Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer

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Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

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Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

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Reversed graph embedding resolves complex single-cell trajectories

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The biology and function of fibroblasts in cancer

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Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

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Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

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Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

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Targeting mesothelin-CD24 axis repolarizes tumor-associated macrophages to potentiate PD-1 blockade therapy in high-grade serous ovarian cancer

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Engineered exosomes: a promising approach for overcoming challenges in pancreatic cancer therapy

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MIF confers survival advantage to pancreatic CAFs by suppressing interferon pathway‐induced p53‐dependent apoptosis

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Role of autophagy in cancer-associated fibroblast activation, signaling and metabolic reprograming

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Hippo pathway in cancer cells induces NCAM1+αSMA+ fibroblasts to modulate tumor microenvironment

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INHBA+ macrophages and Pro-inflammatory CAFs are associated with distinctive immunosuppressive tumor microenvironment in submucous Fibrosis-Derived oral squamous cell carcinoma

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Single-cell RNA reveals a tumorigenic microenvironment in the interface zone of human breast tumors

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Tumor-mesothelium HOXA11-PDGF BB/TGF β1-miR-181a-5p-Egr1 feedforward amplifier circuity propels mesothelial fibrosis and peritoneal metastasis of gastric cancer

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Single-cell transcriptomic analysis of human pleura reveals stromal heterogeneity and informs in vitro models of mesothelioma

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PRRX1-OLR1 axis supports CAFs-mediated lung cancer progression and immune suppression

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IGFBP2 Drives Regulatory T Cell Differentiation through STAT3/IDO Signaling Pathway in Pancreatic Cancer

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Nanotechnology-enhanced immunotherapies for pancreatic ductal adenocarcinoma: challenges and opportunities

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Redefining Chemoresistance: Natural Bioactives as Molecular Modulators at the Cancer–Tumor Microenvironment Interface

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Ovarian cancer metastasis to the human omentum disrupts organ homeostasis and induces fundamental tissue reprogramming

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Complement-secreting CAFs are associated with better prognosis in pancreatic cancer: single-cell multiomics

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Myofibroblast programming blocks differentiation of TLS-organizing fibroblastic reticular cells in pancreatic cancer

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Intrinsic features of the cancer cell as drivers of immune checkpoint blockade response and refractoriness

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Tumor Stroma as a Therapeutic Target for Pancreatic Ductal Adenocarcinoma

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Cancer-associated fibroblasts: heterogeneity and their role in the tumor immune response

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HLA ‐ DR –Expressing Fibroblast‐Like Synoviocytes Are Inducible Antigen Presenting Cells That Present Autoantigens in Lyme Arthritis

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Crosstalk between cancer-associated fibroblasts and non-neuroendocrine tumor cells in small cell lung cancer involves in glycolysis and antigen-presenting features

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Mesothelial and immune cells interplay in the tumor microenvironment

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Cell lineage tracing: Methods, applications, and challenges

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NADPH oxidase 1/4 dual inhibition impairs transforming growth factor-beta protumorigenic effects in cholangiocarcinoma cancer-associated fibroblasts

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Manipulating regulatory T cells: is it the key to unlocking effective immunotherapy for pancreatic ductal adenocarcinoma?

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Drug Delivery System Targeting Cancer-Associated Fibroblast for Improving Immunotherapy

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Depletion of tumor-derived CXCL5 improves T cell infiltration and anti-PD-1 therapy response in an obese model of pancreatic cancer

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Cancer-associated fibroblasts: Just on the opposite side of antitumour immunity?

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Targeting Cancer-Associated Fibroblasts in Prostate Cancer: Recent Advances and Therapeutic Opportunities

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Cancer-associated fibroblasts as key regulators of lipid metabolism in the tumour microenvironment

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Novel strategy for oncogenic alteration-induced lipid metabolism reprogramming in pancreatic cancer

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Fundamental insights and molecular interactions in pancreatic cancer: Pathways to therapeutic approaches

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Cancer-Associated Endocrine Cells Participate in Pancreatic Carcinogenesis

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Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy

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Cancer-associated fibroblasts as a potential novel liquid biopsy marker in cancer patients

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Insights into the Mechanisms of Immune‐Checkpoint Inhibitors Gained from Spatiotemporal Dynamics of the Tumor Microenvironment

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Heterocellular crosstalk and architecture of the pancreatic tumour microenvironment

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Heterogeneity and plasticity of cancer-associated fibroblasts

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Forces exerted and transduced by cancer‐associated fibroblasts during cancer progression

