Privileged scaffolds for library design and drug discovery

The evolving role of natural products in drug discovery

Koehn, F. E., & Carter, G. T. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1657 · Cited by 2,579

Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery

Schreiber, S. L. (2000) · Science · doi:10.1126/science.287.5460.1964 · Cited by 2,571

Drugs for bad bugs: confronting the challenges of antibacterial discovery

Payne, D. J., Gwynn, M. N., Holmes, D. J., & Pompliano, D. L. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2201 · Cited by 2,512

A Planning Strategy for Diversity‐Oriented Synthesis

Burke, M. D., & Schreiber, S. L. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200300626 · Cited by 1,493

Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists

Evans, B., Rittle, K. E., Bock, M. G., DiPardo, R. M., Freidinger, R. M., Whitter, W. L., Lundell, G. F., Veber, D. F., Anderson, P., Chang, R. S. L., et al. (1988) · Journal of Medicinal Chemistry · doi:10.1021/jm00120a002 · Cited by 1,460

Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors

Gray, N. S., Wodicka, L. M., Thunnissen, A. M. W. H., Norman, T., Kwon, S., Espinoza, F. H., Morgan, D. O., Barnes, G., Leclerc, S., Meijer, L., et al. (1998) · Science · doi:10.1126/science.281.5376.533 · Cited by 808

From Nature to Drug Discovery: The Indole Scaffold as a ‘Privileged Structure’

Alves, F. R. S., Barreiro, E. J., & Fraga, C. A. M. (2009) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955709788452649 · Cited by 606

Diversity-oriented synthesis: Exploring the intersections between chemistry and biology

Tan, D. S. (2005) · Nature Chemical Biology · doi:10.1038/nchembio0705-74 · Cited by 605

Privileged Structures: Applications in Drug Discovery

DeSimone, R., Currie, K., Mitchell, S. A., Darrow, J. W., & Pippin, D. A. (2004) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207043328544 · Cited by 579

Towards the Optimal Screening Collection: A Synthesis Strategy

Nielsen, T. E., & Schreiber, S. L. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200703073 · Cited by 553

Inhibition of noroviruses by piperazine derivatives

Dou, D., He, G., Mandadapu, S. R., Aravapalli, S., Kim, Y., Chang, K., & Groutas, W. C. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.10.122 · Cited by 45

Aza‐[4+3] and Aza‐[3+2] Annulations for Synthesis of Dihydroazepines and Dihydropyrroles from Alkynes, Sulfonyl Azides, and 1,3‐Dienes

Kim, S., Mo, J., Kim, J., Ryu, T., & Lee, P. H. (2014) · Asian Journal of Organic Chemistry · doi:10.1002/ajoc.201402071 · Cited by 44

Asymmetric catalysis with chiral cyclopentadienyl complexes to access privileged scaffolds

Davies, C., Shaaban, S., & Waldmann, H. (2022) · Trends in Chemistry · doi:10.1016/j.trechm.2022.01.005 · Cited by 44

Catalytic Asymmetric Spirocyclizing Diels–Alder Reactions of Enones: Stereoselective Total and Formal Syntheses of α-Chamigrene, β-Chamigrene, Laurencenone C, Colletoic Acid, and Omphalic Acid

Ghosh, S., Erchinger, J. E., Maji, R., & List, B. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c01971 · Cited by 44

Coordination Versatility of NHC-metal Topologies in Asymmetric Catalysis: Synthetic Insights and Recent Trends

Jayaraj, A., Raveedran, A. V., Latha, A. T., Priyadarshini, D., & Chinna Ayya Swamy, P. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214922 · Cited by 44

Orthogonal aerobic conversion of N-benzyl amidoximes to 1,2,4-oxadiazoles or quinazolinones

Zhang, F., Wang, Y., & Chiba, S. (2013) · Organic & Biomolecular Chemistry · doi:10.1039/c3ob41393d · Cited by 44

Plasmodium Gametocyte Inhibition Identified from a Natural-Product-Based Fragment Library

Vu, H., Roullier, C., Campitelli, M. R., Trenholme, K. R., Gardiner, D. L., Andrews, K. T., Skinner‐Adams, T. S., Crowther, G. J., Voorhis, W. C. V., & Quinn, R. J. (2013) · ACS Chemical Biology · doi:10.1021/cb400582b · Cited by 47

3-Haloquinolines by Friedländer Reaction of α-Haloketones

Ryabukhin, S. V., Naumchik, V. S., Plaskon, A. S., Grygorenko, O. O., & Tolmachev, A. A. (2011) · The Journal of Organic Chemistry · doi:10.1021/jo2008252 · Cited by 44

Gold‐catalyzed Rapid Construction of Nitrogen‐containing Heterocyclic Compound Library with Scaffold Diversity and Molecular Complexity

Qiao, J., Jia, X., Li, P., Liu, X., Zhao, J., Zhou, Y., Wang, J., Liu, H. S., & Zhao, F. (2019) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201801494 · Cited by 44

Repurposing mosloflavone/5,6,7-trimethoxyflavone-resveratrol hybrids: Discovery of novel p38-α MAPK inhibitors as potent interceptors of macrophage-dependent production of proinflammatory mediators

Hassan, A. H. E., Yoo, S. Y., Lee, K. W., Yoon, Y. M., Ryu, H. W., Jeong, Y., Shin, J., Kang, S., Kim, S.-Y., Lee, H., et al. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.07.030 · Cited by 44

Recent progress toward the asymmetric synthesis of carbon-substituted piperazine pharmacophores and oxidative related heterocycles

Magriotis, P. Α. (2020) · RSC Medicinal Chemistry · doi:10.1039/d0md00053a · Cited by 44

Iron-catalyzed α-C–H functionalization of π-bonds: cross-dehydrogenative coupling and mechanistic insights

Wang, Y., Zhu, J., Guo, R., Lindberg, H., & Wang, Y. (2020) · Chemical Science · doi:10.1039/d0sc05091a · Cited by 44

Rh 2 (II)-Catalyzed Intermolecular N -Aryl Aziridination of Olefins Using Nonactivated N Atom Precursors

Deng, T., Mazumdar, W., Yoshinaga, Y., Patel, P., Malo, D., Malo, T., Wink, D. J., & Driver, T. G. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c09229 · Cited by 44

Oxidative Geminal Functionalization of Organoboron Compounds

He, Z., Trinchera, P., Adachi, S., Denis, J. D. S., & Yudin, A. K. (2012) · Angewandte Chemie · doi:10.1002/ange.201206501 · Cited by 44

Cu-Catalyzed Aerobic Molecular Transformation of Imine and Enamine Derivatives for Synthesis of Azaheterocycles

Chiba, S. (2013) · Bulletin of the Chemical Society of Japan · doi:10.1246/bcsj.20130220 · Cited by 43

Intercalation of Benzoxaborolate Anions in Layered Double Hydroxides: Toward Hybrid Formulations for Benzoxaborole Drugs

Sene, S., Bégu, S., Gervais, C., Guillaume Renaudin, A., Mesbah, A., Smith, M. E., Mutin, P. H., van der Lee, A., Nédélec, J., Bonhomme, C., et al. (2015) · Chemistry of Materials · doi:10.1021/cm504181w · Cited by 43

Evolution of a strategy for preparing bioactive small molecules by sequential multicomponent assembly processes, cyclizations, and diversification

Sahn, J. J., Granger, B. A., & Martin, S. F. (2014) · Organic & Biomolecular Chemistry · doi:10.1039/c4ob00835a · Cited by 43

Diversity‐Oriented Synthesis of Furo[3,2‐c]coumarins and Benzofuranyl Chromenones through Chemoselective Acylation/Wittig Reaction

Yang, S., Wang, C., Lin, C., Karanam, P., Reddy, G. M., Tsai, Y., & Lin, W. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201711524 · Cited by 43

Visible-Light-Induced Copper-Catalyzed Intermolecular Markovnikov Hydroamination of Alkenes

Xiong, Y., & Zhang, G. (2019) · Organic Letters · doi:10.1021/acs.orglett.9b02863 · Cited by 43

Discovery of New Pyrazolopyridine, Furopyridine, and Pyridine Derivatives as CDK2 Inhibitors: Design, Synthesis, Docking Studies, and Anti-Proliferative Activity

Abdel‐Rahman, A. A. ‐., Shaban, A. K. F., Nassar, I. F., El-kady, D. S., Ismail, N. S. M., Mahmoud, S. F., Awad, H. M., & El‐Sayed, W. A. (2021) · Molecules · doi:10.3390/molecules26133923 · Cited by 42

Structure‐Based Repurposing of FDA‐Approved Drugs as TNF‐α Inhibitors

Leung, C., Chan, D. S., Kwan, M. H., Cheng, Z., Wong, C., Zhu, G., Fong, W. F., & Ma, D. (2011) · ChemMedChem · doi:10.1002/cmdc.201100016 · Cited by 42

PhI(OAc) 2 -mediated functionalisation of unactivated alkenes for the synthesis of pyrazoline and isoxazoline derivatives

Hu, X., Feng, G., Chen, J., Yan, D., Zhao, Q., Wei, Q., & Xiao, W. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob00029g · Cited by 42

Solid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like library

Moura‐Letts, G., DiBlasi, C. M., Bauer, R. A., & Tan, D. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015268108 · Cited by 43

Identification of a New Scaffold for Hsp90 C-Terminal Inhibition

Zhao, H., Moroni, E., Colombo, G., & Blagg, B. S. J. (2013) · ACS Medicinal Chemistry Letters · doi:10.1021/ml400404s · Cited by 42

Systematic Enumeration of Heteroaromatic Ring Systems as Reagents for Use in Medicinal Chemistry

Ward, R. A., & Kettle, J. G. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm200338a · Cited by 42

A NADH-accepting imine reductase variant: Immobilization and cofactor regeneration by oxidative deamination

Gand, M., Thöle, C., Müller, H., Brundiek, H. B., Bashiri, G., & Höhne, M. (2016) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2016.05.006 · Cited by 42

Transition-Metal-Free Cross-Coupling of Indium Organometallics with Chromene and Isochroman Acetals Mediated by BF3·OEt2

Gil-Negrete, J. M., Sestelo, J. P., & Sarandeses, L. A. (2016) · Organic Letters · doi:10.1021/acs.orglett.6b02058 · Cited by 42

Enantioselective, Copper-Catalyzed Alkynylation of Ketimines To Deliver Isoquinolines with α-Diaryl Tetrasubstituted Stereocenters

Dasgupta, S., Liu, J., Shoffler, C. A., Yap, G. P. A., & Watson, M. P. (2016) · Organic Letters · doi:10.1021/acs.orglett.6b02787 · Cited by 42

Discovery of anilino-furo[2,3- d ]pyrimidine derivatives as dual inhibitors of EGFR/HER2 tyrosine kinase and their anticancer activity

Hossam, M., Lasheen, D. S., Ismail, N. S. M., Esmat, A., Mansour, A. M., Singab, A. N. B., & Abouzid, K. A. M. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.12.022 · Cited by 42

Accramycin A, A New Aromatic Polyketide, from the Soil Bacterium, Streptomyces sp. MA37

MAGLANGIT, F. F., Fang, Q., Leman, V., Soldatou, S., Ebel, R., Kyeremeh, K., & Deng, H. (2019) · Molecules · doi:10.3390/molecules24183384 · Cited by 42

Magic Rings: Navigation in the Ring Chemical Space Guided by the Bioactive Rings

Ertl, P. (2021) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.1c00761 · Cited by 41

Cp 2 Fe Mediated Electrochemical Synthesis of Phosphonylated Spirocyclic Indolines via Dearomatization of Indoles

Mo, K., Zhou, X., Wang, J., Wu, J., & Zhao, Y. (2023) · Organic Letters · doi:10.1021/acs.orglett.3c01368 · Cited by 41

Solvent-free and ‘on-water’ multicomponent assembling of salicylaldehydes, malononitrile and 3-methyl-2-pyrazolin-5-one: A fast and efficient route to the 2-amino-4-(1H-pyrazol-4-yl)-4H-chromene scaffold

Elinson, M. N., Nasybullin, R. F., Ryzhkov, F. V., & Egorov, M. P. (2013) · Comptes Rendus Chimie · doi:10.1016/j.crci.2013.08.002 · Cited by 41

An efficient iron-promoted synthesis of 6H-indolo[2,3-b]quinolines and neocryptolepine derivatives

Yan, Z., Wan, C., Wan, J., & Wang, Z. (2016) · Organic & Biomolecular Chemistry · doi:10.1039/c6ob00469e · Cited by 41

Protein–Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery

Milhas, S., Raux, B., Betzi, S., Derviaux, C., Roche, P., Restouin, A., Basse, M.-J., Rebuffet, E., Lugari, A., Badol, M., et al. (2016) · ACS Chemical Biology · doi:10.1021/acschembio.6b00286 · Cited by 42

Synthesis of novel pyrazolo[3,4- b ]quinolinyl acetamide analogs, their evaluation for antimicrobial and anticancer activities, validation by molecular modeling and CoMFA analysis

Jitender Dev, G., Poornachandra, Y., Kuchukulla, R. R., Kumar, R., Ravikumar, N., Swaroop, D. K., Ranjithreddy, P., Kumar, G. S., Nanubolu, J. B., Kumar, C. G., et al. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.02.052 · Cited by 41

Synthesis of Azepinoindoles via Rhodium-Catalyzed Formal Aza-[4 + 3] Cycloaddition Reaction of 3-Diazoindolin-2-imines with 1,3-Dienes in One-Pot

Kim, S., Kim, H., Um, K., & Lee, P. H. (2017) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.7b01150 · Cited by 41

Consecutive Ring Expansion and Contraction for the Synthesis of 1‐Aryl Tetrahydroisoquinolines and Tetrahydrobenzazepines from Readily Available Heterocyclic Precursors

Hill, J., Matlock, J. V., Lefebvre, Q., Cooper, K. G., & Clayden, J. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201802188 · Cited by 41

Synthesis, Structure, Chemical Stability, and In Vitro Cytotoxic Properties of Novel Quinoline-3-Carbaldehyde Hydrazones Bearing a 1,2,4-Triazole or Benzotriazole Moiety

Korcz, M., Sa̧czewski, F., Bednarski, P. J., & Kornicka, A. (2018) · Molecules · doi:10.3390/molecules23061497 · Cited by 41

Copper supported on functionalized MCM-41 as a novel and a powerful heterogeneous nanocatalyst for the synthesis of benzothiazoles

Pesyan, N. N., Batmani, H., & Havasi, F. (2018) · Polyhedron · doi:10.1016/j.poly.2018.11.005 · Cited by 41

Molecular Oxygen-Promoted General and Site-Specific Alkylation with Organoboronic Acid

Ling, A., Zhang, L., Tan, R. X., & Liu, Z. (2018) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.8b02277 · Cited by 41

CgPhen-DalPhos Enables the Nickel-Catalyzed O-Arylation of Tertiary Alcohols with (Hetero)Aryl Electrophiles

Morrison, K. M., McGuire, R. T., Ferguson, M. J., & Stradiotto, M. (2021) · ACS Catalysis · doi:10.1021/acscatal.1c03010 · Cited by 41

Recent report on indoles as a privileged anti-viral scaffold in drug discovery

Singh, A., Bhutani, C., Khanna, P., Talwar, S., Singh, S. K., & Khanna, L. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.117017 · Cited by 40

Structure–activity relationship and antitumor activity of thio-benzodiazepines as p53–MDM2 protein–protein interaction inhibitors

Guo, Z., Zhuang, C., Zhu, L., Zhang, Y., Yao, J., Dong, G., Wang, S., Liu, Y., Chen, H., Sheng, C., et al. (2012) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2012.08.003 · Cited by 41

Synthesis of novel trifluoromethyl substituted furo[2,3- b ]pyridine and pyrido[3′,2′:4,5]furo[3,2- d ]pyrimidine derivatives as potential anticancer agents

Kumar, R. N., Poornachandra, Y., Punna, N., Gannarapu, M. R., Kumar, N. R., Palreddy, R., Kumar, C. G., & Narsaiah, B. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.11.007 · Cited by 40

Tandem Copper‐Catalyzed N‐Arylation–Condensation and van Leusen Reaction: Synthesis of 1,4‐Benzodiazepines and Imidazobenzodiazepines (ImBDs)

Murugesh, V., Harish, B., Adiseshu, M., Nanubolu, J. B., & Suresh, S. (2016) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201501048 · Cited by 40

Preparation of trans-2-Substituted-4-halopiperidines and cis-2-Substituted-4-halotetrahydropyrans via AlCl3-Catalyzed Prins Reaction

Liu, G., Cui, B., Xu, R., & Li, Y. (2016) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.6b00725 · Cited by 40

Pass and Swiss ADME collaborated in silico docking approach to the synthesis of certain pyrazoline spacer compounds for dihydrofolate reductase inhibition and antimalarial activity

Lohidakshan, K. K., Rajan, M. P. R., Andhale, G. S., Paul, M., & Jerin, J. (2018) · Bangladesh Journal of Pharmacology · doi:10.3329/bjp.v13i1.33625 · Cited by 41

p-Toluenesulfonic acid doped polystyrene (PS-PTSA): solvent-free microwave assisted cross-coupling-cyclization–oxidation to build one-pot diversely functionalized pyrrole from aldehyde, amine, active methylene, and nitroalkane

Shinde, V. V., Lee, S. D., Jeong, Y. S., & Jeong, Y. T. (2015) · Tetrahedron Letters · doi:10.1016/j.tetlet.2014.12.126 · Cited by 40

Studies on the mechanism of the Cadogan–Sundberg indole synthesis

Majgier-Báranowska, H., Williams, J. D., Li, B., & Peet, N. P. (2012) · Tetrahedron Letters · doi:10.1016/j.tetlet.2012.06.146 · Cited by 40

Catalysis of Cascade and Multicomponent Reactions of Carbonyl Compounds and CH Acids by Electricity

Elinson, M. N., Vereshchagin, A. N., & Ryzhkov, F. V. (2016) · The Chemical Record · doi:10.1002/tcr.201600044 · Cited by 40

One-Pot Access to a Library of Structurally Diverse Nicotinamide Derivatives via a Three-Component Formal Aza [3 + 3] Cycloaddition

Tenti, G., Ramos, M. T., & Menéndez, J. C. (2012) · ACS Combinatorial Science · doi:10.1021/co300081k · Cited by 39

Application of Imine Reductases (IREDs) in Micro‐Aqueous Reaction Systems

Maugeri, Z., & Rother, D. (2016) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201501154 · Cited by 39

Design and synthesis of short amphiphilic cationic peptidomimetics based on biphenyl backbone as antibacterial agents

Kuppusamy, R., Yasir, M., Berry, T., Cranfield, C. G., Nizalapur, S., Yee, E. M. H., Kimyon, Ö., Taunk, A., Ho, K. K. K., Cornell, B. A., et al. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.10.066 · Cited by 39

Metal-, Photocatalyst-, and Light-Free Minisci C–H Alkylation of N-Heteroarenes with Oxalates

Dong, J., Wang, Z., Wang, X., Song, H., Liu, Y., & Wang, Q. (2019) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.9b00972 · Cited by 39

Nickel-Catalyzed Diastereoselective Reductive Cross-Coupling of Disubstituted Cycloalkyl Iodides with Aryl Iodides

Song, X., Guo, M.-M., Xu, S., Shen, C., Zhou, X., Chu, X., Ma, M., & Shen, Z. (2021) · Organic Letters · doi:10.1021/acs.orglett.1c01649 · Cited by 39

Free energy perturbation (FEP)-guided scaffold hopping

Wu, D., Zheng, X., Liu, R., Li, Z., Jiang, Z., Zhou, Q., Huang, Y., Wu, X.-N., Zhang, C., Huang, Y., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.09.027 · Cited by 39

Electrochemical Synthesis of Isoxazolines: Method and Mechanism

Holman, S. D. L., Wills, A. G., Fazakerley, N. J., Poole, D. L., Coe, D. M., Berlouis, L. E. A., & Reid, M. (2022) · Chemistry - A European Journal · doi:10.1002/chem.202103728 · Cited by 39

Facile and Unified Approach to Skeletally Diverse, Privileged Scaffolds

Sahn, J. J., Su, J. Y., & Martin, S. F. (2011) · Organic Letters · doi:10.1021/ol200709h · Cited by 40

Development of Azaindole-Based Frameworks as Potential Antiviral Agents and Their Future Perspectives

Urvashi, U., Kumar, J. B. S., Das, P., & Tandon, V. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00444 · Cited by 38

Synthesis and evaluation of linearly fused thiadiazolocoumarins as prospects with broad-spectrum bioactivity

Jibroo, R. N., Mustafa, Y. F., & Al-Shakarchi, W. (2024) · Results in Chemistry · doi:10.1016/j.rechem.2024.101494 · Cited by 38

An Allenic Pauson–Khand Approach to 6,12-Guaianolides

Grillet, F., Huang, C., & Brummond, K. M. (2011) · Organic Letters · doi:10.1021/ol2028515 · Cited by 38

Synthesis, characterization, DNA-binding studies and acetylcholinesterase inhibition activity of new 3-formyl chromone derivatives

Parveen, M., Malla, A. M., Yaseen, Z., Ali, A. A., & Alam, M. (2013) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2013.11.019 · Cited by 38

A solvent free, four-component synthesis and 1,3-dipolar cycloaddition of 4(H)-pyrans with nitrile oxides: Synthesis and discovery of antimycobacterial activity of enantiomerically pure 1,2,4-oxadiazoles

Almansour, A. I., Kumar, R. S., Arumugam, N., & Sriram, D. (2012) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2012.04.021 · Cited by 38

A new concise synthesis of 2,3-dihydroquinazolin-4(1 H )-one derivatives

Desroses, M., Scobie, M., & Helleday, T. (2013) · New Journal of Chemistry · doi:10.1039/c3nj00618b · Cited by 38

Privileged Structures Meet Human T-Cell Leukemia Virus-1 (HTLV-1): C2-Symmetric 3,4-Disubstituted Pyrrolidines as Nonpeptidic HTLV-1 Protease Inhibitors

Kuhnert, M., Blum, A., Steuber, H., & Diederich, W. E. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b00346 · Cited by 38

Design and synthesis of DNA-encoded libraries based on a benzodiazepine and a pyrazolopyrimidine scaffold

Škopić, M. K., Bugain, O., Jung, K., Onstein, S., Brandherm, S., Kalliokoski, T., & Brunschweiger, A. (2016) · MedChemComm · doi:10.1039/c6md00243a · Cited by 38

Microwave-Assisted Cascade Strategy for the Synthesis of Indolo[2,3-b]quinolines from 2-(Phenylethynyl)anilines and Aryl Isothiocynates

Ali, W., Dahiya, A., Pandey, R., Alam, T., & Patel, B. K. (2017) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.6b02912 · Cited by 38

Current insights into anti-HIV drug discovery and development: a review of recent patent literature (2014–2017)

Zuo, X., Huo, Z., Kang, D., Wu, G., Zhou, Z., Liu, X., & Zhan, P. (2018) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2018.1438410 · Cited by 38

A metal-free cross-dehydrogenative coupling of N-carbamoyl tetrahydroisoquinoline by sodium persulfate

Chen, W., Zheng, H., Pan, X., Xie, Z., Zan, X., Sun, B., Liu, L., & Lou, H. (2014) · Tetrahedron Letters · doi:10.1016/j.tetlet.2014.03.094 · Cited by 38

Enantioselective Copper-Catalyzed Borylative Cyclization with Cyclic Imides

Whyte, A., Torelli, A., Mirabi, B., & Lautens, M. (2019) · Organic Letters · doi:10.1021/acs.orglett.9b03144 · Cited by 38

Catalytic formation of N3-substituted quinazoline-2,4(1 H ,3 H )-diones by Pd( ii )EN@GO composite and its mechanistic investigations through DFT calculations

Biswas, S., Khatun, R., Dolai, M., Biswas, I. H., Haque, N., Sengupta, M., Islam, M. S., & Islam, S. M. (2019) · New Journal of Chemistry · doi:10.1039/c9nj04288a · Cited by 38

Recent Advances in Synthetic Hetaryne Chemistry

Hosoya, T., Yoshida, S., & Nakamura, Y. (2019) · Heterocycles · doi:10.3987/rev-19-917 · Cited by 38

Multicomponent Assembly and Diversification of Novel Heterocyclic Scaffolds Derived from 2-Arylpiperidines

Hardy, S., & Martin, S. F. (2011) · Organic Letters · doi:10.1021/ol201010s · Cited by 37

Rapid preparation of triazolyl substituted NH-heterocyclic kinase inhibitors via one-pot Sonogashira coupling–TMS-deprotection–CuAAC sequence

Merkul, E., Klukas, F., Dorsch, D., Grädler, U., Greiner, H. E., & Mueller, T. J. J. (2011) · Organic & Biomolecular Chemistry · doi:10.1039/c1ob05586k · Cited by 38

Structure-Guided Screening for Functionally Selective D2 Dopamine Receptor Ligands from a Virtual Chemical Library

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Discovery and Structure–Activity-Relationship Study of N -Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β- d -ribose 2′-Oxidase

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