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Defining a Cancer Dependency Map

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TEAD mediates YAP-dependent gene induction and growth control

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The Hippo Signaling Pathway in Development and Cancer

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Synthetic lethality across normal tissues is strongly associated with cancer risk, onset, and tumor suppressor specificity

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Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium

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FAK Inhibitor-Based Combinations with MEK or PKC Inhibitors Trigger Synergistic Antitumor Effects in Uveal Melanoma

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Publication trends of research on uveal melanoma during 2000–2020: a 20-year bibliometric study

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MOB: Pivotal Conserved Proteins in Cytokinesis, Cell Architecture and Tissue Homeostasis

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KITlow Cells Mediate Imatinib Resistance in Gastrointestinal Stromal Tumor

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Novel Approaches to the Systemic Management of Uveal Melanoma

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Integrated, Longitudinal Analysis of Cell-free DNA in Uveal Melanoma

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Targeting the Hippo Pathway in Prostate Cancer: What’s New?

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Specific human endogenous retroviruses predict metastatic potential in uveal melanoma

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Synergism of FAK and ROS1 inhibitors in the treatment of CDH1-deficient cancers mediated by FAK-YAP signaling

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Mechanism and application of feedback loops formed by mechanotransduction and histone modifications

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YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer

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Activation of skeletal muscle FAPs by LPA requires the Hippo signaling via the FAK pathway

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Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells

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FAK mediates mechanical signaling to maintain epithelial homeostasis through YAP/TAZ-TEADs

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BACH1 promotes lung adenocarcinoma cell metastasis through transcriptional activation of ITGA2

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Molecular characterization of colorectal adenoma and colorectal cancer via integrated genomic transcriptomic analysis

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Biological characteristics and clinical management of uveal and conjunctival melanoma

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GNAQ/GNA11-Related Benign and Malignant Entities—A Common Histoembriologic Origin or a Tissue-Dependent Coincidence

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C1632 inhibits ovarian cancer cell growth and migration by inhibiting LIN28 B/let-7/FAK signaling pathway and FAK phosphorylation

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The role of signaling pathways mediated by the GPCRs CysLTR1/2 in melanocyte proliferation and senescence

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Diosmin reduces the stability of Snail and Cyclin D1 by targeting FAK to inhibit NSCLC progression

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The Role of Yes‐Associated Protein in Inflammatory Diseases and Cancer

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Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal melanoma

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Materiomechanobiology: bridging material sciences, mechanics and cell biology for advanced therapeutics

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A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC

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Chromosomal 3p loss and 8q gain drive vasculogenic mimicry via HIF-2α and VE-cadherin activation in uveal melanoma

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ILK regulates osteogenic differentiation of Human Periodontal Ligament Stem Cells through YAP‐mediated Mechanical Memory

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ELISL: early–late integrated synthetic lethality prediction in cancer

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Phosphorylation analysis of the Hippo-YAP pathway using Phos-tag

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Regulator of G protein signaling 2 inhibits Gαq-dependent uveal melanoma cell growth

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Multi-Platform Omics Analysis for Identification of Molecular Characteristics and Therapeutic Targets of Uveal Melanoma

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Exploring recent advances in signaling pathways and hallmarks of uveal melanoma: a comprehensive review

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Cytoskeletal Remodelling as an Achilles’ Heel for Therapy Resistance in Melanoma

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Overcoming selection bias in synthetic lethality prediction

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Uveal melanoma modeling in mice and zebrafish

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Notochord segmentation in zebrafish controlled by iterative mechanical signaling

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Kinome profiling identifies MARK3 and STK10 as potential therapeutic targets in uveal melanoma

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Uveal melanoma: laboratory advances and new frontiers in patient care

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Gα12 signaling regulates transcriptional and phenotypic responses that promote glioblastoma tumor invasion

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Synthetic lethality-based prediction of anti-SARS-CoV-2 targets

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Nuclear focal adhesion kinase induces APC/C activator protein CDH1-mediated cyclin-dependent kinase 4/6 degradation and inhibits melanoma proliferation

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Integrating Genetic Alterations and the Hippo Pathway in Head and Neck Squamous Cell Carcinoma for Future Precision Medicine

