Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer

Integrated analysis of multimodal single-cell data

Hao, Y., Hao, S., Andersen-Nissen, E., Mauck, W. M., Zheng, S., Butler, A., Lee, M. J., Wilk, A. J., Darby, C., Zagar, M., et al. (2020) · doi:10.1101/2020.10.12.335331 · Cited by 15,508

Comprehensive Integration of Single-Cell Data

Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W. M., Hao, Y., Stoeckius, M., Smibert, P., & Satija, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.031 · Cited by 15,453

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

Zhou, Y., Zhou, B., Pache, L., Chang, M., Khodabakhshi, A. H., Tanaseichuk, O., Benner, C., & Chanda, S. K. (2019) · Nature Communications · doi:10.1038/s41467-019-09234-6 · Cited by 14,611

Integrating single-cell transcriptomic data across different conditions, technologies, and species

Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

Rahib, L., Smith, B. D., Aizenberg, R., Rosenzweig, A. B., Fleshman, J. M., & Matrisian, L. M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0155 · Cited by 7,094

Reversed graph embedding resolves complex single-cell trajectories

Qiu, X., Mao, Q., Tang, Y., Wang, L., Chawla, R., Pliner, H. A., & Trapnell, C. (2017) · Nature Methods · doi:10.1038/nmeth.4402 · Cited by 5,070

The biology and function of fibroblasts in cancer

Kalluri, R. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.73 · Cited by 4,366

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C.-C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.005 · Cited by 2,681

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

Hingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., Rustgi, A. K., Chang, S., & Tuveson, D. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.023 · Cited by 2,609

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

Öhlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A. S., Ponz-Sarvise, M., Corbo, V., Oni, T. E., Hearn, S. A., Lee, E. J., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162024 · Cited by 2,590

Cancer‑associated fibroblasts in human malignancies, with a particular emphasis on sarcomas (Review)

Benešová, I., Kalkusova, K., Kwon, Y., Táborská, P., Stakheev, D., Krausová, K., Smetanová, J., Ozaniak, A., Bartůňková, J., Smrž, D., et al. (2025) · International Journal of Oncology · doi:10.3892/ijo.2025.5785 · Cited by 3

Wilms Tumor 1–Expressing Stromal Cells Promote Pancreatic Cancer Progression

Bischoff, A. C., Brown, K. L., Lasse-Opsahl, E., Watkoske, H. R., Espinoza, C. E., Okoye, J., Olivei, A., Green, L. M., Rai, R., The, S., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-25-1014

Crosstalk Between Cancer‐Associated Fibroblasts and Immune Cells: Mechanisms and Therapeutic Implications

Li, Y., Di, X., Chen, J., Wei, J., Li, T., Wang, K., Liao, B., & Luo, D. (2025) · MedComm – Oncology · doi:10.1002/mog2.70048 · Cited by 2

Phytonanomedicine: An Assessment of Therapeutic Relevance in Cancer Through Targeting Cancer‐Associated Fibroblast in Tumor Microenvironment

Sahoo, S., Kashyap, A., Muduly, D. K., & Sahoo, S. K. (2026) · Phytotherapy Research · doi:10.1002/ptr.70194 · Cited by 2

Cancer-associated fibroblast heterogeneity and its role in reshaping immunotherapy in solid cancers: potential strategies and clinical promise

Zu, P., & Yu, Z. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1761070 · Cited by 2

Spatial and functional polarization of cancer-associated fibroblasts with CXCR4-mediated immune modulation in hepatocellular carcinoma

Nakamura, D., Nishio, T., Oguma, Y., Taura, K., Koyama, Y., Zhan, M., Kurata, Y., Okura, K., Yoh, T., Nishino, H., et al. (2026) · Hepatology Communications · doi:10.1097/hc9.0000000000000930 · Cited by 2

Cancer-associated fibroblast programs across cancers: Functional axes and double-edged roles in pancreatic ductal adenocarcinoma

Xu, J., Chu, T., Liu, Z., (281351), H. L., Duan, K., Liu, X., Yang, H., Lou, F., Liu, H., Chi, Y., et al. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102275 · Cited by 2

Foxs1-mediated transformation of CD34+ fibroblast to myCAFs promotes tumor growth

Yang, J., Chen, T., Zhang, R., Xu, J., Zhao, X., Yang, M., Chen, Z., Sun, S., Chen, X., Zhang, S., et al. (2026) · EMBO Molecular Medicine · doi:10.1038/s44321-026-00476-8 · Cited by 2

