Extreme Dysbiosis of the Microbiome in Critical Illness
Open accessAbstract
Critical illness may be associated with the loss of normal, “health promoting” bacteria, allowing overgrowth of disease-promoting pathogenic bacteria (dysbiosis), which, in turn, makes patients susceptible to hospital-acquired infections, sepsis, and organ failure. This has significant world health implications, because sepsis is becoming a leading cause of death worldwide, and hospital-acquired infections contribute to significant illness and increased costs. Thus, a trial that monitors the ICU patient microbiome to confirm and characterize this hypothesis is urgently needed. Our study analyzed the microbiomes of 115 critically ill subjects and demonstrated rapid dysbiosis from unexpected environmental sources after ICU admission. These data may provide the first steps toward defining targeted therapies that correct potentially “illness-promoting” dysbiosis with probiotics or with targeted, multimicrobe synthetic “stool pills” that restore a healthy microbiome in the ICU setting to improve patient outcomes.
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Induction of gut dysbiosis in septic patients has been previously reported.
“Induction of gut dysbiosis in septic patients has been previously reported (25, 26).”
From Sepsis-Induced Gut Dysbiosis Mediates the Susceptibility to Sepsis-Associated Encephalopathy in Mice (2022) · cites this paper as [26]
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“Induction of gut dysbiosis in septic patients has been previously reported (25, 26).”
BackgroundGamage, H. K. A. H., Venturini, C., Tetu, S. G., Kabir, M., Nayyar, V., Ginn, A. N., Roychoudhry, B., Thomas, L., Brown, M., Holmes, A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-85946-4 · Cited by 20 · see citing works
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- Authors
- McDonald, D., Ackermann, G., Khailova, L., Baird, C., Heyland, D., Kozar, R., Lemieux, M., Derenski, K., King, J., Vis-Kampen, C., Knight, R., & Wischmeyer, P. E.
- Affiliations
- University of California San Diego (US)
- University of Colorado Denver (US)
- Queen's University (CA)
- University of Maryland Medical Center (US)
- CoxHealth (US)
- Southlake Regional Health Center (CA)
- Corresponding author
- Wischmeyer, Paul E.
- ORCID
- Venue
- mSphere
- Publisher
- American Society for Microbiology
- Published
- 2016-08-31
- Volume
- 1
- Issue
- 4
- ISSN
- 2379-5042 (ISSN-L)
- PMC
- PMC5007431
- OpenAlex
- W2510962849
- Cited by
- 426
- References
- 30
- Citations by year
- 2026: 31 · 2025: 45 · 2024: 47 · 2023: 45 · 2022: 46 · 2021: 58 · 2020: 48 · 2019: 35 · 2018: 33 · 2017: 30 · 2016: 8
- FWCI
- 18.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mSphere (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- NSF (IGERT 1144807)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
- Keywords
- dysbiosis, critical illness, intensive care unit patients, gut microbiota, nosocomial infections, sepsis, microbiome signatures, probiotics, microbiota restoration, fecal microbiota, oral microbiota, skin microbiome
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