The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma
Open accessAbstract
Summary We developed an RNA sequencing-based pipeline to discover differentially expressed cell surface molecules in neuroblastoma that meet criteria for optimal immunotherapeutic target safety and efficacy. Here we show that GPC2 is a strong candidate immunotherapeutic target in this childhood cancer. We demonstrate high GPC2 expression in neuroblastoma due to MYCN transcriptional activation and/or somatic gain of the GPC2 locus. We confirm GPC2 to be highly expressed on most neuroblastomas, but not detectable at appreciable levels in normal childhood tissues. Additionally, we demonstrate that GPC2 is required for neuroblastoma proliferation. Finally, we develop a GPC2 directed antibody-drug conjugate that is potently cytotoxic to GPC2-expressing neuroblastoma cells. Collectively, these findings validate GPC2 as a non-mutated neuroblastoma oncoprotein and candidate immunotherapeutic target.
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RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
Li, B., & Dewey, C. N. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-323 · Cited by 22,179
A draft map of the human proteome
Kim, M.-S., Pinto, S. M., Getnet, D., Nirujogi, R. S., Manda, S. S., Chaerkady, R., Madugundu, A. K., Kelkar, D. S., Isserlin, R., Jain, S., et al. (2014) · Nature · doi:10.1038/nature13302 · Cited by 2,198
Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma
Yu, A. L., Gilman, A. L., Ozkaynak, M. F., London, W. B., Kreissman, S. G., Chen, H. X., Smith, M., Anderson, B., Villablanca, J. G., Matthay, K. K., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0911123 · Cited by 1,835
Self-citationToil enables reproducible, open source, big biomedical data analyses
Vivian, J., Rao, A. A., Nothaft, F. A., Ketchum, C., Armstrong, J., Novak, A., Pfeil, J., Narkizian, J., Deran, A. D., Musselman-Brown, A., et al. (2017) · Nature Biotechnology · doi:10.1038/nbt.3772 · Cited by 1,365
A map of the cis-regulatory sequences in the mouse genome
Shen, Y., Yue, F., McCleary, D. F., Ye, Z., Edsall, L., Kuan, S., Wagner, U., Dixon, J., Lee, L., Lobanenkov, V. V., et al. (2012) · Nature · doi:10.1038/nature11243 · Cited by 1,361 · cited 2×
“Importantly, the similar mouse and human GPC2 expression profile (Figures 1C and S8F) (Shen et al., 2012), coupled with the equal binding of this ADC to mouse and human GPC2 (Figure 7B), suggests murine models provide a valid assessment of the potential for D3-GPC2-PBD on-target, off-tumor toxicities.”
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Metadata
- Authors
- Bosse, K. R., Raman, P., Zhu, Z., Lane, M., Martinez, D., Heitzeneder, S., Rathi, K. S., Kendsersky, N. M., Randall, M., Donovan, L., Morrissy, S., Sussman, R. T., Zhelev, D. V., Feng, Y., Wang, Y., Hwang, J., Lopez, G., Harenza, J. L., Wei, J. S., Pawel, B., Bhatti, T., Santi, M., Ganguly, A., Khan, J., Marra, M. A., Taylor, M. D., Dimitrov, D. S., Mackall, C. L., & Maris, J. M.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 32
- Issue
- 3
- Pages
- 295-309.e12
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2754294524
- Cited by
- 215
- References
- 5
- FWCI
- 13.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Bosse, K. R., Raman, P., Zhu, Z., Lane, M., Martinez, D., Heitzeneder, S., Rathi, K. S., Kendsersky, N. M., Randall, M., Donovan, L., Morrissy, S., Sussman, R. T., Zhelev, D. V., Feng, Y., Wang, Y., Hwang, J., Lopez, G., Harenza, J. L., Wei, J. S., . . . Maris, J. M. (2017). Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma. Cancer Cell. https://doi.org/10.1016/j.ccell.2017.08.003
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