Tumor-induced immune escape mechanisms and translational immunotherapeutic strategies

Yousefi, M., Farahpour, M. R., Alizadeh, N., Abedian, A., & Baradaran, B. (2026) · Discover Oncology · doi:10.1007/s12672-026-05518-8 · Cited by 2

Single-nucleus multimodal spatial transcriptomics reveals spatial colocalization of neoantigen-expressing tumor cells and cognate T cells

Nagler, A., Sud, A., Ghannam, J. Y., Pomerance, L., Robles-Oteíza, C., Afeyan, A. B., Weir, J. A., Russell, A. J. C., Lu, W. S., Orden, M. V., et al. (2026) · Nature Biotechnology · doi:10.1038/s41587-026-03194-1 · Cited by 2

A novel CAF population coordinates hyper-suppressive regulatory T cell recruitment and localization in lung cancer

Ringham, O. R., Rivera, M., Loffredo, L. F., Ozsoy, M. A., Healy, C. M., Cheng, M. F., Jin, Y., Chen, N., Santos, K. D. L., Azizi, E., et al. (2026) · Nature Immunology · doi:10.1038/s41590-026-02607-2 · Cited by 2

Stroma modulation of radiation response in head and neck squamous cell carcinoma: Insights from zebrafish larvae xenografts

Wahbi, W., Awad, S. A., Salo, T. A., & Al‐Samadi, A. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.113911 · Cited by 2

The necessary role of an efficient tumor immunotherapy by MHC II expression on amateur APCs

Zhong, J., Lin, X., & Hu, H. (2024) · Malignancy Spectrum · doi:10.1002/msp2.29 · Cited by 2

Shaping the microenvironment in peritoneal metastases

Ren, Q., & Vermeulen, L. (2025) · Nature Cancer · doi:10.1038/s43018-024-00878-y · Cited by 3

Road Map to Defeat Pancreatic Cancer

Ferguson, L. P., & Tuveson, D. A. (2025) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-060624-044323 · Cited by 2

Current Organoid Culture Systems in Pancreatic Cancer

Liu, L., Sun, J., Chen, S., Tang, X., Zhang, S., Wang, M., Yue, Q., Zhong, C., & Li, L. (2025) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266392238250423115420 · Cited by 2

FSTL3 is a biomarker of poor prognosis and associated with immunotherapy resistance in ovarian cancer

Chauvin, M. Y., Tromelin, E., Roche-Prellezo, J., Lancia, H. H., Meinsohn, M.-C., Coletti, C. M., Nguyen, N. M., Lafont, V., Michaud, H., Mishra, R. K., et al. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03425-4 · Cited by 4

Cancer associated fibroblasts drive epithelial to mesenchymal transition and classical to basal change in pancreatic ductal adenocarcinoma cells with loss of IL-8 expressionPreprint

Guinn, S. R., Perez, B., Tandurella, J. A., Ramani, M., Lee, J. W., Zabransky, D. J., Kartalia, E., Patel, J. G., Zlomke, H., Nicolson, N. G., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.07.631784 · Cited by 2

SpatioEv: Spatial evolution of protein and morphological features reveals development dynamics of cells and spatial neighbourhoodsPreprint

Wu, S., Amin, S., Lee, C., Richard, J.-B., Merali, N., Morrell, C., Overend, L., Gao, W., Tucci, F., Gordon-Weeks, A. N., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.30.662328 · Cited by 2

Cancer-associated fibroblast-derived stanniocalcin 1 promotes cholangiocarcinoma progression and lymph node metastasis

Yan, J., Liu, Q., Xiao, G., Du, J., Yang, C., Liu, C., Lin, S., Bai, Z., Liu, C., Huang, J., et al. (2024) · Fundamental Research · doi:10.1016/j.fmre.2023.11.022 · Cited by 1

Prognosis and immunotherapy significances of a cancer-associated fibroblasts-related gene signature in bladder urothelial carcinoma

Chen, X., Li, Y., Huang, J., Zhang, Q., Tan, C., Liu, Y., & Du, Z. (2024) · Discover Oncology · doi:10.1007/s12672-024-01505-z · Cited by 1

Frequent mesothelial-to-mesenchymal transition in colorectal cancer contributes to an immunosuppressive microenvironment

Watabe, S., Kikuchi, Y., Komura, D., Watanabe, M., Kato, M., & Uozaki, H. (2025) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-025-04153-y · Cited by 1

HLA-DR expressing lymph node fibroblasts maintain FoxP3+ regulatory T cells and are reduced in rheumatoid arthritis

O’Byrne, A. M., Grasso, C., de Winde, C. M., Mikula, A. M., de Graça, C. G., Semmelink, J. F., Remmerswaal, E. B. M., Bolt, J. W., van de Sande, M. G. H., Mebius, R. E., et al. (2025) · Clinical & Experimental Immunology · doi:10.1093/cei/uxaf042 · Cited by 1

Oncolytic herpes simplex virus reprograms cancer-associated fibroblasts to enhance antitumor immunity in pancreatic cancer

Zhou, F., Yang, K., Wang, H., Han, M., Zhang, D., Wang, J., Wang, H., Wang, Y., Gong, F., Zheng, H., et al. (2025) · Molecular Therapy Oncology · doi:10.1016/j.omton.2025.201021 · Cited by 1

Comparative Analysis of Primary and Liver Fibroblasts Reveals MET as a Potent Target in Pancreatic Cancer Metastasis

Singh, R., Yousefian, N., Allen, W. M., Silva, A. D., Anaraki, C., Michels, A. K., Calderon, S. E., Loveless, I. M., Rastelli, D., George, A., et al. (2026) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2026.101872 · Cited by 1

Oligopeptide-loaded metal-organic framework nanocomposites promote regulatory T cell differentiation against periodontitis

Wang, Y., Gong, X., Chen, H., Niu, P., Liu, Z., & Sun, Y. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.170069 · Cited by 1

Mucin 5ac modulates cancer-associated fibroblast heterogeneity through epigenetic reprogramming of precursor cells

Kehrberg, R. J., Bhyravbhatla, N., Alsafwani, Z. W., Li, X., Natarajan, G., Khan, I. K., Brand, R. E., Jain, M., Batra, S. K., & Sushil Kumar, K. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00926.2024 · Cited by 1

Emerging role of the adaptive immunity in aortic aneurysm and dissection

Hu, Y., Wang, M., & Zhang, Z. (2025) · Vascular Pharmacology · doi:10.1016/j.vph.2025.107558 · Cited by 1

Enhanced MHC Class‐II Expression in Fibroblastic Reticular Cells Associates with Maturation

Roet, J. E. G., de Graça, C. G., de Kok, M., Panocha, D., Konijn, T., Roest, H. P., van der Laan, L. J. W., van Baarsen, L. G. M., de Winde, C. M., & Mebius, R. E. (2025) · European Journal of Immunology · doi:10.1002/eji.70086 · Cited by 1

Spatial organization of stromal subtypes stratifies colorectal cancer patients and predicts clinical outcomes

Frank, M., Ghirardello, G., Howie, J. M., Braun, N., Zirnbauer, R., Stecher, C., Gruener, S., Regele, H. M., Barozzi, I., Bergmann, M. M., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.218228 · Cited by 2

PDK4-driven metabolic reprogramming enhances mesothelial cell invasion in colorectal cancer peritoneal metastasis

Han, L., Zhang, Q., Wu, Y., Luo, W., Mo, S., Fang, H., Li, Q., Wang, R., Cai, G., & Dai, W. (2025) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025148 · Cited by 1

ApCAFs: spatial niches and therapeutic insights across cancers

Li, W., Nsubuga, G., & Biffi, G. (2025) · Trends in cancer · doi:10.1016/j.trecan.2025.12.005 · Cited by 1

Exploring the inherent susceptibility of cancer-associated fibroblasts to oncolytic virus infection

Dam, N., Ioannidis, G., Hawinkels, L. J. A. C., & Kemp, V. (2026) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2026.2617274 · Cited by 1

Taming the Tumor Stroma: A Two-Stage Targeted Nanocapsule for Potent Deep Chemo-Immunotherapy in Triple-Negative Breast Cancer

Xing, B., Shen, X., Jia, X., Zhang, Y., Liu, Z., Guo, X., Li, X., & Liu, Z. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18020184 · Cited by 1

Combining Spatial Transcriptomics and Machine Learning Unravels Fibroblast-Related Biomarkers in Ulcerative Colitis

Kang, K., Li, X., Wang, S., Huang, C., & Wu, Z. (2026) · Inflammation · doi:10.1007/s10753-025-02387-1 · Cited by 1

Tumorigenesis and Tumor Microenvironment in Lung Cancer

Dhillon, P., Carroll, M., & Cheng, H. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48030247 · Cited by 2

Mesothelin/Mucin 16 Signaling in Activated Portal Fibroblasts Drives the Development of Cholestatic Fibrosis and Hepatocellular Carcinoma in Aged Female Multidrug Resistance Protein 2 Knockout Mice

Sakane, S., Nishio, T., Fuji, H., Park, S. Y., Ishizuka, K., Miciano, C., Kimura, Y., Hosseini, M., Diggle, K., Zhang, V., et al. (2026) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2026.101785 · Cited by 1

Dynamic responses of cancer-associated fibroblasts to therapy in primary liver cancer

Ruan, Q., Tan, Y. R., Kim, M., Li, D., Bridle, K. R., O’Rourke, T., Crawford, D. H., & Liang, X. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218566 · Cited by 2

Remodeling the pancreatic tumor microenvironment by chemotherapy: New opportunities for combination therapy

Tang, Y., Luo, X., Zhou, F., Gu, J., Li, X. F., Yang, G., Zhang, T. P., & You, L. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189604 · Cited by 1

Spatial Profiling Identified Senescent Cancer-Associated Fibroblasts Localized in the Border Region of Human Pancreatic Ductal Adenocarcinoma

Harada, Y., Masuda, A., Matsuura, T., Nagata, K., Nanno, Y., Masamune, A., Kodama, Y., Hara, E., & Matsumoto, T. (2026) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2026.101808 · Cited by 1

Deciphering the Heterogeneity of Cancer-Associated Fibroblasts in Prostate Cancer: From Stromal Biology to Clinical Translation

Truong, H. T. T., Kwon, W., Woo, H. J., Kim, M. S., Trần, N. Q., & Joung, J. Y. (2026) · Cancers · doi:10.3390/cancers18101600 · Cited by 1

Reprogramming Cancer-associated Fibroblast: the Emerging Role of Traditional Chinese Medicine

Zhang, T., Zhang, Q.-C., Liu, S.-J., Zhou, L.-S., Cheng, H.-B., Sun, D.-D., & Sun, Y. (2026) · Cancer Bioscience · doi:10.1016/j.cbs.2026.100003 · Cited by 1

The role of cancer-associated fibroblasts in various cancer drug resistance

Dang, F., Na, J., Xiao, L., Tian, X., Shao, J., Zhong, L., & Zhao, Y. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218584 · Cited by 1

ASCL2-mediated macrophage-myofibroblast transition generates immunosuppressive CAF_7 in NSCLC bone metastases

Wang, J., Qian, J., Yang, X., Huang, C., Wei, T., Zhou, J., Zhong, G., Zh, Z., & Zhang, Y. (2026) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-026-03735-1 · Cited by 3

Pharmacogenomic characterization of a uric acid metabolism-related signature associated with prognosis and drug sensitivity in gastric cancer

Wu, W., & Wei, Z. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05609-x · Cited by 1

Fibroblasts: a diverse population of cells balancing homeostasis, wound healing, regeneration, inflammation, fibrosis, and cancer across organs

Yang, X., Steffani, M., Nadella, S., Sheppard, D., Rieder, F., Rinkevich, Y., Kramann, R., Tuveson, D. A., & Schwabe, R. F. (2026) · JCI Insight · doi:10.1172/jci.insight.202529 · Cited by 1

Catalytic profiling of extracellular vesicles maps altered cancer metabolism

Chen, Q., Zhang, Y., Natalia, A., Zhou, J., Yu, Z., Ding, X., Ong, C. J., So, J. B. Y., & Shao, H. (2026) · Nature Nanotechnology · doi:10.1038/s41565-026-02230-0 · Cited by 1

Cancer-Associated Fibroblast Heterogeneity and Extracellular Matrix Remodeling as Orchestrators of Drug Resistance in Upper Gastrointestinal Cancers: Insights from Spatial Multi-Omics and Therapeutic Implications

Mirzabeigi, Y., Youssef, J., Gonzalez, J. S., Martinez, T., Avellan, R., Wong, A. G., Perez, M., Carvajal, L. L., Abou-Kheir, W. G., & Bahmad, H. F. (2026) · Cancers · doi:10.3390/cancers18142358 · Cited by 1

Precision targeting of stromal states in pancreatic cancer: a clinical perspective

Wolters, A., Bijlsma, M. F., & Prakash, J. (2026) · Trends in cancer · doi:10.1016/j.trecan.2026.07.003 · Cited by 1

Multi-stromal organoid co-culture modelling reveals epithelial–fibroblast heterogeneity in pancreatic cancer and pancreatitis

Li, W., Jihad, M., Lloyd, E. G., Zaccaria, M., Mucciolo, G., Nsubuga, G., Koonan-Lonappan, A., Henríquez, J. A., Cheng, P. S. W., Harish, S., et al. (2026) · Nature Cell Biology · doi:10.1038/s41556-026-02057-w · Cited by 1

Vitamin D and pancreatic cancer

de Maturana, E. L., Zagorac, S., Malats, N., & Real, F. X. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91338-6.00042-2 · Cited by 1

Pan-cancer analysis identifies EIPR1 as a potential prognostic and immunological biomarker for lung adenocarcinoma and its functional validation

Zheng, X. M., Zhang, X., Yu, J., & Zheng, J. (2025) · Gene · doi:10.1016/j.gene.2025.149439 · Cited by 1

Prognostic Value of TBC1D1 and Its Relationship With the Tumor Microenvironment in Pancreatic Cancer: A Study Based on Single‐Cell Sequencing

Yang, L., Duan, Y., Yu, J. G., Deng, D., Ma, L., Yu, R., Song, W., Yu, J., Lan, C., & Yi, P. (2025) · FASEB BioAdvances · doi:10.1096/fba.2025-00092 · Cited by 1

Bibliometric analysis of global research trends in pancreatic cancer immunotherapy

Fu, T., Chen, Y., Wang, H., He, L., Zhang, J., Zhou, Y., Duan, X., & Zhang, X. (2025) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2025.2538330 · Cited by 1

Editorial: Molecular biomarkers and imaging markers in the prediction, diagnosis, and prognosis of bladder cancer

Luo, Y., Deng, F., Zhang, Y., & Xiao, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1014565 · Cited by 1

Lung CAFs Show T Cells the Velvet Rope

Sherman, M. H. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0944 · Cited by 1

Single-cell transcriptomic analysis of human pleura reveals stromal heterogeneity and informs in vitro models of mesotheliomaPreprint

Obacz, J., Nibhani, R., Adams, T. S., Schupp, J. C., Valer, J. A., Veale, N., Aresu, G., Coonar, A. S., Peryt, A., Biffi, G., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.03.518966 · Cited by 1

An Immunological Synapse Formation Between T Regulatory Cells and Cancer-Associated Fibroblasts Promotes Tumor DevelopmentPreprint

Varveri, A., Papadopoulou, M., Papadovasilakis, Z., Compeer, E. B., Legaki, A., Delis, A. D., Damaskou, V., Boon, L., Papadogiorgaki, S., Samiotaki, M. K., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.22.572969 · Cited by 1

Single-cell and spatial atlas of steatotic liver disease-related hepatocellular carcinomaPreprint

Prawira, A., Xu, H., Leow, W. Q., Otsuka, M., Chen, Z., Rahbari, M., Hazirah, S. N., Wasser, M., Chung, A. Y. F., Goh, B. K. P., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.09.593073 · Cited by 1

Coordinated changes in thymic stromal and hematopoietic cells that define the perinatal to juvenile transitionPreprint

Vasudev, A., Moore, C. R., Calindi, A., Kang, S., Helm, B. R., Srinivasan, J., Shah, S., Zong, R., Singarapu, N., Casey, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.04.641047 · Cited by 1

ecDNA-driven oncogene super-expressors shape immunoevasive tumor microenvironmentPreprint

Qiao, K., Yang, Q., Li, T., Chen, X., Yazgan, Z., Kim, Y. J., Gilbreath, C., Lim, J. Y. S., Xie, Y., Sun, X., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.15.688565 · Cited by 1

ProAgio, a Novel Integrin αvβ3 Targeted Cytotoxin, Suppresses Tumor Growth and Reprograms the PDAC MicroenvironmentPreprint

Bandi, D. S. R., Sarvesh, S., Nagaraju, G. P., Kim, H., Foote, J. B., Bae, S., Yoon, K. J., Malla, M., Masood, A., Akce, M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.15.699725 · Cited by 1

Tracing back to one of the origins of immune evasion in pancreatic cancer

Henríquez, J. A., & Biffi, G. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.05.002

Immunotherapy in Pancreatic Cancer

Yeung, Z. P., & Kundranda, M. N. (2023) · Springer eBooks · doi:10.1007/978-3-031-38623-7_6

Cancer-associated fibroblasts induced by colorectal cancer cells inhibit γδT cells killing function through the ERK/COX-2/PGE2 pathwaysPreprint

Xi, X., Chen, Y., Deng, T., Zhu, J., Zhao, Y., Liu, S., Qiu, K., Ke, Y., Li, G., Zhu, Y., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-3874261/v1

Unravelling the Metastatic Niche in Breast Cancer Patients with Bone Metastasis through Single-cell RNA SequencingPreprint

Li, X., Gao, Z., Yang, M., Yang, C., Yang, D., Cui, W., Wu, D., & Zhou, J. (2024) · Research Square · doi:10.21203/rs.3.rs-3952364/v1

Components of the microenvironment of soft tissue sarcomas. Part I

Lokhonina, А. V., Jumaniyazova, E. D., Dzhalilova, D. S., Kosyreva, A. M., Казарян, Г. Г., & Fatkhudinov, T. (2024) · Bone and soft tissue sarcomas tumors of the skin · doi:10.17650/2219-4614-2024-16-1-25-33

Comparison of Different Approaches to Single Cell RNA Sequencing of Cancer Associated FibroblastsPreprint

Kung, H., Loycano, M., Zheng, L., Chen, S. Y., & Zimmerman, J. W. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.29.591011

MRPL27 as a new prognostic biomarker involved in immune cell infiltration and hepatocellular carcinoma progressionPreprint

Yang, J., Lin, Q., Liu, X., Chen, K., Chen, X., Han, J., & Liao, Z. (2024) · Research Square · doi:10.21203/rs.3.rs-4335610/v1

In silico analysis and validation of the cancer-associated fibroblasts-related gene CAMK4 promotes bladder cancer progression

Su, X., Guo, Y., & Li, Y. (2026) · Scientific Reports · doi:10.1038/s41598-026-60370-8

Single cell and spatial analysis of immune-hot and immune-cold tumours identifies fibroblast subtypes associated with distinct immunological niches and positive immunotherapy responsePreprint

Jenkins, B. H., Tracy, I., Rodrigues, M. F. S., Smith, M. J., Martinez, B. R., Edmond, M., Mahadevan, S. K., Rao, A. S., Zong, H., Liu, K., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-5125055/v1

The Bladder Tumor Microenvironment

Gao, H., Nikolos, F., Satkunasivam, R., & Chan, K. S. (2024) · Springer eBooks · doi:10.1007/978-3-031-68505-7_12

Antigen Presentation by Graft Myofibroblasts Leads to Murine Heart Transplantation Rejection through the Autophagy Signaling PathwayPreprint

Gong, W., Wu, Z., Luo, B., Kong, D., Miao, X., Liu, H., Xie, W., Hu, C., He, J., Cao, D., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-5850890/v1

TWIST1 mediated transcriptional activation of SPON2 drives colorectal peritoneal metastasis through activation of cancer-associated fibroblast signaling networkPreprint

Zhou, Z., Ferlita, A. L., Palavalli, M. H., Chen, X., Tyler, L. A., Ejaz, A. M., Beane, J. D., Polanco, P. M., Huang, H., & Kim, A. C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.11.648429

Pancreatic Cancer Immunotherapy: A Team-Based Approach

Patel, K., Lee, P. P., Weng, J. K., Melstrom, L. G., Raoof, M., Lewis, A., & Chung, V. M. (2025) · Cancer treatment and research · doi:10.1007/978-3-031-97242-3_11

Exploiting TGF-β-mediated Stromal Programming in Homologous Recombination-Deficient Pancreatic CancerPreprint

Roger, É., Mummey, H. M., Zimmer, E., Srinivasan, D., Härle, A., Moubri, L., Beutel, A. K., Singh, R., Ekizce, M., Melzer, M. K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.16.676458

Tumor-intrinsic MHC-II activation in pancreatic ductal adenocarcinoma enhances immune response and treatment efficacyPreprint

Chen, C., Gribbin, K. P., Li, X., Ozmen, T. Y., Ozmen, F., Sivagnanam, S., Kim, J., Blise, K. E., Yang, X., Zhang, Y., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.21.683745

Tissue-Specific Tolerance Mechanisms and Lymph Node Co-Drainage Converge To Shape T Cell Immunity in the Upper Digestive System and Regulate Pancreatic Cancer ProgressionPreprint

Zhou, Y. D., Wang, Z. P., Schaffer, E., Komnick, M. R., Brown, H. M., Taylor, G. M., Fiske, K. L., Sheehan, C. S., Dermody, T. S., Muir, A., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5930562