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Reciprocal positive regulation between BRD4 and YAP in GNAQ-mutant uveal melanoma cells confers sensitivity to BET inhibitors

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Protein Kinase Signaling Networks Driven by Oncogenic Gq/11 in Uveal Melanoma Identified by Phosphoproteomic and Bioinformatic Analyses

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The Molecular Pathology of Eye Tumors: A 2019 Update Main Interests for Routine Clinical Practice

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Uveal Melanoma: Molecular and Genetic Mechanisms of Development and Therapeutic Approaches

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To Explore the Mechanism and Experimental Verification of Brucine Inhibition of Glioblastoma Based on Network Pharmacology

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High-throughput transcriptional profiling combined with angiogenesis antibody array analysis in an orbital venous malformation cohort

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Beta-arrestins operate an on/off control switch for focal adhesion kinase activity

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Targeting focal adhesion kinase: from molecular mechanisms to next-generation cancer therapeutics

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Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation

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Going Rogue: Mechanisms, Regulation, and Roles of Mutationally Activated Gα in Human Cancer

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SLInterpreter: An Exploratory and Iterative Human-AI Collaborative System for GNN-Based Synthetic Lethal Prediction

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An Agrin–YAP/TAZ Rigidity Sensing Module Drives EGFR‐Addicted Lung Tumorigenesis

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Enhanced membrane binding of oncogenic G protein αqQ209L confers resistance to inhibitor YM-254890

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Causes, consequences and clinical significance of aneuploidy across melanoma subtypes

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IGF1R Inhibition Enhances the Therapeutic Effects of Gq/11 Inhibition in Metastatic Uveal Melanoma Progression

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Combined Mcl-1 and YAP1/TAZ inhibition for treatment of metastatic uveal melanoma

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Loss of NF1 Accelerates Uveal and Intradermal Melanoma Tumorigenesis, and Oncogenic GNAQ Transforms Schwann Cells

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Systemic and Liver-Directed Therapies in Metastatic Uveal Melanoma: State-of-the-Art and Novel Perspectives

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Mechanotransduction in fibrosis: Mechanisms and treatment targets

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MITF deficiency and oncogenic GNAQ each promote proliferation programs in zebrafish melanocyte lineage cells

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Disruption of the interaction between mutationally activated Gαq and Gβγ attenuates aberrant signaling

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Merlin–YAP signaling: emerging mechanisms, functions, and therapeutic approaches

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PTK2 promotes uveal melanoma metastasis by activating epithelial‐to‐mesenchymal transition

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Recent advances in the molecular genetic mechanisms and immune microenvironment of uveal melanoma

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Hippo signaling in cancer: regulatory mechanisms and therapeutic strategies

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Phospholysine phosphohistidine inorganic pyrophosphate phosphatase suppresses insulin‐like growth factor 1 receptor expression to inhibit cell adhesion and proliferation in gastric cancer

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GZ17-6.02 kills PDX isolates of uveal melanoma

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New Mechanisms Underlying Oncogenesis in Dbl Family Rho Guanine Nucleotide Exchange Factors

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FAK regulates trophoblast functions of invasion and proliferation through Rap1 pathway in early-onset preeclampsia

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BTSCs exosomes derived NamiRNA-enhancer network of miR-151a-3p mediates a positive feedback loop and promotes the progression of glioma via FAK phosphorylation

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Ephexin3/ARHGEF5 Together with Cell Migration Signaling Partners within the Tumor Microenvironment Define Prognostic Transcriptional Signatures in Multiple Cancer Types

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AMBRA1 and FAK1: crosstalking for improved targeted therapy in melanoma

Leo, L. D., & Zio, D. D. (2021) · Molecular & Cellular Oncology · doi:10.1080/23723556.2021.1949955 · Cited by 3

Enhanced Gαq Signaling in TSC2 -Deficient Cells Is Required for Their Neoplastic Behavior

Trefier, A., Tousson-Abouelazm, N., Yamani, L., Ibrahim, S., Joung, K.-B., Pietrobon, A., Yockell‐Lelièvre, J., Hébert, T. E., Ladak, R. J., Takano, T., et al. (2024) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2024-0111oc · Cited by 3

Transcriptomic Analysis of Metastatic Uveal Melanoma and Differences in Male and Female Patients

Doddi, S., Hamoud, A.-R. A., Eby, H., Zhang, X., Imami, A. S., Shedroff, E., Schiefer, I. T., MORENO-LOPEZ, J., Gamm, D. M., Meller, J., et al. (2024) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20452 · Cited by 2

Focal adhesion kinase inhibition induces membrane accumulation of aquaporin-2 in renal epithelial cells by actin depolymerization and endocytosis inhibition

Tchakal-Mesbahi, A., He, J., Zhu, S., Huang, M., Fukushima, K., Bouley, R., Brown, D., & Lu, H. A. J. (2025) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00091.2025 · Cited by 3

Decoding the mechanical language of the tumor microenvironment: From physical forces to malignant behaviors

Zhao, L., Han, Y., Du, J., & Zhao, X. (2026) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2026.113170 · Cited by 2

Functional genomic screens uncover FERMT2 as a critical regulator of YAP/TAZ-driven tumorigenicity

Chiesa, A., Poli, V., Croci, O., Biagioni, F., Fuentes, P., Marenda, M., Dondi, A., Rodighiero, S., Filipuzzi, M., Sberna, S., et al. (2026) · Cell Death and Differentiation · doi:10.1038/s41418-026-01694-w · Cited by 3

Upregulated LINC00922 Promotes Epithelial-Mesenchymal Transition and Indicates a Dismal Prognosis in Gastric Cancer

Chen, X., Hu, L., Mao, X., Chen, H., She, Y., Chi, H., Zeng, H., Guo, L., & Han, Y. (2022) · Journal of Oncology · doi:10.1155/2022/1608936 · Cited by 2

The guanine nucleotide exchange factor Ric-8A regulates the sensitivity of constitutively active Gαq to the inhibitor YM-254890

Dwyer, M. B., Luo, J., Todd, T. D., Blumer, K., Tall, G. G., & Wedegaertner, P. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108426 · Cited by 2

LHPP Attenuates Lipid Dysfunction of Uveal Melanoma by Relieving the Histidine Phosphorylation of ACO2

Yang, Z. H., Ma, L., Fu, Y., He, X., Luo, Y., Ge, S., Jia, R., Huang, J., & Fan, X. (2025) · Research · doi:10.34133/research.0896 · Cited by 2

Inhibition of anti-apoptotic BCL2 overcomes adaptive resistance to co-targeting of the protein kinase FAK and MEK in GNAQ-driven uveal melanoma

Lubrano, S., Cervantes‐Villagrana, R. D., Arang, N., Officer, A., Adame-Garcia, S. R., Cuesta-Margolles, G., Aplin, A. E., & Gutkind, J. S. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110712 · Cited by 2

Multiplexed Quantitative Screens of Single Cell Shape and YAP/TAZ Localisation Identify DOCK5 as a Coincident Detector of Polarity and Adhesion During MigrationPreprint

Vargas, P. P., Arias-García, M., Roumeliotis, T. I., Choudhary, J. S., & Bakal, C. (2020) · SSRN Electronic Journal · doi:10.1101/2020.07.24.218313 · Cited by 2

Signaling, Physiology, and Targeting of GPCR ‐Regulated Phospholipase C Enzymes

Chandan, N. R., Smrcka, A. V., & Phan, H. T. N. (2022) · doi:10.1002/9781119564782.ch14 · Cited by 2

Unraveling Resistance Mechanisms to Gαq Pathway Inhibition in Uveal Melanoma: Insights from Signaling-Activation Library Screening

Lubrano, S., Cervantes‐Villagrana, R. D., Arang, N., Cardenas-Alcoser, E. S., Sato, K., Cuesta-Margolles, G., Paradis, J. S., Acosta, M., & Gutkind, J. S. (2025) · Cancers · doi:10.3390/cancers18010074 · Cited by 1

Extracellular matrix rigidity controls breast cancer metastasis via TYK2-mediated mechanotransduction

Hu, Z., Majeski, H. E., Mestre‐Farrera, A., Cai, S., Lalezarzadeh, A., Zhang, Y., Arimoto, K., Zhang, D., Piwnica-Worms, H. M., Fattet, L., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-70518-9 · Cited by 1

Canonical and noncanonical heterotrimeric G-protein signaling in uveal melanoma: Established mechanisms and emerging spindle-orientation hypotheses

Woodard, G. E., Jardín, I., & Rosado, J. A. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118108 · Cited by 1

Glucose Metabolism in Immune Regulation: From Mechanisms to Therapeutic Opportunities

Malemnganba, T., Pandey, A. K., Kar, S., & Prajapati, V. K. (2026) · Journal of Cellular Biochemistry · doi:10.1002/jcb.70111 · Cited by 2

Improving therapy in metastatic uveal melanoma by understanding prior failures

Olson, D. J., & Luke, J. J. (2020) · Oncoscience · doi:10.18632/oncoscience.510 · Cited by 1

Oncogenic Gαq activates RhoJ through PDZ-RhoGEF

Cervantes‐Villagrana, R. D., Color-Aparicio, V. M., Castillo‐Kauil, A., García‐Jiménez, I., Beltrán‐Navarro, Y. M., Reyes‐Cruz, G., & Vázquez‐Prado, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115734 · Cited by 1

Intraocular and Orbital Cancers

Lambert-Cheatham, N. A., Jusufbegovic, D., & Corson, T. W. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00024-4 · Cited by 1

Present Status of the Therapeutic Approaches to Treat Uveal Melanoma

Mandal, A., Varghese, M. V., & James, J. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-5422-0_199 · Cited by 1

A luciferase fragment complementation assay to detect focal adhesion kinase (FAK) signaling events

Estep, J. A., Sun, L. O., & Riccomagno, M. M. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e15282 · Cited by 1

Whole exome precision oncology targeting synthetic lethal vulnerabilities across the tumor transcriptomePreprint

Lee, J. S., Nair, N. U., Chapman, L. M., Sinha, S., Wang, K., Cha, H., Rubin, E., Berger, R., Lazar, V., Kurzrock, R., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.16.951699 · Cited by 1

FAK-SFK Signaling Integrates ECM Rigidity Sensing and Engagement of ERBB2 to Activate YAP and Promote Invasive Growth and Metastasis in Breast CancerPreprint

Wang, X., & Wang, S. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.03.502677 · Cited by 1

AACR 2019 — Congrès de l’association américaine de recherche contre le cancer

Pudlarz, T., Naoun, N., Beinse, G., Soares, D. G., & Lotz, J. (2019) · ONCOLOGIE · doi:10.3166/onco-2019-0036

The GNAQ-oncogenic signaling network: Targeting FAK and its synthetic lethal interactome as a precision therapeutic approach against uveal melanoma

Arang, N. (2022) · eScholarship (California Digital Library)

Abstract IA08: Regulation of YAP by tyrosine phosphorylation of core Hippo pathway components: Lessons learned from the GNAQ oncogene and FAK

Gutkind, J. S. (2020) · Molecular Cancer Research · doi:10.1158/1557-3125.hippo19-ia08

Abstract 6406: FAK and MEK co-targeting: A new multimodal precision therapy for GNAQ-driven uveal melanoma

Paradis, J. S., Acosta, M., Arang, N., Saddawi‐Konefka, R., Kishore, A., Sugase, T., Feng, X., Wood, K. C., Coma, S., Terai, M., et al. (2020) · Cancer Research · doi:10.1158/1538-7445.am2020-6406

FAK Is a Critical Mediator of GNAQ-Driven Uveal Melanoma

(2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-rw2019-024

Identifying novel molecular vulnerabilities to PTK2/FAK inhibition in G α q‐driven uveal melanoma using a kinome‐wide CRISPR/Cas9 screen

Kishore, A., Feng, X., Arang, N., Wu, X., Pachter, J. A., Schlaepfer, D. D., Tamayo, P., Cheng, Q., & Gutkind, J. S. (2019) · The FASEB Journal · doi:10.1096/fasebj.2019.33.1_supplement.647.15 · Cited by 1