Gutkind, J. Silvio

G-protein-coupled receptors and signaling networks: emerging paradigms

Marinissen, M. J., & Gutkind, J. S. (2001) · Trends in Pharmacological Sciences

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

Cited by 1,049

The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades

Gutkind, J. S. (1998) · Journal of Biological Chemistry

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

Cited by 812

Augmented Wnt signaling in a mammalian model of accelerated aging

Liu, H., Fergusson, M. M., Castilho, R. M., Liu, J., Cao, L., Chen, J., Malide, D., Rovira, I. I., Schimel, D., Kuo, C. J., et al. (2007) · Science

Wnt/β-catenin signaling in development and cancerTelomeres, Telomerase, and Senescence

Cited by 755

mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging

Castilho, R. M., Squarize, C. H., Chodosh, L. A., Williams, B. O., & Gutkind, J. S. (2009) · Cell stem cell

Hair Growth and DisordersWnt/β-catenin signaling in development and cancer

Cited by 371

Ultrasensitive Electrochemical Immunosensor for Oral Cancer Biomarker IL-6 Using Carbon Nanotube Forest Electrodes and Multilabel Amplification

Malhotra, R., Patel, V., Vaqué, J. P., Gutkind, J. S., & Rusling, J. F. (2010) · Analytical Chemistry

Electrochemical sensors and biosensorsAdvanced biosensing and bioanalysis techniques

Cited by 361

Signaling from E-cadherins to the MAPK Pathway by the Recruitment and Activation of Epidermal Growth Factor Receptors upon Cell-Cell Contact Formation

Pece, S., & Gutkind, J. S. (2000) · Journal of Biological Chemistry

Cell Adhesion Molecules ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 345

mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis

Iglesias-Bartolome, R., Patel, V., Cotrim, A., Leelahavanichkul, K., Molinolo, A. A., Mitchell, J. B., & Gutkind, J. S. (2012) · Cell Stem Cell

Oral health in cancer treatmentTelomeres, Telomerase, and Senescence

Cited by 284

Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative

Molinolo, A. A., Hewitt, S. M., Amornphimoltham, P., Keelawat, S., Rangdaeng, S., Meneses García, A., Raimondi, A. R., Jufe, R., Itoiz, M., Gao, Y., et al. (2007) · Clinical Cancer Research

PI3K/AKT/mTOR signaling in cancerHead and Neck Cancer Studies

Cited by 243

Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck

Amornphimoltham, P., Patel, V., Sodhi, A., Nikitakis, N. G., Sauk, J. J., Sausville, E. A., Molinolo, A. A., & Gutkind, J. S. (2005) · Cancer Research

PI3K/AKT/mTOR signaling in cancerHead and Neck Cancer Studies

Cited by 238

A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK

Feng, X., Arang, N., Rigiracciolo, D. C., Lee, J. S., Yeerna, H., Wang, Z., Lubrano, S., Kishore, A., Pachter, J. A., König, G. M., et al. (2019) · Cancer Cell

Hippo pathway signaling and YAP/TAZOcular Oncology and Treatments

Cited by 237

RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?

Fukuhara, S., Chikumi, H., & Gutkind, J. S. (2001) · Oncogene

Protein Kinase Regulation and GTPase SignalingReceptor Mechanisms and Signaling

Cited by 219

Accelerated wound healing by mTOR activation in genetically defined mouse models

Squarize, C. H., Castilho, R. M., Bugge, T. H., & Gutkind, J. S. (2010) · PLoS ONE

Wound Healing and TreatmentsPI3K/AKT/mTOR signaling in cancer

Cited by 203

Assembly and activation of the Hippo signalome by FAT1 tumor suppressor

Martin, D., Degese, M. S., Vitale-Cross, L., Iglesias-Bartolome, R., Valera, J. L. C., Wang, Z., Feng, X., Yeerna, H., Vadmal, V., Moroishi, T., et al. (2018) · Nature Communications

Hippo pathway signaling and YAP/TAZCancer-related molecular mechanisms research

Cited by 174

Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model

Czerninski, R., Amornphimoltham, P., Patel, V., Molinolo, A. A., & Gutkind, J. S. (2009) · Cancer Prevention Research

PI3K/AKT/mTOR signaling in cancerHead and Neck Cancer Studies

Cited by 140

Mitogen-Activated Protein Kinases Promote WNT/β-Catenin Signaling via Phosphorylation of LRP6

Červenka, I., Wolf, J., Mašek, J., Krejci, P., Wilcox, W. R., Kozubík, A., Schulte, G., Gutkind, J. S., & Bryja, V. (2011) · Molecular and Cellular Biology

Wnt/β-catenin signaling in development and cancerSignaling Pathways in Disease

Cited by 117

Interpretation of cancer mutations using a multiscale map of protein systems

Zheng, F., Kelly, M. R., Ramms, D. J., Heintschel, M. L., Tao, K., Tutuncuoglu, B., Lee, J. J., Ono, K., Foussard, H., Chen, M., et al. (2021) · Science

Bioinformatics and Genomic NetworksCancer Genomics and Diagnostics

Cited by 81

GNASR201C Induces Pancreatic Cystic Neoplasms in Mice That Express Activated KRAS by Inhibiting YAP1 Signaling

Ideno, N., Yamaguchi, H., Ghosh, B., Gupta, S., Okumura, T., Steffen, D. J., Fisher, C. G., Wood, L. D., Singhi, A. D., Nakamura, M., et al. (2018) · Gastroenterology

Pancreatic and Hepatic Oncology ResearchHippo pathway signaling and YAP/TAZ

Cited by 80

Structural and Biochemical Basis for Ubiquitin Ligase Recruitment by Arrestin-related Domain-containing Protein-3 (ARRDC3)

Qi, S., O'Hayre, M., Gutkind, J. S., & Hurley, J. H. (2014) · Journal of Biological Chemistry

Receptor Mechanisms and SignalingUbiquitin and proteasome pathways

Cited by 72

Inhibition of Mammalian target of rapamycin by rapamycin causes the regression of carcinogen-induced skin tumor lesions

Amornphimoltham, P., Leelahavanichkul, K., Molinolo, A., Patel, V., & Gutkind, J. S. (2008) · Clinical Cancer Research

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 63

A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAFV600E colorectal tumors

Ruiz-Saenz, A., Atreya, C. E., Wang, C., Pan, B., Dreyer, C. A., Brunen, D., Prahallad, A., Muñoz, D. P., Ramms, D. J., Burghi, V., et al. (2023) · Nature Cancer

Colorectal Cancer Treatments and StudiesMelanoma and MAPK Pathways

Cited by 39

Insights into epithelial cell senescence from transcriptome and secretome analysis of human oral keratinocytes

Schwartz, R. E., Shokhirev, M. N., Andrade, L. R., Gutkind, J. S., Iglesias-Bartolome, R., & Shadel, G. S. (2021) · Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 23

Structural and dynamic changes in P-Rex1 upon activation by PIP 3 and inhibition by IP 4

Ravala, S. K., Adame-Garcia, S. R., Li, S., Chen, C.-L., Cianfrocco, M. A., Gutkind, J. S., Cash, J. N., & Tesmer, J. J. G. (2023) · bioRxiv (Cold Spring Harbor Laboratory)

Protein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

Cited by 0