Diagnostic value of isolated plasma biomarkers and its combination in neurodegenerative dementias: A multicenter cohort study
Open accessAbstract
BACKGROUND: Plasma amyloid-β (Aβ), phosphorylated tau-181 (p-tau181), neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) potentially aid in the diagnosis of neurodegenerative dementias. We aim to conduct a comprehensive comparison between different biomarkers and their combination, which is lacking, in a multicenter Chinese dementia cohort consisting of Alzheimer's disease (AD), frontotemporal dementia (FTD), and progressive supranuclear palsy (PSP). METHODS: We enrolled 92 demented patients [64 AD, 16 FTD, and 12 PSP with dementia] and 20 healthy controls (HC). Their plasma Αβ, p-tau181, NfL, and GFAP were detected by highly sensitive-single molecule immunoassays. Αβ pathology in patients was measured by cerebrospinal fluid or/and amyloid positron emission tomography. RESULTS: All plasma biomarkers tested were significantly altered in dementia patients compared with HC, especially Aβ42/Aβ40 and NfL showed significant performance in distinguishing AD from HC. A combination of plasma Aβ42/Aβ40, p-tau181, NfL, and GFAP could discriminate FTD or PSP well from HC and was able to distinguish AD and non-AD (FTD/PSP). CONCLUSIONS: Our results confirmed the diagnostic performance of individual plasma biomarkers Aβ42/Aβ40, p-tau181, NfL, and GFAP in Chinese dementia patients and noted that a combination of these biomarkers may be more accurate in identifying FTD/PSP patients and distinguishing AD from non-AD dementia.
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Some studies reported elevated blood GFAP in participants with FTD compared to controls.
“Indeed, some studies reported elevated blood GFAP in participants with FTD compared to controls [8–18] but others observed no such GFAP increase in FTD [19–22].”
From Comprehensive cross-sectional and longitudinal comparisons of plasma glial fibrillary acidic protein and neurofilament light across FTD spectrum disorders (2025) · cites this paper as [17]
Cites
Classification and Regression by randomForest
Liaw, A. I., & Wiener, M. C. (2007) · Cited by 18,594 · see citing works
ggplot2: Elegant Graphics for Data Analysis
Ginestet, C. E. (2011) · Journal of the Royal Statistical Society Series A (Statistics in Society) · doi:10.1111/j.1467-985x.2010.00676_9.x · Cited by 14,484 · see citing works
NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease
Jack, C. R., Bennett, D. A., Blennow, K., Carrillo, M. C., Dunn, B., Haeberlein, S. B., Holtzman, D. M., Jagust, W., Jessen, F., Karlawish, J., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.02.018 · Cited by 10,537 · see citing works
A New Clinical Scale for the Staging of Dementia
Hughes, C. P., Berg, L., Danziger, W., Coben, L. A., & Martin, R. L. (1982) · British Journal of Psychiatry · doi:10.1192/bjp.140.6.566 · Cited by 7,056 · see citing works
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Rascovsky, K., Hodges, J. R., Knopman, D., Mendez, M. F., Kramer, J. H., Neuhaus, J., van Swieten, J. C., Seelaar, H., Dopper, E. G. P., Onyike, C. U., et al. (2011) · Brain · doi:10.1093/brain/awr179 · Cited by 5,221 · see citing works
Classification of primary progressive aphasia and its variants
Gorno-Tempini, M. L., Hillis, A. E., Weintraub, S., Kertesz, A., Mendez, M., Cappa, S. F., Ogar, J. M., Rohrer, J. D., Black, S., Boeve, B. F., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31821103e6 · Cited by 5,141 · see citing works
Litvan, I., Agid, Y., Calne, D., Campbell, G., Dubois, B., Duvoisin, R. C., Goetz, C. G., Golbe, L. I., Grafman, J., Growdon, J. H., et al. (1996) · Neurology · doi:10.1212/wnl.47.1.1 · Cited by 2,538 · see citing works
Olsson, B., Lautner, R., Andreasson, U., Öhrfelt, A., Portelius, E., Bjerke, M., Hölttä, M., Rosén, C., Olsson, C., Strobel, G., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00070-3 · Cited by 2,049 · see citing works
