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Treatment of Chronic Myelogenous Leukemia by Blocking Cytokine Alterations Found in Normal Stem and Progenitor Cells
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“Recent studies utilizing a mouse model of chronic myeloid leukemia (CML) showed that leukemia in this model is dependent on increased levels of inflammatory cytokine IL-6, and that blocking IL-6/IL6R signaling prevents CML development (Reynaud et al., 2011; Welner et al., 2015).”
From Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis (2018) · cites this paper as Welner et al., 2015
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Raise standards for preclinical cancer research
Begley, C. G., & Ellis, L. M. (2012) · Nature · doi:10.1038/483531a · Cited by 2,979 · cited 12×
“Error bars represent mean ± SD.”
ResultInfluentialThe bone marrow niche for haematopoietic stem cells
Morrison, S. J., & Scadden, D. T. (2014) · Nature · doi:10.1038/nature12984 · Cited by 2,451
Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.048 · Cited by 1,908
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.
Lessard, J., & Sauvageau, G. (2003) · Nature · doi:10.1038/nature01572 · Cited by 1,452
Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia
Raaijmakers, M. H. G. P., Mukherjee, S., Guo, S., Zhang, S., Kobayashi, T., Schoonmaker, J. A., Ebert, B. L., Al-Shahrour, F., Hasserjian, R. P., Scadden, E. O., et al. (2010) · Nature · doi:10.1038/nature08851 · Cited by 1,115
Reynaud, D., Pietras, E., Barry-Holson, K., Mir, A., Binnewies, M., Jeanne, M., Sala-Torra, O., Radich, J. P., & Passegué, E. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.10.012 · Cited by 335
Research works printed but not linked: 47
- Anand, 1998, Abnormal levels of proinflammatory cytokines in serum and monocyte cultures from patients with chronic myeloid leukemia in different stages, and their role in prognosis, Hematol. Oncol., 16, 143, 10.1002/(SICI)1099-1069(199812)16:4<143::AID-HON628>3.0.CO;2-U · DOI
- Ben-Neriah, 1986, The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene, Science, 233, 212, 10.1126/science.3460176 · DOI
- Cappella, 2008, A novel method based on click chemistry, which overcomes limitations of cell cycle analysis by classical determination of BrdU incorporation, allowing multiplex antibody staining, Cytometry A, 73, 626, 10.1002/cyto.a.20582 · DOI
- Cashman, 1998, MCP-1, not MIP-1alpha, is the endogenous chemokine that cooperates with TGF-beta to inhibit the cycling of primitive normal but not leukemic (CML) progenitors in long-term human marrow cultures, Blood, 92, 2338, 10.1182/blood.V92.7.2338 · DOI
- Challen, 2009, Mouse hematopoietic stem cell identification and analysis, Cytometry A, 75, 14, 10.1002/cyto.a.20674 · DOI
- Colmone, 2008, Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells, Science, 322, 1861, 10.1126/science.1164390 · DOI · Paper page
- Dazzi, 1998, The kinetics and extent of engraftment of chronic myelogenous leukemia cells in non-obese diabetic/severe combined immunodeficiency mice reflect the phase of the donor’s disease: an in vivo model of chronic myelogenous leukemia biology, Blood, 92, 1390, 10.1182/blood.V92.4.1390 · DOI
- Eaves, 1993, The biology of normal and neoplastic stem cells in CML, Leuk. Lymphoma, 11, 245, 10.3109/10428199309047894 · DOI
- Eaves, 1993, Unresponsiveness of primitive chronic myeloid leukemia cells to macrophage inflammatory protein 1 alpha, an inhibitor of primitive normal hematopoietic cells, Proc. Natl. Acad. Sci. USA, 90, 12015, 10.1073/pnas.90.24.12015 · DOI
- Fialkow, 1977, Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage, Am. J. Med., 63, 125, 10.1016/0002-9343(77)90124-3 · DOI
- Hartwell, 2013, Niche-based screening identifies small-molecule inhibitors of leukemia stem cells, Nat. Chem. Biol., 9, 840, 10.1038/nchembio.1367 · DOI
- Heidel, 2012, Genetic and pharmacologic inhibition of β-catenin targets imatinib-resistant leukemia stem cells in CML, Cell Stem Cell, 10, 412, 10.1016/j.stem.2012.02.017 · DOI
- Holyoake, 1999, Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia, Blood, 94, 2056, 10.1182/blood.V94.6.2056 · DOI
- Hooberman, 1989, Unexpected heterogeneity of BCR-ABL fusion mRNA detected by polymerase chain reaction in Philadelphia chromosome-positive acute lymphoblastic leukemia, Proc. Natl. Acad. Sci. USA, 86, 4259, 10.1073/pnas.86.11.4259 · DOI
- Hu, 2006, Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice, Proc. Natl. Acad. Sci. USA, 103, 16870, 10.1073/pnas.0606509103 · DOI
- Hu, 2009, Kinetics of normal hematopoietic stem and progenitor cells in a Notch1-induced leukemia model, Blood, 114, 3783, 10.1182/blood-2009-06-227843 · DOI
- Kiel, 2005, SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells, Cell, 121, 1109, 10.1016/j.cell.2005.05.026 · DOI · Paper page
- Kleppe, 2015, JAK-STAT pathway activation in malignant and nonmalignant cells contributes to MPN pathogenesis and therapeutic response, Cancer Discov., 5, 316, 10.1158/2159-8290.CD-14-0736 · DOI
- Koschmieder, 2005, Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis, Blood, 105, 324, 10.1182/blood-2003-12-4369 · DOI · Paper page
- Krause, 2013, Differential regulation of myeloid leukemias by the bone marrow microenvironment, Nat. Med., 19, 1513, 10.1038/nm.3364 · DOI
- Levine, 2008, Myeloproliferative disorders, Blood, 112, 2190, 10.1182/blood-2008-03-077966 · DOI
- Maeda, 2005, IL-6 blocks a discrete early step in lymphopoiesis, Blood, 106, 879, 10.1182/blood-2005-02-0456 · DOI
- Maguer-Satta, 1996, BCR-ABL expression in different subpopulations of functionally characterized Ph+ CD34+ cells from patients with chronic myeloid leukemia, Blood, 88, 1796, 10.1182/blood.V88.5.1796.1796 · DOI
- Mayle, 2013, Flow cytometry analysis of murine hematopoietic stem cells, Cytometry A, 83, 27, 10.1002/cyto.a.22093 · DOI
- Mercier, 2012, The bone marrow at the crossroads of blood and immunity, Nat. Rev. Immunol., 12, 49, 10.1038/nri3132 · DOI
- Mohtashami, 2010, Direct comparison of Dll1- and Dll4-mediated Notch activation levels shows differential lymphomyeloid lineage commitment outcomes, J. Immunol., 185, 867, 10.4049/jimmunol.1000782 · DOI
- Petzer, 1996, Characterization of primitive subpopulations of normal and leukemic cells present in the blood of patients with newly diagnosed as well as established chronic myeloid leukemia, Blood, 88, 2162, 10.1182/blood.V88.6.2162.bloodjournal8862162 · DOI
- Savona, 2008, Getting to the stem of chronic myeloid leukaemia, Nat. Rev. Cancer, 8, 341, 10.1038/nrc2368 · DOI
- Sawyers, 1999, Chronic myeloid leukemia, N. Engl. J. Med., 340, 1330, 10.1056/NEJM199904293401706 · DOI
- Schemionek, 2010, BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells, Blood, 115, 3185, 10.1182/blood-2009-04-215376 · DOI · Paper page
- Schepers, 2013, Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche, Cell Stem Cell, 13, 285, 10.1016/j.stem.2013.06.009 · DOI · Paper page
- Schmidt, 2011, Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia, Cancer Cell, 19, 740, 10.1016/j.ccr.2011.05.007 · DOI
- Spangrude, 1995, Long-term repopulation of irradiated mice with limiting numbers of purified hematopoietic stem cells: in vivo expansion of stem cell phenotype but not function, Blood, 85, 1006, 10.1182/blood.V85.4.1006.bloodjournal8541006 · DOI
- Staber, 2013, Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells, Mol. Cell, 49, 934, 10.1016/j.molcel.2013.01.007 · DOI · Paper page
- Szilvassy, 1990, Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy, Proc. Natl. Acad. Sci. USA, 87, 8736, 10.1073/pnas.87.22.8736 · DOI
