The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice
Open accessAbstract
SUMMARY Long non-coding RNAs (lncRNAs) are critical for regulating HOX genes, aberration of which is a dominant mechanism for leukemic transformation. How HOX gene-associated lncRNAs regulate hematopoietic stem cell (HSC) function and contribute to leukemogenesis remains elusive. We found that HOTTIP is aberrantly activated in acute myeloid leukemia (AML) to alter HOXA-driven topologically associated domain (TAD) and gene expression. HOTTIP loss attenuates leukemogenesis of transplanted mice, while reactivation of HOTTIP restores leukemic TADs, transcription, and leukemogenesis in the CTCF-boundary-attenuated AML cells. Hottip aberration in mice abnormally promotes HSC self-renewal leading to AML-like disease by altering the homeotic/hematopoietic gene-associated chromatin signature and transcription program. Hottip aberration acts as an oncogenic event to perturb HSC function by reprogramming leukemic-associated chromatin and gene transcription.
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“To exclude any effect of possible regulatory elements presented in the genomic HOTTIP region, we created CRISPR-dCas9-KRAB mediated HOTTIP epigenetic silenced clones using the KRAB repressive domain that recruits H3K9 methyltransferase Suv39H1 (Gilbert et al., 2013) to specifically target the promoter region of HOTTIP…”
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Metadata
- Authors
- Luo, H., Zhu, G., Xu, J., Lai, Q., Yan, B., Guo, Y., Fung, T. K., Zeisig, B. B., Cui, Y., Zha, J., Cogle, C., Wang, F., Xu, B., Yang, F.-C., Li, W., So, C. W. E., Qiu, Y., Xu, M., & Huang, S.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 36
- Issue
- 6
- Pages
- 645-659.e8
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2904407571
- Cited by
- 192
- References
- 14
- FWCI
- 6.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Luo, H., Zhu, G., Xu, J., Lai, Q., Yan, B., Guo, Y., Fung, T. K., Zeisig, B. B., Cui, Y., Zha, J., Cogle, C., Wang, F., Xu, B., Yang, F.-C., Li, W., So, C. W. E., Qiu, Y., Xu, M., & Huang, S. (2019). HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice. Cancer Cell. https://doi.org/10.1016/j.ccell.2019.10.011
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