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Single-cell transcriptome analysis profiling lymphatic invasion-related TME in colorectal cancer

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Cancer‐associated fibroblast‐derived colony‐stimulating factor 2 confers acquired osimertinib resistance in lung adenocarcinoma via promoting ribosome biosynthesis

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Integrative transcriptome analysis reveals the molecular events underlying impaired T-cell responses in EGFR-mutant lung cancer

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Resveratrol inhibits pancreatic cancer proliferation and metastasis by depleting senescent tumor-associated fibroblasts

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Metabolic and Immunological Implications of MME+CAF-Mediated Hypoxia Signaling in Pancreatic Cancer Progression: Therapeutic Insights and Translational Opportunities

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P-cadherin mechanoactivates tumor-mesothelium metabolic coupling to promote ovarian cancer metastasis

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Nanomaterials in cancer immunotherapy: targeting cancer-associated fibroblasts

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MUC16 and TP53 family co-regulate tumor-stromal heterogeneity in pancreatic adenocarcinoma

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Hepatic Stellate Cells Functional Heterogeneity in Liver Cancer

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A pan-cancer single-cell transcriptional analysis of antigen-presenting cancer-associated fibroblasts in the tumor microenvironment

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Pancreatic ductal adenocarcinoma microenvironment: Soluble factors and cancer associated fibroblasts as modulators of NK cell functions

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Fibroblast Activation Protein-α Expression in Cancer-Associated Fibroblasts Shows the Poor Survival of Colorectal Cancer via Immune-Mediated Pathways

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Depletion of Adipose Stroma-Like Cancer-Associated Fibroblasts Potentiates Pancreatic Cancer Immunotherapy

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Organoids, tissue slices and organotypic cultures: Advancing our understanding of pancreatic ductal adenocarcinoma through in vitro and ex vivo models

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Targeting Mesothelin Enhances Personalized Neoantigen Vaccine Induced Antitumor Immune Response in Orthotopic Pancreatic Cancer Mouse Models

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Aberrant expression of collagen type X in solid tumor stroma is associated with EMT, immunosuppressive and pro-metastatic pathways, bone marrow stromal cell signatures, and poor survival prognosis

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Reciprocal Modulation of Tumour and Immune Cell Motility: Uncovering Dynamic Interplays and Therapeutic Approaches

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Localization and movement of Tregs in gastrointestinal tract: a systematic review

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An Ionic Liquid Ablation Agent for Local Ablation and Immune Activation in Pancreatic Cancer

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Cancer-associated fibroblasts (CAFs) derived from MFAP2 promote CRC proliferation and metastasis while suppressing CD8+ T cell-mediated antitumor immunity

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Decoding the CAF–TAM axis: multi-omics dissection and therapeutic targeting of stromal–immune crosstalk in the tumor microenvironment

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Interplay between MAP kinases and tumor microenvironment: Opportunity for immunotherapy in pancreatic cancer

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Heterogeneity of primary and metastatic CAFs: From differential treatment outcomes to treatment opportunities (Review)

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Cancer-associated fibroblasts mediate resistance to anti-EGFR therapies in cancer

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Panoramic tumor microenvironment in pancreatic ductal adenocarcinoma

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A Comprehensive Exploration of Agents Targeting Tumor Microenvironment: Challenges and Future Perspectives

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The impact of POSTN on tumor cell behavior and the tumor microenvironment in lung adenocarcinoma

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Cancer-associated fibroblasts in breast cancer in the single-cell era: Opportunities and challenges

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Immunochemotherapeutic nanoparticles inhibit cancer-promoting fibroblasts subtypes for pancreatic ductal adenocarcinoma

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What’s in a name? An emerging framework for cancer-associated fibroblasts, myofibroblasts, and fibroblasts

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The Emerging Role of the Single-Cell and Spatial Tumor Microenvironment in High-Grade Serous Ovarian CancerPreprint

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Cellular crosstalk of regulatory T cells in pancreatic ductal adenocarcinoma

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Emerging roles for tumor stroma in antigen presentation and anti-cancer immunity

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MC1R regulates T regulatory cell differentiation through metabolic reprogramming to promote colon cancer

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Unraveling the metastatic niche in breast cancer bone metastasis through single-cell RNA sequencing

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High-resolution subtyping of fibroblasts in gastric cancer reveals diversity among fibroblast subsets and an association between the MFAP5-fibroblast subset and immunotherapy