IGFBPs define distinct pro-tumorigenic CAF subtypes in lung cancer tumour-microenvironmentPreprint

Yengkhom, G., Nandgaonkar, K. K., Ramanathan, S., Schlegel, J. A., Dong, M., Thorat, R. A., Kumar, R., Yadav, S. C., Prabhash, K., & Arandkar, S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.03.692056

Multi-stromal organoid co-cultures model pancreatic cancer and pancreatitis epithelial cell-fibroblast heterogeneityPreprint

Li, W., Jihad, M., Lloyd, E. G., Mucciolo, G., Henríquez, J. A., Zaccaria, M., Cheng, P. S. W., Harish, S., Mills, S., Johnson, P. M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.05.692494

Additional file 1 of Integrative analysis of spatial and single-cell transcriptome data from human pancreatic cancer reveals an intermediate cancer cell population associated with poor prognosis

Kim, S., Leem, G., Choi, J., Koh, Y., Lee, S., Nam, S.-H., Kim, J. S., Park, C. H., Hwang, H. K., Min, K. I., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25123881

Additional file 1 of Association between high expression of intratumoral fibroblast activation protein and survival in patients with intrahepatic cholangiocarcinoma

Waki, Y., Morine, Y., Noma, T., Takasu, C., Teraoku, H., Yamada, S., Saito, Y., Ikemoto, T., & Shimada, M. (2023) · Figshare · doi:10.6084/m9.figshare.24655835

Additional file 3 of Integrative analysis of spatial and single-cell transcriptome data from human pancreatic cancer reveals an intermediate cancer cell population associated with poor prognosis

Kim, S., Leem, G., Choi, J., Koh, Y., Lee, S., Nam, S.-H., Kim, J. S., Park, C. H., Hwang, H. K., Min, K. I., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26675240

Additional file 2 of Integrative analysis of spatial and single-cell transcriptome data from human pancreatic cancer reveals an intermediate cancer cell population associated with poor prognosis

Kim, S., Leem, G., Choi, J., Koh, Y., Lee, S., Nam, S.-H., Kim, J. S., Park, C. H., Hwang, H. K., Min, K. I., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25124095

Additional file 1 of PRRX1-OLR1 axis supports CAFs-mediated lung cancer progression and immune suppression

Sun, Y., Ying, K., Sun, J., Wang, Y., Qiu, L., Ji, M., Sun, L., & Chen, J. (2024) · Figshare · doi:10.6084/m9.figshare.26308973

Additional file 1 of Colorectal carcinoma peritoneal metastases-derived organoids: results and perspective of a model for tailoring hyperthermic intraperitoneal chemotherapy from bench-to-bedside

Varinelli, L., Battistessa, D., Guagliò, M., Zanutto, S., Illescas, O., Lorenc, E., Pisati, F., D, S. K. M., Cattaneo, L., Sabella, G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25744371

Research progress on the influence of tumor microenvironment on immunotherapy for pancreatic ductal adenocarcinoma

Yuntao, Y. A. N. G., Zhang, Y., Shen, Z., Chen, S., Zhang, Y., & Wang, X. (2026) · Open Medicine · doi:10.1515/med-2025-1323 · Cited by 1

Transforming role of cancer associated fibroblasts: From therapeutic barriers to promising targets

Chang, J., Yu, X., Xiong, N., Zhu, M., Yang, C., Zhao, Wang, C., Wang, S., Ye, Y., & Shen, Z. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105143

CMTM6-Silencing Microbial Immunotherapy Reprograms PDAC Tumors and Restores T-cell FunctionPreprint

Chabu, C. Y., Kazmierczak, R. A., Hasani, M., Patterson, N., Wang, Q., Canti, L., Tesfay, M. Z., Cios, A., Dhagat-Mehta, B., Pastor, M. Q., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.26.701790

ARNTL deregulation promotes ovarian cancer progression and metastasis by activating cancer-associated fibroblasts

Zhang, Y., Lin, J., Liu, N., Chen, W., Zhang, L., Yuan, H., & Chen, Y. (2026) · Journal of Ovarian Research · doi:10.1186/s13048-026-02044-7 · Cited by 1

TWIST1 mediated transcriptional activation of SPON2 drives colorectal cancer peritoneal metastasis through stromal cell signaling network

Zhou, Z., Ferlita, A. L., Palavalli, M. H., Chen, X., Tyler, L. A., Ejaz, A. M., Beane, J. D., Polanco, P. M., Huang, H., & Kim, A. C. (2026) · Oncogene · doi:10.1038/s41388-026-03743-7

Role of the stromal microenvironment in PDAC and resistance to therapies

Ode, A. (2024) · theses.fr (ABES) · doi:10.70675/0452e0e9z98e8z47d9za007zd4b472926aab

Cancer associated fibroblasts stimulate cancer resistance to therapy

Zajac, O. (2024) · theses.fr (ABES) · doi:10.70675/62ded90az3604z4c61zb521z8878a12ed0d9

Stroma-nerve axis in pancreatic ductal adenocarcinoma: Bidirectional regulatory mechanisms and clinical translation hypothesis

Yu, Y.-N., Jin, S.-Q., Lu, Y.-T., & Han, L.-Z. (2026) · World Journal of Clinical Oncology · doi:10.5306/wjco.v17.i4.117197

Tissue-specific tolerance mechanisms and lymph node co-drainage shape T cell immunity in the upper digestive system and pancreatic cancer progression

Zhou, Y. D., Wang, P., Schaffer, E., Komnick, M. R., Brown, H. M., Taylor, G. M., Fiske, K. L., Sheehan, C., Dermody, T. S., Muir, A., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117324

The resilient subset: cancer stem cells at the core of immunotherapy resistance

Gajón, J. A., Esperante, D., Ko, N., Jimenez-Miranda, A., Muñoz-Cruz, S., Fuentes‐Pananá, E. M., & Bonifaz, L. C. (2025) · Immunotherapy Advances · doi:10.1093/immadv/ltag006

From guardians to traitors: molecular mechanisms of tumor-induced T cell betrayal

Ye, P., 匡洪宇, Lin, A., Tang, B., Wang, Q., Zhang, H., Wong, H. Z. H., Zhang, J., Cheng, Q., Glaviano, A., et al. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02669-8

Cancer‐Associated Fibroblasts: Central Players in the Plastic Pancreatic Cancer Microenvironment and Therapeutic Targeting

Qin, Z., Ma, J., Jü, R., & Guo, L. (2026) · Organ medicine. · doi:10.1002/orm2.70044

The clinical ionizable lipid SM-102 enhances photochemical immunogenic cell death by verteporfin-conjugated liposomes and improves survival in vivo

Shah, N., Quaye, M. B., Sudula, B., Kulkarni, N., Upreti, A., Malkoochi, A., Aileni, T. R., Karambelkar, K., Peterson, A., Mahmoud, D., et al. (2026) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-026-00909-w

Emerging concepts, hot topics, and open questions in today’s pancreatic cancer research

Keber, C. U., Schmitt, M., Visekruna, A., Brichkina, A. I., von Strandmann, E. P., Bartsch, J. W., Huber, M., Bauer, U., Gress, T. M., & Lauth, M. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189614

Abstract C078: Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer

Huang, H., Wang, Z., Zhang, Y., Pradhan, R., Ganguly, D., Chandra, R., Murimwa, G. Z., Wright, S., Gu, X., Maddipati, R., et al. (2022) · Cancer Research · doi:10.1158/1538-7445.panca22-c078 · Cited by 2

Antigen-presenting cancer-associated fibroblasts in pancreatic ductal adenocarcinoma differentially regulate Treg phenotype and function via CXCL9 and CCL22 3293

Maru, S. Y., Mitchell, J. T., Wetzel, M., Groß, N., Andaloori, L., Howe, K., Kartalia, E., Mo, G., Leatherman, J. M., Ho, W. J., et al. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf283.1109

Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially control regulatory T cell phenotype and function via CXCL9 and CCL22Preprint

Maru, S. Y., Wetzel, M., Mitchell, J. T., Groß, N., Andaloori, L., Howe, K., Kartalia, E., Mo, G., Leatherman, J. M., Ho, W. J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.27.645833 · Cited by 4

Abstract 2577: Antigen-presenting CAFs in PDAC differentially regulate Treg phenotype and function via CXCL9 and CCL22

Maru, S. Y., Mitchell, J. T., Wetzel, M., Groß, N., Andaloori, L., Howe, K., Kartalia, E., Mo, G., Leatherman, J. M., Ho, W. J., et al. (2025) · Cancer Research · doi:10.1158/1538-7445.am2025-2577

Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially regulate T-cell phenotype and function

Maru, S. Y., Wetzel, M., Mitchell, J. T., Groß, N., Andaloori, L., Howe, K. L., Kartalia, E., Mo, G., Leatherman, J., Ho, W. J., et al. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkag165