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Cytosolic DNA Sensing in Organismal Tumor Control
Open accessAbstract
Besides constituting a first layer of defense against microbial challenges, the detection of cytosolic DNA is fundamental for mammalian organisms to control malignant transformation and tumor progression. The accumulation of DNA in the cytoplasm can initiate the proliferative inactivation (via cellular senescence) or elimination (via regulated cell death) of neoplastic cell precursors. Moreover, cytosolic DNA sensing is intimately connected to the secretion of cytokines that support innate and adaptive antitumor immunity. Here, we discuss the molecular mechanisms whereby cytosolic DNA enables cell-intrinsic and -extrinsic oncosuppression, and their relevance for the development of novel therapeutic approaches that reinstate anticancer immunosurveillance.
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“Both genomic stress and DDR defects favor the cytosolic accumulation of single-stranded DNA (ssDNA) in support of various oncosuppressive processes, including a cancer-celldependent immunostimulatory response driven by cyclic GMPAMP synthase (CGAS) and stimulator of interferon response cGAMP interactor 1 (STING1; best known as STING) (Vanpouille-Box et al., 2018)”
From Immunomodulation by targeted anticancer agents (2021) · cites this paper as Vanpouille-Box et al., 2018
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Self-citationConsensus guidelines for the definition, detection and interpretation of immunogenic cell death
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Metadata
- Authors
- Vanpouille-Box, C., Demaria, S., Formenti, S. C., & Galluzzi, L.
- Affiliations
- Weill Cornell Medicine (US)
- Corresponding author
- Galluzzi, Lorenzo
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 34
- Issue
- 3
- Pages
- 361-378
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2811281203
- Cited by
- 250
- References
- 187
- Citations by year
- 2026: 9 · 2025: 26 · 2024: 30 · 2023: 39 · 2022: 32 · 2021: 36 · 2020: 34 · 2019: 43 · 2018: 1
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Anna-Maria and Stephen Kellen Foundation
- NIH (R01 CA201246, R01 CA198533)
- The Chemotherapy Foundation
- Breast Cancer Research Foundation
- Weill Cornell Medical College
- Phosplatin Therapeutics
- Sotio a.s.
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Keywords
- cytosolic DNA sensing, tumor control, cellular senescence, regulated cell death, antitumor immunity, cytokine production, oncosuppression, tumor surveillance, innate immunity, malignant transformation, tumor progression
- MeSH terms
- Animals, Cell Transformation, Neoplastic, Cytosol, DNA, Humans, Immunologic Surveillance, Neoplasms, Cellular Senescence, Apoptosis
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