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The Current State of Tumor Microenvironment-Specific Therapies for Non-Small Cell Lung Cancer

Chandra, R., Ehab, J., Hauptmann, E., Gunturu, N. S., Karalis, J. D., Kent, D. O., Heid, C. A., Reznik, S. I., Sarkaria, I. S., Huang, H., et al. (2025) · Cancers · doi:10.3390/cancers17111732 · Cited by 11

Role of metabolic reprogramming of cancer‑associated fibroblasts in tumor development and progression (Review)

Li, R., & Li, Y. (2025) · International Journal of Oncology · doi:10.3892/ijo.2025.5796 · Cited by 9

Design of nano-delivery systems for pancreatic cancer immunotherapy

Fu, S., Gao, C., Yu, Q., Gong, R., Yang, Z., Zang, X., Shan, S., Mombrú, D., Romero, M., Mombrú, Á. W., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.218098 · Cited by 11

Pancreatic Cancer Organoids: Modeling Disease and Guiding Therapy

Morceau, F., El‐Khoury, V., Lee, K., Berna, M. J., & Kwon, Y. (2025) · Cancers · doi:10.3390/cancers17233850 · Cited by 10

High-fat diet induced ECM remodeling attenuates chemosensitivity in prostate cancer via activating Piezo1-dependent mitochondria-ER contacts

Guan, Y., Cao, F., Luo, Y., Li, J., Wu, P., Zhang, J., Qiu, W., Lai, S., Lei, H., & Pang, J. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.218204 · Cited by 10

Tumor heterogeneity: development, mechanisms, and therapeutic implications

Zhang, J., Li, H., Ru, S., Feng, H., Guo, J., Sun, D., Xiang, T., Xu, D., & Luo, Y. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02749-7 · Cited by 12

Orchestration of mesenchymal plasticity and immune evasiveness via rewiring of the metabolic program in pancreatic ductal adenocarcinoma

Hashimoto, A., Handa, H., Hata, S., & Hashimoto, S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1005566 · Cited by 9

COL11A1‐driven positive feedback loop modulates fibroblast transformation and activates pancreatic cancer progression

Sun, D., Dai, T., Ji, Y., Shen, W., & Bian, W. (2023) · Cell Biology International · doi:10.1002/cbin.12009 · Cited by 9

Cellular collusion: cracking the code of immunosuppression and chemo resistance in PDAC

Musiu, C., Lupo, F., Agostini, A., Lionetto, G., Bevere, M., Paiella, S., Carbone, C., Corbo, V., Ugel, S., & Sanctis, F. D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1341079 · Cited by 9

Distinct fibroblast functions associated with fibrotic and immune-mediated inflammatory diseases and their implications for therapeutic development

M. S. Barron, A., Fabre, T., & De, S. (2024) · F1000Research · doi:10.12688/f1000research.143472.1 · Cited by 8

Gene expression dynamics in fibroblasts during early-stage murine pancreatic carcinogenesis

Ohri, N., Häußler, J., Javakhishvili, N., Vieweg, D., Zourelidis, A. A., Trojanowicz, B., Hämmerle, M., Esposito, I., Glaß, M., Sunami, Y., et al. (2024) · iScience · doi:10.1016/j.isci.2024.111572 · Cited by 8

Distinct response to IL-1β blockade in liver- and lung-specific metastasis mouse models of pancreatic cancer with heterogeneous tumor microenvironments

Chen, S. Y., Kung, H., Espinoza, B., Washington, I., Chen, K., Mu, K., Zlomke, H., Loycano, M., Wang, R., Burns, W. R., et al. (2025) · Experimental Hematology and Oncology · doi:10.1186/s40164-025-00607-w · Cited by 8

How Do Cancer Cells Create Cancer‐Associated Fibroblast Subtypes? Impacts of Extracellular Vesicles on Stromal Diversity

Naito, Y. (2025) · Cancer Science · doi:10.1111/cas.70133 · Cited by 8

Emerging role of cancer-associated fibroblasts in the premetastatic niche

Yang, S., Guo, Y., Jia, J., Cui, W., Zhang, X., Wang, Y., Xie, Z., Fang, Y., Ding, X., Chang, L., et al. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02461-0 · Cited by 8

Stress-adapted cancer-associated fibroblasts as mediators of immunosuppression and therapy resistance

Hu, Y., Ge, J., Xin, M., Guo, R., Wu, C., & Ma, W. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218706 · Cited by 13

Exploration of s new biomarker in osteosarcoma and association with clinical outcomes: TOP2A+cancer associated fibroblasts

