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miRNA and mRNA expression analysis reveals potential sex-biased miRNA expression

Guo, Li, Zhang, Qiang, Ma, Xiao, Wang, Jun, Liang, Tingming·2017·Scientific Reports
DOI 10.1038/srep39812PMC PMC5206641
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Abstract

Recent studies suggest that mRNAs may be differentially expressed between males and females. This study aimed to perform expression analysis of mRNA and its main regulatory molecule, microRNA (miRNA), to discuss the potential sex-specific expression patterns using abnormal expression profiles from The Cancer Genome Atlas database. Generally, deregulated miRNAs and mRNAs had consistent expression between males and females, but some miRNAs may be oppositely expressed in specific diseases: up-regulated in one group and down-regulated in another. Studies of miRNA gene families and clusters further confirmed that these sequence or location related miRNAs might have opposing expression between sexes. The specific miRNA might have greater expression divergence across different groups, suggesting flexible expression across different individuals, especially in tumor samples. The typical analysis regardless of the sex will ignore or balance these sex-specific deregulated miRNAs. Compared with flexible miRNAs, their targets of mRNAs showed relative stable expression between males and females. These relevant results provide new insights into miRNA-mRNA interaction and sex difference.

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  • Several groups have observed a sex bias in the levels of miRNA in blood, cancer tissues, and human lymphoblastoid cell lines.

    “Several groups have observed a sex bias in the levels of miRNA in blood, cancer tissues, and human lymphoblastoid cell lines (57, 58).”

    From A mouse tissue atlas of small noncoding RNA (2020) · cites this paper as [57]

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Cited by

Sorted by citations

Authors
Guo, L., Zhang, Q., Ma, X., Wang, J., & Liang, T.
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2017-01-03
Volume
7
Issue
1
ISSN
2045-2322
DOI
10.1038/srep39812
PMC
PMC5206641
Cited by
95
References
0
Language
en
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