- Tanaka, 2011, Anti-interleukin-6 receptor antibody, tocilizumab, for the treatment of autoimmune diseases, FEBS Lett., 585, 3699, 10.1016/j.febslet.2011.03.023 · DOI
- Venezia, 2004, Molecular signatures of proliferation and quiescence in hematopoietic stem cells, PLoS Biol., 2, e301, 10.1371/journal.pbio.0020301 · DOI
- Wang, 1998, High level engraftment of NOD/SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid leukemia in chronic phase, Blood, 91, 2406, 10.1182/blood.V91.7.2406 · DOI
- Wang, 2005, Lymphoid potential of primitive bone marrow progenitors evaluated in vitro, Ann. N Y Acad. Sci., 1044, 210, 10.1196/annals.1349.026 · DOI
- Warr, 2011, Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis and hematological malignancies, Wiley Interdiscip. Rev. Syst. Biol. Med., 3, 681, 10.1002/wsbm.145 · DOI · Paper page
- Welner, 2008, Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection, Blood, 112, 3753, 10.1182/blood-2008-04-151506 · DOI
- Witte, 1988, Closely related BCR/ABL oncogenes are associated with the distinctive clinical biologies of Philadelphia chromosome positive chronic myelogenous and acute lymphocytic leukemia, Curr. Top. Microbiol. Immunol., 141, 42
- Zhang, 1998, Bcr-Abl efficiently induces a myeloproliferative disease and production of excess interleukin-3 and granulocyte-macrophage colony-stimulating factor in mice: a novel model for chronic myelogenous leukemia, Blood, 92, 3829, 10.1182/blood.V92.10.3829.422k14_3829_3840 · DOI
- Zhang, 2010, Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate, Cancer Cell, 17, 427, 10.1016/j.ccr.2010.03.011 · DOI
- Zhang, 2012, Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia, Cancer Cell, 21, 577, 10.1016/j.ccr.2012.02.018 · DOI
- Zhao, 2007, Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo, Cancer Cell, 12, 528, 10.1016/j.ccr.2007.11.003 · DOI
- Zhao, 2014, Conversion of danger signals into cytokine signals by hematopoietic stem and progenitor cells for regulation of stress-induced hematopoiesis, Cell Stem Cell, 14, 445, 10.1016/j.stem.2014.01.007 · DOI · Paper page
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Inflammation: a key regulator of hematopoietic stem cell fate in health and disease
Pietras, E. M. (2017) · Blood · doi:10.1182/blood-2017-06-780882 · Cited by 417
Giustacchini, A., Thongjuea, S., Barkas, N., Woll, P. S., Povinelli, B. J., Booth, C. A. G., Sopp, P., Norfo, R., Rodriguez-Meira, A., Ashley, N., et al. (2017) · Nature Medicine · doi:10.1038/nm.4336 · Cited by 403
Cai, Z., Kotzin, J. J., Ramdas, B., Chen, S., Nelanuthala, S., Palam, L. R., Pandey, R., Mali, R. S., Liu, Y., Kelley, M. R., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.10.013 · Cited by 394
Carey, A., Edwards, D. K., Eide, C. A., Newell, L., Traer, E., Medeiros, B. C., Pollyea, D. A., Deininger, M. W., Collins, R. H., Tyner, J. W., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.018 · Cited by 270
Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors
Henry, C. J., Casás-Selves, M., Kim, J., Zaberezhnyy, V., Aghili, L., Daniel, A. E., Jimenez, L., Azam, T., McNamee, E. N., Clambey, E. T., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci83024 · Cited by 148
Metadata
- Authors
- Welner, R. S., Amabile, G., Bararia, D., Czibere, A., Yang, H., Zhang, H., Pontes, L. L. D. F., Ye, M., Levantini, E., Di Ruscio, A., Martinelli, G., & Tenen, D. G.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 27
- Issue
- 5
- Pages
- 671-681
- ISSN
- 1535-6108
- PMC
- PMC4447336
- Cited by
- 129
- References
- 6
- Language
- en
- Licence
- Funders
- National Medical Research Council
- Ministry of Health -Singapore
- National Research Foundation Singapore
- Ministry of Education - Singapore
- José Carreras Leukämie-Stiftung (1K99CA188595-01, FIJC F11/01)
- National Institutes of Health (CA66996, HL112719)
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