Xu, Y., Chen, P., Liu, D., Xu, Q., Meng, H., & Wang, X. (2023) · The Journal of Gene Medicine · doi:10.1002/jgm.3528 · Cited by 8

Association between high expression of intratumoral fibroblast activation protein and survival in patients with intrahepatic cholangiocarcinoma

Waki, Y., Morine, Y., Noma, T., Takasu, C., Teraoku, H., Yamada, S., Saito, Y., Ikemoto, T., & Shimada, M. (2023) · BMC Gastroenterology · doi:10.1186/s12876-023-03012-x · Cited by 8

Heterogeneity and interplay: the multifaceted role of cancer-associated fibroblasts in the tumor and therapeutic strategies

Liu, Q., Yao, F., Wu, L., Xu, T., Na, J., Shen, Z., Liu, X., Shi, W., Zhao, Y., & Liao, Y. (2024) · Clinical & Translational Oncology · doi:10.1007/s12094-024-03492-7 · Cited by 9

The application of single-cell sequencing in pancreatic neoplasm: analysis, diagnosis and treatment

Lv, G., Zhang, L., Gao, L., Cui, J., Liu, Z., Sun, B., Wang, G., & Tang, Q. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-02023-x · Cited by 8

Mouse Models to Evaluate the Functional Role of the Tumor Microenvironment in Cancer Progression and Therapy ResponsesPreprint

McAndrews, K. M., Mahadevan, K. K., & Kalluri, R. (2024) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041411 · Cited by 8

Depicting the cellular complexity of pancreatic adenocarcinoma by Imaging Mass Cytometry: focus on cancer-associated fibroblasts

Erreni, M., Fumagalli, M. R., D’Anna, R., Sollai, M., Bozzarelli, S., Nappo, G., Zanini, D., Parente, R., Garlanda, C., Rimassa, L., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1472433 · Cited by 7

PPY‐Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer

Cao, M., Peng, W., Cheng, B., Wang, R., Chen, W., Liu, L., Huang, H., Chen, S., Cui, H., Liang, J., et al. (2025) · Advanced Science · doi:10.1002/advs.202413432 · Cited by 8

Cancer associated fibroblasts in tumors: focusing on solid tumors and hematological malignancies

Pan, C., Zheng, L., & Wang, J. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1596947 · Cited by 7

Role of exosomal non‑coding RNAs in cancer‑associated fibroblast‑mediated therapy resistance (Review)

Li, J., Huang, Y. Y., Fu, L., Shi, M., Hu, G., Du, F., Wang, Z., Xiao, Y., Zhang, Y., & Li, Y. (2025) · International Journal of Oncology · doi:10.3892/ijo.2025.5774 · Cited by 9

Abstract C078: Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer

Huang, H., Wang, Z., Zhang, Y., Pradhan, R., Ganguly, D., Chandra, R., Murimwa, G. Z., Wright, S., Gu, X., Maddipati, R., et al. (2022) · Cancer Research · doi:10.1158/1538-7445.panca22-c078 · Cited by 2

Antigen-presenting cancer-associated fibroblasts in pancreatic ductal adenocarcinoma differentially regulate Treg phenotype and function via CXCL9 and CCL22 3293

Maru, S. Y., Mitchell, J. T., Wetzel, M., Groß, N., Andaloori, L., Howe, K., Kartalia, E., Mo, G., Leatherman, J. M., Ho, W. J., et al. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf283.1109

Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially control regulatory T cell phenotype and function via CXCL9 and CCL22Preprint

Maru, S. Y., Wetzel, M., Mitchell, J. T., Groß, N., Andaloori, L., Howe, K., Kartalia, E., Mo, G., Leatherman, J. M., Ho, W. J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.27.645833 · Cited by 4

Abstract 2577: Antigen-presenting CAFs in PDAC differentially regulate Treg phenotype and function via CXCL9 and CCL22

Maru, S. Y., Mitchell, J. T., Wetzel, M., Groß, N., Andaloori, L., Howe, K., Kartalia, E., Mo, G., Leatherman, J. M., Ho, W. J., et al. (2025) · Cancer Research · doi:10.1158/1538-7445.am2025-2577

Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially regulate T-cell phenotype and function

Maru, S. Y., Wetzel, M., Mitchell, J. T., Groß, N., Andaloori, L., Howe, K. L., Kartalia, E., Mo, G., Leatherman, J., Ho, W. J., et al. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkag165