A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

Gao, J., Aksoy, B. A., Dogrusoz, U., Dresdner, G., Gross, B., Sumer, S. O., Sun, Y., Jacobsen, A., Sinha, R., Larsson, E., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2004088 · Cited by 15,160

The Molecular Signatures Database Hallmark Gene Set Collection

Liberzon, A., Birger, C., Thorvaldsdóttir, H., Ghandi, M., Mesirov, J. P., & Tamayo, P. (2015) · Cell Systems · doi:10.1016/j.cels.2015.12.004 · Cited by 13,807

The cancer genome atlas pan-cancer analysis project

The Cancer Genome Atlas Research Network, Weinstein, J. N., Collisson, E. A., Mills, G. B., Shaw, K. R. M., Ozenberger, B. A., Ellrott, K., Shmulevich, I., Sander, C., & Stuart, J. M. (2013) · Nature Genetics · doi:10.1038/ng.2764 · Cited by 9,092

Modeling Survival Data: Extending the Cox Model

Therneau, T. M., & Grambsch, P. M. (2000) · Statistics for Biology and Health · doi:10.1007/978-1-4757-3294-8 · Cited by 8,674

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

Barretina, J., Caponigro, G., Stransky, N., Venkatesan, K., Margolin, A. A., Kim, S., Wilson, C. J., Lehár, J., Kryukov, G. V., Sonkin, D., et al. (2012) · Nature · doi:10.1038/nature11003 · Cited by 7,950

Defining a Cancer Dependency Map

Tsherniak, A., Vazquez, F., Montgomery, P. G., Weir, B. A., Kryukov, G., Cowley, G. S., Gill, S., Harrington, W. F., Pantel, S., Krill-Burger, J. M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.06.010 · Cited by 3,276

TEAD mediates YAP-dependent gene induction and growth control

Zhao, B., Ye, X., Yu, J., Li, L., Li, W., Li, S., Yu, J., Lin, J. D., Wang, C.-Y., Chinnaiyan, A. M., et al. (2008) · Genes & Development · doi:10.1101/gad.1664408 · Cited by 2,498

Systematic identification of genomic markers of drug sensitivity in cancer cells

Garnett, M. J., Edelman, E. J., Heidorn, S. J., Greenman, C. D., Dastur, A., Lau, K. W., Greninger, P., Thompson, I. R., Luo, X., Soares, J., et al. (2012) · Nature · doi:10.1038/nature11005 · Cited by 2,456

The Hippo Signaling Pathway in Development and Cancer

Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.09.011 · Cited by 2,317

Uveal melanoma

Jager, M. J., Shields, C. L., Cebulla, C. M., Abdel‐Rahman, M. H., Grossniklaus, H. E., Stern, M., Carvajal, R. D., Belfort, R. N., Jia, R., Shields, J. A., et al. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-0158-0 · Cited by 857

The present and future of the Cancer Dependency Map

Arafeh, R., Shibue, T., Dempster, J. M., Hahn, W. C., & Vazquez, F. (2025) · Nature Reviews Cancer · doi:10.1038/s41568-024-00763-x · Cited by 454

Targeting FAK in anticancer combination therapies

Dawson, J. C., Serrels, A., Stupack, D. G., Schlaepfer, D. D., & Frame, M. C. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00340-6 · Cited by 407

Control of cellular responses to mechanical cues through YAP/TAZ regulation

Dasgupta, I., & McCollum, D. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.007963 · Cited by 360

The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

Cunningham, R., & Hansen, C. G. (2022) · Clinical Science · doi:10.1042/cs20201474 · Cited by 355

Advances in the clinical management of uveal melanoma

Carvajal, R. D., Sacco, J. J., Jager, M. J., Eschelman, D. J., Bagge, R. O., Harbour, J. W., Chieng, N. D., Patel, S. P., Joshua, A. M., & Piperno-Neumann, S. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00714-1 · Cited by 289

YAP/TAZ: Drivers of Tumor Growth, Metastasis, and Resistance to Therapy

Thompson, B. J. (2020) · BioEssays · doi:10.1002/bies.201900162 · Cited by 261

Big data in basic and translational cancer research

Jiang, P., Sinha, S., Aldape, K., Hannenhalli, S., Sahinalp, C., & Ruppin, E. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-022-00502-0 · Cited by 254

YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches

Piccolo, S., Panciera, T., Contessotto, P., & Cordenonsi, M. (2022) · Nature Cancer · doi:10.1038/s43018-022-00473-z · Cited by 264

Illuminating the Onco-GPCRome: Novel G protein–coupled receptor-driven oncocrine networks and targets for cancer immunotherapy

Wu, V. H., Yeerna, H., Nohata, N., Chiou, J., Harismendy, O., Raimondi, F., Inoue, A., Russell, R. B., Tamayo, P., & Gutkind, J. S. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.005601 · Cited by 185

Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular Mechanotransduction

Xie, W., Wei, X., Kang, H., Jiang, H., Chu, Z., Lin, Y., Hou, Y., & Wei, Q. (2023) · Advanced Science · doi:10.1002/advs.202204594 · Cited by 189

Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance

Uchihara, T., Miyake, K., Yonemura, A., Komohara, Y., Itoyama, R., Koiwa, M., Yasuda, T., Arima, K., Harada, K., Eto, K., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-3803 · Cited by 159

Synthetic lethality-mediated precision oncology via the tumor transcriptome

Lee, J. S., Nair, N. U., Dinstag, G., Chapman, L. M., Chung, Y., Wang, K., Sinha, S., Cha, H., Kim, D., Schperberg, A. V., et al. (2021) · Cell · doi:10.1016/j.cell.2021.03.030 · Cited by 158

Molecular profiling of driver events in metastatic uveal melanoma

Karlsson, J. W., Nilsson, L. M., Mitra, S., Alsén, S., Shelke, G. V., Sah, V. R., Forsberg, E. M. V., Stierner, U. K., All‐Eriksson, C., Einarsdottir, B. O., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15606-0 · Cited by 155

G Protein‐Coupled receptors and heterotrimeric G proteins as cancer drivers

Arang, N., & Gutkind, J. S. (2020) · FEBS Letters · doi:10.1002/1873-3468.14017 · Cited by 151

Focal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer

Haderk, F., Chou, Y., Čech, L., Fernández-Méndez, C., Yu, J. X., Olivas, V. R., Meraz, I. M., Rabago, D. B., Kerr, D. L., Gómez, C. F., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47423-0 · Cited by 108

GNAQ and GNA11 Genes: A Comprehensive Review on Oncogenesis, Prognosis and Therapeutic Opportunities in Uveal Melanoma

Silva, P., Fernández‐Díaz, D., Bande, M. F., Pardo, M., Loidi, L., & Blanco‐Teijeiro, M. J. (2022) · Cancers · doi:10.3390/cancers14133066 · Cited by 107

FAK-targeted and combination therapies for the treatment of cancer: an overview of phase I and II clinical trials

Mohanty, A. R., Pharaon, R. R., Nam, A., Salgia, S. K., Kulkarni, P., & Massarelli, E. (2020) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2020.1740680 · Cited by 103

Photo-tunable hydrogels reveal cellular sensing of rapid rigidity changes through the accumulation of mechanical signaling molecules

Yang, J., Wang, P., Zhang, Y., Zhang, M., Sun, Q., Chen, H., Dong, L., Chu, Z., Xue, B., Hoff, W. D., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.09.016 · Cited by 95

Targeted Therapy of Uveal Melanoma: Recent Failures and New Perspectives

Croce, M., Ferrini, S., Pfeffer, U., & Gangemi, R. M. R. (2019) · Cancers · doi:10.3390/cancers11060846 · Cited by 94

Roles and inhibitors of FAK in cancer: current advances and future directions

Hu, H.-H., Wang, S., Shang, H.-L., Lv, H., Chen, B., Gao, S., & Chen, X. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1274209 · Cited by 100

IGF-1/IGF-1R/FAK/YAP Transduction Signaling Prompts Growth Effects in Triple-Negative Breast Cancer (TNBC) Cells

Rigiracciolo, D. C., Nohata, N., Lappano, R., Cirillo, F., Talia, M., Scordamaglia, D., Gutkind, J. S., & Maggiolini, M. (2020) · Cells · doi:10.3390/cells9041010 · Cited by 88

The Hippo Pathway Effectors YAP/TAZ-TEAD Oncoproteins as Emerging Therapeutic Targets in the Tumor Microenvironment

Mokhtari, R. B., Ashayeri, N., Baghaie, L., Sambi, M., Satari, K., Baluch, N., Bosykh, D. A., Szewczuk, M. R., & Chakraborty, S. (2023) · Cancers · doi:10.3390/cancers15133468 · Cited by 92

Transcription factors in fibroblast plasticity and CAF heterogeneity

Melchionna, R., Trono, P., Carlo, A. D., Modugno, F. D., & Nisticò, P. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02934-4 · Cited by 92

Sturge-Weber Syndrome: A Review of Pathophysiology, Genetics, Clinical Features, and Current Management Approache

Sánchez‐Espino, L. F., Ivars, M., Antoñanzas, J., & Baselga, E. (2023) · The Application of Clinical Genetics · doi:10.2147/tacg.s363685 · Cited by 85

Focal Adhesion Kinase (FAK) Inhibition Synergizes with KRAS G12C Inhibitors in Treating Cancer through the Regulation of the FAK–YAP Signaling

Zhang, B., Zhang, Y., Zhang, J., Liu, P., Jiao, B., Wang, Z., & Ren, R. (2021) · Advanced Science · doi:10.1002/advs.202100250 · Cited by 83

Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature

Hooglugt, A., van der Stoel, M. M., Boon, R. A., & Huveneers, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.612802 · Cited by 82

Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ -Driven Uveal Melanoma

Paradis, J. S., Acosta, M., Saddawi‐Konefka, R., Kishore, A., Lubrano, S., Gomes, F., Arang, N., Tiago, M., Coma, S., Wu, X., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-3363 · Cited by 81

Heterotrimeric Gq proteins as therapeutic targets?

Kostenis, E., Pfeil, E. M., & Annala, S. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.007061 · Cited by 78

Gαs–Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant Gαs-PKA Signaling

Ramms, D. J., Raimondi, F., Arang, N., Herberg, F. W., Taylor, S. S., & Gutkind, J. S. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000269 · Cited by 73

FAK, vinculin, and talin control mechanosensitive YAP nuclear localization

Holland, E. N., Fernández, M., Zhou, D. W., O’Neill, E. B., Woodfolk, A. U., Mora‐Boza, A., Fu, J., Schlaepfer, D. D., & García, A. J. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122542 · Cited by 78

Functional characterization of uveal melanoma oncogenes

Ma, J., Weng, L., Bastian, B. C., & Chen, X. (2020) · Oncogene · doi:10.1038/s41388-020-01569-5 · Cited by 70

EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1

Ando, T., Arang, N., Wang, Z., Costea, D. E., Feng, X., Goto, Y., Izumi, H., Gilardi, M., Ando, K., & Gutkind, J. S. (2021) · Communications Biology · doi:10.1038/s42003-021-02744-4 · Cited by 67

So Close, yet so Far: Discrepancies between Uveal and Other Melanomas. A Position Paper from UM Cure 2020

Rodrigues, M. J., de Koning, L., Coupland, S. E., Jochemsen, A. G., Marais, R., Stern, M., Valente, A., Barnhill, R. L., Cassoux, N., Evans, A., et al. (2019) · Cancers · doi:10.3390/cancers11071032 · Cited by 67

Functional and clinical characteristics of focal adhesion kinases in cancer progression

Zhang, Z., Li, J., Jiao, S., Han, G., Zhu, J., & Liu, T. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1040311 · Cited by 66

STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells

Kim, J. W., Berrios, C. J., Kim, M., Schade, A. E., Adelmant, G., Yeerna, H., Damato, E., Iniguez, A. B., Swanson, S. K., Florens, L. A., et al. (2020) · eLife · doi:10.7554/elife.53003 · Cited by 54

Uveal melanoma: progress in molecular biology and therapeutics

Li, Y., Shi, J., Yang, J., Ge, S., Zhang, J., Jia, R., & Fan, X. (2020) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835920965852 · Cited by 55

A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis

Hoj, J. P., Mayro, B., & Pendergast, A. M. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.018 · Cited by 54

VE-Cadherin modulates β-catenin/TCF-4 to enhance Vasculogenic Mimicry

Delgado‐Bellido, D., Zamudio-Martínez, E., Fernández‐Cortés, M., Herrera-Campos, A. B., Olmedo-Pelayo, J., Perez, C. J., Expósito, J., de Álava, E., Amaral, A. T., O’Valle, F., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05666-7 · Cited by 52

MOB (Mps one Binder) Proteins in the Hippo Pathway and Cancer

Gündoğdu, R., & Hergovich, A. (2019) · Cells · doi:10.3390/cells8060569 · Cited by 50

Focal Adhesion Kinase Fine Tunes Multifaced Signals toward Breast Cancer Progression

Rigiracciolo, D. C., Cirillo, F., Talia, M., Muglia, L., Gutkind, J. S., Maggiolini, M., & Lappano, R. (2021) · Cancers · doi:10.3390/cancers13040645 · Cited by 55

Computational methods, databases and tools for synthetic lethality prediction

Wang, J., Zhang, Q., Han, J., Zhao, Y., Zhao, C., Yan, B., Dai, C., Wu, L., Wen, Y., Zhang, Y., et al. (2022) · Briefings in Bioinformatics · doi:10.1093/bib/bbac106 · Cited by 52

Pathogenesis of Port-Wine Stains: Directions for Future Therapies

Liu, L., Li, X., Zhao, Q., Yang, L., & Jiang, X. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012139 · Cited by 51

Hippo‐Yap/Taz signaling: Complex network interactions and impact in epithelial cell behavior

van Soldt, B. J., & Cardoso, W. V. (2019) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.371 · Cited by 50

Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK–YAP signaling axis

Goto, Y., Ando, T., Izumi, H., Feng, X., Arang, N., Gilardi, M., Wang, Z., Ando, K., & Gutkind, J. S. (2020) · Oncogene · doi:10.1038/s41388-020-1272-x · Cited by 47

FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma

Lubrano, S., Cervantes‐Villagrana, R. D., Faraji, F., Ramirez, S. I., Sato, K., Adame-Garcia, S. R., Officer, A., Arang, N., Rigiracciolo, D. C., Quiroz, P. Y. A., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.02.001 · Cited by 51

New Insights on the Nuclear Functions and Targeting of FAK in Cancer

Pomella, S., Cassandri, M., Braghini, M. R., Marampon, F., Alisi, A., & Rota, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23041998 · Cited by 49

GPR39 Overexpression in OSCC Promotes YAP-Sustained Malignant Progression

Jiang, Y., Li, T., Wu, Y., Xu, H., Xie, C., Dong, Y., Zhong, L., Wang, Z., Zhao, H., Zhou, Y., et al. (2020) · Journal of Dental Research · doi:10.1177/0022034520915877 · Cited by 44

Targeting primary and metastatic uveal melanoma with a G protein inhibitor

Onken, M. D., Makepeace, C. M., Kaltenbronn, K. M., Choi, J., Hernandez-Aya, L. F., Weilbaecher, K. N., Piggott, K., Rao, P. K., Yuede, C. M., Dixon, A. J., et al. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100403 · Cited by 44

Harnessing the Co-vulnerabilities of Amino Acid-Restricted Cancers

Pathria, G., & Ronai, Z. A. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.009 · Cited by 41

PARP Inhibition Increases the Response to Chemotherapy in Uveal Melanoma

de Koning, L., Decaudin, D., Botty, R. E., Nicolas, A., Carita, G., Schuller, M., Ouine, B., Cartier, A., Naguez, A., Fleury, J., et al. (2019) · Cancers · doi:10.3390/cancers11060751 · Cited by 44

Focal adhesion kinase (FAK) inhibitor‐defactinib suppresses the malignant progression of human esophageal squamous cell carcinoma (ESCC) cells via effective blockade of PI3K/AKT axis and downstream molecular network

Zhang, L., Zhao, D., Wang, Y., Zhang, W., Zhang, J., Fan, J., Zhan, Q., & Chen, J. (2020) · Molecular Carcinogenesis · doi:10.1002/mc.23273 · Cited by 38

Emerging Therapeutic Opportunities Based on Current Knowledge of Uveal Melanoma Biology

Vivet-Noguer, R., Tarin, M., Roman‐Roman, S., & Alsafadi, S. (2019) · Cancers · doi:10.3390/cancers11071019 · Cited by 43

LACTB suppresses melanoma progression by attenuating PP1A and YAP interaction

Ma, Y., Wang, L., He, F., Yang, J., Ding, Y., Ge, S., Fan, X., Zhou, Y., Xu, X., & Jia, R. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.02.022 · Cited by 39

Context-dependent transcriptional regulations of YAP/TAZ in cancer

Guo, Y., Luo, J., Zou, H., Liu, C., Deng, L., & Li, P. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.12.019 · Cited by 40

Genomic Hippo Pathway Alterations and Persistent YAP/TAZ Activation: New Hallmarks in Head and Neck Cancer

Faraji, F., Ramirez, S. I., Quiroz, P. Y. A., Mendez-Molina, A. N., & Gutkind, J. S. (2022) · Cells · doi:10.3390/cells11081370 · Cited by 41

Overexpression of Mothers Against Decapentaplegic Homolog 7 Activates the Yes‐Associated Protein/NOTCH Cascade and Promotes Liver Carcinogenesis in Mice and Humans

Wang, H., Song, X., Liao, H., Wang, P., Zhang, Y., Che, L., Zhang, J., Zhou, Y., Cigliano, A., Ament, C. E., et al. (2020) · Hepatology · doi:10.1002/hep.31692 · Cited by 38

Long noncoding RNA H19 regulates the therapeutic efficacy of mesenchymal stem cells in rats with severe acute pancreatitis by sponging miR-138-5p and miR-141-3p

Song, G., Zhou, J., Song, R., Liu, D., Yu, W., Xie, W., Ma, Z., Gong, J., Meng, H., Yang, T., et al. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01940-z · Cited by 36

Secondary Somatic Mutations in G-Protein-Related Pathways and Mutation Signatures in Uveal Melanoma

Piaggio, F., Tozzo, V., Bernardi, C., Croce, M., Puzone, R., Viaggi, S., Patrone, S., Barla, A., Coviello, D. A., Jager, M. J., et al. (2019) · Cancers · doi:10.3390/cancers11111688 · Cited by 34

Multi-Functional Regulation by YAP/TAZ Signaling Networks in Tumor Progression and Metastasis

Thrash, H. L., & Pendergast, A. M. (2023) · Cancers · doi:10.3390/cancers15194701 · Cited by 35

G protein‐coupled receptors can control the Hippo/YAP pathway through Gq signaling

Zindel, D., Mensat, P., Vol, C., Homayed, Z., Charrier‐Savournin, F., Trinquet, E., Banères, J., Pin, J., Pannequin, J., Roux, T., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202002159r · Cited by 35

The future of targeted kinase inhibitors in melanoma

Caksa, S., Baqai, U., & Aplin, A. E. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108200 · Cited by 37

FACEts of mechanical regulation in the morphogenesis of craniofacial structures

Du, W. T., Bhojwani, A., & Hu, J. K. (2021) · International Journal of Oral Science · doi:10.1038/s41368-020-00110-4 · Cited by 35

Genetic drivers of non‐cutaneous melanomas: Challenges and opportunities in a heterogeneous landscape

Vergara, I. A., Wilmott, J. S., Long, G. V., & Scolyer, R. A. (2021) · Experimental Dermatology · doi:10.1111/exd.14287 · Cited by 35

MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ

Schrenk, S., Bischoff, L. J., Goines, J., Cai, Y., Vemaraju, S., Odaka, Y., Good, S., Palumbo, J. S., Szabo, S., Reynaud, D., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37516-7 · Cited by 32

Targeting sulfation-dependent mechanoreciprocity between matrix and osteoblasts to mitigate bone loss

Zheng, C., Liu, H., Zhao, P., Lu, W., Song, S., He, T., Fan, J., Wang, D., Yang, P., Jie, Q., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adg3983 · Cited by 30

Transcriptional activators YAP/TAZ and AXL orchestrate dedifferentiation, cell fate, and metastasis in human osteosarcoma

Lamhamedi-Cherradi, S.-E., Mohiuddin, S., Mishra, D. K., Krishnan, S., Velasco, A. R., Vetter, A. M., Pence, K. A., McCall, D. C., Truong, D. D., Cuglievan, B., et al. (2021) · Cancer Gene Therapy · doi:10.1038/s41417-020-00281-6 · Cited by 30

Genetic Landscape and Emerging Therapies in Uveal Melanoma

Seedor, R. S., Orloff, M. M., & Sato, T. (2021) · Cancers · doi:10.3390/cancers13215503 · Cited by 31

YAP and TAZ: Monocorial and bicorial transcriptional co-activators in human cancers

Sardo, F. L., Canu, V., Maugeri‐Saccà, M., Strano, S., & Blandino, G. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188756 · Cited by 30

Update on GNA Alterations in Cancer: Implications for Uveal Melanoma Treatment

Larribère, L., & Utikal, J. S. (2020) · Cancers · doi:10.3390/cancers12061524 · Cited by 31

Recent Advances in Molecular and Genetic Research on Uveal Melanoma

Fuentes-Rodriguez, A., Mitchell, A., Guérin, S. L., & Landreville, S. (2024) · Cells · doi:10.3390/cells13121023 · Cited by 30

Targeted degradation of endogenous YAP by nanobody bioPROTAC inhibits tumor progression

Zhou, R., Wang, H., Zhang, G., Liu, Y., Liu, X., Li, Z., Shi, G., Yuan, J., Qu, C., Li, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-64426-7 · Cited by 28

Preclinical evaluation of drug combinations identifies co-inhibition of Bcl-2/XL/W and MDM2 as a potential therapy in uveal melanoma

Decaudin, D., Frisch-Dit-Leitz, E., Némati, F., Tarin, M., Naguez, A., Zerara, M., Marande, B., Vivet-Noguer, R., Halilovic, E., Fabre, C., et al. (2020) · European Journal of Cancer · doi:10.1016/j.ejca.2019.12.012 · Cited by 28

Dual roles of FAK in tumor angiogenesis: A review focused on pericyte FAK

Zhang, J., Li, W., Wang, W., Chen, Q., Xu, Z., Deng, M., Zhou, L., & He, G. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175694 · Cited by 28

Capillary malformations

Hammill, A. M., & Boscolo, E. (2024) · Journal of Clinical Investigation · doi:10.1172/jci172842 · Cited by 27

Role of Hippo-YAP1/TAZ pathway and its crosstalk in cardiac biology

Chen, X., Yuan, W., Li, Y., Luo, J., & Hou, N. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.47142 · Cited by 28

Targeting Oncogenic Gαq/11 in Uveal Melanoma

Lapadula, D., & Benovic, J. (2021) · Cancers · doi:10.3390/cancers13246195 · Cited by 31

PI3K/Akt/YAP signaling promotes migration and invasion of DLD‑1 colorectal cancer cells

Takeda, T., Yamamoto, Y., Tsubaki, M., Matsuda, T., Kimura, A., Shimo, N., & Nishida, S. (2022) · Oncology Letters · doi:10.3892/ol.2022.13226 · Cited by 29

GNAQ mutations drive port wine birthmark-associated Sturge-Weber syndrome: A review of pathobiology, therapies, and current models

Trigt, W. K. V., Kelly, K. M., & Hughes, C. C. W. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.1006027 · Cited by 29

Integrative Copy Number Analysis of Uveal Melanoma Reveals Novel Candidate Genes Involved in Tumorigenesis Including a Tumor Suppressor Role for PHF10/BAF45a

Anbunathan, H., Verstraten, R., Singh, A. D., Harbour, J. W., & Bowcock, A. M. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-3052 · Cited by 26

YAP Activity is Not Associated with Survival of Uveal Melanoma Patients and Cell Lines

Kim, Y. J., Lee, S. C., Kim, S. E., Kim, S. K., Kim, S. K., & Lee, C. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-63391-z · Cited by 25

High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma

Arang, N., Lubrano, S., Ceribelli, M., Rigiracciolo, D. C., Saddawi‐Konefka, R., Faraji, F., Ramirez, S. I., Kim, D., Tosto, F. A., Stevenson, E. J., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101244 · Cited by 26

MITF deficiency accelerates GNAQ-driven uveal melanoma

Phelps, G. B., Hagen, H. R., Amsterdam, A., & Lees, J. A. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2107006119 · Cited by 23

Nociceptive adenosine A2A receptor on trigeminal nerves orchestrates CGRP release to regulate the progression of oral squamous cell carcinoma

Jiang, L., Zhou, Y., Tang, S., Yang, D., Zhang, Y., Zhang, J., Yang, F., Zhou, T., Xia, X., Chen, Q., et al. (2024) · International Journal of Oral Science · doi:10.1038/s41368-024-00308-w · Cited by 23

Synergic Interactions Between Hepatic Stellate Cells and Uveal Melanoma in Metastatic Growth

Piquet, L., Dewit, L., Schoonjans, N., Millet, M., Bérubé, J., Gerges, P. R. A., Bordeleau, F., & Landreville, S. (2019) · Cancers · doi:10.3390/cancers11081043 · Cited by 24

State-of-the-art in Metastatic Uveal Melanoma Treatment: A 2025 Update

Ziogas, D. C., Foteinou, D., Theocharopoulos, C., Martinos, A., Petsiou, D., Anastasopoulou, A. N., & Gogas, H. J. (2025) · Current Oncology Reports · doi:10.1007/s11912-025-01684-0 · Cited by 22

Development of Combination Strategies for Focal Adhesion Kinase Inhibition in Diffuse Gastric Cancer

Peng, K., Zhang, F., Wang, Y., Sahgal, P., Li, T., Zhou, J. R., Liang, X., Zhang, Y., Sethi, N. S., Liu, T., et al. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-1609 · Cited by 22

New targeted and epigenetic therapeutic strategies for the treatment of uveal melanoma

Wei, A. Z., Maniar, A. B., & Carvajal, R. D. (2022) · Cancer Gene Therapy · doi:10.1038/s41417-022-00443-8 · Cited by 20

Guanine nucleotide exchange factors for Rho GTPases (RhoGEFs) as oncogenic effectors and strategic therapeutic targets in metastatic cancer

Cervantes‐Villagrana, R. D., García‐Jiménez, I., & Vázquez‐Prado, J. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110749 · Cited by 20

Focal adhesion kinase/Src family kinase axis-mediated tyrosine phosphorylation of metabolic enzymes facilitates tumor metastasis

Chen, J., Zhang, J., Zhu, Y., Zhu, Y., Pang, J., Wu, Q., Wang, Y., & Zhan, Q. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02395-5 · Cited by 19

Uveal melanoma–associated mutations in PLCβ4 are constitutively activating and promote melanocyte proliferation and tumorigenesis

Phan, H. T. N., Kim, N. H., Wei, W., Tall, G. G., & Smrcka, A. V. (2021) · Science Signaling · doi:10.1126/scisignal.abj4243 · Cited by 21

Catalytic site mutations confer multiple states of G protein activation

Hewitt, N., Ma, N., Arang, N., Martin, S. A., Prakash, A., DiBerto, J. F., Knight, K. M., Ghosh, S., Olsen, R. H. J., Roth, B. L., et al. (2023) · Science Signaling · doi:10.1126/scisignal.abq7842 · Cited by 18

Uveal melanoma: Recent advances in immunotherapy

Sorrentino, F. S., Rosa, F. D., Terlizzi, P. D., Toneatto, G., Gabai, A., Finocchio, L., Salati, C., Spadea, L., & Zeppieri, M. (2024) · World Journal of Clinical Oncology · doi:10.5306/wjco.v15.i1.23 · Cited by 19

Emerging roles for the YAP/TAZ transcriptional regulators in brain tumour pathology and targeting options

Strepkos, D., Markouli, M., Papavassiliou, K. A., Papavassiliou, A. G., & Piperi, C. (2021) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12762 · Cited by 21

Whole-genome CRISPR screening identifies PI3K/AKT as a downstream component of the oncogenic GNAQ–focal adhesion kinase signaling circuitry

Arang, N., Lubrano, S., Rigiracciolo, D. C., Nachmanson, D., Lippman, S. M., Mali, P., Harismendy, O., & Gutkind, J. S. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102866 · Cited by 20

Circ_UTRN ameliorates caerulein-induced acute pancreatitis in vitro via reducing inflammation and promoting apoptosis through miR-320-3p/PTK2 axis

Sun, Q., Liang, R., Li, M., & Zhou, H. (2021) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgab161 · Cited by 18

Uveal Melanoma: A European Network to Face the Many Challenges of a Rare Cancer

Piperno-Neumann, S., Piulats, J. M., Goebeler, M., Galloway, I., Lugowska, I. A., Becker, J. C., Vihinen, P., Calster, J. V., Hadjistilianou, T., Proença, R. D., et al. (2019) · Cancers · doi:10.3390/cancers11060817 · Cited by 18

G protein-coupled receptors as promising targets in cancer

Almeria, C. V. P., Setiawan, I. M., Siderius, M. H., & Smit, M. J. (2020) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2020.10.005 · Cited by 17

Emerging therapeutic strategies for metastatic uveal melanoma: Targeting driver mutations

Liu, X., Run‐hua, Z., Pan, J., Li, Z., Yu, L., & Li, Y. (2024) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.13161 · Cited by 20

A Review of MicroRNA in Uveal Melanoma

Li, Y. F., Dong, L., Li, Y., & Wei, W. B. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s253946 · Cited by 17

The GNAQ-oncogenic signaling network: Targeting FAK and its synthetic lethal interactome as a precision therapeutic approach against uveal melanoma

Arang, N. (2022) · eScholarship (California Digital Library)

Abstract IA08: Regulation of YAP by tyrosine phosphorylation of core Hippo pathway components: Lessons learned from the GNAQ oncogene and FAK

Gutkind, J. S. (2020) · Molecular Cancer Research · doi:10.1158/1557-3125.hippo19-ia08

Abstract 6406: FAK and MEK co-targeting: A new multimodal precision therapy for GNAQ-driven uveal melanoma

Paradis, J. S., Acosta, M., Arang, N., Saddawi‐Konefka, R., Kishore, A., Sugase, T., Feng, X., Wood, K. C., Coma, S., Terai, M., et al. (2020) · Cancer Research · doi:10.1158/1538-7445.am2020-6406

FAK Is a Critical Mediator of GNAQ-Driven Uveal Melanoma

(2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-rw2019-024

Identifying novel molecular vulnerabilities to PTK2/FAK inhibition in G α q‐driven uveal melanoma using a kinome‐wide CRISPR/Cas9 screen

Kishore, A., Feng, X., Arang, N., Wu, X., Pachter, J. A., Schlaepfer, D. D., Tamayo, P., Cheng, Q., & Gutkind, J. S. (2019) · The FASEB Journal · doi:10.1096/fasebj.2019.33.1_supplement.647.15 · Cited by 1