The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Comprehensive Characterization of Molecular Differences in Cancer between Male and Female Patients
Open accessAbstract
Summary An individual’s sex has been long recognized as a key factor affecting cancer incidence, prognosis and treatment responses. However, the molecular basis for sex disparities in cancer remains poorly understood. We performed a comprehensive analysis of molecular differences between male and female patients in 13 cancer types of The Cancer Genome Atlas and revealed two sex-effect groups associated with distinct incidence and mortality profiles. One group contains a small number of sex-affected genes, whereas the other shows much more extensive sex-biased molecular signatures. Importantly, 53% of clinically actionable genes (60/114) show sex-biased signatures. Our study provides a systematic molecular-level understanding of sex effects in diverse cancers and suggests a pressing need to develop sex-specific therapeutic strategies in certain cancer types.
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Self-citationComprehensive molecular profiling of lung adenocarcinoma
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Self-citationmiRNA and mRNA expression analysis reveals potential sex-biased miRNA expression
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Haupt, S., Caramia, F., Herschtal, A., Soussi, T., Lozano, G., Chen, H., Liang, H., Speed, T. P., & Haupt, Y. (2019) · Nature Communications · doi:10.1038/s41467-019-13266-3 · Cited by 94
Self-citationXia, Y., Dai, R., Wang, K., Jiao, C., Zhang, C., Xu, Y., Li, H., Jing, X., Chen, Y., Jiang, Y., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-019-0416-2 · Cited by 80
Self-citationSex and gender differences in cancer pathogenesis and pharmacology
Bernardez, B., Higuera, O., Martinez-Callejo, V., Cardeña-Gutiérrez, A., Marcos Rodríguez, J. A., Santaballa Bertrán, A., Majem, M., & Moreno-Martínez, M.-E. (2025) · Clinical and Translational Oncology · doi:10.1007/s12094-025-03894-1 · Cited by 27
Metadata
- Authors
- Yuan, Y., Liu, L., Chen, H., Wang, Y., Xu, Y., Mao, H., Li, J., Mills, G. B., Shu, Y., Li, L., & Liang, H.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 29
- Issue
- 5
- Pages
- 711-722
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2346113315
- Cited by
- 331
- References
- 8
- FWCI
- 19.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yuan, Y., Liu, L., Chen, H., Wang, Y., Xu, Y., Mao, H., Li, J., Mills, G. B., Shu, Y., Li, L., & Liang, H. (2016). Comprehensive Characterization of Molecular Differences in Cancer between Male and Female Patients. Cancer Cell. https://doi.org/10.1016/j.ccell.2016.04.001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