High performance plasma amyloid-β biomarkers for Alzheimer's disease
Nakamura, A., Kaneko, N., Villemagne, V. L., Kato, T., Doecke, J., Doré, V., Fowler, C., Li, Q.-X., Martins, R., Rowe, C., et al. (2018) · Nature · doi:10.1038/nature25456 · Cited by 1,681 · see citing works
Janelidze, S., Mattsson, N., Palmqvist, S., Smith, R., Beach, T. G., Serrano, G. E., Chai, X., Proctor, N. K., Eichenlaub, U., Zetterberg, H., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0755-1 · Cited by 1,247 · see citing works
Katzman, R., Zhang, M., Ouang-Ya-Qu, Wang, Z., Liu, W. T., Yu, E., Wong, S.-C., Salmon, D. P., & Grant, I. (1988) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(88)90034-0 · Cited by 1,040 · see citing works
Defining imaging biomarker cut points for brain aging and Alzheimer's disease
Jack, C. R., Wiste, H. J., Weigand, S. D., Therneau, T. M., Lowe, V. J., Knopman, D. S., Gunter, J. L., Senjem, M. L., Jones, D. T., Kantarci, K., et al. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.08.005 · Cited by 931 · see citing works
Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) investigators, Thijssen, E. H., La Joie, R., Wolf, A., Strom, A., Wang, P., Iaccarino, L., Bourakova, V., Cobigo, Y., Heuer, H., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0762-2 · Cited by 761 · see citing works
Mattsson, N., Cullen, N. C., Andreasson, U., Zetterberg, H., & Blennow, K. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.0765 · Cited by 726 · see citing works
Benedet, A. L., Milà-Alomà, M., Vrillon, A., Ashton, N. J., Pascoal, T. A., Lussier, F., Karikari, T. K., Hourregue, C., Cognat, E., Dumurgier, J., et al. (2021) · JAMA Neurology · doi:10.1001/jamaneurol.2021.3671 · Cited by 638 · see citing works
A multicentre validation study of the diagnostic value of plasma neurofilament light.
Ashton, N. J., Janelidze, S., Al Khleifat, A., Leuzy, A., van der Ende, E. L., Karikari, T. K., Benedet, A. L., Pascoal, T. A., Lleó, A., Parnetti, L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23620-z · Cited by 545 · see citing works
Palmqvist, S., Tideman, P., Cullen, N., Zetterberg, H., Blennow, K., Initiative, T. A. D. N., Dage, J. L., Stomrud, E., Janelidze, S., Mattsson-Carlgren, N., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01348-z · Cited by 524 · see citing works
Boxer, A. L., Yu, J.-T., Golbe, L. I., Litvan, I., Lang, A. E., & Höglinger, G. U. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30157-6 · Cited by 485 · see citing works
Hall, S., Öhrfelt, A., Constantinescu, R., Andreasson, U., Surova, Y., Bostrom, F., Nilsson, C., Widner, H., Decraemer, H., Nägga, K., et al. (2012) · Archives of Neurology · doi:10.1001/archneurol.2012.1654 · Cited by 473 · see citing works
Karikari, T. K., Benedet, A. L., Ashton, N. J., Lantero‐Rodriguez, J., Snellman, A., Suárez‐Calvet, M., Saha‐Chaudhuri, P., Lussier, F. Z., Kvartsberg, H., Moscoso, A., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00923-z · Cited by 348 · see citing works
The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's disease
Simrén, J., Leuzy, A., Karikari, T. K., Hye, A., Benedet, A. L., Lantero‐Rodriguez, J., Mattsson, N., Schöll, M., Mecocci, P., Vellas, B. J., et al. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12283 · Cited by 334 · see citing works
Sengupta, U., & Kayed, R. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102270 · Cited by 303 · see citing works
Hampel, H., Hu, Y., Cummings, J., Mattke, S., Iwatsubo, T., Nakamura, A., Vellas, B., O’Bryant, S., Shaw, L. M., Cho, M., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.05.017 · Cited by 283 · see citing works
Axonal damage markers in cerebrospinal fluid are increased in ALS
Brettschneider, J., Petzold, A., Süßmuth, S. D., Ludolph, A. C., & Tumani, H. (2006) · Neurology · doi:10.1212/01.wnl.0000203120.85850.54 · Cited by 261 · see citing works
