The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
The Gut as the Motor of Multiple Organ Dysfunction in Critical Illness
Open accessAbstract
Synopsis All elements of the gut – the epithelium, the immune system, and the microbiome – are impacted by critical illness and can, in turn, propagate a pathologic host response leading to multiple organ dysfunction syndrome. Preclinical studies have demonstrated that this can occur by release of toxic gut-derived substances into the mesenteric lymph where they can cause distant damage. Further, intestinal integrity is compromised in critical illness with increases in apoptosis and permeability. There is also increasing recognition that microbes alter their behavior and can become virulent based upon host environmental cues. Gut failure is common in critically ill patients; however, therapeutics targeting the gut have proven to be challenging to implement at the bedside. Numerous strategies to manipulate the microbiome have recently been used with varying success in the ICU.
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Cites
Intestinal permeability – a new target for disease prevention and therapy
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“While bacterial translocation clearly occurs in some preclinical models of critical illness (10), human data has generally remained inconclusive or not supportive of this as a common phenomenon seen in critically ill patients, although it likely occurs in select pathophysiologic conditions (11;12).”
BackgroundDietary effects on human gut microbiome diversity
Xu, Z., & Knight, R. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114514004127 · Cited by 456
INTESTINAL CROSSTALK: A NEW PARADIGM FOR UNDERSTANDING THE GUT AS THE "MOTOR" OF CRITICAL ILLNESS
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Self-citation
Cited by
Human gut microbiota/microbiome in health and diseases: a review
Gomaa, E. Z. (2020) · Antonie van Leeuwenhoek · doi:10.1007/s10482-020-01474-7 · Cited by 1,294
Mechanisms and treatment of organ failure in sepsis
Lelubre, C., & Vincent, J.-L. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0005-7 · Cited by 852
Extreme Dysbiosis of the Microbiome in Critical Illness
McDonald, D., Ackermann, G., Khailova, L., Baird, C., Heyland, D., Kozar, R., Lemieux, M., Derenski, K., King, J., Vis-Kampen, C., et al. (2016) · mSphere · doi:10.1128/msphere.00199-16 · Cited by 426
The role of the gut microbiota in sepsis
Haak, B. W., & Wiersinga, W. J. (2017) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(16)30119-4 · Cited by 367
The gut microbiome’s role in the development, maintenance, and outcomes of sepsis
Adelman, M. W., Woodworth, M. H., Langelier, C., Busch, L. M., Kempker, J. A., Kraft, C. S., & Martin, G. S. (2020) · Critical Care · doi:10.1186/s13054-020-02989-1 · Cited by 342
Metadata
- Authors
- Klingensmith, N. J., & Coopersmith, C. M.
- Venue
- Critical Care Clinics
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 32
- Issue
- 2
- Pages
- 203-212
- ISSN
- 0749-0704 (ISSN-L)
- OpenAlex
- W2295213040
- Cited by
- 417
- References
- 58
- FWCI
- 29.44
- Type
- journal article
- Language
- en
- Open access
- green
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