2019) · Journal of Chemistry · doi:10.1155/2019/2635219 · Cited by 14

Chemoinformatic Approach: The Case of Natural Products of Panama

Olmedo, D. A., & Medina‐Franco, J. L. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.87779 · Cited by 14

Synthesis and biological evaluation in vitro and in silico of N-propionyl-N′-benzeneacylhydrazone derivatives as cruzain inhibitors of Trypanosoma cruzi

Delgado‐Maldonado, T., Nogueda‐Torres, B., Espinoza-Hicks, J. C., Vázquez‐Jiménez, L. K., Paz-González, A. D., Juárez-Saldívar, A., & Rivera, G. (2020) · Molecular Diversity · doi:10.1007/s11030-020-10156-5 · Cited by 14

Calcium-catalyzed formal [3 + 2] annulation of C , N -diacyliminium ions with nucleophilic phenols: a diversity oriented synthesis of 3-aminofurans

Rajesh, P., Almansour, A. I., Arumugam, N., & Yaragorla, S. (2021) · Organic & Biomolecular Chemistry · doi:10.1039/d0ob02276d · Cited by 14

Privileged heterocyclic scaffolds in chemical biology and drug discovery: synthesis and bioactivity

Altomare, C. (2017) · Chemistry of Heterocyclic Compounds · doi:10.1007/s10593-017-2046-4 · Cited by 8

Privileged Structures Revisited

Schneider, P., & Schneider, G. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201702816 · Cited by 127

Privileged Structures and Motifs (Synthetic and Natural Scaffolds)

Jones, A. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.12316-9 · Cited by 4

Privileged Structures: Applications in Drug Discovery

DeSimone, R., Currie, K., Mitchell, S. A., Darrow, J. W., & Pippin, D. A. (2004) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207043328544 · Cited by 579

Scaffold composition and biological relevance of screening libraries

Shelat, A. A., & Guy, R. K. (2007) · Nature Chemical Biology · doi:10.1038/nchembio0807-442 · Cited by 170