Elahi, F. M., Casaletto, K. B., Joie, R. L., Walters, S. M., Harvey, D. J., Wolf, A. A., Edwards, L., Contreras, W. R., Karydas, A., Cobigo, Y., et al. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.09.004 · Cited by 250 · see citing works
Chouliaras, L., Thomas, A., Malpetti, M., Donaghy, P., Kane, J., Mak, E., Savulich, G., Prats-Sedano, M. A., Heslegrave, A. J., Zetterberg, H., et al. (2022) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2021-327788 · Cited by 199 · see citing works
Baiardi, S., Quadalti, C., Mammana, A., Dellavalle, S., Zenesini, C., Sambati, L., Pantieri, R., Polischi, B., Romano, L., Suffritti, M., et al. (2022) · Alzheimer's Research & Therapy · doi:10.1186/s13195-022-01093-6 · Cited by 193 · see citing works
An accurate fully automated panel of plasma biomarkers for Alzheimer's disease
Palmqvist, S., Stomrud, E., Cullen, N. C., Janelidze, S., Manuilova, E., Jethwa, A., Bittner, T., Eichenlaub, U., Suridjan, I., Kollmorgen, G., et al. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12751 · Cited by 161 · see citing works
Plasma Tau and Neurofilament Light in Frontotemporal Lobar Degeneration and Alzheimer Disease
Illán-Gala, I., Lleo, A., Karydas, A., Staffaroni, A. M., Zetterberg, H., Sivasankaran, R., Grinberg, L. T., Spina, S., Kramer, J. H., Ramos, E. M., et al. (2021) · Neurology · doi:10.1212/wnl.0000000000011226 · Cited by 150 · see citing works
Fluid biomarkers in frontotemporal dementia: past, present and future
Swift, I. J., Sogorb-Esteve, A., Heller, C., Synofzik, M., Otto, M., Graff, C., Galimberti, D., Todd, E., Heslegrave, A. J., van der Ende, E. L., et al. (2021) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2020-323520 · Cited by 122 · see citing works
Serum neurofilament light chain in behavioral variant frontotemporal dementia
Steinacker, P., Anderl-Straub, S., Diehl-Schmid, J., Semler, E., Uttner, I., von Arnim, C. A. F., Barthel, H., Danek, A., Fassbender, K., Fliessbach, K., et al. (2018) · Neurology · doi:10.1212/wnl.0000000000006318 · Cited by 116 · see citing works
Huang, L., Chen, K.-L., Lin, B.-Y., Tang, L., Zhao, Q.-H., Lv, Y.-R., & Guo, Q.-H. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s174293 · Cited by 112 · see citing works
CSF tau microtubule-binding region identifies pathological changes in primary tauopathies
Horie, K., Barthélemy, N. R., Spina, S., VandeVrede, L. A., He, Y., Paterson, R. W., Wright, B. A., Day, G. S., Davis, A. A., Karch, C. M. M., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-02075-9 · Cited by 96 · see citing works
Shen, X., Huang, S., Cui, M., Zhao, Q., Guo, Y., Huang, Y., Zhang, W., Ma, Y., Chen, S.-D., Zhang, Y.-R., et al. (2023) · Clinical Chemistry · doi:10.1093/clinchem/hvad018 · Cited by 96 · see citing works
Self-citationOeckl, P., Anderl-Straub, S., Von Arnim, C. A. F., Baldeiras, I., Diehl-Schmid, J., Grimmer, T., Halbgebauer, S., Kort, A. M., Lima, M., Marques, T. M., et al. (2022) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2021-328547 · Cited by 94 · see citing works
Gmitrowicz, A., & Kucharska, A. (1995) · PubMed · Cited by 93 · see citing works
Gao, F., Lv, X., Dai, L., Wang, Q., Wang, P., Cheng, Z., Xie, Q., Ni, M., Wu, Y., Chai, X., et al. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12700 · Cited by 86 · see citing works
Relevance of biomarkers across different neurodegenerative diseases
Ehrenberg, A. J., Khatun, A., Coomans, E. M., Betts, M. J., Capraro, F., Thijssen, E. H., Senkevich, K. A., Bharucha, T., Jafarpour, M., Young, P. N. E., et al. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00601-w · Cited by 79 · see citing works
Zhou, F., Sun, Y., Xie, X., & Zhao, Y. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01254-1 · Cited by 75 · see citing works
Serum neurofilament light chain in progressive supranuclear palsy
Kaat, L. D., Meeter, L. H. H., Chiu, W. Z., Melhem, S., Boon, A. J. W., Blennow, K., Zetterberg, H., & Swieten, J. C. V. (2018) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2018.06.018 · Cited by 68 · see citing works
Salivary Distinctiveness and Modifications in Males with Diabetes and Behçet’s Disease
Aljerf, L., & Alhaffar, I. (2017) · Biochemistry Research International · doi:10.1155/2017/9596202 · Cited by 48 · see citing works
Dreger, M., Steinbach, R., Gaur, N., Metzner, K., Stubendorff, B., Witte, O. W., & Großkreutz, J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.651651 · Cited by 37 · see citing works
Honig, L. S., Kang, M. S., Lee, A., Reyes‐Dumeyer, D., Piriz, A. L., Soriano, B., Franco, Y., Coronado, Z. D., Recio, P., Mejía, D. R., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.8214 · Cited by 33 · see citing works
Ajong, A. B., Kenfack, B., Ali, I. M., Yakum, M. N., Ukaogo, P. O., Mangala, F. N., Aljerf, L., & Téléfo, P. B. (2023) · PLoS ONE · doi:10.1371/journal.pone.0292303 · Cited by 28 · see citing works
Improvements in the Ecological and Nutritional Aspects of Down's SyndromePreprint
Aljerf, L., & Aljurf, M. (2020) · doi:10.21203/rs.3.rs-30313/v1 · Cited by 24 · see citing works
Cortical event-related potentials in Alzheimer's disease and frontotemporal lobar degeneration
Chen, L., Zhou, Y., Liu, L., Zhang, X., Zhang, H., & Liu, S. (2015) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2015.10.040 · Cited by 19 · see citing works
Ajong, A. B., Kenfack, B., Ali, I. M., Yakum, M. N., Ukaogo, P. O., Mangala, F. N., Aljerf, L., & Téléfo, P. B. (2022) · PLoS ONE · doi:10.1371/journal.pone.0268643 · Cited by 19 · see citing works
Elverman, K. H., Paitel, E. R., Figueroa, C. M., McKindles, R. J., & Nielson, K. A. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201559 · Cited by 18 · see citing works
Ajong, A. B., Kenfack, B., Ali, I. M., Yakum, M. N., Ukaogo, P. O., Mangala, F. N., Aljerf, L., & Téléfo, P. B. (2022) · PLoS ONE · doi:10.1371/journal.pone.0271525 · Cited by 16 · see citing works
Dumurgier, J., Laplanche, J., Mouton‐Liger, F., Lapalus, P., Indart, S., Prévot, M., Peoc’h, K., Hugon, J., & Paquet, C. (2014) · Journal of Neurology · doi:10.1007/s00415-014-7335-6 · Cited by 13 · see citing works
Zhang, L., Li, L., Meng, F., Yu, J. Z., He, F., Lin, Y., Su, Y., Hu, M., Liu, X., Liu, Y., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.704582 · Cited by 9 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Benussi, A., Huber, H., Tan, K., Cantoni, V., Rivolta, J., Cotelli, M. S., Benedet, A. L., Blennow, K., Zetterberg, H., Ashton, N. J., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.14482 · Cited by 33 · see citing works
Blood-Based Biomarkers in Frontotemporal Dementia: A Narrative Review
Liampas, I., Kyriakoulopoulou, P., Karakoida, V., Kavvoura, P. A., Sgantzos, M. N., Bogdanos, D. P., Stamati, P., Dardiotis, E., & Siokas, V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111838 · Cited by 26 · see citing works
Kou, W., Li, S., Yan, R., Zhang, J., Wan, Z., & Feng, T. (2025) · Journal of Neurology · doi:10.1007/s00415-025-13051-x · Cited by 22 · see citing works
Sheth, U., Öijerstedt, L., Heckman, M. G., White, L. J., Heuer, H. W., Lario Lago, A., Forsberg, L. K., Faber, K. M., Foroud, T. M., Rademakers, R., et al. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00821-4 · Cited by 20 · see citing works
Tau biomarkers for neurodegenerative diseases: Current state and perspectives
Vacchi, E., Ruíz‐Barrio, I., & Melli, G. (2025) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2025.107772 · Cited by 11 · see citing works
Suresh, S., Maffei, L., Bauermeister, S., & Raymont, V. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251408510 · Cited by 10 · see citing works
Plasma Biomarkers in the Distinction of Alzheimer’s Disease and Frontotemporal Dementia
Gómez‐Tortosa, E., Agüero, P., Ruiz-González, A., Wagner, S., Téllez, R., Mahíllo, I., Ruiz-Calvo, A., Sainz, M. J., Nystrom, A. L., del Ser, T., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031231 · Cited by 9 · see citing works
Immunological Fluid Biomarkers in Frontotemporal Dementia: A Systematic Review
Erichsen, P. A., Henriksen, E. E., Nielsen, J. E., Ejlerskov, P., Simonsen, A. H., & Toft, A. D. (2025) · Biomolecules · doi:10.3390/biom15040473 · Cited by 7 · see citing works
Caviedes, A., Cabral‐Miranda, F., Orellana, P., Hernández, H., Henriquez, F. A., González-Gómez, R., Pizarro, M., Migeot, J., Ochoa‐Rosales, C., Gonzalez‐Silva, C., et al. (2026) · Nature Aging · doi:10.1038/s43587-025-01061-3 · Cited by 6 · see citing works
Giannakis, A., Konitsiotis, S., & Sioka, C. (2025) · Journal of Neural Transmission · doi:10.1007/s00702-025-02955-7 · Cited by 6 · see citing works
Hanin, A., Quadrio, I., Beaudeux, J., & Lamari, F. (2026) · Journal of Neurology · doi:10.1007/s00415-026-13896-w · Cited by 2 · see citing works
Chai, L., Zhan, Y., Huang, Y., Tian, M., Zhao, G., Ni, J., Xiong, X., Huang, J., & Lin, B. (2026) · Alzheimer s Research & Therapy · doi:10.1186/s13195-026-02104-6 · Cited by 2 · see citing works
Járdánházy, A., Berger, T., Hegen, H., Hemmer, B., Bartosik-Psujek, H., Kes, V. B., Berthele, A., Drulovic, J. S., Habek, M., Horáková, D., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178274 · Cited by 1 · see citing works
Zamani, J., Vahid, A., Wilson, E. N., Hosseini, S. M. H., & Initiative, T. F. L. D. N. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71265 · Cited by 1 · see citing works
Cacciabaudo, F., Agnello, L., Gambino, C. M., Accardi, G., Masucci, A., Tamburello, M., Vassallo, R., & Ciaccio, M. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48040358 · Cited by 1 · see citing works
Yan, K., He, S., Jia, X., Li, H., Liu, D., & Chen, J. (2026) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823261432112 · Cited by 1 · see citing works
Salari, M., Rezaei, K., Qalamzan, M. J., Sadeghzadeh, S., Hojjatipour, F., Golzarian, M.-J., & Etemadifar, M. (2025) · Research Square · doi:10.21203/rs.3.rs-6526460/v1
Upadhyay, K. D., Viramgami, A., Singh, D., Kulkarni, N., Chudasama, B., Sivaperumal, P., & Balachandar, R. (2025) · Research Square · doi:10.21203/rs.3.rs-7788186/v1
Magro, G., Laterza, V., Mechelli, A., Tosto, F., Longo, A., Camastra, C., & Quattrone, A. (2026) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2026.126162
- Authors
- Chen, Y., Wang, Y., Tao, Q., Lu, P., Meng, F., Zhuang, L., Qiao, S., Zhang, Y., Luo, B., Liu, Y., & Peng, G.
- Affiliations
- First Affiliated Hospital Zhejiang University (CN)
- Shaoxing People's Hospital (CN)
- Sir Run Run Shaw Hospital (CN)
- Zhejiang Hospital (CN)
- Tongde Hospital of Zhejiang Province (CN)
- Saarland University (DE)
- Corresponding author
- Luo, Benyan
- Liu, Yang
- Peng, Guoping
- ORCID
- Venue
- Clinica Chimica Acta
- Publisher
- Elsevier BV
- Published
- 2024-05
- Volume
- 558
- Pages
- 118784
- ISSN
- 0009-8981 (ISSN-L)
- OpenAlex
- W4394014176
- Cited by
- 21
- References
- 51
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 2
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Clinica Chimica Acta (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- plasma biomarkers, neurodegenerative dementia, Alzheimer's disease, frontotemporal dementia, progressive supranuclear palsy, amyloid-beta, phosphorylated tau 181, neurofilament light chain, glial fibrillary acidic protein, combined biomarker detection, differential diagnosis
- MeSH terms
- Aged, Alzheimer Disease, Dementia, Female, Glial Fibrillary Acidic Protein, Humans, Male, Middle Aged, Cohort Studies, Biomarkers, Amyloid beta-Peptides, tau Proteins, Neurofilament Proteins, Frontotemporal Dementia
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