Small molecule chemical probes of microRNA function
Open accessAbstract
MicroRNAs (miRNAs) are small, non-coding RNAs that control protein expression. Aberrant miRNA expression has been linked to various human diseases, and thus miRNAs have been explored as diagnostic markers and therapeutic targets. Although it is challenging to target RNA with small molecules in general, there have been successful campaigns that have identified small molecule modulators of miRNA function by targeting various pathways. For example, small molecules that modulate transcription and target nuclease processing sites in miRNA precursors have been identified. Herein, we describe challenges in developing chemical probes that target miRNAs and highlight aspects of miRNA cellular biology elucidated by using small molecule chemical probes. We expect that this area will expand dramatically in the near future as progress is made in understanding small molecule recognition of RNA.
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There have been several successful cases that have identified small-molecule modulators of miRNAs.
“there have been several successful cases that have identified small-molecule modulators of miRNAs (Velagapudi et al., 2015)”
From microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain (2015) · cites this paper as Velagapudi et al., 2015
Several small molecules have been identified to modulate miRNAs.
“In addition, several small molecules have been identified to modulate miRNAs [148].”
From MicroRNAs in brain cholesterol metabolism and their implications for Alzheimer's disease (2016) · cites this paper as [148]
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- Authors
- Velagapudi, S. P., Vummidi, B. R., & Disney, M. D.
- Affiliations
- Scripps Research Institute (US)
- Corresponding author
- Disney, Matthew D.
- ORCID
- Disney, Matthew D.
- Venue
- Current Opinion in Chemical Biology
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 24
- Pages
- 97-103
- ISSN
- 1367-5931 (ISSN-L)
- PMC
- PMC4382669
- OpenAlex
- W2088778501
- Cited by
- 46
- References
- 49
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 4 · 2018: 7 · 2017: 2 · 2016: 11 · 2015: 5
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Chemical Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- R01GM097455
- Swiss National Science Foundation Prospective Researcher Fellowship
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- microRNA, chemical probes, microRNA function, RNA-targeting small molecules, microRNA precursors, transcriptional regulation, microRNA biogenesis, therapeutic target, diagnostic biomarkers
- MeSH terms
- Animals, Base Sequence, Humans, Molecular Sequence Data, Molecular Probes, Molecular Probe Techniques, Transcriptional Activation, MicroRNAs, Small Molecule Libraries, Drug Discovery
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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