Cytosolic DNA Sensing in Organismal Tumor Control

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

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A Toll-like receptor recognizes bacterial DNA

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Elements of cancer immunity and the cancer–immune set point

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Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1232458 · Cited by 4,996

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Ishikawa, H., & Barber, G. N. (2008) · Nature · doi:10.1038/nature07317 · Cited by 3,576

Immunogenic cell death in cancer and infectious disease

Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L., & Kroemer, G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.107 · Cited by 3,119

Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

Apetoh, L., Ghiringhelli, F., Tesniere, A., Obeid, M., Ortiz, C., Criollo, A., Mignot, G., Maiuri, M. C., Ullrich, E., Saulnier, P., et al. (2007) · Nature Medicine · doi:10.1038/nm1622 · Cited by 3,056

Cellular senescence: from physiology to pathology

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Type I interferons in infectious disease

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Molecular mechanisms of cisplatin resistance

Galluzzi, L., Senovilla, L., Vitale, I., Michels, J., Martins, I., Kepp, O., Castedo, M., & Kroemer, G. (2012) · Oncogene · doi:10.1038/onc.2011.384 · Cited by 2,760

Replication stress response defects are associated with response to immune checkpoint blockade in nonhypermutated cancers

McGrail, D. J., Pilie, P. G., Dai, H., Lam, T., Liang, Y., Voorwerk, L., Kok, M., Zhang, X. H.-F., Rosen, J. M., Heimberger, A. B., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abe6201 · Cited by 36

Enhancing immunotherapy outcomes by targeted remodeling of the tumor microenvironment via combined cGAS-STING pathway strategies

Huang, M., Cha, Z., Liu, R., Lin, M., Gafoor, N. A., Kong, T., Ge, F., & Chen, W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1399926 · Cited by 36

Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway

Baba, T., Yoshida, T., Tanabe, Y., Nishimura, T., Morishita, S., Gotoh, N., Hirao, A., Hanayama, R., & Mukaida, N. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03587-x · Cited by 33

Breast Cancer Predisposition Genes and Synthetic Lethality

Neiger, H. E., Siegler, E. L., & Shi, Y. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115614 · Cited by 33

Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells

Abt, E. R., Le, T. M., Dann, A. M., Capri, J. R., Poddar, S., Lok, V. M., Li, L., Liang, K., Creech, A. L., Rashid, K., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110236 · Cited by 33

Type I interferon signaling in malignant blasts contributes to treatment efficacy in AML patients

Holíček, P., Truxová, I., Raková, J., Šálek, C., Hensler, M., Kovář, M., Reiniš, M., Mikyšková, R., Pasulka, J., Vosahlikova, S., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05728-w · Cited by 31

Targeting the DNA replication stress phenotype of KRAS mutant cancer cells

Zubaidi, T. A., Gehrisch, O. H. F., Genois, M., Liu, Q., Lü, S., Kung, J., Xie, Y., Schuemann, J., Lu, H., Hata, A. N., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-83142-y · Cited by 34

DNASE1L3 arrests tumor angiogenesis by impairing the senescence-associated secretory phenotype in response to stress

Guo, D., Ma, D., Liu, P., Lan, J., Liu, Z., & Liu, Q. (2021) · Aging · doi:10.18632/aging.202740 · Cited by 31

Radiopharmaceuticals as combinatorial partners for immune checkpoint inhibitors

Pouget, J., Chan, T. A.-T., Galluzzi, L., & Constanzo, J. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.07.014 · Cited by 32

Synergistic treatment strategy: combining CAR-NK cell therapy and radiotherapy to combat solid tumors

He, J., Yan, Y., Zhang, J., Wei, Z., Li, H., & Xing, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1298683 · Cited by 31

cGAS‐STING signaling in cancer: Regulation and therapeutic targeting

Fan, X., Song, X., Chen, W., Liang, H., Nakatsukasa, H., & Zhang, D. (2023) · MedComm – Oncology · doi:10.1002/mog2.49 · Cited by 28

Mitochondrial control of innate immune signaling by irradiated cancer cells

Yamazaki, T., & Galluzzi, L. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1797292 · Cited by 31

The role of extracellular DNA (exDNA) in cellular processes

Fernández-Domínguez, I. J., Manzo-Merino, J., Taja‐Chayeb, L., Dueñas‐González, A., Pérez‐Cárdenas, E., & Trejo‐Becerril, C. (2021) · Cancer Biology & Therapy · doi:10.1080/15384047.2021.1890319 · Cited by 28

Crosstalk between cGAS-STING pathway and autophagy in cancer immunity

Lu, Q., Chen, Y., Li, J., Zhu, F., & Zheng, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1139595 · Cited by 28

At the Crossroads of the cGAS-cGAMP-STING Pathway and the DNA Damage Response: Implications for Cancer Progression and Treatment

Korneenko, T. V., Pestov, N. B., Nevzorov, I. A., Daks, A. A., Николаевич, Т. К., Солопова, О. Н., & Barlev, N. A. (2023) · Pharmaceuticals · doi:10.3390/ph16121675 · Cited by 29

CX-5461 Treatment Leads to Cytosolic DNA-Mediated STING Activation in Ovarian Cancer

Cornelison, R., Biswas, K., Llaneza, D. C., Harris, A. R., Sosale, N. G., Lazzara, M. J., & Landen, C. N. (2021) · Cancers · doi:10.3390/cancers13205056 · Cited by 26

Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour Regression

Proctor, M. A., Cruz, J. L. G., Daignault, S. M., Veitch, M., Zeng, B., Ehmann, A., Sabdia, M. B., Snell, C. E., Keane, C., Dolcetti, R., et al. (2021) · Cancers · doi:10.3390/cancers13153733 · Cited by 25

Regulation of Anion Channel LRRC8 Volume-Regulated Anion Channels in Transport of 2′3′-Cyclic GMP–AMP and Cisplatin under Steady State and Inflammation

Chen, X., Wang, L., Cao, L., Li, T., Li, Z., Sun, Y., Ding, J., Zhou, C., Xie, Y., Yue, N., et al. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2000989 · Cited by 24

Immunogenic Cell Death Driven by Radiation—Impact on the Tumor Microenvironment

Yamazaki, T., Vanpouille‐Box, C., Demaria, S., & Galluzzi, L. (2020) · Cancer treatment and research · doi:10.1007/978-3-030-38862-1_10 · Cited by 28

DNA Repair Inhibition Leads to Active Export of Repetitive Sequences to the Cytoplasm Triggering an Inflammatory Response

Song, X., Aw, J. T. M., Ma, F., Cheung, M. F., Leung, D., & Herrup, K. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.0845-21.2021 · Cited by 23

Cellular Discrepancy of Platinum Complexes in Interfering with Mitochondrial DNA

Jin, S., He, Y., Feng, C., Yuan, J., Guo, Y., Guo, Z., & Wang, X. (2025) · ACS Central Science · doi:10.1021/acscentsci.4c01941 · Cited by 23

Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy

Martino, M. D., Tkach, M., Bruni, S., Rocha, D., Mercogliano, M. F., Cenciarini, M. E., Chervo, M. F., Proietti, C. J., Dingli, F., Loew, D., et al. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1715767 · Cited by 23

Mechanistic rationales for combining immunotherapy with radiotherapy

Chi, A., & Nguyen, N. P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1125905 · Cited by 25

Context-dependent impact of type I interferon signaling in cancer

Ruiz-Iglesias, A., Guilbaud, E., Galluzzi, L., & Mañes, S. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02495-4 · Cited by 25

The Killer’s Web: Interconnection between Inflammation, Epigenetics and Nutrition in Cancer

Mecca, M., Picerno, S., & Cortellino, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052750 · Cited by 24

Radiation Induced Upregulation of DNA Sensing Pathways is Cell-Type Dependent and Can Mediate the Off-Target Effects

Jesenko, T., Bošnjak, M., Markelc, B., Serša, G., Žnidar, K., Heller, L. C., & Čemažar, M. (2020) · Cancers · doi:10.3390/cancers12113365 · Cited by 22

Impact of radiation therapy on the immunological tumor microenvironment

Guilbaud, E., Naulin, F., Meziani, L., Deutsch, É., & Galluzzi, L. (2025) · Cell chemical biology · doi:10.1016/j.chembiol.2025.04.001 · Cited by 25

Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy

G�rard, M., Chatelain, C., Delaunay, T., Tostivint, E. P., Bennouna, J., & Fonteneau, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.695770 · Cited by 25

Immunogenic cell death-inducing metal complexes: From the benchtop to the clinic

Sen, S., Karoscik, K., Maier, E. Y., & Arambula, J. F. (2023) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2023.102277 · Cited by 23

Biomaterial-enabled therapeutic modulation of cGAS-STING signaling for enhancing antitumor immunity

Liu, Y., Yang, F., Wang, X., Yang, B., Li, M., & Luo, Z. Y. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.03.026 · Cited by 24

STING-driven interferon signaling triggers metabolic alterations in pancreas cancer cells visualized by [ 18 F]FLT PET imaging

Liang, K., Abt, E. R., Le, T. M., Cho, A. E.-H., Dann, A. M., Cui, J., Li, L., Rashid, K., Creech, A. L., Liu, W., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2105390118 · Cited by 20

Combining radiotherapy and immunotherapy in definitive treatment of head and neck squamous cell carcinoma: review of current clinical trials

Plavc, G., & Strojan, P. (2020) · Radiology and Oncology · doi:10.2478/raon-2020-0060 · Cited by 20

Cyclic Guanosine Monophosphate–Adenosine Monophosphate Synthase (cGAS), a Multifaceted Platform of Intracellular DNA Sensing

Verrier, E. R., & Langevin, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.637399 · Cited by 18

A Link between Replicative Stress, Lamin Proteins, and Inflammation

Willaume, S., Rass, E., Fontanilla-Ramirez, P., Moussa, A., Wanschoor, P., & Bertrand, P. (2021) · Genes · doi:10.3390/genes12040552 · Cited by 28

Stress-induced cellular senescence contributes to chronic inflammation and cancer progression.

KOBASHIGAWA, S., M. SAKAGUCHI, Y., MASUNAGA, S., & MORI, E. (2019) · Thermal Medicine · doi:10.3191/thermalmed.35.41 · Cited by 18

Tissue factor promotes TREX1 protein stability to evade cGAS-STING innate immune response in pancreatic ductal adenocarcinoma

Xue, Y., Wang, Y., Ren, Z., & Yu, K. (2024) · Oncogene · doi:10.1038/s41388-024-03248-1 · Cited by 20

Immunological signatures from irradiated cancer-associated fibroblasts

Berzaghi, R., Gundersen, K., Pedersen, B. D., Utne, A., Yang, N., Hellevik, T., & Martínez-Zubiaurre, I. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1433237 · Cited by 22

Targeting protein kinases benefits cancer immunotherapy

Zhang, Z., Bu, L., Luo, J., & Guo, J. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188738 · Cited by 18

Self-modifying NanoEnhancers facilitating lysosomal escape for cGAS-STING cascading activation in tumor immunotherapy

Ge, Y., Bao, Y., Shao, A., Jin, K., Mao, Z., Tong, W., & Ye, J. (2024) · Nano Today · doi:10.1016/j.nantod.2024.102391 · Cited by 17

Immunotherapies for locally aggressive cancers

Adams, S. C., Nambiar, A., Bressler, E. M., Raut, C. P., Colson, Y. L., Wong, W. W., & Grinstaff, M. W. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115331 · Cited by 15

The microbiota in radiotherapy-induced cancer immunosurveillance

Chen, J., Deutsch, É., Kroemer, G., Galluzzi, L., & Zitvogel, L. (2025) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-025-01052-8 · Cited by 18

Mitotic SENP3 activation couples with cGAS signaling in tumor cells to stimulate anti-tumor immunity

Hu, G., Chen, Y., Yang, X., Wang, Y., He, J., Wang, T., Fan, Q., Deng, L., Tu, J., Tan, H., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05063-6 · Cited by 14

MEK Inhibition Sensitizes Pancreatic Cancer to STING Agonism by Tumor Cell–intrinsic Amplification of Type I IFN Signaling

Ghukasyan, R., Liang, K., Chau, K., Li, L., Chan, C., Abt, E. R., Le, T. M., Park, J. Y., Wu, N., Premji, A., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-3322 · Cited by 14

Micronuclei and Their Association with Infertility, Pregnancy Complications, Developmental Defects, Anaemias, Inflammation, Diabetes, Chronic Kidney Disease, Obesity, Cardiovascular Disease, Neurodegenerative Diseases and Cancer

Bonassi, S., & Fenech, M. F. (2019) · Royal Society of Chemistry eBooks · doi:10.1039/9781788013604-00038 · Cited by 15

Immuno-epigenetic escape of cancer stem cells

Galluzzi, L., & Kroemer, G. (2022) · Nature Immunology · doi:10.1038/s41590-022-01293-0 · Cited by 14

Are charged particles a good match for combination with immunotherapy? Current knowledge and perspectives

Helm, A., Totis, C., Durante, M., & Fournier, C. (2023) · International review of cytology · doi:10.1016/bs.ircmb.2023.01.001 · Cited by 13

Targeting Cancer Stem Cells through Epigenetic Modulation of Interferon Response

Huang, J.-L., Chen, S., & Lin, C. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12040556 · Cited by 13

High mobility group A1 (HMGA1) promotes esophageal squamous cell carcinoma progression by inhibiting STING-mediated anti-tumor immunity

He, K.-Y., Zhao, A., Guo, J.-R., Wu, D., Liu, H., Gao, F., Liu, M., Yang, J.-Y., Lei, X., Li, J.-Q., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60221-6 · Cited by 13

The Impact of Tumor Cell-Intrinsic Expression of Cyclic GMP-AMP Synthase (cGAS)-Stimulator of Interferon Genes (STING) on the Infiltration of CD8+ T Cells and Clinical Outcomes in Mismatch Repair Proficient/Microsatellite Stable Colorectal Cancer

Nakajima, S., Kaneta, A., Okayama, H., Saito, K., Kikuchi, T., Endo, E., Matsumoto, T., Fukai, S., Sakuma, M., Sato, T., et al. (2023) · Cancers · doi:10.3390/cancers15102826 · Cited by 12

Ku70 senses cytosolic DNA and assembles a tumor-suppressive signalosome

Pandey, A., Shen, C. X., Feng, S., Tuipulotu, D. E., Ngo, C., Liu, C., Kurera, M., Mathur, A., Venkataraman, S., Zhang, J., et al. (2024) · Science Advances · doi:10.1126/sciadv.adh3409 · Cited by 12

Detection and quantification of cytosolic DNA

Spada, S., Yamazaki, T., & Vanpouille‐Box, C. (2019) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2019.07.042 · Cited by 13

Identification and in vitro and in vivo validation of the key role of GSDME in pyroptosis-related genes signature in hepatocellular carcinoma

Chen, X., Yang, M., Wang, L., Wang, Y., Tu, J., Zhou, X., & Yuan, X. (2023) · BMC Cancer · doi:10.1186/s12885-023-10850-1 · Cited by 12

A pyrophosphatase-coupled assay to monitor the NTase activity of cGAS

Hooy, R. M., & Sohn, J. (2019) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2019.06.005 · Cited by 10

Activation of RIG-I signaling to increase the pro-inflammatory phenotype of a tumor

Elion, D. L., & Cook, R. S. (2019) · Oncotarget · doi:10.18632/oncotarget.26729 · Cited by 12

Basics of radiobiology

Pouget, J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822960-6.00137-x · Cited by 13

Disulfiram combined with chemoimmunotherapy potentiates pancreatic cancer treatment efficacy through the activation of cGAS-STING signaling pathway via suppressing PARP1 expression.

Huang, S., Xie, P., Huang, X., Chen, Z., Yang, J., Wang, J., Liu, C., Li, H., & Zhou, B. (2023) · PubMed Central · Cited by 11

Pure abscopal effect of radiotherapy in a salivary gland carcinoma: Case report, literature review, and a search for new approaches

Ellerin, B. E., Demandante, C. G. N., & Martins, J. T. (2020) · Cancer/Radiothérapie · doi:10.1016/j.canrad.2020.01.001 · Cited by 10

Discovery of a non‐nucleotide stimulator of interferon genes (STING) agonist with systemic antitumor effect

Wang, X., Zhan, Z., Wang, Z., Zhang, Y., Zhao, K., Han, L., Zhou, X., Guo, Y., Fan, F., Ding, J., et al. (2024) · MedComm · doi:10.1002/mco2.70001 · Cited by 10

Systemic Inactivation of TREX1 Induces Selective Inflammation of the Tumor Microenvironment and Invigorated T-cell–Mediated Tumor Control

Marinković, E., Chen, M., Schubert, N., Dar, E. D., Poth, T., Leung, J. Y., Lohre, J., Sahni, J. M., Tun, C., Rajeswaran, P., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-2262 · Cited by 11

Identification and validation of a seven‐gene prognostic marker in colon cancer based on single‐cell transcriptome analysis

Zhou, Y., Guo, Y., & Wang, Y. (2022) · IET Systems Biology · doi:10.1049/syb2.12041 · Cited by 10

Immunogenic cell death (ICD)-inducers in non-small-cell lung carcinoma (NSCLC): current knowledge and future perspective

Kashefizadeh, A., & Kazemizadeh, H. (2022) · Clinical & Translational Oncology · doi:10.1007/s12094-022-02949-x · Cited by 10

Cancer Cells Thrive on Stress

Galluzzi, L., & Kroemer, G. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.03.005 · Cited by 10

Identification of MICALL2 as a Novel Prognostic Biomarker Correlating with Inflammation and T Cell Exhaustion of Kidney Renal Clear Cell Carcinoma

Lin, W., Chen, W., Zhong, J., Ueki, H., Xu, A., Watanabe, M., Araki, M., Liu, C., Nasu, Y., & Huang, P. (2022) · Journal of Cancer · doi:10.7150/jca.66922 · Cited by 10

DNA-PK–Mediated Cytoplasmic DNA Sensing Stimulates Glycolysis to Promote Lung Squamous Cell Carcinoma Malignancy and Chemoresistance

Wang, H., Zhang, Y., Tian, Y., Yang, W., Wang, Y., Hou, H., Pan, H., Pei, S., Zhu, H., Gu, Z., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-23-0744 · Cited by 9

Adaptive inhibition of CGAS signaling by TREX1

Lira, M. C., Vanpouille‐Box, C., & Galluzzi, L. (2024) · Trends in cancer · doi:10.1016/j.trecan.2024.02.001 · Cited by 9

Molecular mechanisms and therapeutic strategies of cGAS-STING pathway in liver disease: the quest continues

Fan, Y., Dong, Z., Wu, Y., & Wen, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1692365 · Cited by 10

Methods to Detect Immunogenic Cell Death In Vivo

Yamazaki, T., Buqué, A., Rybstein, M. D., Chen, J., Sato, A., & Galluzzi, L. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9773-2_20 · Cited by 9

Chemotherapy With or Without Bevacizumab Should Be the Standard of Care for First-Line Unresectable Epithelioid Mesothelioma

Fennell, D. A., & Dulloo, S. (2021) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2021.08.004 · Cited by 9

Cytosolic DNA composition is determined by genomic instability mechanism and regulates dendritic cell-mediated anti-tumor immunity

Mosley, S. R., Chen, A., Doell, D. N. W., Choi, S., Mowat, C., Meier‐Stephenson, F., Meier‐Stephenson, V., & Baker, K. (2025) · Cell Reports · doi:10.1016/j.celrep.2024.115177 · Cited by 9

Adjuvant COX inhibition augments STING signaling and cytolytic T cell infiltration in irradiated 4T1 tumors

Ridnour, L. A., Cheng, R. Y. S., Kedei, N., Somasundaram, V., Bhattacharyya, D. D., Basudhar, D., Wink, A. L., Walke, A. J., Kim, C., Heinz, W. F., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.165356 · Cited by 11

A novel melanin complex displayed the affinity to HepG2 cell membrane and nucleus

Xin, C., Cheng, C., Hou, K., Bao, M., Zhang, H., & Wang, Z. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.111923 · Cited by 8

Using epigenetic modifiers to target cancer stem cell immunoevasion

Galassi, C., Vitale, I., & Galluzzi, L. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.11.003 · Cited by 8

Development of a risk model to predict prognosis in breast cancer based on cGAS-STING-related genes

Chen, C., Wang, J., Dong, C., LIM, D. J., & Feng, Z. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1121018 · Cited by 8

PARP7 and nucleic acid-driven oncosuppression

Naulin, F., Guilbaud, E., & Galluzzi, L. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01182-6 · Cited by 7

The mitochondrial protease ClpP is a metabolic vulnerability and an immunogenic trigger against multiple myeloma

Perini, T., Zordan, P., Pizzo, R. D., Resnati, M., Viviani, L., Stefanoni, D., Cassina, L., Orfanelli, U., Trudu, M., Oliva, L., et al. (2025) · Blood · doi:10.1182/blood.2024026340 · Cited by 6

Molecular mechanisms of immune cell death in immunosenescence

Verduijn, J., Coutant, K., Fane, M. E., & Galluzzi, L. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01535-2 · Cited by 9

Chromosomal instability drives immunosuppression and metastatic dissemination

Vitale, I., Galassi, C., & Galluzzi, L. (2023) · Cell Research · doi:10.1038/s41422-023-00876-2 · Cited by 6

First-line treatment with KN046, chemotherapy and palliative radiotherapy for advanced esophageal squamous cell carcinoma: an open-label, dose escalation, and dose expansion phase Ib trial

Zhao, Q., Su, X., Xue, J., Liu, Y., Zhu, J., Cai, X., & Qin, S. (2024) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-024-03769-4 · Cited by 8

Harnessing Genomic Stress for Antitumor Immunity

Pu, C., Tao, S., Xu, J., & Huang, M. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8221 · Cited by 6

Poly(I:C), a double stranded RNA analog, activates the anti-viral DNA sensors in buffalo fibroblasts

Chera, J. S., Kumar, S., Bairagi, A. K., Kumar, A., Chandra, P., Vats, A., Ali, M., Roshan, M., Kataria, R. S., & De, S. (2023) · Veterinary Vaccine · doi:10.1016/j.vetvac.2023.100016 · Cited by 6

Molecular subtypes based on DNA sensors predict prognosis and tumor immunophenotype in hepatocellular carcinoma

Lin, H., Pang, W.-P., Yuan, H., Kong, Y., Long, F., Zhang, R., Yang, L., Fang, Q.-L., Pan, A., Fan, X., et al. (2023) · Aging · doi:10.18632/aging.204870 · Cited by 5

EGFR blockade activates interferon

Yoshida, R., & Barbie, D. A. (2020) · Nature Cancer · doi:10.1038/s43018-020-0055-1 · Cited by 6

Preface: Endoplasmic reticulum in health and disease

Kepp, O., & Galluzzi, L. (2020) · International review of cytology · doi:10.1016/s1937-6448(20)30020-4 · Cited by 6

Enhanced B cell electroporation efficiency via inhibition of DNA-induced apoptosis and pyroptosis with pan-caspase inhibitor

Yang, G., Deng-gao, W., Zhao, X., Hao, D., Zhang, Z.-Q., & Liu, D. (2025) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2025.101542 · Cited by 6

MRE11 mobilizes CGAS and drives ZBP1-dependent necroptosis

Beltrán‐Visiedo, M., Balachandran, S., & Galluzzi, L. (2024) · Cell Research · doi:10.1038/s41422-024-00939-y · Cited by 6

Role of N6-methyladenosine methylation in head and neck cancer and its regulation of innate immune pathways

Cao, L., Huang, G., Fan, J., Liu, X., & Ma, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1458884 · Cited by 5

Discovery of Airway-Administered Ionophores for Mn2+ to Mitigate Lung Metastasis by Targeting Disseminated Tumor Cell

Wang, Y., Fan, N., Wang, R., Li, X., Zhao, F., Miao, L., Wang, X., Yan, X., Zhang, Z., Wu, X., et al. (2025) · ACS Nano · doi:10.1021/acsnano.5c01732 · Cited by 5

Nucleic Acid Sensing at the Interface Between Innate and Adaptive Immunity

Vanpouille‐Box, C., & Galluzzi, L. (2019) · International review of cytology · doi:10.1016/s1937-6448(19)30030-9 · Cited by 5

Targeting immune checkpoint therapy: The role of manganese in tumor immunotherapy

Lyu, X., Li, B., & Lin, Z. (2025) · Cancer Pathogenesis and Therapy · doi:10.1016/j.cpt.2025.10.001 · Cited by 4

Repurposing of Commercially Existing Molecular Target Therapies to Boost the Clinical Efficacy of Immune Checkpoint Blockade

Sinha, D., Moseley, P., Lu, X., Wright, Q., Gabrielli, B. G., Frazer, I. H., & Cruz, J. L. G. (2022) · Cancers · doi:10.3390/cancers14246150 · Cited by 4

Dysregulation of BCL-2 family proteins in blood neoplasm: therapeutic relevance of antineoplastic agent venetoclax

Tayeb, F. J. (2024) · Exploration of Medicine · doi:10.37349/emed.2024.00223 · Cited by 5

Innate immunity in tumour immunoediting and immunosurveillance

Zhang, Z., Zhang, Y., & Lieberman, J. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00650-7 · Cited by 4

Cytosolic DNA structures produced by mismatch repair deficiency coordinate anti-tumor immunity in colorectal cancer

Mosley, S. R., Lapa, N., Namdar, A., Catley, T. E., Meier‐Stephenson, F., Mowat, C., Gao, P., Sun, X., Meier‐Stephenson, V., Pyne, A. L. B., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117012 · Cited by 4

PIKfyve Inhibition Induces Antitumor Immunogenicity by Attenuating STING Trafficking and Lysosomal Degradation

He, J., Huang, R., Zong, C., Li, Q., Wang, Y., Zheng, G., Wang, Y., Yang, X., Fang, Y., Fang, F., et al. (2025) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-24-0405 · Cited by 3

Pro-inflammatory RNA:DNA Hybrids Are p53 Independently Boosted by Hyperbaric Oxygen: a Subcellular Distribution Analysis by Automated Quantitative Imaging

Santis, I. D., Zanoni, M., Pignatta, S., Longobardi, P., Tesei, A., & Bevilacqua, A. (2022) · Molecular Imaging and Biology · doi:10.1007/s11307-022-01778-2 · Cited by 3

Quantification of beta-galactosidase activity as a marker of radiation-driven cellular senescence

Klapp, V., Bloy, N., Petroni, G., & Martino, M. D. (2022) · Methods in cell biology · doi:10.1016/bs.mcb.2022.10.001 · Cited by 3

Preface: Life through death—Key role of cellular suicide for colonial and organismal homeostasis

Spetz, J. K. E., & Galluzzi, L. (2020) · International review of cytology · doi:10.1016/s1937-6448(20)30047-2 · Cited by 3

Development of therapeutic cancer vaccines based on cancer immunity cycle

Zhang, J., Zheng, Y., Xu, L., Gao, J., Ou, Z., Zhu, M., & Wang, W. (2025) · Frontiers of Medicine · doi:10.1007/s11684-025-1134-6 · Cited by 2

C/EBPβ deficiency enhances keratinocyte apoptosis after UVB-induced DNA damage via regulation of the type I IFN and TNF responses

Tobin, E. E., Sharma, A., Kros, S. T., Jima, D. D., Gray, S., & Hall, J. R. (2025) · Frontiers in Cell Death · doi:10.3389/fceld.2025.1658598 · Cited by 2

Quantification of cytosolic DNA species by immunofluorescence microscopy and automated image analysis

Sato, A., Bloy, N., Galassi, C., Jiménez‐Cortegana, C., Klapp, V., Aretz, A., Guilbaud, E., Yamazaki, T., Petroni, G., Galluzzi, L., et al. (2022) · Methods in cell biology · doi:10.1016/bs.mcb.2022.05.004 · Cited by 2

Detection and quantification of cytosolic DNA

Spada, S., Yamazaki, T., & Vanpouille‐Box, C. (2019) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2019.07.042 · Cited by 13

Sensing the Breaks: Cytosolic Chromatin in Senescence and Cancer

Micco, R. D. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.10.009 · Cited by 12

Negative Regulation of Cytosolic Sensing of DNA

Abe, T., & Shapira, S. D. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.09.002 · Cited by 29

Cloning and Characterization of Cytosolic DNA in Tumors

Yujia, S., & Stephan, G. (2013) · Frontiers in Immunology · doi:10.3389/conf.fimmu.2013.02.00436

DNA sensing and immune responses in cancer therapy

Qiao, J., Tang, H., & Fu, Y. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2016.12.005 · Cited by 17