Cited by 426Gut microbiota and healthSepsis Diagnosis and TreatmentNosocomial Infections in ICU

Extreme Dysbiosis of the Microbiome in Critical Illness

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McDonald, Daniel, Ackermann, Gail, Khailova, Ludmila, Baird, Christine, Heyland, Daren, Kozar, Rosemary, Lemieux, Margot, Derenski, Karrie +4 more·2016·mSphere

Abstract

Critical illness may be associated with the loss of normal, “health promoting” bacteria, allowing overgrowth of disease-promoting pathogenic bacteria (dysbiosis), which, in turn, makes patients susceptible to hospital-acquired infections, sepsis, and organ failure. This has significant world health implications, because sepsis is becoming a leading cause of death worldwide, and hospital-acquired infections contribute to significant illness and increased costs. Thus, a trial that monitors the ICU patient microbiome to confirm and characterize this hypothesis is urgently needed. Our study analyzed the microbiomes of 115 critically ill subjects and demonstrated rapid dysbiosis from unexpected environmental sources after ICU admission. These data may provide the first steps toward defining targeted therapies that correct potentially “illness-promoting” dysbiosis with probiotics or with targeted, multimicrobe synthetic “stool pills” that restore a healthy microbiome in the ICU setting to improve patient outcomes.

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Authors
McDonald, D., Ackermann, G., Khailova, L., Baird, C., Heyland, D., Kozar, R., Lemieux, M., Derenski, K., King, J., Vis-Kampen, C., Knight, R., & Wischmeyer, P. E.
Affiliations
  • University of California San Diego (US)
  • University of Colorado Denver (US)
  • Queen's University (CA)
  • University of Maryland Medical Center (US)
  • CoxHealth (US)
  • Southlake Regional Health Center (CA)
Corresponding author
Wischmeyer, Paul E.
Venue
mSphere
Published
2016-08-31
Volume
1
Issue
4
ISSN
2379-5042 (ISSN-L)
OpenAlex
W2510962849
Cited by
426
References
30
Citations by year
2026: 31 · 2025: 45 · 2024: 47 · 2023: 45 · 2022: 46 · 2021: 58 · 2020: 48 · 2019: 35 · 2018: 33 · 2017: 30 · 2016: 8
FWCI
18.26
Type
journal article
Language
en
Open access
Locations
  • mSphere (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders
NSF (IGERT 1144807)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
Keywords
dysbiosis, critical illness, intensive care unit patients, gut microbiota, nosocomial infections, sepsis, microbiome signatures, probiotics, microbiota restoration, fecal microbiota, oral microbiota, skin microbiome

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